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Entry version 129 (13 Nov 2019)
Sequence version 1 (01 Dec 2001)
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Protein

KICSTOR complex protein ITFG2

Gene

ITFG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9639288 Amino acids regulate mTORC1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q969R8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
KICSTOR complex protein ITFG2Curated
Alternative name(s):
Integrin-alpha FG-GAP repeat-containing protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITFG2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30879 ITFG2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617421 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969R8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000111203

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485507

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q969R8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ITFG2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74731058

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002892921 – 447KICSTOR complex protein ITFG2Add BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei104PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q969R8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q969R8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q969R8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q969R8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969R8

PeptideAtlas

More...
PeptideAtlasi
Q969R8

PRoteomics IDEntifications database

More...
PRIDEi
Q969R8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67246
75823 [Q969R8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969R8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969R8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111203 Expressed in 200 organ(s), highest expression level in right lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q969R8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969R8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038664
HPA038665

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the KICSTOR complex composed of KPTN, ITFG2, C12orf66 and SZT2. SZT2 probably serves as a link between the other three proteins in the KICSTOR complex and may mediate the direct interaction with the GATOR complex via GATOR1. The KICSTOR complex interacts directly with the GATOR1 complex and most probably indirectly with the GATOR2 complexe in an amino acid-independent manner.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120948, 19 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q969R8

Protein interaction database and analysis system

More...
IntActi
Q969R8, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000228799

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati19 – 48FG-GAP 1; atypicalAdd BLAST30
Repeati126 – 155FG-GAP 2; atypicalAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEQ3 Eukaryota
ENOG410XPME LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005378

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007901

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969R8

KEGG Orthology (KO)

More...
KOi
K23296

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNKGKNF

Database of Orthologous Groups

More...
OrthoDBi
1128880at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969R8

TreeFam database of animal gene trees

More...
TreeFami
TF329010

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031793 KICSTOR_ITFG2
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR16317 PTHR16317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15907 Itfg2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969R8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSVSYVQRV ALEFSGSLFP HAICLGDVDN DTLNELVVGD TSGKVSVYKN
60 70 80 90 100
DDSRPWLTCS CQGMLTCVGV GDVCNKGKNL LVAVSAEGWF HLFDLTPAKV
110 120 130 140 150
LDASGHHETL IGEEQRPVFK QHIPANTKVM LISDIDGDGC RELVVGYTDR
160 170 180 190 200
VVRAFRWEEL GEGPEHLTGQ LVSLKKWMLE GQVDSLSVTL GPLGLPELMV
210 220 230 240 250
SQPGCAYAIL LCTWKKDTGS PPASEGPTDG SRETPAARDV VLHQTSGRIH
260 270 280 290 300
NKNVSTHLIG NIKQGHGTES SGSGLFALCT LDGTLKLMEE MEEADKLLWS
310 320 330 340 350
VQVDHQLFAL EKLDVTGNGH EEVVACAWDG QTYIIDHNRT VVRFQVDENI
360 370 380 390 400
RAFCAGLYAC KEGRNSPCLV YVTFNQKIYV YWEVQLERME STNLVKLLET
410 420 430 440
KPEYHSLLQE LGVDPDDLPV TRALLHQTLY HPDQPPQCAP SSLQDPT
Length:447
Mass (Da):49,313
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CB025338EE04A17
GO
Isoform 2 (identifier: Q969R8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-147: DGDGCRELVVGY → GGHAYLCRQPGE
     148-447: Missing.

