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Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Gene

PPP2R3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi286 – 2971Sequence analysisAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Alternative name(s):
Protein phosphatase subunit G5PR
Rhabdomyosarcoma antigen MU-RMS-40.6A/6C
Gene namesi
Name:PPP2R3C
Synonyms:C14orf10, G5PR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000092020.10
HGNCiHGNC:17485 PPP2R3C
MIMi615902 gene
neXtProtiNX_Q969Q6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000092020
PharmGKBiPA162400008

Polymorphism and mutation databases

BioMutaiPPP2R3C
DMDMi74762643

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002778331 – 453Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gammaAdd BLAST453

Proteomic databases

EPDiQ969Q6
MaxQBiQ969Q6
PaxDbiQ969Q6
PeptideAtlasiQ969Q6
PRIDEiQ969Q6
ProteomicsDBi75817
75818 [Q969Q6-2]

PTM databases

iPTMnetiQ969Q6
PhosphoSitePlusiQ969Q6

Expressioni

Tissue specificityi

Ubiquitously expressed in brain and other tissues.2 Publications

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000092020 Expressed in 221 organ(s), highest expression level in testis
CleanExiHS_PPP2R3C
ExpressionAtlasiQ969Q6 baseline and differential
GenevisibleiQ969Q6 HS

Organism-specific databases

HPAiHPA040835
HPA058834

Interactioni

Subunit structurei

Interacts with MCM3AP/GANP. Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.By similarity2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi120344, 31 interactors
IntActiQ969Q6, 34 interactors
MINTiQ969Q6
STRINGi9606.ENSP00000261475

Structurei

3D structure databases

ProteinModelPortaliQ969Q6
SMRiQ969Q6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini273 – 308EF-hand 1Add BLAST36
Domaini341 – 376EF-hand 2Add BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi226 – 229Poly-Phe4

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2562 Eukaryota
ENOG410XRBK LUCA
GeneTreeiENSGT00530000063265
HOVERGENiHBG055242
KOiK11583
OMAiSQESNWF
OrthoDBiEOG091G06I8
PhylomeDBiQ969Q6
TreeFamiTF318412

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR039865 PPP2R3C
PANTHERiPTHR12085 PTHR12085, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969Q6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDWKEVLRRR LATPNTCPNK KKSEQELKDE EMDLFTKYYS EWKGGRKNTN
60 70 80 90 100
EFYKTIPRFY YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW
110 120 130 140 150
FLLDKHQTPP MIGEEAMINY ENFLKVGEKA GAKCKQFFTA KVFAKLLHTD
160 170 180 190 200
SYGRISIMQF FNYVMRKVWL HQTRIGLSLY DVAGQGYLRE SDLENYILEL
210 220 230 240 250
IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI QDILACSFLD
260 270 280 290 300
DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR
310 320 330 340 350
YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF
360 370 380 390 400
KLLDIENKGY LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP
410 420 430 440 450
KDPLKISLQD LINSNQGDTV TTILIDLNGF WTYENREALV ANDSENSADL

DDT
Length:453
Mass (Da):53,316
Last modified:December 1, 2001 - v1
Checksum:i9749B7188B2F7599
GO
Isoform 2 (identifier: Q969Q6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:343
Mass (Da):39,806
Checksum:iA921EE6858995288
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q86US5Q86US5_HUMAN
Chromosome 14 open reading frame tr...
PPP2R3C C14ORF10
190Annotation score:
A0A0C4DGK2A0A0C4DGK2_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
167Annotation score:
H0YJC5H0YJC5_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
226Annotation score:
H0YJV0H0YJV0_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
128Annotation score:
G3V2K1G3V2K1_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
226Annotation score:
G3V561G3V561_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
134Annotation score:
H0YJ16H0YJ16_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
41Annotation score:
G3V5U8G3V5U8_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
106Annotation score:
G3V3V5G3V3V5_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
29Annotation score:
G3V3T9G3V3T9_HUMAN
Serine/threonine-protein phosphatas...
PPP2R3C
53Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAT44532 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAT44533 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106H → R in BAA91308 (PubMed:14702039).Curated1
Sequence conflicti240I → T in AAT44532 (Ref. 6) Curated1
Sequence conflicti301Y → H in BAA91308 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0231131 – 110Missing in isoform 2. 2 PublicationsAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157304 mRNA Translation: AAO17045.1
AK000651 mRNA Translation: BAA91308.1
AK293717 mRNA Translation: BAG57148.1
CH471078 Genomic DNA Translation: EAW65886.1
CH471078 Genomic DNA Translation: EAW65887.1
CH471078 Genomic DNA Translation: EAW65889.1
CH471078 Genomic DNA Translation: EAW65890.1
BC006823 mRNA Translation: AAH06823.1
BC010293 mRNA Translation: AAH10293.1
BC012563 mRNA Translation: AAH12563.1
BC063438 mRNA Translation: AAH63438.1
BX248043 mRNA Translation: CAD62352.1
AY518535 mRNA Translation: AAT44532.1 Different initiation.
AY518537 mRNA Translation: AAT44533.1 Different initiation.
CCDSiCCDS9654.1 [Q969Q6-1]
RefSeqiNP_001292084.1, NM_001305155.1 [Q969Q6-2]
NP_001292085.1, NM_001305156.1 [Q969Q6-2]
NP_060387.2, NM_017917.3 [Q969Q6-1]
XP_005267839.1, XM_005267782.3 [Q969Q6-1]
UniGeneiHs.530712
Hs.621667

