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Protein

Oxysterol-binding protein 2

Gene

OSBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds 7-ketocholesterol.

GO - Molecular functioni

  • cholesterol binding Source: BHF-UCL
  • lipid binding Source: GO_Central
  • sterol binding Source: GO_Central
  • sterol transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein 2
Alternative name(s):
Oxysterol-binding protein-related protein 4
Short name:
ORP-4
Short name:
OSBP-related protein 4
Gene namesi
Name:OSBP2
Synonyms:KIAA1664, ORP4, OSBPL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000184792.15
HGNCiHGNC:8504 OSBP2
MIMi606729 gene
neXtProtiNX_Q969R2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23762
OpenTargetsiENSG00000184792
PharmGKBiPA32823

Polymorphism and mutation databases

BioMutaiOSBP2
DMDMi88984633

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003661 – 916Oxysterol-binding protein 2Add BLAST916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287PhosphoserineBy similarity1
Modified residuei763PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ969R2
MaxQBiQ969R2
PaxDbiQ969R2
PeptideAtlasiQ969R2
PRIDEiQ969R2
ProteomicsDBi75819

PTM databases

iPTMnetiQ969R2
PhosphoSitePlusiQ969R2

Expressioni

Tissue specificityi

Expressed mainly in retina, testis, and fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000184792 Expressed in 165 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_OSBP2
ExpressionAtlasiQ969R2 baseline and differential
GenevisibleiQ969R2 HS

Organism-specific databases

HPAiHPA021514

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LNX1Q8TBB13EBI-7405817,EBI-739832

Protein-protein interaction databases

BioGridi117263, 12 interactors
ELMiQ969R2
IntActiQ969R2, 8 interactors
MINTiQ969R2
STRINGi9606.ENSP00000332576

Chemistry databases

BindingDBiQ969R2

Structurei

3D structure databases

ProteinModelPortaliQ969R2
SMRiQ969R2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 274PHPROSITE-ProRule annotationAdd BLAST93

Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00760000119155
HOGENOMiHOG000231233
HOVERGENiHBG053374
InParanoidiQ969R2
KOiK20462
OMAiEINHTCR
OrthoDBiEOG091G04HK
PhylomeDBiQ969R2
TreeFamiTF320922

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969R2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKAAAPSRG GGCGGRSRGL SSLFTVVPCL SCHTAAPGMS ASTSGSGPEP
60 70 80 90 100
KPQPQPVPEP ERGPLSEQVS EAVSEAVPRS EPVSETTSEP EPGAGQPSEL
110 120 130 140 150
LQGSRPGSES SSGVGAGPFT KAASEPLSRA VGSATFLRPE SGSLPALKPL
160 170 180 190 200
PLLRPGQAKT PLGVPMSGTG TTSSAPLALL PLDSFEGWLL KWTNYLKGYQ
210 220 230 240 250
RRWFVLGNGL LSYYRNQGEM AHTCRGTINL STAHIDTEDS CGILLTSGAR
260 270 280 290 300
SYHLKASSEV DRQQWITALE LAKAKAVRVM NTHSDDSGDD DEATTPADKS
310 320 330 340 350
ELHHTLKNLS LKLDDLSTCN DLIAKHGAAL QRSLTELDGL KIPSESGEKL
360 370 380 390 400
KVVNERATLF RITSNAMINA CRDFLELAEI HSRKWQRALQ YEQEQRVHLE
410 420 430 440 450
ETIEQLAKQH NSLERAFHSA PGRPANPSKS FIEGSLLTPK GEDSEEDEDT
460 470 480 490 500
EYFDAMEDST SFITVITEAK EDSRKAEGST GTSSVDWSSA DNVLDGASLV
510 520 530 540 550
PKGSSKVKRR VRIPNKPNYS LNLWSIMKNC IGRELSRIPM PVNFNEPLSM
560 570 580 590 600
LQRLTEDLEY HHLLDKAVHC TSSVEQMCLV AAFSVSSYST TVHRIAKPFN
610 620 630 640 650
PMLGETFELD RLDDMGLRSL CEQVSHHPPS AAHYVFSKHG WSLWQEITIS
660 670 680 690 700
SKFRGKYISI MPLGAIHLEF QASGNHYVWR KSTSTVHNII VGKLWIDQSG
710 720 730 740 750
DIEIVNHKTN DRCQLKFLPY SYFSKEAARK VTGVVSDSQG KAHYVLSGSW
760 770 780 790 800
DEQMECSKVM HSSPSSPSSD GKQKTVYQTL SAKLLWKKYP LPENAENMYY
810 820 830 840 850
FSELALTLNE HEEGVAPTDS RLRPDQRLME KGRWDEANTE KQRLEEKQRL
860 870 880 890 900
SRRRRLEACG PGSSCSSEEE KEADAYTPLW FEKRLDPLTG EMACVYKGGY
910
WEAKEKQDWH MCPNIF
Length:916
Mass (Da):101,266
Last modified:February 21, 2006 - v2
Checksum:i3EAC49EB56516F18
GO
Isoform 2 (identifier: Q969R2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     473-473: Missing.

