UniProtKB - Q969S0 (S35B4_HUMAN)
Protein
UDP-xylose and UDP-N-acetylglucosamine transporter
Gene
SLC35B4
Organism
Homo sapiens (Human)
Status
Functioni
Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.1 Publication
GO - Molecular functioni
- transmembrane transporter activity Source: GO_Central
- UDP-N-acetylglucosamine transmembrane transporter activity Source: UniProtKB
- UDP-xylose transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
- regulation of gluconeogenesis Source: Ensembl
- UDP-N-acetylglucosamine transmembrane transport Source: UniProtKB
- UDP-xylose transmembrane transport Source: UniProtKB
Keywordsi
Biological process | Sugar transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q969S0 |
Reactomei | R-HSA-727802, Transport of nucleotide sugars |
Protein family/group databases
TCDBi | 2.A.7.10.2, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-xylose and UDP-N-acetylglucosamine transporterAlternative name(s): Solute carrier family 35 member B4 YEA4 homolog |
Gene namesi | Name:SLC35B4 Synonyms:YEA4 ORF Names:PSEC0055 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20584, SLC35B4 |
MIMi | 610923, gene |
neXtProti | NX_Q969S0 |
VEuPathDBi | HostDB:ENSG00000205060.10 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: CACAO
- integral component of endoplasmic reticulum membrane Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: Reactome
- integral component of Golgi membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 30 – 50 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 59 – 79 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 153 – 173 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 229 – 249 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 251 – 267 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 268 – 288 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 291 – 311 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 84912 |
OpenTargetsi | ENSG00000205060 |
PharmGKBi | PA134922110 |
Miscellaneous databases
Pharosi | Q969S0, Tbio |
Genetic variation databases
BioMutai | SLC35B4 |
DMDMi | 74751727 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213385 | 1 – 331 | UDP-xylose and UDP-N-acetylglucosamine transporterAdd BLAST | 331 |
Proteomic databases
MassIVEi | Q969S0 |
MaxQBi | Q969S0 |
PaxDbi | Q969S0 |
PeptideAtlasi | Q969S0 |
PRIDEi | Q969S0 |
ProteomicsDBi | 75824 [Q969S0-1] 75825 [Q969S0-2] 75826 [Q969S0-3] |
PTM databases
iPTMneti | Q969S0 |
PhosphoSitePlusi | Q969S0 |
SwissPalmi | Q969S0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000205060, Expressed in middle temporal gyrus and 210 other tissues |
ExpressionAtlasi | Q969S0, baseline and differential |
Genevisiblei | Q969S0, HS |
Organism-specific databases
HPAi | ENSG00000205060, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ969S0
Protein-protein interaction databases
BioGRIDi | 124349, 36 interactors |
IntActi | Q969S0, 33 interactors |
STRINGi | 9606.ENSP00000367770 |
Miscellaneous databases
RNActi | Q969S0, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1583, Eukaryota |
GeneTreei | ENSGT00390000002915 |
HOGENOMi | CLU_033007_1_0_1 |
InParanoidi | Q969S0 |
OMAi | NNYAFDF |
OrthoDBi | 1209974at2759 |
PhylomeDBi | Q969S0 |
TreeFami | TF312926 |
Family and domain databases
InterProi | View protein in InterPro IPR013657, UAA |
Pfami | View protein in Pfam PF08449, UAA, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q969S0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRPALAVGLV FAGCCSNVIF LELLARKHPG CGNIVTFAQF LFIAVEGFLF
60 70 80 90 100
EADLGRKPPA IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS
110 120 130 140 150
LIANMILGII ILKKRYSIFK YTSIALVSVG IFICTFMSAK QVTSQSSLSE
160 170 180 190 200
NDGFQAFVWW LLGIGALTFA LLMSARMGIF QETLYKRFGK HSKEALFYNH
210 220 230 240 250
ALPLPGFVFL ASDIYDHAVL FNKSELYEIP VIGVTLPIMW FYLLMNIITQ
260 270 280 290 300
YVCIRGVFIL TTECASLTVT LVVTLRKFVS LIFSILYFQN PFTLWHWLGT
310 320 330
LFVFIGTLMY TEVWNNLGTT KSEPQKDSKK N
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WAW0 | F8WAW0_HUMAN | UDP-xylose and UDP-N-acetylglucosam... | SLC35B4 | 132 | Annotation score: |
Sequence cautioni
The sequence BAB55325 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 | L → P in BAD96594 (Ref. 6) Curated | 1 | |
Sequence conflicti | 119 | F → S in BAD96594 (Ref. 6) Curated | 1 | |
