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Protein

ADP-ribosylation factor-like protein 11

Gene

ARL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in apoptosis. May act as a tumor suppressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 26GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 11
Alternative name(s):
ADP-ribosylation factor-like tumor suppressor protein 1
Gene namesi
Name:ARL11
Synonyms:ARLTS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000152213.3
HGNCiHGNC:24046 ARL11
MIMi609351 gene
neXtProtiNX_Q969Q4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Leukemia, chronic lymphocytic (CLL)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival.
See also OMIM:151400

Organism-specific databases

DisGeNETi115761
MalaCardsiARL11
MIMi151400 phenotype
OpenTargetsiENSG00000152213
Orphaneti67038 B-cell chronic lymphocytic leukemia
PharmGKBiPA134974627

Polymorphism and mutation databases

BioMutaiARL11
DMDMi74751726

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074792 – 196ADP-ribosylation factor-like protein 11Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ969Q4
PaxDbiQ969Q4
PeptideAtlasiQ969Q4
PRIDEiQ969Q4
ProteomicsDBi75815

PTM databases

iPTMnetiQ969Q4
PhosphoSitePlusiQ969Q4

Expressioni

Tissue specificityi

Expressed in lung and leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000152213 Expressed in 112 organ(s), highest expression level in blood
CleanExiHS_ARL11
GenevisibleiQ969Q4 HS

Organism-specific databases

HPAiHPA040855
HPA040887

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156453EBI-751892,EBI-358993

Protein-protein interaction databases

BioGridi125454, 8 interactors
IntActiQ969Q4, 1 interactor
STRINGi9606.ENSP00000282026

Structurei

3D structure databases

ProteinModelPortaliQ969Q4
SMRiQ969Q4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00930000150892
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiQ969Q4
KOiK07959
OMAiWELRACS
OrthoDBiEOG091G0O0X
PhylomeDBiQ969Q4
TreeFamiTF105471

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969Q4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP
60 70 80 90 100
LKAPGHVSLT LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA
110 120 130 140 150
AELTEVLNDP NMAGVPFLVL ANKQEAPDAL PLLKIRNRLS LERFQDHCWE
160 170 180 190
LRGCSALTGE GLPEALQSLW SLLKSRSCMC LQARAHGAER GDSKRS
Length:196
Mass (Da):21,391
Last modified:December 1, 2001 - v1
Checksum:i99389B2A2389149E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02374222S → L1 PublicationCorresponds to variant dbSNP:rs147389782Ensembl.1
Natural variantiVAR_048318120L → M. Corresponds to variant dbSNP:rs35712316Ensembl.1
Natural variantiVAR_023743131P → L1 PublicationCorresponds to variant dbSNP:rs147120792Ensembl.1
Natural variantiVAR_023744148C → R1 PublicationCorresponds to variant dbSNP:rs3803185Ensembl.1
Natural variantiVAR_023745164E → K1 PublicationCorresponds to variant dbSNP:rs146850453Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441378 mRNA Translation: AAP19650.1
AK091249 mRNA Translation: BAC03621.1
AL135901 Genomic DNA No translation available.
BC013150 mRNA Translation: AAH13150.1
CCDSiCCDS9419.1
RefSeqiNP_612459.1, NM_138450.5
XP_005266310.1, XM_005266253.3
UniGeneiHs.558599

Genome annotation databases

EnsembliENST00000282026; ENSP00000282026; ENSG00000152213
GeneIDi115761
KEGGihsa:115761
UCSCiuc001vdf.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441378 mRNA Translation: AAP19650.1
AK091249 mRNA Translation: BAC03621.1
AL135901 Genomic DNA No translation available.
BC013150 mRNA Translation: AAH13150.1
CCDSiCCDS9419.1
RefSeqiNP_612459.1, NM_138450.5
XP_005266310.1, XM_005266253.3
UniGeneiHs.558599

3D structure databases

ProteinModelPortaliQ969Q4
SMRiQ969Q4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125454, 8 interactors
IntActiQ969Q4, 1 interactor
STRINGi9606.ENSP00000282026

PTM databases

iPTMnetiQ969Q4
PhosphoSitePlusiQ969Q4

Polymorphism and mutation databases

BioMutaiARL11
DMDMi74751726

Proteomic databases

EPDiQ969Q4
PaxDbiQ969Q4
PeptideAtlasiQ969Q4
PRIDEiQ969Q4
ProteomicsDBi75815

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282026; ENSP00000282026; ENSG00000152213
GeneIDi115761
KEGGihsa:115761
UCSCiuc001vdf.2 human

Organism-specific databases

CTDi115761
DisGeNETi115761
EuPathDBiHostDB:ENSG00000152213.3
GeneCardsiARL11
HGNCiHGNC:24046 ARL11
HPAiHPA040855
HPA040887
MalaCardsiARL11
MIMi151400 phenotype
609351 gene
neXtProtiNX_Q969Q4
OpenTargetsiENSG00000152213
Orphaneti67038 B-cell chronic lymphocytic leukemia
PharmGKBiPA134974627
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00930000150892
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiQ969Q4
KOiK07959
OMAiWELRACS
OrthoDBiEOG091G0O0X
PhylomeDBiQ969Q4
TreeFamiTF105471

Miscellaneous databases

ChiTaRSiARL11 human
GeneWikiiARL11
GenomeRNAii115761
PROiPR:Q969Q4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152213 Expressed in 112 organ(s), highest expression level in blood
CleanExiHS_ARL11
GenevisibleiQ969Q4 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARL11_HUMAN
AccessioniPrimary (citable) accession number: Q969Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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