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Protein

Mitochondrial import receptor subunit TOM40B

Gene

TOMM40L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential channel-forming protein implicated in import of protein precursors into mitochondria.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPorin
Biological processIon transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40B
Alternative name(s):
Protein TOMM40-like
Gene namesi
Name:TOMM40L
Synonyms:TOMM40B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158882.12
HGNCiHGNC:25756 TOMM40L
neXtProtiNX_Q969M1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000158882
PharmGKBiPA142670714

Polymorphism and mutation databases

DMDMi74751722

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515361 – 308Mitochondrial import receptor subunit TOM40BAdd BLAST308

Proteomic databases

EPDiQ969M1
MaxQBiQ969M1
PaxDbiQ969M1
PeptideAtlasiQ969M1
PRIDEiQ969M1
ProteomicsDBi75790

PTM databases

iPTMnetiQ969M1
PhosphoSitePlusiQ969M1

Expressioni

Gene expression databases

BgeeiENSG00000158882 Expressed in 177 organ(s), highest expression level in heart left ventricle
CleanExiHS_TOMM40L
GenevisibleiQ969M1 HS

Organism-specific databases

HPAiHPA051304

Interactioni

Subunit structurei

Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123906, 7 interactors
IntActiQ969M1, 1 interactor
STRINGi9606.ENSP00000356966

Structurei

3D structure databases

ProteinModelPortaliQ969M1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni281 – 308Required for mitochondrial targetingBy similarityAdd BLAST28

Sequence similaritiesi

Belongs to the Tom40 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3296 Eukaryota
ENOG410XS2U LUCA
GeneTreeiENSGT00390000003308
HOGENOMiHOG000007440
HOVERGENiHBG054707
InParanoidiQ969M1
KOiK11518
OMAiIEGVKMI
OrthoDBiEOG091G0MNA
PhylomeDBiQ969M1
TreeFamiTF106204

Family and domain databases

CDDicd07305 Porin3_Tom40, 1 hit
InterProiView protein in InterPro
IPR027246 Porin_Euk/Tom40
IPR037930 Tom40
PANTHERiPTHR10802 PTHR10802, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q969M1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNTLGLAPM GTLPRRSPRR EEPLPNPGSF DELHRLCKDV FPAQMEGVKL
60 70 80 90 100
VVNKVLSSHF QVAHTIHMSA LGLPGYHLHA AYAGDWQLSP TEVFPTVVGD
110 120 130 140 150
MDSSGSLNAQ VLLLLAERLR AKAVFQTQQA KFLTWQFDGE YRGDDYTATL
160 170 180 190 200
TLGNPDLIGE SVIMVAHFLQ SLTHRLVLGG ELVYHRRPGE EGAILTLAGK
210 220 230 240 250
YSAVHWVATL NVGSGGAHAS YYHRANEQVQ VGVEFEANTR LQDTTFSFGY
260 270 280 290 300
HLTLPQANMV FRGLVDSNWC VGAVLEKKMP PLPVTLALGA FLNHWRNRFH

CGFSITVG
Length:308
Mass (Da):33,917
Last modified:December 1, 2001 - v1
Checksum:iB4347CD0610434D3
GO
Isoform 2 (identifier: Q969M1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-126: Missing.

Note: No experimental confirmation available.
Show »
Length:274
Mass (Da):30,289
Checksum:iF14BE80F40C82D83
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035815100D → N in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05488593 – 126Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027704 mRNA Translation: BAB55309.1
AK297848 mRNA Translation: BAH12676.1
BX537951 mRNA Translation: CAD97918.1
AL590714 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52611.1
CH471121 Genomic DNA Translation: EAW52615.1
CH471121 Genomic DNA Translation: EAW52616.1
BC014946 mRNA Translation: AAH14946.1
CCDSiCCDS1227.1 [Q969M1-1]
CCDS65700.1 [Q969M1-2]
RefSeqiNP_001273302.1, NM_001286373.1 [Q969M1-2]
NP_115550.2, NM_032174.5 [Q969M1-1]
XP_006711635.1, XM_006711572.2 [Q969M1-1]
XP_016857970.1, XM_017002481.1 [Q969M1-1]
XP_016857971.1, XM_017002482.1 [Q969M1-2]
UniGeneiHs.321653

