Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 150 (31 Jul 2019)
Sequence version 2 (21 Feb 2006)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Oxysterol-binding protein 2

Gene

OSBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds 7-ketocholesterol.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxysterol-binding protein 2
Alternative name(s):
Oxysterol-binding protein-related protein 4
Short name:
ORP-4
Short name:
OSBP-related protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OSBP2
Synonyms:KIAA1664, ORP4, OSBPL4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8504 OSBP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606729 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969R2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23762

Open Targets

More...
OpenTargetsi
ENSG00000184792

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32823

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OSBP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
88984633

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001003661 – 916Oxysterol-binding protein 2Add BLAST916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei287PhosphoserineBy similarity1
Modified residuei763PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q969R2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q969R2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969R2

PeptideAtlas

More...
PeptideAtlasi
Q969R2

PRoteomics IDEntifications database

More...
PRIDEi
Q969R2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
25910
4454
5124
58834
72634
75819 [Q969R2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969R2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969R2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in retina, testis, and fetal liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184792 Expressed in 165 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q969R2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969R2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021514

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
LNX1Q8TBB13EBI-7405817,EBI-739832

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117263, 12 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q969R2

Protein interaction database and analysis system

More...
IntActi
Q969R2, 8 interactors

Molecular INTeraction database

More...
MINTi
Q969R2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000332576

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q969R2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q969R2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini182 – 274PHPROSITE-ProRule annotationAdd BLAST93

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1737 Eukaryota
ENOG410XP9E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157987

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231233

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969R2

KEGG Orthology (KO)

More...
KOi
K20462

Identification of Orthologs from Complete Genome Data

More...
OMAi
EINHTCR

Database of Orthologous Groups

More...
OrthoDBi
542090at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969R2

TreeFam database of animal gene trees

More...
TreeFami
TF320922

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10972 PTHR10972, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF144000 SSF144000, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969R2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKAAAPSRG GGCGGRSRGL SSLFTVVPCL SCHTAAPGMS ASTSGSGPEP
60 70 80 90 100
KPQPQPVPEP ERGPLSEQVS EAVSEAVPRS EPVSETTSEP EPGAGQPSEL
110 120 130 140 150
LQGSRPGSES SSGVGAGPFT KAASEPLSRA VGSATFLRPE SGSLPALKPL
160 170 180 190 200
PLLRPGQAKT PLGVPMSGTG TTSSAPLALL PLDSFEGWLL KWTNYLKGYQ
210 220 230 240 250
RRWFVLGNGL LSYYRNQGEM AHTCRGTINL STAHIDTEDS CGILLTSGAR
260 270 280 290 300
SYHLKASSEV DRQQWITALE LAKAKAVRVM NTHSDDSGDD DEATTPADKS
310 320 330 340 350
ELHHTLKNLS LKLDDLSTCN DLIAKHGAAL QRSLTELDGL KIPSESGEKL
360 370 380 390 400
KVVNERATLF RITSNAMINA CRDFLELAEI HSRKWQRALQ YEQEQRVHLE
410 420 430 440 450
ETIEQLAKQH NSLERAFHSA PGRPANPSKS FIEGSLLTPK GEDSEEDEDT
460 470 480 490 500
EYFDAMEDST SFITVITEAK EDSRKAEGST GTSSVDWSSA DNVLDGASLV
510 520 530 540 550
PKGSSKVKRR VRIPNKPNYS LNLWSIMKNC IGRELSRIPM PVNFNEPLSM
560 570 580 590 600
LQRLTEDLEY HHLLDKAVHC TSSVEQMCLV AAFSVSSYST TVHRIAKPFN
610 620 630 640 650
PMLGETFELD RLDDMGLRSL CEQVSHHPPS AAHYVFSKHG WSLWQEITIS
660 670 680 690 700
SKFRGKYISI MPLGAIHLEF QASGNHYVWR KSTSTVHNII VGKLWIDQSG
710 720 730 740 750
DIEIVNHKTN DRCQLKFLPY SYFSKEAARK VTGVVSDSQG KAHYVLSGSW
760 770 780 790 800
DEQMECSKVM HSSPSSPSSD GKQKTVYQTL SAKLLWKKYP LPENAENMYY
810 820 830 840 850
FSELALTLNE HEEGVAPTDS RLRPDQRLME KGRWDEANTE KQRLEEKQRL
860 870 880 890 900
SRRRRLEACG PGSSCSSEEE KEADAYTPLW FEKRLDPLTG EMACVYKGGY
910
WEAKEKQDWH MCPNIF
Length:916
Mass (Da):101,266
Last modified:February 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EAC49EB56516F18
GO
Isoform 2 (identifier: Q969R2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     473-473: Missing.