Note: No experimental confirmation available.
Show »
Length:915
Mass (Da):101,179
Checksum:i383DAC37FA97D07D
GO
Isoform 3 (identifier: Q969R2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MGKAAAPSRG...SASTSGSGPE → MHRQRTRTMS...FWRPQERPTD
     50-214: Missing.
     473-473: Missing.

Note: No experimental confirmation available.
Show »
Length:750
Mass (Da):84,744
Checksum:iBC03397834C53F0E
GO
Isoform 4 (identifier: Q969R2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-366: Missing.
     473-473: Missing.

Note: No experimental confirmation available.
Show »
Length:549
Mass (Da):62,750
Checksum:i9B88DB107BE1A215
GO
Isoform 5 (identifier: Q969R2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-455: Missing.
     473-473: Missing.

Note: No experimental confirmation available.
Show »
Length:460
Mass (Da):52,423
Checksum:i64D8EE88C312401A
GO
Isoform 6 (identifier: Q969R2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-284: MGKAAAPSRG...KAVRVMNTHS → MKGRGCWDTASVRSFCSSGCLNKFKK
     869-869: E → EA

Show »
Length:659
Mass (Da):74,658
Checksum:i59C2935A3EF1A0F5
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6ZN50Q6ZN50_HUMAN
Oxysterol-binding protein
OSBP2 hCG_41303
743Annotation score:
H7C428H7C428_HUMAN
Oxysterol-binding protein
OSBP2
588Annotation score:
H7C368H7C368_HUMAN
Oxysterol-binding protein
OSBP2
450Annotation score:
A0A0A0MSB4A0A0A0MSB4_HUMAN
Oxysterol-binding protein
OSBP2
636Annotation score:
H7C1R2H7C1R2_HUMAN
Oxysterol-binding protein 2
OSBP2
298Annotation score:
C9JS84C9JS84_HUMAN
Oxysterol-binding protein 2
OSBP2
174Annotation score:
H7C313H7C313_HUMAN
Oxysterol-binding protein 2
OSBP2
196Annotation score:
C9J7J0C9J7J0_HUMAN
Oxysterol-binding protein 2
OSBP2
25Annotation score:
H7C001H7C001_HUMAN
Oxysterol-binding protein 2
OSBP2
74Annotation score:

Sequence cautioni

The sequence AAK56864 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAK56865 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB33334 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34T → A in BAB33334 (PubMed:11258795).Curated1
Sequence conflicti552Q → H in BAG59036 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053546760M → V. Corresponds to variant dbSNP:rs34240867Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0552621 – 455Missing in isoform 5. 1 PublicationAdd BLAST455
Alternative sequenceiVSP_0552631 – 366Missing in isoform 4. 1 PublicationAdd BLAST366
Alternative sequenceiVSP_0557511 – 284MGKAA…MNTHS → MKGRGCWDTASVRSFCSSGC LNKFKK in isoform 6. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_0548861 – 49MGKAA…GSGPE → MHRQRTRTMSSLAAKRLGMN RRPAGSGGGGGEAATWGHRF WRPQERPTD in isoform 3. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_05488750 – 214Missing in isoform 3. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_054520473Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_055752869E → EA in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288741 mRNA Translation: AAK56864.1 Different initiation.
AF288742 Genomic DNA Translation: AAK56865.1 Different initiation.
AF323731 mRNA Translation: AAG53406.1
AB051451 mRNA Translation: BAB33334.2 Different initiation.
AK093196 mRNA Translation: BAC04091.1
AK296525 mRNA Translation: BAG59156.1
AK300323 mRNA Translation: BAG62075.1
AK296354 mRNA Translation: BAG59036.1
AC004542 Genomic DNA Translation: AAC12953.1
AL022336 Genomic DNA No translation available.
AL079299 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59916.1
BC118914 mRNA Translation: AAI18915.1
CCDSiCCDS43002.1 [Q969R2-1]
CCDS63446.1 [Q969R2-3]
CCDS63448.1 [Q969R2-2]
CCDS63449.1 [Q969R2-6]
CCDS63450.1 [Q969R2-4]
CCDS63451.1 [Q969R2-5]
PIRiT02435
RefSeqiNP_001269667.1, NM_001282738.1 [Q969R2-3]
NP_001269668.1, NM_001282739.1 [Q969R2-2]
NP_001269669.1, NM_001282740.1 [Q969R2-4]
NP_001269670.1, NM_001282741.1 [Q969R2-6]
NP_001269671.1, NM_001282742.1 [Q969R2-5]
NP_110385.1, NM_030758.3 [Q969R2-1]
XP_016884201.1, XM_017028712.1
UniGeneiHs.517546

