ARL11

Functionⁱ

May play a role in apoptosis. May act as a tumor suppressor.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	19 – 26	GTPBy similarity	8
Nucleotide bindingⁱ	63 – 67	GTPBy similarity	5
Nucleotide bindingⁱ	122 – 125	GTPBy similarity	4

GO - Molecular functionⁱ

GTP binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

hematopoietic progenitor cell differentiation Source: Ensembl
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ADP-ribosylation factor-like protein 11 Alternative name(s): ADP-ribosylation factor-like tumor suppressor protein 1
Gene namesⁱ	Name:ARL11 Synonyms:ARLTS1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000152213.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24046 ARL11
MIMⁱ	609351 gene
neXtProtⁱ	NX_Q969Q4

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Leukemia, chronic lymphocytic (CLL)

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	115761
MalaCards human disease database More...MalaCardsⁱ	ARL11
MIMⁱ	151400 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000152213
Orphanetⁱ	67038 B-cell chronic lymphocytic leukemia
PharmGKBⁱ	PA134974627

Polymorphism and mutation databases

BioMutaⁱ	ARL11
DMDMⁱ	74751726

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedSequence analysis
ChainⁱPRO_0000207479	2 – 196	ADP-ribosylation factor-like protein 11Add BLAST		195

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	2	N-myristoyl glycineSequence analysis		1

Keywords - PTMⁱ

Lipoprotein, Myristate

Proteomic databases

EPDⁱ	Q969Q4
PaxDbⁱ	Q969Q4
PeptideAtlas More...PeptideAtlasⁱ	Q969Q4
PRIDEⁱ	Q969Q4
ProteomicsDBⁱ	75815

PTM databases

iPTMnetⁱ	Q969Q4
PhosphoSitePlusⁱ	Q969Q4

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000152213 Expressed in 112 organ(s), highest expression level in blood
CleanExⁱ	HS_ARL11
Genevisibleⁱ	Q969Q4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040855 HPA040887

HPAⁱ

HPA040855
HPA040887

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TRIP13	Q15645	3	EBI-751892,EBI-358993

With

Entry

#Exp.

IntAct

Notes

TRIP13

Q15645

3

EBI-751892,EBI-358993

Protein-protein interaction databases

BioGridⁱ	125454, 8 interactors
IntActⁱ	Q969Q4, 1 interactor
STRINGⁱ	9606.ENSP00000282026

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q969Q4
SMRⁱ	Q969Q4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0070 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150892
HOGENOMⁱ	HOG000163691
HOVERGENⁱ	HBG002073
InParanoidⁱ	Q969Q4
KEGG Orthology (KO) More...KOⁱ	K07959
OMAⁱ	WELRACS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O0X
PhylomeDBⁱ	Q969Q4
TreeFamⁱ	TF105471

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR006689 Small_GTPase_ARF/SAR
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00025 Arf, 1 hit
PRINTSⁱ	PR00328 SAR1GTPBP
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51417 ARF, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q969Q4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP 
        60         70         80         90        100
LKAPGHVSLT LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA 
       110        120        130        140        150
AELTEVLNDP NMAGVPFLVL ANKQEAPDAL PLLKIRNRLS LERFQDHCWE 
       160        170        180        190 
LRGCSALTGE GLPEALQSLW SLLKSRSCMC LQARAHGAER GDSKRS

Length:196

Mass (Da):21,391

Last modified:December 1, 2001 - v1

Checksum:ⁱ99389B2A2389149E

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_023742	22	S → L1 PublicationCorresponds to variant dbSNP:rs147389782Ensembl.	1
Natural variantⁱVAR_048318	120	L → M. Corresponds to variant dbSNP:rs35712316Ensembl.	1
Natural variantⁱVAR_023743	131	P → L1 PublicationCorresponds to variant dbSNP:rs147120792Ensembl.	1
Natural variantⁱVAR_023744	148	C → R1 PublicationCorresponds to variant dbSNP:rs3803185Ensembl.	1
Natural variantⁱVAR_023745	164	E → K1 PublicationCorresponds to variant dbSNP:rs146850453Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF441378 mRNA Translation: AAP19650.1 AK091249 mRNA Translation: BAC03621.1 AL135901 Genomic DNA No translation available. BC013150 mRNA Translation: AAH13150.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9419.1
NCBI Reference Sequences More...RefSeqⁱ	NP_612459.1, NM_138450.5 XP_005266310.1, XM_005266253.3
UniGeneⁱ	Hs.558599