Note: No experimental confirmation available.
Show »
Length:915
Mass (Da):101,179
Checksum:i383DAC37FA97D07D
GO
Isoform 3 (identifier: Q969R2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MGKAAAPSRG...SASTSGSGPE → MHRQRTRTMS...FWRPQERPTD
     50-214: Missing.
     473-473: Missing.

Note: No experimental confirmation available.
Show »
Length:750
Mass (Da):84,744
Checksum:iBC03397834C53F0E
GO
Isoform 4 (identifier: Q969R2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-366: Missing.
     473-473: Missing.

Note: No experimental confirmation available.
Show »
Length:549
Mass (Da):62,750
Checksum:i9B88DB107BE1A215
GO
Isoform 5 (identifier: Q969R2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-455: Missing.
     473-473: Missing.

Note: No experimental confirmation available.
Show »
Length:460
Mass (Da):52,423
Checksum:i64D8EE88C312401A
GO
Isoform 6 (identifier: Q969R2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-284: MGKAAAPSRG...KAVRVMNTHS → MKGRGCWDTASVRSFCSSGCLNKFKK
     869-869: E → EA

Show »
Length:659
Mass (Da):74,658
Checksum:i59C2935A3EF1A0F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6ZN50Q6ZN50_HUMAN
Oxysterol-binding protein
OSBP2 hCG_41303
743Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C428H7C428_HUMAN
Oxysterol-binding protein
OSBP2
588Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSB4A0A0A0MSB4_HUMAN
Oxysterol-binding protein
OSBP2
636Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C368H7C368_HUMAN
Oxysterol-binding protein
OSBP2
450Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1R2H7C1R2_HUMAN
Oxysterol-binding protein 2
OSBP2
298Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JS84C9JS84_HUMAN
Oxysterol-binding protein 2
OSBP2
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C313H7C313_HUMAN
Oxysterol-binding protein 2
OSBP2
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C001H7C001_HUMAN
Oxysterol-binding protein 2
OSBP2
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7J0C9J7J0_HUMAN
Oxysterol-binding protein 2
OSBP2
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK56864 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAK56865 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB33334 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34T → A in BAB33334 (PubMed:11258795).Curated1
Sequence conflicti552Q → H in BAG59036 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053546760M → V. Corresponds to variant dbSNP:rs34240867Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0552621 – 455Missing in isoform 5. 1 PublicationAdd BLAST455
Alternative sequenceiVSP_0552631 – 366Missing in isoform 4. 1 PublicationAdd BLAST366
Alternative sequenceiVSP_0557511 – 284MGKAA…MNTHS → MKGRGCWDTASVRSFCSSGC LNKFKK in isoform 6. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_0548861 – 49MGKAA…GSGPE → MHRQRTRTMSSLAAKRLGMN RRPAGSGGGGGEAATWGHRF WRPQERPTD in isoform 3. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_05488750 – 214Missing in isoform 3. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_054520473Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_055752869E → EA in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF288741 mRNA Translation: AAK56864.1 Different initiation.
AF288742 Genomic DNA Translation: AAK56865.1 Different initiation.
AF323731 mRNA Translation: AAG53406.1
AB051451 mRNA Translation: BAB33334.2 Different initiation.
AK093196 mRNA Translation: BAC04091.1
AK296525 mRNA Translation: BAG59156.1
AK300323 mRNA Translation: BAG62075.1
AK296354 mRNA Translation: BAG59036.1
AC004542 Genomic DNA Translation: AAC12953.1
AL022336 Genomic DNA No translation available.
AL079299 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59916.1
BC118914 mRNA Translation: AAI18915.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43002.1 [Q969R2-1]
CCDS63446.1 [Q969R2-3]
CCDS63448.1 [Q969R2-2]
CCDS63449.1 [Q969R2-6]
CCDS63450.1 [Q969R2-4]
CCDS63451.1 [Q969R2-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
T02435

