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Entry version 142 (13 Nov 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Zinc finger protein 622

Gene

ZNF622

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri4 – 28U1-type 1Add BLAST25
Zinc fingeri67 – 91U1-type 2Add BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q969S3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 622
Alternative name(s):
Zinc finger-like protein 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF622
Synonyms:ZPR9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30958 ZNF622

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608694 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969S3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000173545

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134992557

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q969S3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF622

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50401777

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001918152 – 477Zinc finger protein 622Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei276PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q969S3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q969S3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q969S3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q969S3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969S3

PeptideAtlas

More...
PeptideAtlasi
Q969S3

PRoteomics IDEntifications database

More...
PRIDEi
Q969S3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75831

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969S3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969S3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173545 Expressed in 199 organ(s), highest expression level in left ventricle myocardium

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969S3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036514
HPA036515

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homo- and heterodimer.

Interacts with MELK and MYBL2 (PubMed:11802789, PubMed:12645566).

Interacts with DNAJC21 (PubMed:27346687).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9968314EBI-2687480,EBI-476263

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124717, 62 interactors

Protein interaction database and analysis system

More...
IntActi
Q969S3, 30 interactors

Molecular INTeraction database

More...
MINTi
Q969S3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310042

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi195 – 242Glu-richAdd BLAST48
Compositional biasi199 – 203Poly-Glu5
Compositional biasi236 – 242Poly-Glu7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 28U1-type 1Add BLAST25
Zinc fingeri67 – 91U1-type 2Add BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2785 Eukaryota
ENOG410XPH0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018047

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000183078

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969S3

KEGG Orthology (KO)

More...
KOi
K14816

Identification of Orthologs from Complete Genome Data

More...
OMAi
VANYFIC

Database of Orthologous Groups

More...
OrthoDBi
1383726at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969S3

TreeFam database of animal gene trees

More...
TreeFami
TF313094

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR041661 ZN622/Rei1/Reh1_Znf-C2H2
IPR040025 Znf622/Rei1/Reh1
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR13182 PTHR13182, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12756 zf-C2H2_2, 1 hit
PF12171 zf-C2H2_jaz, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 4 hits
SM00451 ZnF_U1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q969S3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATYTCITCR VAFRDADMQR AHYKTDWHRY NLRRKVASMA PVTAEGFQER
60 70 80 90 100
VRAQRAVAEE ESKGSATYCT VCSKKFASFN AYENHLKSRR HVELEKKAVQ
110 120 130 140 150
AVNRKVEMMN EKNLEKGLGV DSVDKDAMNA AIQQAIKAQP SMSPKKAPPA
160 170 180 190 200
PAKEARNVVA VGTGGRGTHD RDPSEKPPRL QWFEQQAKKL AKQQEEDSEE
210 220 230 240 250
EEEDLDGDDW EDIDSDEELE CEDTEAMDDV VEQDAEEEEA EEGPPLGAIP
260 270 280 290 300
ITDCLFCSHH SSSLMKNVAH MTKDHSFFIP DIEYLSDIKG LIKYLGEKVG
310 320 330 340 350
VGKICLWCNE KGKSFYSTEA VQAHMNDKSH CKLFTDGDAA LEFADFYDFR
360 370 380 390 400
SSYPDHKEGE DPNKAEELPS EKNLEYDDET MELILPSGAR VGHRSLMRYY
410 420 430 440 450
KQRFGLSRAV AVAKNRKAVG RVLQQYRALG WTGSTGAALM RERDMQYVQR
460 470
MKSKWMLKTG MKNNATKQMH FRVQVRF
Length:477
Mass (Da):54,272
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88E75FAEAB46C62B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY046059 mRNA Translation: AAL02121.1
BC008752 mRNA Translation: AAH08752.1
BC010545 mRNA Translation: AAH10545.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3886.1

NCBI Reference Sequences

More...
RefSeqi
NP_219482.1, NM_033414.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308683; ENSP00000310042; ENSG00000173545

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
90441

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:90441

UCSC genome browser

More...
UCSCi
uc003jfq.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046059 mRNA Translation: AAL02121.1
BC008752 mRNA Translation: AAH08752.1
BC010545 mRNA Translation: AAH10545.1
CCDSiCCDS3886.1
RefSeqiNP_219482.1, NM_033414.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124717, 62 interactors
IntActiQ969S3, 30 interactors
MINTiQ969S3
STRINGi9606.ENSP00000310042

PTM databases

iPTMnetiQ969S3
PhosphoSitePlusiQ969S3

Polymorphism and mutation databases

BioMutaiZNF622
DMDMi50401777

Proteomic databases

EPDiQ969S3
jPOSTiQ969S3
MassIVEiQ969S3
MaxQBiQ969S3
PaxDbiQ969S3
PeptideAtlasiQ969S3
PRIDEiQ969S3
ProteomicsDBi75831

Genome annotation databases

EnsembliENST00000308683; ENSP00000310042; ENSG00000173545
GeneIDi90441
KEGGihsa:90441
UCSCiuc003jfq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90441

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF622
HGNCiHGNC:30958 ZNF622
HPAiHPA036514
HPA036515
MIMi608694 gene
neXtProtiNX_Q969S3
OpenTargetsiENSG00000173545
PharmGKBiPA134992557

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2785 Eukaryota
ENOG410XPH0 LUCA
GeneTreeiENSGT00390000018047
HOGENOMiHOG000183078
InParanoidiQ969S3
KOiK14816
OMAiVANYFIC
OrthoDBi1383726at2759
PhylomeDBiQ969S3
TreeFamiTF313094

Enzyme and pathway databases

SIGNORiQ969S3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF622 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
90441
PharosiQ969S3

Protein Ontology

More...
PROi
PR:Q969S3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173545 Expressed in 199 organ(s), highest expression level in left ventricle myocardium
GenevisibleiQ969S3 HS

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR041661 ZN622/Rei1/Reh1_Znf-C2H2
IPR040025 Znf622/Rei1/Reh1
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR13182 PTHR13182, 1 hit
PfamiView protein in Pfam
PF12756 zf-C2H2_2, 1 hit
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SM00451 ZnF_U1, 2 hits
SUPFAMiSSF57667 SSF57667, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN622_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969S3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: November 13, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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