Genome annotation databases

Ensemblⁱ	ENST00000282026; ENSP00000282026; ENSG00000152213
GeneIDⁱ	115761
KEGGⁱ	hsa:115761
UCSC genome browser More...UCSCⁱ	uc001vdf.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q969Q4	ADP-ribosylation factor-like protein 11		MACMU		196	UniRef90_Q969Q4
ADP-ribosylation factor-like tumor suppressor protein 1		MACFA		196
ADP ribosylation factor like GTPase 11		PANTR		196
Uncharacterized protein		PANPA		196
Uncharacterized protein		COLAP		196
+11

Protein	Similar proteins		Species	Score	Length	Source
Q969Q4	ADP-ribosylation factor-like protein 11		RAT		173	UniRef50_Q969Q4
ADP-ribosylation factor-like protein 11		MOUSE		176
ADP-ribosylation factor-like protein 11		BOVIN		182
ADP-ribosylation factor-like protein 11		MACMU		196
ADP-ribosylation factor-like tumor suppressor protein 1		MACFA		196
+129

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF441378 mRNA Translation: AAP19650.1 AK091249 mRNA Translation: BAC03621.1 AL135901 Genomic DNA No translation available. BC013150 mRNA Translation: AAH13150.1
CCDSⁱ	CCDS9419.1
RefSeqⁱ	NP_612459.1, NM_138450.5 XP_005266310.1, XM_005266253.3
UniGeneⁱ	Hs.558599

3D structure databases

ProteinModelPortalⁱ	Q969Q4
SMRⁱ	Q969Q4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125454, 8 interactors
IntActⁱ	Q969Q4, 1 interactor
STRINGⁱ	9606.ENSP00000282026

PTM databases

iPTMnetⁱ	Q969Q4
PhosphoSitePlusⁱ	Q969Q4

Polymorphism and mutation databases

BioMutaⁱ	ARL11
DMDMⁱ	74751726

Proteomic databases

EPDⁱ	Q969Q4
PaxDbⁱ	Q969Q4
PeptideAtlasⁱ	Q969Q4
PRIDEⁱ	Q969Q4
ProteomicsDBⁱ	75815

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000282026; ENSP00000282026; ENSG00000152213
GeneIDⁱ	115761
KEGGⁱ	hsa:115761
UCSCⁱ	uc001vdf.2 human

Organism-specific databases

CTDⁱ	115761
DisGeNETⁱ	115761
EuPathDBⁱ	HostDB:ENSG00000152213.3
GeneCardsⁱ	ARL11
HGNCⁱ	HGNC:24046 ARL11
HPAⁱ	HPA040855 HPA040887
MalaCardsⁱ	ARL11
MIMⁱ	151400 phenotype 609351 gene
neXtProtⁱ	NX_Q969Q4
OpenTargetsⁱ	ENSG00000152213
Orphanetⁱ	67038 B-cell chronic lymphocytic leukemia
PharmGKBⁱ	PA134974627
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0070 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00930000150892
HOGENOMⁱ	HOG000163691
HOVERGENⁱ	HBG002073
InParanoidⁱ	Q969Q4
KOⁱ	K07959
OMAⁱ	WELRACS
OrthoDBⁱ	EOG091G0O0X
PhylomeDBⁱ	Q969Q4
TreeFamⁱ	TF105471

Miscellaneous databases

ChiTaRSⁱ	ARL11 human
GeneWikiⁱ	ARL11
GenomeRNAiⁱ	115761
Protein Ontology More...PROⁱ	PR:Q969Q4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000152213 Expressed in 112 organ(s), highest expression level in blood
CleanExⁱ	HS_ARL11
Genevisibleⁱ	Q969Q4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR006689 Small_GTPase_ARF/SAR
Pfamⁱ	View protein in Pfam PF00025 Arf, 1 hit
PRINTSⁱ	PR00328 SAR1GTPBP
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51417 ARF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARL11_HUMAN
Accessionⁱ	Q969Q4Primary (citable) accession number: Q969Q4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM

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UniProtKB - Q969Q4 (ARL11_HUMAN)

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ADP-ribosylation factor-like protein 11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Leukemia, chronic lymphocytic (CLL)

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