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Entry version 151 (13 Nov 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Gene

PPP2R3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate MCM3AP phosphorylation through phosphatase recruitment (By similarity). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex (PubMed:24333728). May play a role in the activation-induced cell death of B-cells (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi286 – 2971Sequence analysisAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Alternative name(s):
Protein phosphatase subunit G5PR
Rhabdomyosarcoma antigen MU-RMS-40.6A/6C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP2R3C
Synonyms:C14orf10, G5PR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17485 PPP2R3C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615902 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969Q6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Gonadal dysgenesis, dysmorphic facies, retinal dystrophy, and myopathy (GDRM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by 46,XY complete gonadal dysgenesis and extragonadal anomalies, including typical facial gestalt, low birth weight, myopathy, rod and cone dystrophy, anal atresia, omphalocele, sensorineural hearing loss, dry and scaly skin, skeletal abnormalities, renal agenesis and neuromotor delay.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_082202103L → P in GDRM; unknown pathological significance. 1 Publication1
Natural variantiVAR_082203193L → S in GDRM; unknown pathological significance. 1 Publication1
Natural variantiVAR_082204350F → S in GDRM; unknown pathological significance. 1 Publication1
Spermatogenic failure 36 (SPGF36)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant infertility disorder due to teratozoospermia, with spermatozoa showing anomalies of the head, acrosome, and nucleus.
Related information in OMIM

Keywords - Diseasei

Cone-rod dystrophy, Deafness, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
55012

MalaCards human disease database

More...
MalaCardsi
PPP2R3C
MIMi618419 phenotype
618420 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000092020

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400008

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q969Q6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP2R3C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762643

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002778331 – 453Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gammaAdd BLAST453

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q969Q6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q969Q6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q969Q6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q969Q6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969Q6

PeptideAtlas

More...
PeptideAtlasi
Q969Q6

PRoteomics IDEntifications database

More...
PRIDEi
Q969Q6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75817 [Q969Q6-1]
75818 [Q969Q6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969Q6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969Q6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed in brain and other tissues.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000092020 Expressed in 221 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q969Q6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969Q6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040835
HPA058834

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MCM3AP/GANP.

Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120344, 32 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q969Q6

Protein interaction database and analysis system

More...
IntActi
Q969Q6, 35 interactors

Molecular INTeraction database

More...
MINTi
Q969Q6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261475

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q969Q6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini273 – 308EF-hand 1Add BLAST36
Domaini341 – 376EF-hand 2Add BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi226 – 229Poly-Phe4

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2562 Eukaryota
ENOG410XRBK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155583

KEGG Orthology (KO)

More...
KOi
K11583

Identification of Orthologs from Complete Genome Data

More...
OMAi
RFYYKLP

Database of Orthologous Groups

More...
OrthoDBi
541286at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969Q6

TreeFam database of animal gene trees

More...
TreeFami
TF318412

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR041534 EF-hand_13
IPR018247 EF_Hand_1_Ca_BS
IPR039865 PPP2R3C

The PANTHER Classification System

More...
PANTHERi
PTHR12085 PTHR12085, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17958 EF-hand_13, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969Q6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDWKEVLRRR LATPNTCPNK KKSEQELKDE EMDLFTKYYS EWKGGRKNTN
60 70 80 90 100
EFYKTIPRFY YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW
110 120 130 140 150
FLLDKHQTPP MIGEEAMINY ENFLKVGEKA GAKCKQFFTA KVFAKLLHTD
160 170 180 190 200
SYGRISIMQF FNYVMRKVWL HQTRIGLSLY DVAGQGYLRE SDLENYILEL
210 220 230 240 250
IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI QDILACSFLD
260 270 280 290 300
DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR
310 320 330 340 350
YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF
360 370 380 390 400
KLLDIENKGY LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP
410 420 430 440 450
KDPLKISLQD LINSNQGDTV TTILIDLNGF WTYENREALV ANDSENSADL

DDT
Length:453
Mass (Da):53,316
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9749B7188B2F7599
GO
Isoform 2 (identifier: Q969Q6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:343
Mass (Da):39,806
Checksum:iA921EE6858995288
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q86US5Q86US5_HUMAN
Chromosome 14 open reading frame tr...
PPP2R3C C14ORF10
190Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGK2A0A0C4DGK2_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
167Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJC5H0YJC5_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2K1G3V2K1_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJV0H0YJV0_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5U8G3V5U8_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ16H0YJ16_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V561G3V561_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3V5G3V3V5_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V228G3V228_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAT44532 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAT44533 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106H → R in BAA91308 (PubMed:14702039).Curated1
Sequence conflicti240I → T in AAT44532 (Ref. 6) Curated1
Sequence conflicti301Y → H in BAA91308 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_082202103L → P in GDRM; unknown pathological significance. 1 Publication1
Natural variantiVAR_082203193L → S in GDRM; unknown pathological significance. 1 Publication1
Natural variantiVAR_082204350F → S in GDRM; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0231131 – 110Missing in isoform 2. 2 PublicationsAdd BLAST110

