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UniProtKB - Q969P6 (TOP1M_HUMAN)

Entry version 180 (23 Feb 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

DNA topoisomerase I, mitochondrial

Gene

TOP1MT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.PROSITE-ProRule annotation EC:5.6.2.1

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+1 Publication, Mg2+1 PublicationNote: Divalent metal ions (calcium or magnesium).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei559O-(3'-phospho-DNA)-tyrosine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Isomerase, Topoisomerase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		5.6.2.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q969P6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q969P6

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q969P6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA topoisomerase I, mitochondrial (EC:5.6.2.1PROSITE-ProRule annotation)
Short name:
TOP1mt
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOP1MT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29787, TOP1MT

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606387, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q969P6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000184428

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		116447

Open Targets

More...OpenTargetsi		ENSG00000184428

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134922772

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q969P6, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2362989

Drug and drug target database

More...DrugBanki		DB00762, Irinotecan
DB01030, Topotecan

DrugCentral

More...DrugCentrali		Q969P6

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TOP1MT

Domain mapping of disease mutations (DMDM)

More...DMDMi		20140694

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 50Mitochondrion1 PublicationAdd BLAST50
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003479751 – 601DNA topoisomerase I, mitochondrialAdd BLAST551

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q969P6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q969P6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q969P6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q969P6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q969P6

PeptideAtlas

More...PeptideAtlasi		Q969P6

PRoteomics IDEntifications database

More...PRIDEi		Q969P6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17936
75812 [Q969P6-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q969P6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q969P6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q969P6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000184428, Expressed in testis and 173 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q969P6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q969P6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000184428, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei152Interaction with DNABy similarity1
Sitei200Interaction with DNABy similarity1
Sitei248Interaction with DNABy similarity1
Sitei279Interaction with DNABy similarity1
Sitei337Interaction with DNABy similarity1
Sitei368Interaction with DNABy similarity1
Sitei410Interaction with DNABy similarity1
Sitei468Interaction with DNABy similarity1
Sitei486Interaction with DNABy similarity1

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125510, 24 interactors

Protein interaction database and analysis system

More...IntActi		Q969P6, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000328835

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q969P6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q969P6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 48DisorderedSequence analysisAdd BLAST27
Regioni261 – 262Interaction with DNABy similarity2
Regioni324 – 329Interaction with DNABy similarity6
Regioni421 – 423Interaction with DNABy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type IB topoisomerase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0981, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162943

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009193_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q969P6

Identification of Orthologs from Complete Genome Data

More...OMAi		RYNAANR

Database of Orthologous Groups

More...OrthoDBi		303947at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q969P6

TreeFam database of animal gene trees

More...TreeFami		TF105281

Family and domain databases

Conserved Domains Database

More...CDDi		cd00659, Topo_IB_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.41, 1 hit
1.10.132.10, 1 hit
2.170.11.10, 1 hit
3.90.15.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011010, DNA_brk_join_enz
IPR013034, DNA_topo_DNA_db_N_dom1
IPR013030, DNA_topo_DNA_db_N_dom2
IPR001631, TopoI
IPR018521, TopoI_AS
IPR025834, TopoI_C_dom
IPR014711, TopoI_cat_a-hlx-sub_euk
IPR014727, TopoI_cat_a/b-sub_euk
IPR013500, TopoI_cat_euk
IPR008336, TopoI_DNA-bd_euk
IPR036202, TopoI_DNA-bd_euk_N_sf
IPR013499, TopoI_euk

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14370, Topo_C_assoc, 1 hit
PF01028, Topoisom_I, 1 hit
PF02919, Topoisom_I_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00416, EUTPISMRASEI