Show »
Length:147
Mass (Da):15,974
Checksum:iF2EF9A7497BA507A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YG72H0YG72_HUMAN
KICSTOR complex protein ITFG2
ITFG2
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1D0F5H1D0_HUMAN
Integrin alpha FG-GAP repeat contai...
ITFG2
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGR0H0YGR0_HUMAN
KICSTOR complex protein ITFG2
ITFG2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFM4H0YFM4_HUMAN
KICSTOR complex protein ITFG2
ITFG2
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7E0A0A2R8Y7E0_HUMAN
KICSTOR complex protein ITFG2
ITFG2
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti68V → A in BAB55145 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055985136 – 147DGDGC…LVVGY → GGHAYLCRQPGE in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_055986148 – 447Missing in isoform 2. 1 PublicationAdd BLAST300

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY599883 mRNA Translation: AAT09136.1
AK027483 mRNA Translation: BAB55145.1
AK291110 mRNA Translation: BAF83799.1
AC005841 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88886.1
CH471116 Genomic DNA Translation: EAW88887.1
BC006552 mRNA Translation: AAH06552.1
BC013399 mRNA Translation: AAH13399.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8513.1 [Q969R8-1]

NCBI Reference Sequences

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RefSeqi
NP_060933.3, NM_018463.3 [Q969R8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000228799; ENSP00000228799; ENSG00000111203 [Q969R8-1]
ENST00000540929; ENSP00000443329; ENSG00000111203 [Q969R8-2]
ENST00000644517; ENSP00000496068; ENSG00000111203 [Q969R8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55846

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55846

UCSC genome browser

More...
UCSCi
uc001qlb.3 human [Q969R8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY599883 mRNA Translation: AAT09136.1
AK027483 mRNA Translation: BAB55145.1
AK291110 mRNA Translation: BAF83799.1
AC005841 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88886.1
CH471116 Genomic DNA Translation: EAW88887.1
BC006552 mRNA Translation: AAH06552.1
BC013399 mRNA Translation: AAH13399.1
CCDSiCCDS8513.1 [Q969R8-1]
RefSeqiNP_060933.3, NM_018463.3 [Q969R8-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120948, 19 interactors
CORUMiQ969R8
IntActiQ969R8, 14 interactors
STRINGi9606.ENSP00000228799

PTM databases

iPTMnetiQ969R8
PhosphoSitePlusiQ969R8

Polymorphism and mutation databases

BioMutaiITFG2
DMDMi74731058

Proteomic databases

EPDiQ969R8
jPOSTiQ969R8
MassIVEiQ969R8
MaxQBiQ969R8
PaxDbiQ969R8
PeptideAtlasiQ969R8
PRIDEiQ969R8
ProteomicsDBi67246
75823 [Q969R8-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55846

Genome annotation databases

EnsembliENST00000228799; ENSP00000228799; ENSG00000111203 [Q969R8-1]
ENST00000540929; ENSP00000443329; ENSG00000111203 [Q969R8-2]
ENST00000644517; ENSP00000496068; ENSG00000111203 [Q969R8-2]
GeneIDi55846
KEGGihsa:55846
UCSCiuc001qlb.3 human [Q969R8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55846

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ITFG2
HGNCiHGNC:30879 ITFG2
HPAiHPA038664
HPA038665
MIMi617421 gene
neXtProtiNX_Q969R8
OpenTargetsiENSG00000111203
PharmGKBiPA143485507

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEQ3 Eukaryota
ENOG410XPME LUCA
GeneTreeiENSGT00390000005378
HOGENOMiHOG000007901
InParanoidiQ969R8
KOiK23296
OMAiCNKGKNF
OrthoDBi1128880at2759
PhylomeDBiQ969R8
TreeFamiTF329010

Enzyme and pathway databases

ReactomeiR-HSA-9639288 Amino acids regulate mTORC1
SignaLinkiQ969R8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ITFG2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55846
PharosiQ969R8

Protein Ontology

More...
PROi
PR:Q969R8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111203 Expressed in 200 organ(s), highest expression level in right lobe of thyroid gland
ExpressionAtlasiQ969R8 baseline and differential
GenevisibleiQ969R8 HS

Family and domain databases

InterProiView protein in InterPro
IPR031793 KICSTOR_ITFG2
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR16317 PTHR16317, 1 hit
PfamiView protein in Pfam
PF15907 Itfg2, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITFG2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969R8
Secondary accession number(s): A8K4Z5
, D3DUQ2, Q6PKU5, Q96SX6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 1, 2001
Last modified: November 13, 2019
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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