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY157304 mRNA Translation: AAO17045.1
AK000651 mRNA Translation: BAA91308.1
AK293717 mRNA Translation: BAG57148.1
CH471078 Genomic DNA Translation: EAW65886.1
CH471078 Genomic DNA Translation: EAW65887.1
CH471078 Genomic DNA Translation: EAW65889.1
CH471078 Genomic DNA Translation: EAW65890.1
BC006823 mRNA Translation: AAH06823.1
BC010293 mRNA Translation: AAH10293.1
BC012563 mRNA Translation: AAH12563.1
BC063438 mRNA Translation: AAH63438.1
BX248043 mRNA Translation: CAD62352.1
AY518535 mRNA Translation: AAT44532.1 Different initiation.
AY518537 mRNA Translation: AAT44533.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS9654.1 [Q969Q6-1]

NCBI Reference Sequences

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RefSeqi
NP_001292084.1, NM_001305155.1 [Q969Q6-2]
NP_001292085.1, NM_001305156.1 [Q969Q6-2]
NP_060387.2, NM_017917.3 [Q969Q6-1]
XP_005267839.1, XM_005267782.3 [Q969Q6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000261475; ENSP00000261475; ENSG00000092020 [Q969Q6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55012

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55012

UCSC genome browser

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UCSCi
uc001wss.4 human [Q969Q6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157304 mRNA Translation: AAO17045.1
AK000651 mRNA Translation: BAA91308.1
AK293717 mRNA Translation: BAG57148.1
CH471078 Genomic DNA Translation: EAW65886.1
CH471078 Genomic DNA Translation: EAW65887.1
CH471078 Genomic DNA Translation: EAW65889.1
CH471078 Genomic DNA Translation: EAW65890.1
BC006823 mRNA Translation: AAH06823.1
BC010293 mRNA Translation: AAH10293.1
BC012563 mRNA Translation: AAH12563.1
BC063438 mRNA Translation: AAH63438.1
BX248043 mRNA Translation: CAD62352.1
AY518535 mRNA Translation: AAT44532.1 Different initiation.
AY518537 mRNA Translation: AAT44533.1 Different initiation.
CCDSiCCDS9654.1 [Q969Q6-1]
RefSeqiNP_001292084.1, NM_001305155.1 [Q969Q6-2]
NP_001292085.1, NM_001305156.1 [Q969Q6-2]
NP_060387.2, NM_017917.3 [Q969Q6-1]
XP_005267839.1, XM_005267782.3 [Q969Q6-1]

3D structure databases

SMRiQ969Q6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120344, 32 interactors
CORUMiQ969Q6
IntActiQ969Q6, 35 interactors
MINTiQ969Q6
STRINGi9606.ENSP00000261475

PTM databases

iPTMnetiQ969Q6
PhosphoSitePlusiQ969Q6

Polymorphism and mutation databases

BioMutaiPPP2R3C
DMDMi74762643

Proteomic databases

EPDiQ969Q6
jPOSTiQ969Q6
MassIVEiQ969Q6
MaxQBiQ969Q6
PaxDbiQ969Q6
PeptideAtlasiQ969Q6
PRIDEiQ969Q6
ProteomicsDBi75817 [Q969Q6-1]
75818 [Q969Q6-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55012

Genome annotation databases

EnsembliENST00000261475; ENSP00000261475; ENSG00000092020 [Q969Q6-1]
GeneIDi55012
KEGGihsa:55012
UCSCiuc001wss.4 human [Q969Q6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55012
DisGeNETi55012

GeneCards: human genes, protein and diseases

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GeneCardsi
PPP2R3C
HGNCiHGNC:17485 PPP2R3C
HPAiHPA040835
HPA058834
MalaCardsiPPP2R3C
MIMi615902 gene
618419 phenotype
618420 phenotype
neXtProtiNX_Q969Q6
OpenTargetsiENSG00000092020
PharmGKBiPA162400008

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2562 Eukaryota
ENOG410XRBK LUCA
GeneTreeiENSGT00940000155583
KOiK11583
OMAiRFYYKLP
OrthoDBi541286at2759
PhylomeDBiQ969Q6
TreeFamiTF318412

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPP2R3C human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PPP2R3C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55012
PharosiQ969Q6

Protein Ontology

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PROi
PR:Q969Q6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000092020 Expressed in 221 organ(s), highest expression level in testis
ExpressionAtlasiQ969Q6 baseline and differential
GenevisibleiQ969Q6 HS

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR041534 EF-hand_13
IPR018247 EF_Hand_1_Ca_BS
IPR039865 PPP2R3C
PANTHERiPTHR12085 PTHR12085, 1 hit
PfamiView protein in Pfam
PF17958 EF-hand_13, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2R3C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969Q6
Secondary accession number(s): B4DEN7
, D3DS97, D3DS98, Q5GJ55, Q5GJ56, Q6P4G2, Q86TZ3, Q9NWR9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 1, 2001
Last modified: November 13, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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