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Protein

U7 snRNA-associated Sm-like protein LSm10

Gene

LSM10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.1 Publication

GO - Molecular functioni

  • histone pre-mRNA DCP binding Source: UniProtKB
  • U7 snRNA binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
U7 snRNA-associated Sm-like protein LSm10
Gene namesi
Name:LSM10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000181817.5
HGNCiHGNC:17562 LSM10
MIMi617909 gene
neXtProtiNX_Q969L4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84967
OpenTargetsiENSG00000181817
PharmGKBiPA134977215

Polymorphism and mutation databases

BioMutaiLSM10
DMDMi20177959

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255851 – 123U7 snRNA-associated Sm-like protein LSm10Add BLAST123

Post-translational modificationi

Not methylated. Methylation is not necessary for interaction with SMN.

Proteomic databases

EPDiQ969L4
MaxQBiQ969L4
PaxDbiQ969L4
PeptideAtlasiQ969L4
PRIDEiQ969L4
ProteomicsDBi75789

PTM databases

PhosphoSitePlusiQ969L4

Expressioni

Gene expression databases

BgeeiENSG00000181817 Expressed in 189 organ(s), highest expression level in muscle of leg
CleanExiHS_LSM10
GenevisibleiQ969L4 HS

Organism-specific databases

HPAiHPA048469

Interactioni

Subunit structurei

Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LSM3P623104EBI-373268,EBI-348239

Protein-protein interaction databases

BioGridi124397, 16 interactors
CORUMiQ969L4
IntActiQ969L4, 4 interactors
STRINGi9606.ENSP00000319341

Structurei

3D structure databases

ProteinModelPortaliQ969L4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3428 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00510000048364
HOGENOMiHOG000230640
HOVERGENiHBG052366
InParanoidiQ969L4
OMAiNTLNCWP
OrthoDBiEOG091G0TWE
PhylomeDBiQ969L4
TreeFamiTF332356

Family and domain databases

InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequencei

Sequence statusi: Complete.

Q969L4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVSHSVKER TISENSLIIL LQGLQGRVTT VDLRDESVAH GRIDNVDAFM
60 70 80 90 100
NIRLAKVTYT DRWGHQVKLD DLFVTGRNVR YVHIPDDVNI TSTIEQQLQI
110 120
IHRVRNFGGK GQGRWEFPPK NCK
Length:123
Mass (Da):14,080
Last modified:December 1, 2001 - v1
Checksum:iB994B1DC6776BB02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394685 mRNA Translation: AAL07689.1
BC007623 mRNA Translation: AAH07623.1
CCDSiCCDS408.1
RefSeqiNP_116270.1, NM_032881.2
UniGeneiHs.603131

Genome annotation databases

EnsembliENST00000315732; ENSP00000319341; ENSG00000181817
GeneIDi84967
KEGGihsa:84967
UCSCiuc001cao.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394685 mRNA Translation: AAL07689.1
BC007623 mRNA Translation: AAH07623.1
CCDSiCCDS408.1
RefSeqiNP_116270.1, NM_032881.2
UniGeneiHs.603131

3D structure databases

ProteinModelPortaliQ969L4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124397, 16 interactors
CORUMiQ969L4
IntActiQ969L4, 4 interactors
STRINGi9606.ENSP00000319341

PTM databases

PhosphoSitePlusiQ969L4

Polymorphism and mutation databases

BioMutaiLSM10
DMDMi20177959

Proteomic databases

EPDiQ969L4
MaxQBiQ969L4
PaxDbiQ969L4
PeptideAtlasiQ969L4
PRIDEiQ969L4
ProteomicsDBi75789

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315732; ENSP00000319341; ENSG00000181817
GeneIDi84967
KEGGihsa:84967
UCSCiuc001cao.1 human

Organism-specific databases

CTDi84967
DisGeNETi84967
EuPathDBiHostDB:ENSG00000181817.5
GeneCardsiLSM10
HGNCiHGNC:17562 LSM10
HPAiHPA048469
MIMi617909 gene
neXtProtiNX_Q969L4
OpenTargetsiENSG00000181817
PharmGKBiPA134977215
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3428 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00510000048364
HOGENOMiHOG000230640
HOVERGENiHBG052366
InParanoidiQ969L4
OMAiNTLNCWP
OrthoDBiEOG091G0TWE
PhylomeDBiQ969L4
TreeFamiTF332356

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Miscellaneous databases

ChiTaRSiLSM10 human
GeneWikiiLSM10
GenomeRNAii84967
PROiPR:Q969L4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181817 Expressed in 189 organ(s), highest expression level in muscle of leg
CleanExiHS_LSM10
GenevisibleiQ969L4 HS

Family and domain databases

InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSM10_HUMAN
AccessioniPrimary (citable) accession number: Q969L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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