Genome annotation databases

EnsembliENST00000332585; ENSP00000332576; ENSG00000184792 [Q969R2-1]
ENST00000401475; ENSP00000385254; ENSG00000184792 [Q969R2-4]
ENST00000437268; ENSP00000389200; ENSG00000184792 [Q969R2-6]
ENST00000438716; ENSP00000411052; ENSG00000184792 [Q969R2-3]
ENST00000446658; ENSP00000392080; ENSG00000184792 [Q969R2-2]
ENST00000535268; ENSP00000438713; ENSG00000184792 [Q969R2-5]
GeneIDi23762
KEGGihsa:23762
UCSCiuc003aiy.1 human [Q969R2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288741 mRNA Translation: AAK56864.1 Different initiation.
AF288742 Genomic DNA Translation: AAK56865.1 Different initiation.
AF323731 mRNA Translation: AAG53406.1
AB051451 mRNA Translation: BAB33334.2 Different initiation.
AK093196 mRNA Translation: BAC04091.1
AK296525 mRNA Translation: BAG59156.1
AK300323 mRNA Translation: BAG62075.1
AK296354 mRNA Translation: BAG59036.1
AC004542 Genomic DNA Translation: AAC12953.1
AL022336 Genomic DNA No translation available.
AL079299 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59916.1
BC118914 mRNA Translation: AAI18915.1
CCDSiCCDS43002.1 [Q969R2-1]
CCDS63446.1 [Q969R2-3]
CCDS63448.1 [Q969R2-2]
CCDS63449.1 [Q969R2-6]
CCDS63450.1 [Q969R2-4]
CCDS63451.1 [Q969R2-5]
PIRiT02435
RefSeqiNP_001269667.1, NM_001282738.1 [Q969R2-3]
NP_001269668.1, NM_001282739.1 [Q969R2-2]
NP_001269669.1, NM_001282740.1 [Q969R2-4]
NP_001269670.1, NM_001282741.1 [Q969R2-6]
NP_001269671.1, NM_001282742.1 [Q969R2-5]
NP_110385.1, NM_030758.3 [Q969R2-1]
XP_016884201.1, XM_017028712.1
UniGeneiHs.517546

3D structure databases

ProteinModelPortaliQ969R2
SMRiQ969R2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117263, 12 interactors
ELMiQ969R2
IntActiQ969R2, 8 interactors
MINTiQ969R2
STRINGi9606.ENSP00000332576

Chemistry databases

BindingDBiQ969R2

PTM databases

iPTMnetiQ969R2
PhosphoSitePlusiQ969R2

Polymorphism and mutation databases

BioMutaiOSBP2
DMDMi88984633

Proteomic databases

EPDiQ969R2
MaxQBiQ969R2
PaxDbiQ969R2
PeptideAtlasiQ969R2
PRIDEiQ969R2
ProteomicsDBi75819

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332585; ENSP00000332576; ENSG00000184792 [Q969R2-1]
ENST00000401475; ENSP00000385254; ENSG00000184792 [Q969R2-4]
ENST00000437268; ENSP00000389200; ENSG00000184792 [Q969R2-6]
ENST00000438716; ENSP00000411052; ENSG00000184792 [Q969R2-3]
ENST00000446658; ENSP00000392080; ENSG00000184792 [Q969R2-2]
ENST00000535268; ENSP00000438713; ENSG00000184792 [Q969R2-5]
GeneIDi23762
KEGGihsa:23762
UCSCiuc003aiy.1 human [Q969R2-1]

Organism-specific databases

CTDi23762
DisGeNETi23762
EuPathDBiHostDB:ENSG00000184792.15
GeneCardsiOSBP2
H-InvDBiHIX0041322
HGNCiHGNC:8504 OSBP2
HPAiHPA021514
MIMi606729 gene
neXtProtiNX_Q969R2
OpenTargetsiENSG00000184792
PharmGKBiPA32823
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00760000119155
HOGENOMiHOG000231233
HOVERGENiHBG053374
InParanoidiQ969R2
KOiK20462
OMAiEINHTCR
OrthoDBiEOG091G04HK
PhylomeDBiQ969R2
TreeFamiTF320922

Miscellaneous databases

ChiTaRSiOSBP2 human
GeneWikiiOSBP2
GenomeRNAii23762
PROiPR:Q969R2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184792 Expressed in 165 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_OSBP2
ExpressionAtlasiQ969R2 baseline and differential
GenevisibleiQ969R2 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSBP2_HUMAN
AccessioniPrimary (citable) accession number: Q969R2
Secondary accession number(s): B0QYG1
, B4DK24, B4DKE4, B4DTR3, F5H2A3, O60396, Q0VF99, Q8NA37, Q9BY96, Q9BZF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 21, 2006
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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