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UniProtKB - Q969S3 (ZN622_HUMAN)
Protein
Zinc finger protein 622
Gene
ZNF622
Organism
Homo sapiens (Human)
Status
Functioni
May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 4 – 28 | U1-type 1Add BLAST | 25 | |
Zinc fingeri | 67 – 91 | U1-type 2Add BLAST | 25 |
GO - Molecular functioni
- RNA binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- intrinsic apoptotic signaling pathway in response to oxidative stress Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of JNK cascade Source: UniProtKB
- positive regulation of kinase activity Source: UniProtKB
- positive regulation of MAPK cascade Source: UniProtKB
- ribosomal large subunit biogenesis Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q969S3 |
SignaLinki | Q969S3 |
SIGNORi | Q969S3 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 622Alternative name(s): Zinc finger-like protein 9 |
Gene namesi | Name:ZNF622 Synonyms:ZPR9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30958, ZNF622 |
MIMi | 608694, gene |
neXtProti | NX_Q969S3 |
VEuPathDBi | HostDB:ENSG00000173545 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Other locations
- preribosome, large subunit precursor Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 90441 |
OpenTargetsi | ENSG00000173545 |
PharmGKBi | PA134992557 |
Miscellaneous databases
Pharosi | Q969S3, Tbio |
Genetic variation databases
BioMutai | ZNF622 |
DMDMi | 50401777 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000191815 | 2 – 477 | Zinc finger protein 622Add BLAST | 476 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 276 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.1 Publication
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q969S3 |
jPOSTi | Q969S3 |
MassIVEi | Q969S3 |
MaxQBi | Q969S3 |
PaxDbi | Q969S3 |
PeptideAtlasi | Q969S3 |
PRIDEi | Q969S3 |
ProteomicsDBi | 75831 |
PTM databases
iPTMneti | Q969S3 |
MetOSitei | Q969S3 |
PhosphoSitePlusi | Q969S3 |
Expressioni
Tissue specificityi
Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000173545, Expressed in left ventricle myocardium and 215 other tissues |
Genevisiblei | Q969S3, HS |
Organism-specific databases
HPAi | ENSG00000173545, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Q969S3
With | #Exp. | IntAct |
---|---|---|
BEND7 - isoform 2 [Q8N7W2-2] | 3 | EBI-2687480,EBI-10181188 |
MACROH2A1 [O75367] | 3 | EBI-2687480,EBI-2868511 |
MAP3K5 [Q99683] | 14 | EBI-2687480,EBI-476263 |
Protein-protein interaction databases
BioGRIDi | 124717, 106 interactors |
IntActi | Q969S3, 33 interactors |
MINTi | Q969S3 |
STRINGi | 9606.ENSP00000310042 |
Miscellaneous databases
RNActi | Q969S3, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 135 – 212 | DisorderedSequence analysisAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 196 – 212 | Acidic residuesSequence analysisAdd BLAST | 17 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 4 – 28 | U1-type 1Add BLAST | 25 | |
Zinc fingeri | 67 – 91 | U1-type 2Add BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2785, Eukaryota |
GeneTreei | ENSGT00390000018047 |
HOGENOMi | CLU_018787_0_2_1 |
InParanoidi | Q969S3 |
OMAi | YAEYYDY |
OrthoDBi | 1383726at2759 |
PhylomeDBi | Q969S3 |
TreeFami | TF313094 |
Family and domain databases
InterProi | View protein in InterPro IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR041661, ZN622/Rei1/Reh1_Znf-C2H2 IPR040025, Znf622/Rei1/Reh1 IPR022755, Znf_C2H2_jaz IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR13182, PTHR13182, 1 hit |
Pfami | View protein in Pfam PF12756, zf-C2H2_2, 1 hit PF12171, zf-C2H2_jaz, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits SM00451, ZnF_U1, 2 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q969S3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATYTCITCR VAFRDADMQR AHYKTDWHRY NLRRKVASMA PVTAEGFQER
