UniProtKB - Q969R8 (ITFG2_HUMAN)
KICSTOR complex protein ITFG2
ITFG2
Functioni
GO - Biological processi
- cellular response to amino acid starvation Source: UniProtKB
- cellular response to glucose starvation Source: UniProtKB
- germinal center B cell differentiation Source: Ensembl
- negative regulation of TORC1 signaling Source: UniProtKB
- regulation of TOR signaling Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q969R8 |
Reactomei | R-HSA-9639288, Amino acids regulate mTORC1 |
SignaLinki | Q969R8 |
Names & Taxonomyi
Protein namesi | Recommended name: KICSTOR complex protein ITFG2CuratedAlternative name(s): Integrin-alpha FG-GAP repeat-containing protein 2Imported |
Gene namesi | Name:ITFG2Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30879, ITFG2 |
MIMi | 617421, gene |
neXtProti | NX_Q969R8 |
VEuPathDBi | HostDB:ENSG00000111203.11 |
Subcellular locationi
Lysosome
- Lysosome membrane 1 Publication
Note: Localization to lysosomes is amino acid-independent.1 Publication
Cytosol
- cytosol Source: Ensembl
Lysosome
- lysosomal membrane Source: UniProtKB
Nucleus
- nucleoplasm Source: Ensembl
Other locations
- KICSTOR complex Source: UniProtKB
Keywords - Cellular componenti
Lysosome, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000111203 |
PharmGKBi | PA143485507 |
Miscellaneous databases
Pharosi | Q969R8, Tbio |
Genetic variation databases
BioMutai | ITFG2 |
DMDMi | 74731058 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000289292 | 1 – 447 | KICSTOR complex protein ITFG2Add BLAST | 447 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 104 | PhosphoserineCombined sources | 1 | |
Modified residuei | 220 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q969R8 |
jPOSTi | Q969R8 |
MassIVEi | Q969R8 |
MaxQBi | Q969R8 |
PaxDbi | Q969R8 |
PeptideAtlasi | Q969R8 |
PRIDEi | Q969R8 |
ProteomicsDBi | 67246 75823 [Q969R8-1] |
PTM databases
iPTMneti | Q969R8 |
PhosphoSitePlusi | Q969R8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111203, Expressed in sural nerve and 214 other tissues |
ExpressionAtlasi | Q969R8, baseline and differential |
Genevisiblei | Q969R8, HS |
Organism-specific databases
HPAi | ENSG00000111203, Low tissue specificity |
Interactioni
Subunit structurei
Part of the KICSTOR complex composed of KPTN, ITFG2, C12orf66 and SZT2. SZT2 probably serves as a link between the other three proteins in the KICSTOR complex and may mediate the direct interaction with the GATOR complex via GATOR1. The KICSTOR complex interacts directly with the GATOR1 complex and most probably indirectly with the GATOR2 complexe in an amino acid-independent manner.
1 PublicationProtein-protein interaction databases
BioGRIDi | 120948, 19 interactors |
CORUMi | Q969R8 |
IntActi | Q969R8, 14 interactors |
STRINGi | 9606.ENSP00000228799 |
Miscellaneous databases
RNActi | Q969R8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 19 – 48 | FG-GAP 1; atypicalAdd BLAST | 30 | |
Repeati | 126 – 155 | FG-GAP 2; atypicalAdd BLAST | 30 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QUBC, Eukaryota |
GeneTreei | ENSGT00390000005378 |
HOGENOMi | CLU_021730_0_0_1 |
InParanoidi | Q969R8 |
OMAi | CKEGKNS |
PhylomeDBi | Q969R8 |
TreeFami | TF329010 |
Family and domain databases
InterProi | View protein in InterPro IPR031793, KICSTOR_ITFG2 IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR16317, PTHR16317, 1 hit |
Pfami | View protein in Pfam PF15907, Itfg2, 1 hit |
SUPFAMi | SSF50978, SSF50978, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRSVSYVQRV ALEFSGSLFP HAICLGDVDN DTLNELVVGD TSGKVSVYKN
60 70 80 90 100
DDSRPWLTCS CQGMLTCVGV GDVCNKGKNL LVAVSAEGWF HLFDLTPAKV
110 120 130 140 150
LDASGHHETL IGEEQRPVFK QHIPANTKVM LISDIDGDGC RELVVGYTDR
160 170 180 190 200
VVRAFRWEEL GEGPEHLTGQ LVSLKKWMLE GQVDSLSVTL GPLGLPELMV
210 220 230 240 250
SQPGCAYAIL LCTWKKDTGS PPASEGPTDG SRETPAARDV VLHQTSGRIH
260 270 280 290 300
NKNVSTHLIG NIKQGHGTES SGSGLFALCT LDGTLKLMEE MEEADKLLWS
310 320 330 340 350
VQVDHQLFAL EKLDVTGNGH EEVVACAWDG QTYIIDHNRT VVRFQVDENI
360 370 380 390 400
RAFCAGLYAC KEGRNSPCLV YVTFNQKIYV YWEVQLERME STNLVKLLET
410 420 430 440
KPEYHSLLQE LGVDPDDLPV TRALLHQTLY HPDQPPQCAP SSLQDPT
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YGR0 | H0YGR0_HUMAN | KICSTOR complex protein ITFG2 | ITFG2 | 59 | Annotation score: | ||
