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Protein

Endonuclease 8-like 2

Gene

NEIL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.PROSITE-ProRule annotation EC:4.2.99.18

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Acetylation of Lys-50 leads to loss of DNA nicking activity. Acetylation of Lys-154 has no effect.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2Schiff-base intermediate with DNACurated1
Active sitei3Proton donorCurated1
Active sitei50Proton donor; for beta-elimination activityCurated1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei231DNABy similarity1
Active sitei310Proton donor; for delta-elimination activityCurated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri284 – 320FPG-typePROSITE-ProRule annotationAdd BLAST37

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Glycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA repair
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.2.23 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329 Cleavage of the damaged pyrimidine
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endonuclease 8-like 2 (EC:3.2.2.-, EC:4.2.99.18)
Alternative name(s):
DNA glycosylase/AP lyase Neil2
DNA-(apurinic or apyrimidinic site) lyase Neil2
Endonuclease VIII-like 2
Nei homolog 2
Short name:
NEH2
Nei-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEIL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000154328.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18956 NEIL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608933 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969S2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi50K → R: Loss of glycosylase and AP lyase activity. 2 Publications1
Mutagenesisi154K → R: No effect on glycosylase and AP lyase activity. 1 Publication1
Mutagenesisi291C → S: Loss of glycosylase and AP lyase activity. 1 Publication1
Mutagenesisi295H → A: Loss of glycosylase and AP lyase activity. 1 Publication1
Mutagenesisi310R → Q: Strongly reduces strand AP lyase activity. 1 Publication1
Mutagenesisi315C → S: Loss of glycosylase and AP lyase activity. 1 Publication1
Mutagenesisi318C → S: Loss of glycosylase and AP lyase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
252969

Open Targets

More...
OpenTargetsi
ENSG00000154328

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38769

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NEIL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56404653

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001709082 – 332Endonuclease 8-like 2Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50N6-acetyllysine1 Publication1
Modified residuei68PhosphoserineCombined sources1
Modified residuei154N6-acetyllysine1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q969S2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q969S2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969S2

PeptideAtlas

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PeptideAtlasi
Q969S2

PRoteomics IDEntifications database

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PRIDEi
Q969S2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75827
75828 [Q969S2-2]
75829 [Q969S2-3]
75830 [Q969S2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q969S2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q969S2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000154328 Expressed in 183 organ(s), highest expression level in female gonad

CleanEx database of gene expression profiles

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CleanExi
HS_NEIL2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q969S2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q969S2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA073029
HPA073916

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds EP300.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
128946, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q969S2

Protein interaction database and analysis system

More...
IntActi
Q969S2, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000284503

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q969S2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The zinc-finger domain is important for DNA binding.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FPG family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri284 – 320FPG-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJ89 Eukaryota
ENOG4112BNS LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153230

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000069913

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG082014

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q969S2

KEGG Orthology (KO)

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KOi
K10568

Identification of Orthologs from Complete Genome Data

More...
OMAi
SIWVNEF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0G2K

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969S2

TreeFam database of animal gene trees

More...
TreeFami
TF331502

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015886 DNA_glyclase/AP_lyase_DNA-bd
IPR012319 FPG_cat
IPR010979 Ribosomal_S13-like_H2TH
IPR000214 Znf_DNA_glyclase/AP_lyase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06831 H2TH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01232 H2TH, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46946 SSF46946, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51068 FPG_CAT, 1 hit
PS51066 ZF_FPG_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969S2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEGPLVRKF HHLVSPFVGQ QVVKTGGSSK KLQPASLQSL WLQDTQVHGK
60 70 80 90 100
KLFLRFDLDE EMGPPGSSPT PEPPQKEVQK EGAADPKQVG EPSGQKTLDG
110 120 130 140 150
SSRSAELVPQ GEDDSEYLER DAPAGDAGRW LRVSFGLFGS VWVNDFSRAK
160 170 180 190 200
KANKRGDWRD PSPRLVLHFG GGGFLAFYNC QLSWSSSPVV TPTCDILSEK
210 220 230 240 250
FHRGQALEAL GQAQPVCYTL LDQRYFSGLG NIIKNEALYR AGIHPLSLGS
260 270 280 290 300
VLSASRREVL VDHVVEFSTA WLQGKFQGRP QHTQVYQKEQ CPAGHQVMKE
310 320 330
AFGPEDGLQR LTWWCPQCQP QLSEEPEQCQ FS
Length:332
Mass (Da):36,826
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A8E76B75ABADE6D
GO
Isoform 2 (identifier: Q969S2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-94: Missing.

