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Protein

Lethal(3)malignant brain tumor-like protein 2

Gene

L3MBTL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 116FCS-typePROSITE-ProRule annotationAdd BLAST36

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • methylated histone binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 2
Short name:
H-l(3)mbt-like protein 2
Short name:
L(3)mbt-like protein 2
Gene namesi
Name:L3MBTL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100395.14
HGNCiHGNC:18594 L3MBTL2
MIMi611865 gene
neXtProtiNX_Q969R5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83746
OpenTargetsiENSG00000100395
PharmGKBiPA38356

Polymorphism and mutation databases

BioMutaiL3MBTL2
DMDMi27734418

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844481 – 705Lethal(3)malignant brain tumor-like protein 2Add BLAST705

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei76PhosphothreonineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Cross-linki405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki659Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki675Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei683PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Cross-linki700Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki700Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ969R5
MaxQBiQ969R5
PaxDbiQ969R5
PeptideAtlasiQ969R5
PRIDEiQ969R5
ProteomicsDBi75820
75821 [Q969R5-2]
75822 [Q969R5-3]

PTM databases

iPTMnetiQ969R5
PhosphoSitePlusiQ969R5

Expressioni

Gene expression databases

BgeeiENSG00000100395 Expressed in 201 organ(s), highest expression level in quadriceps femoris
CleanExiHS_L3MBTL2
ExpressionAtlasiQ969R5 baseline and differential
GenevisibleiQ969R5 HS

Organism-specific databases

HPAiHPA000815

Interactioni

Subunit structurei

Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123753, 64 interactors
CORUMiQ969R5
DIPiDIP-56748N
IntActiQ969R5, 88 interactors
MINTiQ969R5
STRINGi9606.ENSP00000216237

Structurei

Secondary structure

1705
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ969R5
SMRiQ969R5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ969R5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati179 – 283MBT 1Add BLAST105
Repeati291 – 391MBT 2Add BLAST101
Repeati397 – 500MBT 3Add BLAST104
Repeati508 – 604MBT 4Add BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 20Poly-Glu4
Compositional biasi620 – 624Poly-Lys5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 116FCS-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IMEW Eukaryota
ENOG410ZYE4 LUCA
GeneTreeiENSGT00760000119024
HOGENOMiHOG000231220
HOVERGENiHBG057974
InParanoidiQ969R5
OMAiDGWDNEY
OrthoDBiEOG091G0312
PhylomeDBiQ969R5
TreeFamiTF316498

Family and domain databases

Gene3Di3.30.60.160, 1 hit
InterProiView protein in InterPro
IPR038038 L3MBTL2
IPR004092 Mbt
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf
PANTHERiPTHR12247:SF64 PTHR12247:SF64, 1 hit
PfamiView protein in Pfam
PF02820 MBT, 4 hits
SMARTiView protein in SMART
SM00561 MBT, 4 hits
PROSITEiView protein in PROSITE
PS51079 MBT, 4 hits
PS51024 ZF_FCS, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969R5-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKPRSIEET PSSEPMEEEE DDDLELFGGY DSFRSYNSSV GSESSSYLEE
60 70 80 90 100
SSEAENEDRE AGELPTSPLH LLSPGTPRSL DGSGSEPAVC EMCGIVGTRE
110 120 130 140 150
AFFSKTKRFC SVSCSRSYSS NSKKASILAR LQGKPPTKKA KVLHKAAWSA
160 170 180 190 200
KIGAFLHSQG TGQLADGTPT GQDALVLGFD WGKFLKDHSY KAAPVSCFKH
210 220 230 240 250
VPLYDQWEDV MKGMKVEVLN SDAVLPSRVY WIASVIQTAG YRVLLRYEGF
260 270 280 290 300
ENDASHDFWC NLGTVDVHPI GWCAINSKIL VPPRTIHAKF TDWKGYLMKR
310 320 330 340 350
LVGSRTLPVD FHIKMVESMK YPFRQGMRLE VVDKSQVSRT RMAVVDTVIG
360 370 380 390 400
GRLRLLYEDG DSDDDFWCHM WSPLIHPVGW SRRVGHGIKM SERRSDMAHH
410 420 430 440 450
PTFRKIYCDA VPYLFKKVRA VYTEGGWFEE GMKLEAIDPL NLGNICVATV
460 470 480 490 500
CKVLLDGYLM ICVDGGPSTD GLDWFCYHAS SHAIFPATFC QKNDIELTPP
510 520 530 540 550
KGYEAQTFNW ENYLEKTKSK AAPSRLFNMD CPNHGFKVGM KLEAVDLMEP
560 570 580 590 600
RLICVATVKR VVHRLLSIHF DGWDSEYDQW VDCESPDIYP VGWCELTGYQ
610 620 630 640 650
LQPPVAAEPA TPLKAKEATK KKKKQFGKKR KRIPPTKTRP LRQGSKKPLL
660 670 680 690 700
EDDPQGARKI SSEPVPGEII AVRVKEEHLD VASPDKASSP ELPVSVENIK

