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Protein

Zinc finger protein 622

Gene

ZNF622

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 28U1-type 1Add BLAST25
Zinc fingeri67 – 91U1-type 2Add BLAST25

GO - Molecular functioni

GO - Biological processi

  • intrinsic apoptotic signaling pathway in response to oxidative stress Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of JNK cascade Source: UniProtKB
  • positive regulation of kinase activity Source: UniProtKB
  • positive regulation of MAPK cascade Source: UniProtKB
  • ribosomal large subunit biogenesis Source: GO_Central

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ969S3

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 622
Alternative name(s):
Zinc finger-like protein 9
Gene namesi
Name:ZNF622
Synonyms:ZPR9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000173545.4
HGNCiHGNC:30958 ZNF622
MIMi608694 gene
neXtProtiNX_Q969S3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173545
PharmGKBiPA134992557

Polymorphism and mutation databases

BioMutaiZNF622
DMDMi50401777

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001918152 – 477Zinc finger protein 622Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei276PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ969S3
MaxQBiQ969S3
PaxDbiQ969S3
PeptideAtlasiQ969S3
PRIDEiQ969S3
ProteomicsDBi75831

PTM databases

iPTMnetiQ969S3
PhosphoSitePlusiQ969S3

Expressioni

Tissue specificityi

Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.1 Publication

Gene expression databases

BgeeiENSG00000173545
CleanExiHS_ZNF622
GenevisibleiQ969S3 HS

Organism-specific databases

HPAiHPA036514
HPA036515

Interactioni

Subunit structurei

Homo- and heterodimer. Interacts with MELK and MYBL2 (PubMed:11802789, PubMed:12645566). Interacts with DNAJC21 (PubMed:27346687).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAP3K5Q9968314EBI-2687480,EBI-476263

Protein-protein interaction databases

BioGridi124717, 53 interactors
IntActiQ969S3, 22 interactors
MINTiQ969S3
STRINGi9606.ENSP00000310042

Structurei

3D structure databases

ProteinModelPortaliQ969S3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 242Glu-richAdd BLAST48
Compositional biasi199 – 203Poly-Glu5
Compositional biasi236 – 242Poly-Glu7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 28U1-type 1Add BLAST25
Zinc fingeri67 – 91U1-type 2Add BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2785 Eukaryota
ENOG410XPH0 LUCA
GeneTreeiENSGT00390000018047
HOGENOMiHOG000183078
HOVERGENiHBG056035
InParanoidiQ969S3
KOiK14816
OMAiVDKDAMN
OrthoDBiEOG091G0BCO
PhylomeDBiQ969S3
TreeFamiTF313094

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SM00451 ZnF_U1, 2 hits
SUPFAMiSSF57667 SSF57667, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYTCITCR VAFRDADMQR AHYKTDWHRY NLRRKVASMA PVTAEGFQER
60 70 80 90 100
VRAQRAVAEE ESKGSATYCT VCSKKFASFN AYENHLKSRR HVELEKKAVQ
110 120 130 140 150
AVNRKVEMMN EKNLEKGLGV DSVDKDAMNA AIQQAIKAQP SMSPKKAPPA
160 170 180 190 200
PAKEARNVVA VGTGGRGTHD RDPSEKPPRL QWFEQQAKKL AKQQEEDSEE
210 220 230 240 250
EEEDLDGDDW EDIDSDEELE CEDTEAMDDV VEQDAEEEEA EEGPPLGAIP
260 270 280 290 300
ITDCLFCSHH SSSLMKNVAH MTKDHSFFIP DIEYLSDIKG LIKYLGEKVG
310 320 330 340 350
VGKICLWCNE KGKSFYSTEA VQAHMNDKSH CKLFTDGDAA LEFADFYDFR
360 370 380 390 400
SSYPDHKEGE DPNKAEELPS EKNLEYDDET MELILPSGAR VGHRSLMRYY
410 420 430 440 450
KQRFGLSRAV AVAKNRKAVG RVLQQYRALG WTGSTGAALM RERDMQYVQR
460 470
MKSKWMLKTG MKNNATKQMH FRVQVRF
Length:477
Mass (Da):54,272
Last modified:December 1, 2001 - v1
Checksum:i88E75FAEAB46C62B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046059 mRNA Translation: AAL02121.1
BC008752 mRNA Translation: AAH08752.1
BC010545 mRNA Translation: AAH10545.1
CCDSiCCDS3886.1
RefSeqiNP_219482.1, NM_033414.2
UniGeneiHs.60300

Genome annotation databases

EnsembliENST00000308683; ENSP00000310042; ENSG00000173545
GeneIDi90441
KEGGihsa:90441
UCSCiuc003jfq.4 human

Similar proteinsi

Entry informationi

Entry nameiZN622_HUMAN
AccessioniPrimary (citable) accession number: Q969S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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