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UniProtKB - Q969Q4 (ARL11_HUMAN)
Protein
ADP-ribosylation factor-like protein 11
Gene
ARL11
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in apoptosis. May act as a tumor suppressor.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 19 – 26 | GTPBy similarity | 8 | |
Nucleotide bindingi | 63 – 67 | GTPBy similarity | 5 | |
Nucleotide bindingi | 122 – 125 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: GO_Central
GO - Biological processi
- hematopoietic progenitor cell differentiation Source: Ensembl
- intracellular protein transport Source: GO_Central
- vesicle-mediated transport Source: GO_Central
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q969Q4 |
SignaLinki | Q969Q4 |
Names & Taxonomyi
Protein namesi | Recommended name: ADP-ribosylation factor-like protein 11Alternative name(s): ADP-ribosylation factor-like tumor suppressor protein 1 |
Gene namesi | Name:ARL11 Synonyms:ARLTS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24046, ARL11 |
MIMi | 609351, gene |
neXtProti | NX_Q969Q4 |
VEuPathDBi | HostDB:ENSG00000152213 |
Pathology & Biotechi
Involvement in diseasei
Leukemia, chronic lymphocytic (CLL)
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival.
Related information in OMIMOrganism-specific databases
DisGeNETi | 115761 |
MalaCardsi | ARL11 |
MIMi | 151400, phenotype |
OpenTargetsi | ENSG00000152213 |
Orphaneti | 67038, B-cell chronic lymphocytic leukemia |
PharmGKBi | PA134974627 |
Miscellaneous databases
Pharosi | Q969Q4, Tbio |
Genetic variation databases
BioMutai | ARL11 |
DMDMi | 74751726 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedSequence analysis | |||
ChainiPRO_0000207479 | 2 – 196 | ADP-ribosylation factor-like protein 11Add BLAST | 195 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycineSequence analysis | 1 |
Keywords - PTMi
Lipoprotein, MyristateProteomic databases
EPDi | Q969Q4 |
jPOSTi | Q969Q4 |
MassIVEi | Q969Q4 |
PaxDbi | Q969Q4 |
PeptideAtlasi | Q969Q4 |
PRIDEi | Q969Q4 |
ProteomicsDBi | 75815 |
PTM databases
iPTMneti | Q969Q4 |
PhosphoSitePlusi | Q969Q4 |
Expressioni
Tissue specificityi
Expressed in lung and leukocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000152213, Expressed in blood and 133 other tissues |
Genevisiblei | Q969Q4, HS |
Organism-specific databases
HPAi | ENSG00000152213, Tissue enhanced (lymphoid) |
Interactioni
Binary interactionsi
Q969Q4
With | #Exp. | IntAct |
---|---|---|
TRIP13 [Q15645] | 4 | EBI-751892,EBI-358993 |
Protein-protein interaction databases
BioGRIDi | 125454, 13 interactors |
IntActi | Q969Q4, 7 interactors |
STRINGi | 9606.ENSP00000282026 |
Miscellaneous databases
RNActi | Q969Q4, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0070, Eukaryota |
GeneTreei | ENSGT00940000162731 |
HOGENOMi | CLU_040729_9_2_1 |
InParanoidi | Q969Q4 |
OMAi | WRKRDAR |
OrthoDBi | 1271528at2759 |
PhylomeDBi | Q969Q4 |
TreeFami | TF105471 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR024156, Small_GTPase_ARF IPR006689, Small_GTPase_ARF/SAR |
PANTHERi | PTHR11711, PTHR11711, 1 hit |
Pfami | View protein in Pfam PF00025, Arf, 1 hit |
PRINTSi | PR00328, SAR1GTPBP |
SMARTi | View protein in SMART SM00178, SAR, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51417, ARF, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q969Q4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP
60 70 80 90 100
LKAPGHVSLT LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA
110 120 130 140 150
AELTEVLNDP NMAGVPFLVL ANKQEAPDAL PLLKIRNRLS LERFQDHCWE
160 170 180 190
LRGCSALTGE GLPEALQSLW SLLKSRSCMC LQARAHGAER GDSKRS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023742 | 22 | S → L1 PublicationCorresponds to variant dbSNP:rs147389782Ensembl. | 1 | |