60 70 80 90 100
VRAQRAVAEE ESKGSATYCT VCSKKFASFN AYENHLKSRR HVELEKKAVQ
110 120 130 140 150
AVNRKVEMMN EKNLEKGLGV DSVDKDAMNA AIQQAIKAQP SMSPKKAPPA
160 170 180 190 200
PAKEARNVVA VGTGGRGTHD RDPSEKPPRL QWFEQQAKKL AKQQEEDSEE
210 220 230 240 250
EEEDLDGDDW EDIDSDEELE CEDTEAMDDV VEQDAEEEEA EEGPPLGAIP
260 270 280 290 300
ITDCLFCSHH SSSLMKNVAH MTKDHSFFIP DIEYLSDIKG LIKYLGEKVG
310 320 330 340 350
VGKICLWCNE KGKSFYSTEA VQAHMNDKSH CKLFTDGDAA LEFADFYDFR
360 370 380 390 400
SSYPDHKEGE DPNKAEELPS EKNLEYDDET MELILPSGAR VGHRSLMRYY
410 420 430 440 450
KQRFGLSRAV AVAKNRKAVG RVLQQYRALG WTGSTGAALM RERDMQYVQR
460 470
MKSKWMLKTG MKNNATKQMH FRVQVRF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY046059 mRNA Translation: AAL02121.1 BC008752 mRNA Translation: AAH08752.1 BC010545 mRNA Translation: AAH10545.1 |
CCDSi | CCDS3886.1 |
RefSeqi | NP_219482.1, NM_033414.2 |
Genome annotation databases
Ensembli | ENST00000308683; ENSP00000310042; ENSG00000173545 |
GeneIDi | 90441 |
KEGGi | hsa:90441 |
MANE-Selecti | ENST00000308683.3; ENSP00000310042.2; NM_033414.3; NP_219482.1 |
UCSCi | uc003jfq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY046059 mRNA Translation: AAL02121.1 BC008752 mRNA Translation: AAH08752.1 BC010545 mRNA Translation: AAH10545.1 |
CCDSi | CCDS3886.1 |
RefSeqi | NP_219482.1, NM_033414.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6LQM | electron microscopy | 3.09 | 0 | 1-477 | [»] | |
6LSR | electron microscopy | 3.13 | 0 | 1-477 | [»] | |
SMRi | Q969S3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124717, 106 interactors |
IntActi | Q969S3, 33 interactors |
MINTi | Q969S3 |
STRINGi | 9606.ENSP00000310042 |
PTM databases
iPTMneti | Q969S3 |
MetOSitei | Q969S3 |
PhosphoSitePlusi | Q969S3 |
Genetic variation databases
BioMutai | ZNF622 |
DMDMi | 50401777 |
Proteomic databases
EPDi | Q969S3 |
jPOSTi | Q969S3 |
MassIVEi | Q969S3 |
MaxQBi | Q969S3 |
PaxDbi | Q969S3 |
PeptideAtlasi | Q969S3 |
PRIDEi | Q969S3 |
ProteomicsDBi | 75831 |
Protocols and materials databases
Antibodypediai | 22565, 167 antibodies from 22 providers |
DNASUi | 90441 |
Genome annotation databases
Ensembli | ENST00000308683; ENSP00000310042; ENSG00000173545 |
GeneIDi | 90441 |
KEGGi | hsa:90441 |
MANE-Selecti | ENST00000308683.3; ENSP00000310042.2; NM_033414.3; NP_219482.1 |
UCSCi | uc003jfq.4, human |
Organism-specific databases
CTDi | 90441 |
DisGeNETi | 90441 |
GeneCardsi | ZNF622 |
HGNCi | HGNC:30958, ZNF622 |
HPAi | ENSG00000173545, Low tissue specificity |
MIMi | 608694, gene |
neXtProti | NX_Q969S3 |
OpenTargetsi | ENSG00000173545 |
PharmGKBi | PA134992557 |
VEuPathDBi | HostDB:ENSG00000173545 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2785, Eukaryota |
GeneTreei | ENSGT00390000018047 |
HOGENOMi | CLU_018787_0_2_1 |
InParanoidi | Q969S3 |
OMAi | YAEYYDY |
OrthoDBi | 1383726at2759 |
PhylomeDBi | Q969S3 |
TreeFami | TF313094 |
Enzyme and pathway databases
PathwayCommonsi | Q969S3 |
SignaLinki | Q969S3 |
SIGNORi | Q969S3 |
Miscellaneous databases
BioGRID-ORCSi | 90441, 119 hits in 1051 CRISPR screens |
ChiTaRSi | ZNF622, human |
GenomeRNAii | 90441 |
Pharosi | Q969S3, Tbio |
PROi | PR:Q969S3 |
RNActi | Q969S3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173545, Expressed in left ventricle myocardium and 215 other tissues |
Genevisiblei | Q969S3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR041661, ZN622/Rei1/Reh1_Znf-C2H2 IPR040025, Znf622/Rei1/Reh1 IPR022755, Znf_C2H2_jaz IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR13182, PTHR13182, 1 hit |
Pfami | View protein in Pfam PF12756, zf-C2H2_2, 1 hit PF12171, zf-C2H2_jaz, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits SM00451, ZnF_U1, 2 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN622_HUMAN | |
Accessioni | Q969S3Primary (citable) accession number: Q969S3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references