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00435, TOPEUc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56349, SSF56349, 1 hit
SSF56741, SSF56741, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00176, TOPOISOMERASE_I_EUK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969P6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVVRLLRLR AALTLLGEVP RRPASRGVPG SRRTQKGSGA RWEKEKHEDG 
        60         70         80         90        100
VKWRQLEHKG PYFAPPYEPL PDGVRFFYEG RPVRLSVAAE EVATFYGRML 
       110        120        130        140        150
DHEYTTKEVF RKNFFNDWRK EMAVEEREVI KSLDKCDFTE IHRYFVDKAA 
       160        170        180        190        200
ARKVLSREEK QKLKEEAEKL QQEFGYCILD GHQEKIGNFK IEPPGLFRGR 
       210        220        230        240        250
GDHPKMGMLK RRITPEDVVI NCSRDSKIPE PPAGHQWKEV RSDNTVTWLA 
       260        270        280        290        300
AWTESVQNSI KYIMLNPCSK LKGETAWQKF ETARRLRGFV DEIRSQYRAD 
       310        320        330        340        350
WKSREMKTRQ RAVALYFIDK LALRAGNEKE DGEAADTVGC CSLRVEHVQL 
       360        370        380        390        400
HPEADGCQHV VEFDFLGKDC IRYYNRVPVE KPVYKNLQLF MENKDPRDDL 
       410        420        430        440        450
FDRLTTTSLN KHLQELMDGL TAKVFRTYNA SITLQEQLRA LTRAEDSIAA 
       460        470        480        490        500
KILSYNRANR VVAILCNHQR ATPSTFEKSM QNLQTKIQAK KEQVAEARAE 
       510        520        530        540        550
LRRARAEHKA QGDGKSRSVL EKKRRLLEKL QEQLAQLSVQ ATDKEENKQV 
       560        570        580        590        600
ALGTSKLNYL DPRISIAWCK RFRVPVEKIY SKTQRERFAW ALAMAGEDFE 

F
Length:601
Mass (Da):69,872
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA012248D4250C675
GO
Isoform 2 (identifier: Q969P6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.

Show »
Length:503
Mass (Da):58,645
Checksum:i7E0138EE2931B903
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIC7E5RIC7_HUMAN
DNA topoisomerase I
TOP1MT
376Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFS0E5RFS0_HUMAN
DNA topoisomerase I, mitochondrial
TOP1MT
221Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ95E5RJ95_HUMAN
DNA topoisomerase I, mitochondrial
TOP1MT
201Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAR3H0YAR3_HUMAN
DNA topoisomerase I, mitochondrial
TOP1MT
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFE3E5RFE3_HUMAN
DNA topoisomerase I, mitochondrial
TOP1MT
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGR4E5RGR4_HUMAN
DNA topoisomerase I, mitochondrial
TOP1MT
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGR2E5RGR2_HUMAN
DNA topoisomerase I, mitochondrial
TOP1MT
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC03H0YC03_HUMAN
DNA topoisomerase I, mitochondrial
TOP1MT
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ33E5RJ33_HUMAN
DNA topoisomerase I, mitochondrial
TOP1MT
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGE7E5RGE7_HUMAN
DNA topoisomerase I, mitochondrial
TOP1MT
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH44646 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116N → S in BAH14751 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052593256V → I1 PublicationCorresponds to variant dbSNP:rs11544484Ensembl.1
Natural variantiVAR_021863525R → W1 PublicationCorresponds to variant dbSNP:rs2293925Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0447831 – 98Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF349031 AF349030 Genomic DNA Translation: AAL10791.1
AF349017 mRNA Translation: AAL05624.1
AK316380 mRNA Translation: BAH14751.1
AC087793 Genomic DNA No translation available.
BC044646 mRNA Translation: AAH44646.1 Different initiation.
BC052285 mRNA Translation: AAH52285.1
BC071914 mRNA Translation: AAH71914.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS59115.1 [Q969P6-2]
CCDS6400.1 [Q969P6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001245375.1, NM_001258446.1 [Q969P6-2]
NP_001245376.1, NM_001258447.1 [Q969P6-2]
NP_443195.1, NM_052963.2 [Q969P6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000329245; ENSP00000328835; ENSG00000184428
ENST00000519148; ENSP00000429169; ENSG00000184428 [Q969P6-2]
ENST00000521193; ENSP00000428369; ENSG00000184428 [Q969P6-2]
ENST00000523676; ENSP00000429181; ENSG00000184428 [Q969P6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		116447

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:116447

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000329245.9; ENSP00000328835.3; NM_052963.3; NP_443195.1

UCSC genome browser

More...UCSCi		uc003yxz.6, human [Q969P6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349031 AF349030 Genomic DNA Translation: AAL10791.1
AF349017 mRNA Translation: AAL05624.1
AK316380 mRNA Translation: BAH14751.1
AC087793 Genomic DNA No translation available.
BC044646 mRNA Translation: AAH44646.1 Different initiation.
BC052285 mRNA Translation: AAH52285.1
BC071914 mRNA Translation: AAH71914.1
CCDSiCCDS59115.1 [Q969P6-2]
CCDS6400.1 [Q969P6-1]
RefSeqiNP_001245375.1, NM_001258446.1 [Q969P6-2]
NP_001245376.1, NM_001258447.1 [Q969P6-2]
NP_443195.1, NM_052963.2 [Q969P6-1]