H0YG72 | H0YG72_HUMAN | KICSTOR complex protein ITFG2 | ITFG2 | 57 | Annotation score: | ||
F5H1D0 | F5H1D0_HUMAN | Integrin alpha FG-GAP repeat contai... | ITFG2 | 56 | Annotation score: | ||
H0YFM4 | H0YFM4_HUMAN | KICSTOR complex protein ITFG2 | ITFG2 | 131 | Annotation score: | ||
A0A2R8Y7E0 | A0A2R8Y7E0_HUMAN | KICSTOR complex protein ITFG2 | ITFG2 | 49 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 68 | V → A in BAB55145 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055985 | 136 – 147 | DGDGC…LVVGY → GGHAYLCRQPGE in isoform 2. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_055986 | 148 – 447 | Missing in isoform 2. 1 PublicationAdd BLAST | 300 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY599883 mRNA Translation: AAT09136.1 AK027483 mRNA Translation: BAB55145.1 AK291110 mRNA Translation: BAF83799.1 AC005841 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88886.1 CH471116 Genomic DNA Translation: EAW88887.1 BC006552 mRNA Translation: AAH06552.1 BC013399 mRNA Translation: AAH13399.1 |
CCDSi | CCDS8513.1 [Q969R8-1] |
RefSeqi | NP_060933.3, NM_018463.3 [Q969R8-1] |
Genome annotation databases
Ensembli | ENST00000228799; ENSP00000228799; ENSG00000111203 [Q969R8-1] ENST00000540929; ENSP00000443329; ENSG00000111203 [Q969R8-2] ENST00000644517; ENSP00000496068; ENSG00000111203 [Q969R8-2] |
GeneIDi | 55846 |
KEGGi | hsa:55846 |
UCSCi | uc001qlb.3, human [Q969R8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY599883 mRNA Translation: AAT09136.1 AK027483 mRNA Translation: BAB55145.1 AK291110 mRNA Translation: BAF83799.1 AC005841 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88886.1 CH471116 Genomic DNA Translation: EAW88887.1 BC006552 mRNA Translation: AAH06552.1 BC013399 mRNA Translation: AAH13399.1 |
CCDSi | CCDS8513.1 [Q969R8-1] |
RefSeqi | NP_060933.3, NM_018463.3 [Q969R8-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120948, 19 interactors |
CORUMi | Q969R8 |
IntActi | Q969R8, 14 interactors |
STRINGi | 9606.ENSP00000228799 |
PTM databases
iPTMneti | Q969R8 |
PhosphoSitePlusi | Q969R8 |
Genetic variation databases
BioMutai | ITFG2 |
DMDMi | 74731058 |
Proteomic databases
EPDi | Q969R8 |
jPOSTi | Q969R8 |
MassIVEi | Q969R8 |
MaxQBi | Q969R8 |
PaxDbi | Q969R8 |
PeptideAtlasi | Q969R8 |
PRIDEi | Q969R8 |
ProteomicsDBi | 67246 75823 [Q969R8-1] |
Protocols and materials databases
Antibodypediai | 22171, 250 antibodies |
DNASUi | 55846 |
Genome annotation databases
Ensembli | ENST00000228799; ENSP00000228799; ENSG00000111203 [Q969R8-1] ENST00000540929; ENSP00000443329; ENSG00000111203 [Q969R8-2] ENST00000644517; ENSP00000496068; ENSG00000111203 [Q969R8-2] |
GeneIDi | 55846 |
KEGGi | hsa:55846 |
UCSCi | uc001qlb.3, human [Q969R8-1] |
Organism-specific databases
CTDi | 55846 |
GeneCardsi | ITFG2 |
HGNCi | HGNC:30879, ITFG2 |
HPAi | ENSG00000111203, Low tissue specificity |
MIMi | 617421, gene |
neXtProti | NX_Q969R8 |
OpenTargetsi | ENSG00000111203 |
PharmGKBi | PA143485507 |
VEuPathDBi | HostDB:ENSG00000111203.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUBC, Eukaryota |
GeneTreei | ENSGT00390000005378 |
HOGENOMi | CLU_021730_0_0_1 |
InParanoidi | Q969R8 |
OMAi | CKEGKNS |
PhylomeDBi | Q969R8 |
TreeFami | TF329010 |
Enzyme and pathway databases
PathwayCommonsi | Q969R8 |
Reactomei | R-HSA-9639288, Amino acids regulate mTORC1 |
SignaLinki | Q969R8 |
Miscellaneous databases
BioGRID-ORCSi | 55846, 8 hits in 879 CRISPR screens |
ChiTaRSi | ITFG2, human |
GenomeRNAii | 55846 |
Pharosi | Q969R8, Tbio |
PROi | PR:Q969R8 |
RNActi | Q969R8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111203, Expressed in sural nerve and 214 other tissues |
ExpressionAtlasi | Q969R8, baseline and differential |
Genevisiblei | Q969R8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031793, KICSTOR_ITFG2 IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR16317, PTHR16317, 1 hit |
Pfami | View protein in Pfam PF15907, Itfg2, 1 hit |
SUPFAMi | SSF50978, SSF50978, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ITFG2_HUMAN | |
Accessioni | Q969R8Primary (citable) accession number: Q969R8 Secondary accession number(s): A8K4Z5 Q96SX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot