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UniProtKB - Q969P0 (IGSF8_HUMAN)

Protein

Immunoglobulin superfamily member 8

Gene

IGSF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.5 Publications

GO - Biological processi

View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 8
Short name:
IgSF8
Alternative name(s):
CD81 partner 3
Glu-Trp-Ile EWI motif-containing protein 2
Short name:
EWI-2
Keratinocytes-associated transmembrane protein 4
Short name:
KCT-4
LIR-D1
Prostaglandin regulatory-like protein
Short name:
PGRL
CD_antigen: CD316
Gene namesi
Name:IGSF8
Synonyms:CD81P3, EWI2, KCT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162729.13
HGNCiHGNC:17813 IGSF8
MIMi606644 gene
neXtProtiNX_Q969P0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 579ExtracellularSequence analysisAdd BLAST552
Transmembranei580 – 600HelicalSequence analysisAdd BLAST21
Topological domaini601 – 613CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi93185
OpenTargetsiENSG00000162729
PharmGKBiPA29767

Polymorphism and mutation databases

BioMutaiIGSF8
DMDMi74762642

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000022624728 – 613Immunoglobulin superfamily member 8Add BLAST586

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 127PROSITE-ProRule annotation
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi186 ↔ 270PROSITE-ProRule annotation
Disulfide bondi326 ↔ 406PROSITE-ProRule annotation
Glycosylationi327N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi462 ↔ 544PROSITE-ProRule annotation
Glycosylationi463N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei518PhosphoserineCombined sources1
Lipidationi604S-palmitoyl cysteineBy similarity1
Lipidationi605S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ969P0
MaxQBiQ969P0
PaxDbiQ969P0
PeptideAtlasiQ969P0
PRIDEiQ969P0
ProteomicsDBi75806
75807 [Q969P0-2]
75808 [Q969P0-3]

2D gel databases

UCD-2DPAGEiQ969P0

PTM databases

GlyConnecti1394
iPTMnetiQ969P0
PhosphoSitePlusiQ969P0
SwissPalmiQ969P0

Expressioni

Tissue specificityi

Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.3 Publications

Gene expression databases

BgeeiENSG00000162729 Expressed in 163 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_IGSF8
ExpressionAtlasiQ969P0 baseline and differential
GenevisibleiQ969P0 HS

Organism-specific databases

HPAiHPA011917

Interactioni

Subunit structurei

Interacts directly with CD82, CD81/tetraspanin-28 and CD9/tetraspanin-29. Also interacts with integrin alpha-3/beta-1 and integrin alpha-4/beta-1.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi125011, 201 interactors
IntActiQ969P0, 9 interactors
MINTiQ969P0
STRINGi9606.ENSP00000316664

Structurei

3D structure databases

ProteinModelPortaliQ969P0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 149Ig-like C2-type 1Add BLAST122
Domaini162 – 286Ig-like C2-type 2Add BLAST125
Domaini303 – 424Ig-like C2-type 3Add BLAST122
Domaini431 – 560Ig-like C2-type 4Add BLAST130

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi274 – 276EWI motif3

Domaini

The Ig-like C2-type domains 3 and 4 are required for interaction with CD81.By similarity
The short cytoplasmic domain is very basic, interacts with membrane PIPs, and mediates plasma membrane localization.By similarity

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHZZ Eukaryota
ENOG410XSYU LUCA
GeneTreeiENSGT00390000010278
HOGENOMiHOG000113020
HOVERGENiHBG073047
InParanoidiQ969P0
KOiK06730
OMAiNFEWFLY
OrthoDBiEOG091G00OL
PhylomeDBiQ969P0
TreeFamiTF332702

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969P0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGALRPTLLP PSLPLLLLLM LGMGCWAREV LVPEGPLYRV AGTAVSISCN 
        60         70         80         90        100
VTGYEGPAQQ NFEWFLYRPE APDTALGIVS TKDTQFSYAV FKSRVVAGEV 
       110        120        130        140        150
QVQRLQGDAV VLKIARLQAQ DAGIYECHTP STDTRYLGSY SGKVELRVLP 
       160        170        180        190        200
DVLQVSAAPP GPRGRQAPTS PPRMTVHEGQ ELALGCLART STQKHTHLAV 
       210        220        230        240        250
SFGRSVPEAP VGRSTLQEVV GIRSDLAVEA GAPYAERLAA GELRLGKEGT 
       260        270        280        290        300
DRYRMVVGGA QAGDAGTYHC TAAEWIQDPD GSWAQIAEKR AVLAHVDVQT 
       310        320        330        340        350
LSSQLAVTVG PGERRIGPGE PLELLCNVSG ALPPAGRHAA YSVGWEMAPA 
       360        370        380        390        400
GAPGPGRLVA QLDTEGVGSL GPGYEGRHIA MEKVASRTYR LRLEAARPGD 
       410        420        430        440        450
AGTYRCLAKA YVRGSGTRLR EAASARSRPL PVHVREEGVV LEAVAWLAGG 
       460        470        480        490        500
TVYRGETASL LCNISVRGGP PGLRLAASWW VERPEDGELS SVPAQLVGGV 
       510        520        530        540        550
GQDGVAELGV RPGGGPVSVE LVGPRSHRLR LHSLGPEDEG VYHCAPSAWV 
       560        570        580        590        600
QHADYSWYQA GSARSGPVTV YPYMHALDTL FVPLLVGTGV ALVTGATVLG 
       610 
TITCCFMKRL RKR
Length:613
Mass (Da):65,034
Last modified:December 1, 2001 - v1
Checksum:iA7255D54D42EFB88
GO
Isoform 2 (identifier: Q969P0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-241: Missing.
     242-315: ELRLGKEGTD...AVTVGPGERR → MRGRSWHWAA...GSFVWARKGP

Note: No experimental confirmation available.
Show »
Length:372
Mass (Da):40,191
Checksum:i4872C8D6CC303638
GO
Isoform 3 (identifier: Q969P0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-561: Missing.