QETDD
Length:705
Mass (Da):79,110
Last modified:December 1, 2001 - v1
Checksum:i8FC86A440982FFA7
GO
Isoform 2 (identifier: Q969R5-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     608-614: EPATPLK → GKLPRSL
     615-705: Missing.

Show »
Length:614
Mass (Da):69,008
Checksum:i6098B154D7387790
GO
Isoform 3 (identifier: Q969R5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-617: EPATPLKAKE → GVGSRGPKRL
     618-705: Missing.

Show »
Length:617
Mass (Da):69,264
Checksum:i2AD8D020C5715608
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5M2H0Y5M2_HUMAN
Lethal(3)malignant brain tumor-like...
L3MBTL2
288Annotation score:
H7C228H7C228_HUMAN
Lethal(3)malignant brain tumor-like...
L3MBTL2
232Annotation score:
F8WBL1F8WBL1_HUMAN
Lethal(3)malignant brain tumor-like...
L3MBTL2
40Annotation score:

Sequence cautioni

The sequence BAB84917 differs from that shown. Intron retention.Curated
The sequence BAC04936 differs from that shown. Intron retention.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0339987I → V. Corresponds to variant dbSNP:rs3804097Ensembl.1
Natural variantiVAR_015093300R → W. Corresponds to variant dbSNP:rs2277846Ensembl.1
Natural variantiVAR_061675337V → A. Corresponds to variant dbSNP:rs34289721Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003906608 – 617EPATPLKAKE → GVGSRGPKRL in isoform 3. 1 Publication10
Alternative sequenceiVSP_003904608 – 614EPATPLK → GKLPRSL in isoform 2. 1 Publication7
Alternative sequenceiVSP_003905615 – 705Missing in isoform 2. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_003907618 – 705Missing in isoform 3. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ305226 mRNA Translation: CAC37794.1
AJ305227 mRNA Translation: CAC37795.1
AL136564 mRNA Translation: CAB66499.2
AK074091 mRNA Translation: BAB84917.1 Sequence problems.
AK097052 mRNA Translation: BAC04936.1 Sequence problems.
CR456482 mRNA Translation: CAG30368.1
AL035658 Genomic DNA No translation available.
AL035681 Genomic DNA No translation available.
BC017191 mRNA Translation: AAH17191.1
CCDSiCCDS14011.1 [Q969R5-1]
RefSeqiNP_113676.2, NM_031488.4 [Q969R5-1]
UniGeneiHs.517641

Genome annotation databases

EnsembliENST00000216237; ENSP00000216237; ENSG00000100395 [Q969R5-1]
ENST00000452106; ENSP00000414423; ENSG00000100395 [Q969R5-2]
GeneIDi83746
KEGGihsa:83746
UCSCiuc003azo.4 human [Q969R5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ305226 mRNA Translation: CAC37794.1
AJ305227 mRNA Translation: CAC37795.1
AL136564 mRNA Translation: CAB66499.2
AK074091 mRNA Translation: BAB84917.1 Sequence problems.
AK097052 mRNA Translation: BAC04936.1 Sequence problems.
CR456482 mRNA Translation: CAG30368.1
AL035658 Genomic DNA No translation available.
AL035681 Genomic DNA No translation available.
BC017191 mRNA Translation: AAH17191.1
CCDSiCCDS14011.1 [Q969R5-1]
RefSeqiNP_113676.2, NM_031488.4 [Q969R5-1]
UniGeneiHs.517641

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W0TNMR-A82-124[»]
3CEYX-ray2.20A/B170-625[»]
3F70X-ray2.10A/B170-625[»]
ProteinModelPortaliQ969R5
SMRiQ969R5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123753, 64 interactors
CORUMiQ969R5
DIPiDIP-56748N
IntActiQ969R5, 88 interactors
MINTiQ969R5
STRINGi9606.ENSP00000216237

PTM databases

iPTMnetiQ969R5
PhosphoSitePlusiQ969R5

Polymorphism and mutation databases

BioMutaiL3MBTL2
DMDMi27734418

Proteomic databases

EPDiQ969R5
MaxQBiQ969R5
PaxDbiQ969R5
PeptideAtlasiQ969R5
PRIDEiQ969R5
ProteomicsDBi75820
75821 [Q969R5-2]
75822 [Q969R5-3]

Protocols and materials databases

DNASUi83746
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216237; ENSP00000216237; ENSG00000100395 [Q969R5-1]
ENST00000452106; ENSP00000414423; ENSG00000100395 [Q969R5-2]
GeneIDi83746
KEGGihsa:83746
UCSCiuc003azo.4 human [Q969R5-1]

Organism-specific databases

CTDi83746
DisGeNETi83746
EuPathDBiHostDB:ENSG00000100395.14
GeneCardsiL3MBTL2
HGNCiHGNC:18594 L3MBTL2
HPAiHPA000815
MIMi611865 gene
neXtProtiNX_Q969R5
OpenTargetsiENSG00000100395
PharmGKBiPA38356
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMEW Eukaryota
ENOG410ZYE4 LUCA
GeneTreeiENSGT00760000119024
HOGENOMiHOG000231220
HOVERGENiHBG057974
InParanoidiQ969R5
OMAiDGWDNEY
OrthoDBiEOG091G0312
PhylomeDBiQ969R5
TreeFamiTF316498

Enzyme and pathway databases

ReactomeiR-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-8953750 Transcriptional Regulation by E2F6

Miscellaneous databases

ChiTaRSiL3MBTL2 human
EvolutionaryTraceiQ969R5
GeneWikiiL3MBTL2
GenomeRNAii83746
PROiPR:Q969R5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100395 Expressed in 201 organ(s), highest expression level in quadriceps femoris
CleanExiHS_L3MBTL2
ExpressionAtlasiQ969R5 baseline and differential
GenevisibleiQ969R5 HS

Family and domain databases

Gene3Di3.30.60.160, 1 hit
InterProiView protein in InterPro
IPR038038 L3MBTL2
IPR004092 Mbt
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf
PANTHERiPTHR12247:SF64 PTHR12247:SF64, 1 hit
PfamiView protein in Pfam
PF02820 MBT, 4 hits
SMARTiView protein in SMART
SM00561 MBT, 4 hits
PROSITEiView protein in PROSITE
PS51079 MBT, 4 hits
PS51024 ZF_FCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLMBL2_HUMAN
AccessioniPrimary (citable) accession number: Q969R5
Secondary accession number(s): Q8TEN1
, Q96SC4, Q9BQI2, Q9UGS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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