Note: No experimental confirmation available.
Show »
Length:316
Mass (Da):35,247
Checksum:i3183DDC0C41936DC
GO
Isoform 3 (identifier: Q969S2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):29,930
Checksum:iA23E2B89F5256AE6
GO
Isoform 4 (identifier: Q969S2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-163: Missing.

Note: No experimental confirmation available.
Show »
Length:216
Mass (Da):24,136
Checksum:i250E84C5B5DAF3CB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PPL4E9PPL4_HUMAN
Endonuclease 8-like 2
NEIL2
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02058570T → S1 PublicationCorresponds to variant dbSNP:rs8191611Ensembl.1
Natural variantiVAR_020586103R → Q2 PublicationsCorresponds to variant dbSNP:rs8191613Ensembl.1
Natural variantiVAR_020587103R → W1 PublicationCorresponds to variant dbSNP:rs8191612Ensembl.1
Natural variantiVAR_020588257R → L1 PublicationCorresponds to variant dbSNP:rs8191664Ensembl.1
Natural variantiVAR_020589304P → T1 PublicationCorresponds to variant dbSNP:rs8191666Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0122081 – 61Missing in isoform 3. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_04334348 – 163Missing in isoform 4. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_01220979 – 94Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB079070 mRNA Translation: BAC06478.1
AK056206 mRNA Translation: BAB71120.1
AK097389 mRNA Translation: BAC05030.1
AK294224 mRNA Translation: BAG57528.1
BX537529 mRNA Translation: CAD97774.1
AY306127 Genomic DNA Translation: AAP45052.1
AC069185 Genomic DNA No translation available.
BC013952 mRNA Translation: AAH13952.1
BC013964 mRNA Translation: AAH13964.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47802.1 [Q969S2-4]
CCDS47803.1 [Q969S2-3]
CCDS5984.1 [Q969S2-1]

NCBI Reference Sequences

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RefSeqi
NP_001129218.1, NM_001135746.1 [Q969S2-1]
NP_001129219.1, NM_001135747.1 [Q969S2-3]
NP_001129220.1, NM_001135748.1 [Q969S2-4]
NP_659480.1, NM_145043.2 [Q969S2-1]
XP_005272439.1, XM_005272382.2
XP_005272440.1, XM_005272383.2
XP_016868790.1, XM_017013301.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.293818

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000284503; ENSP00000284503; ENSG00000154328 [Q969S2-1]
ENST00000403422; ENSP00000384070; ENSG00000154328 [Q969S2-3]
ENST00000436750; ENSP00000394023; ENSG00000154328 [Q969S2-1]
ENST00000455213; ENSP00000397538; ENSG00000154328 [Q969S2-1]
ENST00000528323; ENSP00000435657; ENSG00000154328 [Q969S2-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
252969