Genome annotation databases

EnsembliENST00000261475; ENSP00000261475; ENSG00000092020 [Q969Q6-1]
GeneIDi55012
KEGGihsa:55012
UCSCiuc001wss.4 human [Q969Q6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157304 mRNA Translation: AAO17045.1
AK000651 mRNA Translation: BAA91308.1
AK293717 mRNA Translation: BAG57148.1
CH471078 Genomic DNA Translation: EAW65886.1
CH471078 Genomic DNA Translation: EAW65887.1
CH471078 Genomic DNA Translation: EAW65889.1
CH471078 Genomic DNA Translation: EAW65890.1
BC006823 mRNA Translation: AAH06823.1
BC010293 mRNA Translation: AAH10293.1
BC012563 mRNA Translation: AAH12563.1
BC063438 mRNA Translation: AAH63438.1
BX248043 mRNA Translation: CAD62352.1
AY518535 mRNA Translation: AAT44532.1 Different initiation.
AY518537 mRNA Translation: AAT44533.1 Different initiation.
CCDSiCCDS9654.1 [Q969Q6-1]
RefSeqiNP_001292084.1, NM_001305155.1 [Q969Q6-2]
NP_001292085.1, NM_001305156.1 [Q969Q6-2]
NP_060387.2, NM_017917.3 [Q969Q6-1]
XP_005267839.1, XM_005267782.3 [Q969Q6-1]
UniGeneiHs.530712
Hs.621667

3D structure databases

ProteinModelPortaliQ969Q6
SMRiQ969Q6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120344, 31 interactors
IntActiQ969Q6, 34 interactors
MINTiQ969Q6
STRINGi9606.ENSP00000261475

PTM databases

iPTMnetiQ969Q6
PhosphoSitePlusiQ969Q6

Polymorphism and mutation databases

BioMutaiPPP2R3C
DMDMi74762643

Proteomic databases

EPDiQ969Q6
MaxQBiQ969Q6
PaxDbiQ969Q6
PeptideAtlasiQ969Q6
PRIDEiQ969Q6
ProteomicsDBi75817
75818 [Q969Q6-2]

Protocols and materials databases

DNASUi55012
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261475; ENSP00000261475; ENSG00000092020 [Q969Q6-1]
GeneIDi55012
KEGGihsa:55012
UCSCiuc001wss.4 human [Q969Q6-1]

Organism-specific databases

CTDi55012
EuPathDBiHostDB:ENSG00000092020.10
GeneCardsiPPP2R3C
H-InvDBiHIX0026726
HGNCiHGNC:17485 PPP2R3C
HPAiHPA040835
HPA058834
MIMi615902 gene
neXtProtiNX_Q969Q6
OpenTargetsiENSG00000092020
PharmGKBiPA162400008
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2562 Eukaryota
ENOG410XRBK LUCA
GeneTreeiENSGT00530000063265
HOVERGENiHBG055242
KOiK11583
OMAiSQESNWF
OrthoDBiEOG091G06I8
PhylomeDBiQ969Q6
TreeFamiTF318412

Miscellaneous databases

ChiTaRSiPPP2R3C human
GeneWikiiPPP2R3C
GenomeRNAii55012
PROiPR:Q969Q6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000092020 Expressed in 221 organ(s), highest expression level in testis
CleanExiHS_PPP2R3C
ExpressionAtlasiQ969Q6 baseline and differential
GenevisibleiQ969Q6 HS

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR039865 PPP2R3C
PANTHERiPTHR12085 PTHR12085, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP2R3C_HUMAN
AccessioniPrimary (citable) accession number: Q969Q6
Secondary accession number(s): B4DEN7
, D3DS97, D3DS98, Q5GJ55, Q5GJ56, Q6P4G2, Q86TZ3, Q9NWR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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