3D structure databases

SMRiQ969P6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125510, 24 interactors
IntActiQ969P6, 11 interactors
STRINGi9606.ENSP00000328835

Chemistry databases

ChEMBLiCHEMBL2362989
DrugBankiDB00762, Irinotecan
DB01030, Topotecan
DrugCentraliQ969P6

PTM databases

iPTMnetiQ969P6
PhosphoSitePlusiQ969P6
SwissPalmiQ969P6

Genetic variation databases

BioMutaiTOP1MT
DMDMi20140694

Proteomic databases

EPDiQ969P6
jPOSTiQ969P6
MassIVEiQ969P6
MaxQBiQ969P6
PaxDbiQ969P6
PeptideAtlasiQ969P6
PRIDEiQ969P6
ProteomicsDBi17936
75812 [Q969P6-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		958, 248 antibodies from 27 providers

The CPTC Antibody Portal

More...CPTCi		Q969P6, 3 antibodies

The DNASU plasmid repository

More...DNASUi		116447

Genome annotation databases

EnsembliENST00000329245; ENSP00000328835; ENSG00000184428
ENST00000519148; ENSP00000429169; ENSG00000184428 [Q969P6-2]
ENST00000521193; ENSP00000428369; ENSG00000184428 [Q969P6-2]
ENST00000523676; ENSP00000429181; ENSG00000184428 [Q969P6-2]
GeneIDi116447
KEGGihsa:116447
MANE-SelectiENST00000329245.9; ENSP00000328835.3; NM_052963.3; NP_443195.1
UCSCiuc003yxz.6, human [Q969P6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		116447
DisGeNETi116447

GeneCards: human genes, protein and diseases

More...GeneCardsi		TOP1MT
HGNCiHGNC:29787, TOP1MT
HPAiENSG00000184428, Low tissue specificity
MIMi606387, gene
neXtProtiNX_Q969P6
OpenTargetsiENSG00000184428
PharmGKBiPA134922772
VEuPathDBiHostDB:ENSG00000184428

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0981, Eukaryota
GeneTreeiENSGT00940000162943
HOGENOMiCLU_009193_2_0_1
InParanoidiQ969P6
OMAiRYNAANR
OrthoDBi303947at2759
PhylomeDBiQ969P6
TreeFamiTF105281

Enzyme and pathway databases

BRENDAi5.6.2.1, 2681
PathwayCommonsiQ969P6
SignaLinkiQ969P6
SIGNORiQ969P6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		116447, 58 hits in 1046 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TOP1MT, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		116447
PharosiQ969P6, Tclin

Protein Ontology

More...PROi		PR:Q969P6
RNActiQ969P6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000184428, Expressed in testis and 173 other tissues
ExpressionAtlasiQ969P6, baseline and differential
GenevisibleiQ969P6, HS

Family and domain databases

CDDicd00659, Topo_IB_C, 1 hit
Gene3Di1.10.10.41, 1 hit
1.10.132.10, 1 hit
2.170.11.10, 1 hit
3.90.15.10, 1 hit
InterProiView protein in InterPro
IPR011010, DNA_brk_join_enz
IPR013034, DNA_topo_DNA_db_N_dom1
IPR013030, DNA_topo_DNA_db_N_dom2
IPR001631, TopoI
IPR018521, TopoI_AS
IPR025834, TopoI_C_dom
IPR014711, TopoI_cat_a-hlx-sub_euk
IPR014727, TopoI_cat_a/b-sub_euk
IPR013500, TopoI_cat_euk
IPR008336, TopoI_DNA-bd_euk
IPR036202, TopoI_DNA-bd_euk_N_sf
IPR013499, TopoI_euk
PfamiView protein in Pfam
PF14370, Topo_C_assoc, 1 hit
PF01028, Topoisom_I, 1 hit
PF02919, Topoisom_I_N, 1 hit
PRINTSiPR00416, EUTPISMRASEI
SMARTiView protein in SMART
SM00435, TOPEUc, 1 hit
SUPFAMiSSF56349, SSF56349, 1 hit
SSF56741, SSF56741, 1 hit
PROSITEiView protein in PROSITE
PS00176, TOPOISOMERASE_I_EUK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOP1M_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969P6
Secondary accession number(s): B7ZAR5
, E7ES89, Q86ST4, Q86V82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: February 23, 2022
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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