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Protein

Protein YIPF5

Gene

YIPF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in transport between endoplasmic reticulum and Golgi.2 Publications

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF5
Alternative name(s):
Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5
Smooth muscle cell-associated protein 5
Short name:
SMAP-5
YIP1 family member 5
YPT-interacting protein 1 A
Gene namesi
Name:YIPF5
Synonyms:FINGER5, YIP1A
ORF Names:PP12723, SB140, UNQ3123/PRO10275
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145817.16
HGNCiHGNC:24877 YIPF5
MIMi611483 gene
neXtProtiNX_Q969M3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 124Cytoplasmic1 PublicationAdd BLAST124
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146LumenalCurated1
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 173CytoplasmicCurated6
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 196LumenalCurated2
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 236CytoplasmicCuratedAdd BLAST19
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81555
OpenTargetsiENSG00000145817
PharmGKBiPA142670548

Polymorphism and mutation databases

DMDMi74760683

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343281 – 257Protein YIPF5Add BLAST257

Proteomic databases

EPDiQ969M3
MaxQBiQ969M3
PaxDbiQ969M3
PeptideAtlasiQ969M3
PRIDEiQ969M3
ProteomicsDBi75792
75793 [Q969M3-2]
75794 [Q969M3-3]

PTM databases

iPTMnetiQ969M3
PhosphoSitePlusiQ969M3
SwissPalmiQ969M3

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in coronary smooth muscles.1 Publication

Inductioni

By TGFB1.1 Publication

Gene expression databases

BgeeiENSG00000145817 Expressed in 222 organ(s), highest expression level in nasal cavity mucosa
CleanExiHS_YIPF5
ExpressionAtlasiQ969M3 baseline and differential
GenevisibleiQ969M3 HS

Organism-specific databases

HPAiHPA042338
HPA073622

Interactioni

Subunit structurei

Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B) (PubMed:11489904). Interacts with YIF1A (PubMed:15990086). May interact with RAB1A (PubMed:15611160). Interacts with YIPF3 and YIPF4 (PubMed:27999994).4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi123519, 53 interactors
IntActiQ969M3, 58 interactors
MINTiQ969M3
STRINGi9606.ENSP00000274496

Structurei

3D structure databases

ProteinModelPortaliQ969M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 106Interaction with Sec23Add BLAST32

Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3103 Eukaryota
COG5080 LUCA
GeneTreeiENSGT00510000046817
HOVERGENiHBG055241
InParanoidiQ969M3
KOiK20363
OMAiFDNLNTD
OrthoDBiEOG091G0Y2Z
PhylomeDBiQ969M3
TreeFamiTF313100

Family and domain databases

InterProiView protein in InterPro
IPR006977 Yip1
PfamiView protein in Pfam
PF04893 Yip1, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969M3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGFENLNTD FYQTSYSIDD QSQQSYDYGG SGGPYSKQYA GYDYSQQGRF
60 70 80 90 100
VPPDMMQPQQ PYTGQIYQPT QAYTPASPQP FYGNNFEDEP PLLEELGINF
110 120 130 140 150
DHIWQKTLTV LHPLKVADGS IMNETDLAGP MVFCLAFGAT LLLAGKIQFG
160 170 180 190 200
YVYGISAIGC LGMFCLLNLM SMTGVSFGCV ASVLGYCLLP MILLSSFAVI
210 220 230 240 250
FSLQGMVGII LTAGIIGWCS FSASKIFISA LAMEGQQLLV AYPCALLYGV

FALISVF
Length:257
Mass (Da):27,989
Last modified:December 1, 2001 - v1
Checksum:iB30EACB0E514DC67
GO
Isoform 2 (identifier: Q969M3-2) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:203
Mass (Da):21,896
Checksum:iC29C76D8D3D7FF6F
GO
Isoform 3 (identifier: Q969M3-3) [UniParc]FASTAAdd to basket
Also known as: I

The sequence of this isoform differs from the canonical sequence as follows:
     242-257: YPCALLYGVFALISVF → LQPNITYGSNYFLFCCLPYPQQHF

Show »
Length:265
Mass (Da):29,107
Checksum:iDBAD311C26DE5A05
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHH4E5RHH4_HUMAN
Protein YIPF
YIPF5
177Annotation score:
E5RGR9E5RGR9_HUMAN
Protein YIPF5
YIPF5
101Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136 – 138AFG → DLA in AAK67644 (Ref. 3) Curated3
Sequence conflicti155I → S in AAG48521 (PubMed:11489904).Curated1
Sequence conflicti187C → W in AAK67644 (Ref. 3) Curated1
Sequence conflicti192I → Y in AAG48521 (PubMed:11489904).Curated1
Sequence conflicti244C → R in BAD97235 (Ref. 7) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0182531 – 54Missing in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_018254242 – 257YPCAL…LISVF → LQPNITYGSNYFLFCCLPYP QQHF in isoform 3. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140225 mRNA Translation: AAG48521.1
AY640925 mRNA Translation: AAV51256.1
AY640926 mRNA Translation: AAV51257.1
AY640927 mRNA Translation: AAV51258.1
AY640928 mRNA Translation: AAV51259.1
AY640929 mRNA No translation available.
AY640934 mRNA Translation: AAV51260.1
AY037152 mRNA Translation: AAK67644.1
AY358863 mRNA Translation: AAQ89222.1
AK054576 mRNA Translation: BAB70763.1
AF318329 mRNA Translation: AAL55836.1
AK223515 mRNA Translation: BAD97235.1
CR749463 mRNA Translation: CAH18295.1
CH471062 Genomic DNA Translation: EAW61864.1
CH471062 Genomic DNA Translation: EAW61865.1
BC007829 mRNA Translation: AAH07829.1
BC014253 mRNA Translation: AAH14253.1
BC024737 mRNA Translation: AAH24737.1
AB014733 mRNA Translation: BAB20270.1
CCDSiCCDS4279.1 [Q969M3-1]
CCDS64277.1 [Q969M3-2]
RefSeqiNP_001020118.1, NM_001024947.3 [Q969M3-1]
NP_001258661.1, NM_001271732.1 [Q969M3-2]
NP_110426.4, NM_030799.8 [Q969M3-1]
UniGeneiHs.372050

