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UniProtKB - Q969K7 (TMM54_HUMAN)

Entry version 135 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Transmembrane protein 54

Gene

TMEM54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q969K7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 54
Alternative name(s):
Beta-casein-like protein
Protein CAC-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM54
Synonyms:BCLP, CAC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24143, TMEM54

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q969K7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000121900.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		113452

Open Targets

More...OpenTargetsi		ENSG00000121900

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670770

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q969K7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM54

Domain mapping of disease mutations (DMDM)

More...DMDMi		74760680

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002269891 – 222Transmembrane protein 54Add BLAST222

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q969K7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q969K7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q969K7

PeptideAtlas

More...PeptideAtlasi		Q969K7

PRoteomics IDEntifications database

More...PRIDEi		Q969K7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75785 [Q969K7-1]
75786 [Q969K7-2]
75787 [Q969K7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q969K7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q969K7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed in cancer cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000121900, Expressed in mucosa of transverse colon and 175 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q969K7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000121900, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125247, 27 interactors

Protein interaction database and analysis system

More...IntActi		Q969K7, 26 interactors

Molecular INTeraction database

More...MINTi		Q969K7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362562

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q969K7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S0UN, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004700

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_089663_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q969K7

Identification of Orthologs from Complete Genome Data

More...OMAi		VPLRWTV

Database of Orthologous Groups

More...OrthoDBi		1133009at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q969K7

TreeFam database of animal gene trees

More...TreeFami		TF332771

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020977, Beta-casein-like

The PANTHER Classification System

More...PANTHERi		PTHR31258, PTHR31258, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12304, BCLP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q969K7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCLRLGGLSV GDFRKVLMKT GLVLVVLGHV SFITAALFHG TVLRYVGTPQ 
        60         70         80         90        100
DAVALQYCVV NILSVTSAIV VITSGIAAIV LSRYLPSTPL RWTVFSSSVA 
       110        120        130        140        150
CALLSLTCAL GLLASIAMTF ATQGKALLAA CTFGSSELLA LAPDCPFDPT 
       160        170        180        190        200
RIYSSSLCLW GIALVLCVAE NVFAVRCAQL THQLLELRPW WGKSSHHMMR 
       210        220 
ENPELVEGRD LLSCTSSEPL TL
Length:222
Mass (Da):23,772
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD6361E5AFD816C0
GO
Isoform 2 (identifier: Q969K7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-90: Missing.

Show »
Length:202
Mass (Da):21,719
Checksum:iDC8F68B9E5ACED42
GO
Isoform 3 (identifier: Q969K7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-123: Missing.

Show »
Length:169
Mass (Da):18,303
Checksum:i6C47BA8F0618B7EA
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA87335 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144D → Y in BAA87335 (PubMed:9500206).Curated1
Sequence conflicti172V → G in BAA87335 (PubMed:9500206).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052342110L → F. Corresponds to variant dbSNP:rs10914632Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01753371 – 123Missing in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_01753271 – 90Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY027543 mRNA Translation: AAK13050.1
AY359883 mRNA Translation: AAQ64021.1
BC001418 mRNA Translation: AAH01418.2
BC013953 mRNA Translation: AAH13953.1
BC023260 mRNA Translation: AAH23260.1
AB012692 mRNA Translation: BAA87335.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS371.1 [Q969K7-1]
CCDS85954.1 [Q969K7-3]

Protein sequence database of the Protein Information Resource

More...PIRi		JC7697

NCBI Reference Sequences

More...RefSeqi		NP_001316652.1, NM_001329723.1 [Q969K7-2]
NP_001316653.1, NM_001329724.1
NP_001316654.1, NM_001329725.1 [Q969K7-3]
NP_277039.1, NM_033504.3 [Q969K7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000329151; ENSP00000328630; ENSG00000121900 [Q969K7-3]
ENST00000373463; ENSP00000362562; ENSG00000121900 [Q969K7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		113452

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:113452

UCSC genome browser

More...UCSCi		uc001bwi.2, human [Q969K7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY027543 mRNA Translation: AAK13050.1
AY359883 mRNA Translation: AAQ64021.1
BC001418 mRNA Translation: AAH01418.2
BC013953 mRNA Translation: AAH13953.1
BC023260 mRNA Translation: AAH23260.1
AB012692 mRNA Translation: BAA87335.1 Frameshift.
CCDSiCCDS371.1 [Q969K7-1]
CCDS85954.1 [Q969K7-3]
PIRiJC7697
RefSeqiNP_001316652.1, NM_001329723.1 [Q969K7-2]
NP_001316653.1, NM_001329724.1
NP_001316654.1, NM_001329725.1 [Q969K7-3]
NP_277039.1, NM_033504.3 [Q969K7-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125247, 27 interactors
IntActiQ969K7, 26 interactors
MINTiQ969K7
STRINGi9606.ENSP00000362562

PTM databases

iPTMnetiQ969K7
PhosphoSitePlusiQ969K7

Genetic variation databases

BioMutaiTMEM54
DMDMi74760680

Proteomic databases

jPOSTiQ969K7
MassIVEiQ969K7
PaxDbiQ969K7
PeptideAtlasiQ969K7
PRIDEiQ969K7
ProteomicsDBi75785 [Q969K7-1]
75786 [Q969K7-2]
75787 [Q969K7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31378, 16 antibodies

The DNASU plasmid repository

More...DNASUi		113452

Genome annotation databases

EnsembliENST00000329151; ENSP00000328630; ENSG00000121900 [Q969K7-3]
ENST00000373463; ENSP00000362562; ENSG00000121900 [Q969K7-1]
GeneIDi113452
KEGGihsa:113452
UCSCiuc001bwi.2, human [Q969K7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		113452
DisGeNETi113452

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM54
HGNCiHGNC:24143, TMEM54
HPAiENSG00000121900, Tissue enhanced (intestine)
neXtProtiNX_Q969K7
OpenTargetsiENSG00000121900
PharmGKBiPA142670770
VEuPathDBiHostDB:ENSG00000121900.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S0UN, Eukaryota
GeneTreeiENSGT00390000004700
HOGENOMiCLU_089663_1_0_1
InParanoidiQ969K7
OMAiVPLRWTV
OrthoDBi1133009at2759
PhylomeDBiQ969K7
TreeFamiTF332771

Enzyme and pathway databases

PathwayCommonsiQ969K7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		113452, 10 hits in 1004 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM54, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		113452
PharosiQ969K7, Tdark

Protein Ontology

More...PROi		PR:Q969K7
RNActiQ969K7, protein

Gene expression databases

BgeeiENSG00000121900, Expressed in mucosa of transverse colon and 175 other tissues
GenevisibleiQ969K7, HS

Family and domain databases

InterProiView protein in InterPro
IPR020977, Beta-casein-like
PANTHERiPTHR31258, PTHR31258, 1 hit
PfamiView protein in Pfam
PF12304, BCLP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMM54_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969K7
Secondary accession number(s): Q6UV18, Q8IVD0, Q9UM12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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