Natural variantiVAR_048318 | 120 | L → M. Corresponds to variant dbSNP:rs35712316Ensembl. | 1 | |
Natural variantiVAR_023743 | 131 | P → L1 PublicationCorresponds to variant dbSNP:rs147120792Ensembl. | 1 | |
Natural variantiVAR_023744 | 148 | C → R1 PublicationCorresponds to variant dbSNP:rs3803185Ensembl. | 1 | |
Natural variantiVAR_023745 | 164 | E → K1 PublicationCorresponds to variant dbSNP:rs146850453Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF441378 mRNA Translation: AAP19650.1 AK091249 mRNA Translation: BAC03621.1 AL135901 Genomic DNA No translation available. BC013150 mRNA Translation: AAH13150.1 |
CCDSi | CCDS9419.1 |
RefSeqi | NP_612459.1, NM_138450.5 XP_005266310.1, XM_005266253.3 |
Genome annotation databases
Ensembli | ENST00000282026; ENSP00000282026; ENSG00000152213 |
GeneIDi | 115761 |
KEGGi | hsa:115761 |
MANE-Selecti | ENST00000282026.2; ENSP00000282026.1; NM_138450.6; NP_612459.1 |
UCSCi | uc001vdf.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF441378 mRNA Translation: AAP19650.1 AK091249 mRNA Translation: BAC03621.1 AL135901 Genomic DNA No translation available. BC013150 mRNA Translation: AAH13150.1 |
CCDSi | CCDS9419.1 |
RefSeqi | NP_612459.1, NM_138450.5 XP_005266310.1, XM_005266253.3 |
3D structure databases
SMRi | Q969Q4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125454, 13 interactors |
IntActi | Q969Q4, 7 interactors |
STRINGi | 9606.ENSP00000282026 |
PTM databases
iPTMneti | Q969Q4 |
PhosphoSitePlusi | Q969Q4 |
Genetic variation databases
BioMutai | ARL11 |
DMDMi | 74751726 |
Proteomic databases
EPDi | Q969Q4 |
jPOSTi | Q969Q4 |
MassIVEi | Q969Q4 |
PaxDbi | Q969Q4 |
PeptideAtlasi | Q969Q4 |
PRIDEi | Q969Q4 |
ProteomicsDBi | 75815 |
Protocols and materials databases
Antibodypediai | 23950, 205 antibodies from 24 providers |
DNASUi | 115761 |
Genome annotation databases
Ensembli | ENST00000282026; ENSP00000282026; ENSG00000152213 |
GeneIDi | 115761 |
KEGGi | hsa:115761 |
MANE-Selecti | ENST00000282026.2; ENSP00000282026.1; NM_138450.6; NP_612459.1 |
UCSCi | uc001vdf.2, human |
Organism-specific databases
CTDi | 115761 |
DisGeNETi | 115761 |
GeneCardsi | ARL11 |
HGNCi | HGNC:24046, ARL11 |
HPAi | ENSG00000152213, Tissue enhanced (lymphoid) |
MalaCardsi | ARL11 |
MIMi | 151400, phenotype 609351, gene |
neXtProti | NX_Q969Q4 |
OpenTargetsi | ENSG00000152213 |
Orphaneti | 67038, B-cell chronic lymphocytic leukemia |
PharmGKBi | PA134974627 |
VEuPathDBi | HostDB:ENSG00000152213 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0070, Eukaryota |
GeneTreei | ENSGT00940000162731 |
HOGENOMi | CLU_040729_9_2_1 |
InParanoidi | Q969Q4 |
OMAi | WRKRDAR |
OrthoDBi | 1271528at2759 |
PhylomeDBi | Q969Q4 |
TreeFami | TF105471 |
Enzyme and pathway databases
PathwayCommonsi | Q969Q4 |
SignaLinki | Q969Q4 |
Miscellaneous databases
BioGRID-ORCSi | 115761, 18 hits in 1038 CRISPR screens |
ChiTaRSi | ARL11, human |
GeneWikii | ARL11 |
GenomeRNAii | 115761 |
Pharosi | Q969Q4, Tbio |
PROi | PR:Q969Q4 |
RNActi | Q969Q4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152213, Expressed in blood and 133 other tissues |
Genevisiblei | Q969Q4, HS |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR024156, Small_GTPase_ARF IPR006689, Small_GTPase_ARF/SAR |
PANTHERi | PTHR11711, PTHR11711, 1 hit |
Pfami | View protein in Pfam PF00025, Arf, 1 hit |
PRINTSi | PR00328, SAR1GTPBP |
SMARTi | View protein in SMART SM00178, SAR, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51417, ARF, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARL11_HUMAN | |
Accessioni | Q969Q4Primary (citable) accession number: Q969Q4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families