Genome annotation databases

EnsembliENST00000274496; ENSP00000274496; ENSG00000145817 [Q969M3-1]
ENST00000448443; ENSP00000397704; ENSG00000145817 [Q969M3-1]
ENST00000513112; ENSP00000425422; ENSG00000145817 [Q969M3-2]
GeneIDi81555
KEGGihsa:81555
UCSCiuc003lnk.6 human [Q969M3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140225 mRNA Translation: AAG48521.1
AY640925 mRNA Translation: AAV51256.1
AY640926 mRNA Translation: AAV51257.1
AY640927 mRNA Translation: AAV51258.1
AY640928 mRNA Translation: AAV51259.1
AY640929 mRNA No translation available.
AY640934 mRNA Translation: AAV51260.1
AY037152 mRNA Translation: AAK67644.1
AY358863 mRNA Translation: AAQ89222.1
AK054576 mRNA Translation: BAB70763.1
AF318329 mRNA Translation: AAL55836.1
AK223515 mRNA Translation: BAD97235.1
CR749463 mRNA Translation: CAH18295.1
CH471062 Genomic DNA Translation: EAW61864.1
CH471062 Genomic DNA Translation: EAW61865.1
BC007829 mRNA Translation: AAH07829.1
BC014253 mRNA Translation: AAH14253.1
BC024737 mRNA Translation: AAH24737.1
AB014733 mRNA Translation: BAB20270.1
CCDSiCCDS4279.1 [Q969M3-1]
CCDS64277.1 [Q969M3-2]
RefSeqiNP_001020118.1, NM_001024947.3 [Q969M3-1]
NP_001258661.1, NM_001271732.1 [Q969M3-2]
NP_110426.4, NM_030799.8 [Q969M3-1]
UniGeneiHs.372050

3D structure databases

ProteinModelPortaliQ969M3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123519, 53 interactors
IntActiQ969M3, 58 interactors
MINTiQ969M3
STRINGi9606.ENSP00000274496

PTM databases

iPTMnetiQ969M3
PhosphoSitePlusiQ969M3
SwissPalmiQ969M3

Polymorphism and mutation databases

DMDMi74760683

Proteomic databases

EPDiQ969M3
MaxQBiQ969M3
PaxDbiQ969M3
PeptideAtlasiQ969M3
PRIDEiQ969M3
ProteomicsDBi75792
75793 [Q969M3-2]
75794 [Q969M3-3]

Protocols and materials databases

DNASUi81555
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274496; ENSP00000274496; ENSG00000145817 [Q969M3-1]
ENST00000448443; ENSP00000397704; ENSG00000145817 [Q969M3-1]
ENST00000513112; ENSP00000425422; ENSG00000145817 [Q969M3-2]
GeneIDi81555
KEGGihsa:81555
UCSCiuc003lnk.6 human [Q969M3-1]

Organism-specific databases

CTDi81555
DisGeNETi81555
EuPathDBiHostDB:ENSG00000145817.16
GeneCardsiYIPF5
H-InvDBiHIX0005274
HGNCiHGNC:24877 YIPF5
HPAiHPA042338
HPA073622
MIMi611483 gene
neXtProtiNX_Q969M3
OpenTargetsiENSG00000145817
PharmGKBiPA142670548
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3103 Eukaryota
COG5080 LUCA
GeneTreeiENSGT00510000046817
HOVERGENiHBG055241
InParanoidiQ969M3
KOiK20363
OMAiFDNLNTD
OrthoDBiEOG091G0Y2Z
PhylomeDBiQ969M3
TreeFamiTF313100

Miscellaneous databases

ChiTaRSiYIPF5 human
GeneWikiiYIPF5
GenomeRNAii81555
PROiPR:Q969M3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145817 Expressed in 222 organ(s), highest expression level in nasal cavity mucosa
CleanExiHS_YIPF5
ExpressionAtlasiQ969M3 baseline and differential
GenevisibleiQ969M3 HS

Family and domain databases

InterProiView protein in InterPro
IPR006977 Yip1
PfamiView protein in Pfam
PF04893 Yip1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYIPF5_HUMAN
AccessioniPrimary (citable) accession number: Q969M3
Secondary accession number(s): D3DQF5
, Q4VSN6, Q53EX4, Q8NHE5, Q9H338, Q9H3U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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