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:252969

UCSC genome browser

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UCSCi
uc003wue.3 human [Q969S2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079070 mRNA Translation: BAC06478.1
AK056206 mRNA Translation: BAB71120.1
AK097389 mRNA Translation: BAC05030.1
AK294224 mRNA Translation: BAG57528.1
BX537529 mRNA Translation: CAD97774.1
AY306127 Genomic DNA Translation: AAP45052.1
AC069185 Genomic DNA No translation available.
BC013952 mRNA Translation: AAH13952.1
BC013964 mRNA Translation: AAH13964.1
CCDSiCCDS47802.1 [Q969S2-4]
CCDS47803.1 [Q969S2-3]
CCDS5984.1 [Q969S2-1]
RefSeqiNP_001129218.1, NM_001135746.1 [Q969S2-1]
NP_001129219.1, NM_001135747.1 [Q969S2-3]
NP_001129220.1, NM_001135748.1 [Q969S2-4]
NP_659480.1, NM_145043.2 [Q969S2-1]
XP_005272439.1, XM_005272382.2
XP_005272440.1, XM_005272383.2
XP_016868790.1, XM_017013301.1
UniGeneiHs.293818

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VZPmodel-A192-319[»]
ProteinModelPortaliQ969S2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128946, 6 interactors
CORUMiQ969S2
IntActiQ969S2, 9 interactors
STRINGi9606.ENSP00000284503

PTM databases

iPTMnetiQ969S2
PhosphoSitePlusiQ969S2

Polymorphism and mutation databases

BioMutaiNEIL2
DMDMi56404653

Proteomic databases

EPDiQ969S2
MaxQBiQ969S2
PaxDbiQ969S2
PeptideAtlasiQ969S2
PRIDEiQ969S2
ProteomicsDBi75827
75828 [Q969S2-2]
75829 [Q969S2-3]
75830 [Q969S2-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
252969
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284503; ENSP00000284503; ENSG00000154328 [Q969S2-1]
ENST00000403422; ENSP00000384070; ENSG00000154328 [Q969S2-3]
ENST00000436750; ENSP00000394023; ENSG00000154328 [Q969S2-1]
ENST00000455213; ENSP00000397538; ENSG00000154328 [Q969S2-1]
ENST00000528323; ENSP00000435657; ENSG00000154328 [Q969S2-4]
GeneIDi252969
KEGGihsa:252969
UCSCiuc003wue.3 human [Q969S2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
252969
DisGeNETi252969
EuPathDBiHostDB:ENSG00000154328.15

GeneCards: human genes, protein and diseases

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GeneCardsi
NEIL2
HGNCiHGNC:18956 NEIL2
HPAiHPA073029
HPA073916
MIMi608933 gene
neXtProtiNX_Q969S2
OpenTargetsiENSG00000154328
PharmGKBiPA38769

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IJ89 Eukaryota
ENOG4112BNS LUCA
GeneTreeiENSGT00940000153230
HOGENOMiHOG000069913
HOVERGENiHBG082014
InParanoidiQ969S2
KOiK10568
OMAiSIWVNEF
OrthoDBiEOG091G0G2K
PhylomeDBiQ969S2
TreeFamiTF331502

Enzyme and pathway databases

BRENDAi3.2.2.23 2681
ReactomeiR-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329 Cleavage of the damaged pyrimidine
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NEIL2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NEIL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
252969

Protein Ontology

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PROi
PR:Q969S2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154328 Expressed in 183 organ(s), highest expression level in female gonad
CleanExiHS_NEIL2
ExpressionAtlasiQ969S2 baseline and differential
GenevisibleiQ969S2 HS

Family and domain databases

InterProiView protein in InterPro
IPR015886 DNA_glyclase/AP_lyase_DNA-bd
IPR012319 FPG_cat
IPR010979 Ribosomal_S13-like_H2TH
IPR000214 Znf_DNA_glyclase/AP_lyase
PfamiView protein in Pfam
PF06831 H2TH, 1 hit
SMARTiView protein in SMART
SM01232 H2TH, 1 hit
SUPFAMiSSF46946 SSF46946, 1 hit
PROSITEiView protein in PROSITE
PS51068 FPG_CAT, 1 hit
PS51066 ZF_FPG_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEIL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969S2
Secondary accession number(s): B4DFR7
, Q7Z3Q7, Q8N842, Q8NG52
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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