Genome annotation databases

EnsembliENST00000367987; ENSP00000356966; ENSG00000158882 [Q969M1-1]
ENST00000367988; ENSP00000356967; ENSG00000158882 [Q969M1-1]
ENST00000545897; ENSP00000443233; ENSG00000158882 [Q969M1-2]
GeneIDi84134
KEGGihsa:84134
UCSCiuc001fzd.5 human [Q969M1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027704 mRNA Translation: BAB55309.1
AK297848 mRNA Translation: BAH12676.1
BX537951 mRNA Translation: CAD97918.1
AL590714 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52611.1
CH471121 Genomic DNA Translation: EAW52615.1
CH471121 Genomic DNA Translation: EAW52616.1
BC014946 mRNA Translation: AAH14946.1
CCDSiCCDS1227.1 [Q969M1-1]
CCDS65700.1 [Q969M1-2]
RefSeqiNP_001273302.1, NM_001286373.1 [Q969M1-2]
NP_115550.2, NM_032174.5 [Q969M1-1]
XP_006711635.1, XM_006711572.2 [Q969M1-1]
XP_016857970.1, XM_017002481.1 [Q969M1-1]
XP_016857971.1, XM_017002482.1 [Q969M1-2]
UniGeneiHs.321653

3D structure databases

ProteinModelPortaliQ969M1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123906, 7 interactors
IntActiQ969M1, 1 interactor
STRINGi9606.ENSP00000356966

PTM databases

iPTMnetiQ969M1
PhosphoSitePlusiQ969M1

Polymorphism and mutation databases

DMDMi74751722

Proteomic databases

EPDiQ969M1
MaxQBiQ969M1
PaxDbiQ969M1
PeptideAtlasiQ969M1
PRIDEiQ969M1
ProteomicsDBi75790

Protocols and materials databases

DNASUi84134
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367987; ENSP00000356966; ENSG00000158882 [Q969M1-1]
ENST00000367988; ENSP00000356967; ENSG00000158882 [Q969M1-1]
ENST00000545897; ENSP00000443233; ENSG00000158882 [Q969M1-2]
GeneIDi84134
KEGGihsa:84134
UCSCiuc001fzd.5 human [Q969M1-1]

Organism-specific databases

CTDi84134
EuPathDBiHostDB:ENSG00000158882.12
GeneCardsiTOMM40L
HGNCiHGNC:25756 TOMM40L
HPAiHPA051304
neXtProtiNX_Q969M1
OpenTargetsiENSG00000158882
PharmGKBiPA142670714
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3296 Eukaryota
ENOG410XS2U LUCA
GeneTreeiENSGT00390000003308
HOGENOMiHOG000007440
HOVERGENiHBG054707
InParanoidiQ969M1
KOiK11518
OMAiIEGVKMI
OrthoDBiEOG091G0MNA
PhylomeDBiQ969M1
TreeFamiTF106204

Miscellaneous databases

ChiTaRSiTOMM40L human
GeneWikiiTOMM40L
GenomeRNAii84134
PROiPR:Q969M1

Gene expression databases

BgeeiENSG00000158882 Expressed in 177 organ(s), highest expression level in heart left ventricle
CleanExiHS_TOMM40L
GenevisibleiQ969M1 HS

Family and domain databases

CDDicd07305 Porin3_Tom40, 1 hit
InterProiView protein in InterPro
IPR027246 Porin_Euk/Tom40
IPR037930 Tom40
PANTHERiPTHR10802 PTHR10802, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM40L_HUMAN
AccessioniPrimary (citable) accession number: Q969M1
Secondary accession number(s): B7Z4U0, D3DVG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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