NCBI Reference Sequences

More...
RefSeqi
NP_001269667.1, NM_001282738.1 [Q969R2-3]
NP_001269668.1, NM_001282739.1 [Q969R2-2]
NP_001269669.1, NM_001282740.1 [Q969R2-4]
NP_001269670.1, NM_001282741.1 [Q969R2-6]
NP_001269671.1, NM_001282742.1 [Q969R2-5]
NP_110385.1, NM_030758.3 [Q969R2-1]
XP_016884201.1, XM_017028712.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332585; ENSP00000332576; ENSG00000184792 [Q969R2-1]
ENST00000401475; ENSP00000385254; ENSG00000184792 [Q969R2-4]
ENST00000437268; ENSP00000389200; ENSG00000184792 [Q969R2-6]
ENST00000438716; ENSP00000411052; ENSG00000184792 [Q969R2-3]
ENST00000446658; ENSP00000392080; ENSG00000184792 [Q969R2-2]
ENST00000535268; ENSP00000438713; ENSG00000184792 [Q969R2-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23762

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23762

UCSC genome browser

More...
UCSCi
uc003aiy.1 human [Q969R2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288741 mRNA Translation: AAK56864.1 Different initiation.
AF288742 Genomic DNA Translation: AAK56865.1 Different initiation.
AF323731 mRNA Translation: AAG53406.1
AB051451 mRNA Translation: BAB33334.2 Different initiation.
AK093196 mRNA Translation: BAC04091.1
AK296525 mRNA Translation: BAG59156.1
AK300323 mRNA Translation: BAG62075.1
AK296354 mRNA Translation: BAG59036.1
AC004542 Genomic DNA Translation: AAC12953.1
AL022336 Genomic DNA No translation available.
AL079299 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59916.1
BC118914 mRNA Translation: AAI18915.1
CCDSiCCDS43002.1 [Q969R2-1]
CCDS63446.1 [Q969R2-3]
CCDS63448.1 [Q969R2-2]
CCDS63449.1 [Q969R2-6]
CCDS63450.1 [Q969R2-4]
CCDS63451.1 [Q969R2-5]
PIRiT02435
RefSeqiNP_001269667.1, NM_001282738.1 [Q969R2-3]
NP_001269668.1, NM_001282739.1 [Q969R2-2]
NP_001269669.1, NM_001282740.1 [Q969R2-4]
NP_001269670.1, NM_001282741.1 [Q969R2-6]
NP_001269671.1, NM_001282742.1 [Q969R2-5]
NP_110385.1, NM_030758.3 [Q969R2-1]
XP_016884201.1, XM_017028712.1

3D structure databases

SMRiQ969R2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117263, 12 interactors
ELMiQ969R2
IntActiQ969R2, 8 interactors
MINTiQ969R2
STRINGi9606.ENSP00000332576

Chemistry databases

BindingDBiQ969R2

PTM databases

iPTMnetiQ969R2
PhosphoSitePlusiQ969R2

Polymorphism and mutation databases

BioMutaiOSBP2
DMDMi88984633

Proteomic databases

jPOSTiQ969R2
MaxQBiQ969R2
PaxDbiQ969R2
PeptideAtlasiQ969R2
PRIDEiQ969R2
ProteomicsDBi25910
4454
5124
58834
72634
75819 [Q969R2-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332585; ENSP00000332576; ENSG00000184792 [Q969R2-1]
ENST00000401475; ENSP00000385254; ENSG00000184792 [Q969R2-4]
ENST00000437268; ENSP00000389200; ENSG00000184792 [Q969R2-6]
ENST00000438716; ENSP00000411052; ENSG00000184792 [Q969R2-3]
ENST00000446658; ENSP00000392080; ENSG00000184792 [Q969R2-2]
ENST00000535268; ENSP00000438713; ENSG00000184792 [Q969R2-5]
GeneIDi23762
KEGGihsa:23762
UCSCiuc003aiy.1 human [Q969R2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23762
DisGeNETi23762

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OSBP2
HGNCiHGNC:8504 OSBP2
HPAiHPA021514
MIMi606729 gene
neXtProtiNX_Q969R2
OpenTargetsiENSG00000184792
PharmGKBiPA32823

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00940000157987
HOGENOMiHOG000231233
InParanoidiQ969R2
KOiK20462
OMAiEINHTCR
OrthoDBi542090at2759
PhylomeDBiQ969R2
TreeFamiTF320922

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OSBP2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
OSBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23762

Protein Ontology

More...
PROi
PR:Q969R2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184792 Expressed in 165 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiQ969R2 baseline and differential
GenevisibleiQ969R2 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSBP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969R2
Secondary accession number(s): B0QYG1
, B4DK24, B4DKE4, B4DTR3, F5H2A3, O60396, Q0VF99, Q8NA37, Q9BY96, Q9BZF0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 21, 2006
Last modified: July 31, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again