Note: No experimental confirmation available.
Show »
Length:526
Mass (Da):55,808
Checksum:iC2A88D773A4F4802
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8Z4C9J8Z4_HUMAN
Immunoglobulin superfamily member 8
IGSF8
301Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti303S → R in AAM94901 (Ref. 4) Curated1
Sequence conflicti306A → P in AAM94901 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0174291 – 241Missing in isoform 2. 1 PublicationAdd BLAST241
Alternative sequenceiVSP_017430242 – 315ELRLG…PGERR → MRGRSWHWAAWRGQAHRSTH TWQCPLGDLCPRHQLGGQLC RKWWESGQTWPWRLELPMLS DWLQGSFVWARKGP in isoform 2. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_017431475 – 561Missing in isoform 3. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF407274 mRNA Translation: AAL01052.1
AY044845 mRNA Translation: AAK92220.1
AY157579 mRNA Translation: AAO13163.1
AF311906 mRNA Translation: AAM94901.1
AK055843 mRNA Translation: BAB71027.1
BC004108 mRNA Translation: AAH04108.2
BC053881 mRNA Translation: AAH53881.1
CCDSiCCDS1195.1 [Q969P0-1]
RefSeqiNP_001193594.1, NM_001206665.2 [Q969P0-1]
NP_001307176.1, NM_001320247.1 [Q969P0-1]
NP_443100.1, NM_052868.5 [Q969P0-1]
XP_016858324.1, XM_017002835.1 [Q969P0-1]
XP_016858325.1, XM_017002836.1 [Q969P0-1]
XP_016858326.1, XM_017002837.1 [Q969P0-1]
UniGeneiHs.332012

Genome annotation databases

EnsembliENST00000314485; ENSP00000316664; ENSG00000162729 [Q969P0-1]
ENST00000368086; ENSP00000357065; ENSG00000162729 [Q969P0-1]
ENST00000614243; ENSP00000477565; ENSG00000162729 [Q969P0-1]
GeneIDi93185
KEGGihsa:93185
UCSCiuc001fuz.4 human [Q969P0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF407274 mRNA Translation: AAL01052.1
AY044845 mRNA Translation: AAK92220.1
AY157579 mRNA Translation: AAO13163.1
AF311906 mRNA Translation: AAM94901.1
AK055843 mRNA Translation: BAB71027.1
BC004108 mRNA Translation: AAH04108.2
BC053881 mRNA Translation: AAH53881.1
CCDSiCCDS1195.1 [Q969P0-1]
RefSeqiNP_001193594.1, NM_001206665.2 [Q969P0-1]
NP_001307176.1, NM_001320247.1 [Q969P0-1]
NP_443100.1, NM_052868.5 [Q969P0-1]
XP_016858324.1, XM_017002835.1 [Q969P0-1]
XP_016858325.1, XM_017002836.1 [Q969P0-1]
XP_016858326.1, XM_017002837.1 [Q969P0-1]
UniGeneiHs.332012

3D structure databases

ProteinModelPortaliQ969P0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125011, 201 interactors
IntActiQ969P0, 9 interactors
MINTiQ969P0
STRINGi9606.ENSP00000316664

PTM databases

GlyConnecti1394
iPTMnetiQ969P0
PhosphoSitePlusiQ969P0
SwissPalmiQ969P0

Polymorphism and mutation databases

BioMutaiIGSF8
DMDMi74762642

2D gel databases

UCD-2DPAGEiQ969P0

Proteomic databases

EPDiQ969P0
MaxQBiQ969P0
PaxDbiQ969P0
PeptideAtlasiQ969P0
PRIDEiQ969P0
ProteomicsDBi75806
75807 [Q969P0-2]
75808 [Q969P0-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314485; ENSP00000316664; ENSG00000162729 [Q969P0-1]
ENST00000368086; ENSP00000357065; ENSG00000162729 [Q969P0-1]
ENST00000614243; ENSP00000477565; ENSG00000162729 [Q969P0-1]
GeneIDi93185
KEGGihsa:93185
UCSCiuc001fuz.4 human [Q969P0-1]

Organism-specific databases

CTDi93185
DisGeNETi93185
EuPathDBiHostDB:ENSG00000162729.13
GeneCardsiIGSF8
HGNCiHGNC:17813 IGSF8
HPAiHPA011917
MIMi606644 gene
neXtProtiNX_Q969P0
OpenTargetsiENSG00000162729
PharmGKBiPA29767
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHZZ Eukaryota
ENOG410XSYU LUCA
GeneTreeiENSGT00390000010278
HOGENOMiHOG000113020
HOVERGENiHBG073047
InParanoidiQ969P0
KOiK06730
OMAiNFEWFLY
OrthoDBiEOG091G00OL
PhylomeDBiQ969P0
TreeFamiTF332702

Miscellaneous databases

ChiTaRSiIGSF8 human
GeneWikiiIGSF8
GenomeRNAii93185
PROiPR:Q969P0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162729 Expressed in 163 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_IGSF8
ExpressionAtlasiQ969P0 baseline and differential
GenevisibleiQ969P0 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIGSF8_HUMAN
AccessioniPrimary (citable) accession number: Q969P0
Secondary accession number(s): Q8NG09, Q96DP4, Q9BTG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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