Sequence conflicti | 179 | I → M in BAD96594 (Ref. 6) Curated | 1 | |
Sequence conflicti | 205 | P → S in BAD96594 (Ref. 6) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016197 | 225 – 231 | ELYEIPV → GEFGVRQ in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_016198 | 232 – 331 | Missing in isoform 2. 1 PublicationAdd BLAST | 100 | |
Alternative sequenceiVSP_016199 | 251 – 253 | YVC → TPT in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_016200 | 254 – 331 | Missing in isoform 3. 1 PublicationAdd BLAST | 78 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ971941 mRNA Translation: CAI98963.1 AB052892 mRNA Translation: BAB61040.1 AJ315497 mRNA Translation: CAC84567.1 AJ315498 mRNA Translation: CAC84568.1 AK027603 mRNA Translation: BAB55225.1 AK027726 mRNA Translation: BAB55325.1 Different initiation. AK075368 mRNA Translation: BAC11573.1 AK222874 mRNA Translation: BAD96594.1 AC008154 Genomic DNA No translation available. CH236950 Genomic DNA Translation: EAL24071.1 CH471070 Genomic DNA Translation: EAW83810.1 BC008413 mRNA Translation: AAH08413.1 |
CCDSi | CCDS34756.1 [Q969S0-1] |
RefSeqi | NP_116215.1, NM_032826.4 [Q969S0-1] |
Genome annotation databases
Ensembli | ENST00000378509; ENSP00000367770; ENSG00000205060 [Q969S0-1] ENST00000470969; ENSP00000485857; ENSG00000205060 [Q969S0-2] |
GeneIDi | 84912 |
KEGGi | hsa:84912 |
UCSCi | uc003vrn.4, human [Q969S0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ971941 mRNA Translation: CAI98963.1 AB052892 mRNA Translation: BAB61040.1 AJ315497 mRNA Translation: CAC84567.1 AJ315498 mRNA Translation: CAC84568.1 AK027603 mRNA Translation: BAB55225.1 AK027726 mRNA Translation: BAB55325.1 Different initiation. AK075368 mRNA Translation: BAC11573.1 AK222874 mRNA Translation: BAD96594.1 AC008154 Genomic DNA No translation available. CH236950 Genomic DNA Translation: EAL24071.1 CH471070 Genomic DNA Translation: EAW83810.1 BC008413 mRNA Translation: AAH08413.1 |
CCDSi | CCDS34756.1 [Q969S0-1] |
RefSeqi | NP_116215.1, NM_032826.4 [Q969S0-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124349, 36 interactors |
IntActi | Q969S0, 33 interactors |
STRINGi | 9606.ENSP00000367770 |
Protein family/group databases
TCDBi | 2.A.7.10.2, the drug/metabolite transporter (dmt) superfamily |
PTM databases
iPTMneti | Q969S0 |
PhosphoSitePlusi | Q969S0 |
SwissPalmi | Q969S0 |
Genetic variation databases
BioMutai | SLC35B4 |
DMDMi | 74751727 |
Proteomic databases
MassIVEi | Q969S0 |
MaxQBi | Q969S0 |
PaxDbi | Q969S0 |
PeptideAtlasi | Q969S0 |
PRIDEi | Q969S0 |
ProteomicsDBi | 75824 [Q969S0-1] 75825 [Q969S0-2] 75826 [Q969S0-3] |
Protocols and materials databases
Antibodypediai | 53731, 34 antibodies |
Genome annotation databases
Ensembli | ENST00000378509; ENSP00000367770; ENSG00000205060 [Q969S0-1] ENST00000470969; ENSP00000485857; ENSG00000205060 [Q969S0-2] |
GeneIDi | 84912 |
KEGGi | hsa:84912 |
UCSCi | uc003vrn.4, human [Q969S0-1] |
Organism-specific databases
CTDi | 84912 |
DisGeNETi | 84912 |
GeneCardsi | SLC35B4 |
HGNCi | HGNC:20584, SLC35B4 |
HPAi | ENSG00000205060, Low tissue specificity |
MIMi | 610923, gene |
neXtProti | NX_Q969S0 |
OpenTargetsi | ENSG00000205060 |
PharmGKBi | PA134922110 |
VEuPathDBi | HostDB:ENSG00000205060.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1583, Eukaryota |
GeneTreei | ENSGT00390000002915 |
HOGENOMi | CLU_033007_1_0_1 |
InParanoidi | Q969S0 |
OMAi | NNYAFDF |
OrthoDBi | 1209974at2759 |
PhylomeDBi | Q969S0 |
TreeFami | TF312926 |
Enzyme and pathway databases
PathwayCommonsi | Q969S0 |
Reactomei | R-HSA-727802, Transport of nucleotide sugars |
Miscellaneous databases
BioGRID-ORCSi | 84912, 6 hits in 992 CRISPR screens |
ChiTaRSi | SLC35B4, human |
GeneWikii | SLC35B4 |
GenomeRNAii | 84912 |
Pharosi | Q969S0, Tbio |
PROi | PR:Q969S0 |
RNActi | Q969S0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000205060, Expressed in middle temporal gyrus and 210 other tissues |
ExpressionAtlasi | Q969S0, baseline and differential |
Genevisiblei | Q969S0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013657, UAA |
Pfami | View protein in Pfam PF08449, UAA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S35B4_HUMAN | |
Accessioni | Q969S0Primary (citable) accession number: Q969S0 Secondary accession number(s): A4D1P3 Q96K33 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families