UniProtKB - Q969K4 (ABTB1_HUMAN)
Protein
Ankyrin repeat and BTB/POZ domain-containing protein 1
Gene
ABTB1
Organism
Homo sapiens (Human)
Status
Functioni
May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes.2 Publications
GO - Molecular functioni
- translation elongation factor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Elongation factor |
Biological process | Protein biosynthesis |
Enzyme and pathway databases
PathwayCommonsi | Q969K4 |
SIGNORi | Q969K4 |
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin repeat and BTB/POZ domain-containing protein 1Alternative name(s): Elongation factor 1A-binding protein |
Gene namesi | ORF Names:PP2259 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18275, ABTB1 |
MIMi | 608308, gene |
neXtProti | NX_Q969K4 |
VEuPathDBi | HostDB:ENSG00000114626.17 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: GO_Central
- ubiquitin ligase complex Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 80325 |
OpenTargetsi | ENSG00000114626 |
PharmGKBi | PA24418 |
Miscellaneous databases
Pharosi | Q969K4, Tbio |
Genetic variation databases
BioMutai | ABTB1 |
DMDMi | 74751721 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000248267 | 1 – 478 | Ankyrin repeat and BTB/POZ domain-containing protein 1Add BLAST | 478 |
Proteomic databases
jPOSTi | Q969K4 |
MassIVEi | Q969K4 |
PaxDbi | Q969K4 |
PeptideAtlasi | Q969K4 |
PRIDEi | Q969K4 |
ProteomicsDBi | 75781 [Q969K4-1] 75782 [Q969K4-2] 75783 [Q969K4-3] 75784 [Q969K4-4] |
PTM databases
iPTMneti | Q969K4 |
PhosphoSitePlusi | Q969K4 |
Expressioni
Tissue specificityi
Ubiquitously expressed in all fetal tissues examined including heart, brain, liver, and kidney. Also expressed at lower levels in both adult heart and hypertrophic heart.1 Publication
Gene expression databases
Bgeei | ENSG00000114626, Expressed in prostate gland and 203 other tissues |
ExpressionAtlasi | Q969K4, baseline and differential |
Genevisiblei | Q969K4, HS |
Organism-specific databases
HPAi | ENSG00000114626, Tissue enhanced (blood) |
Interactioni
Binary interactionsi
Hide detailsQ969K4
Protein-protein interaction databases
BioGRIDi | 123237, 13 interactors |
IntActi | Q969K4, 12 interactors |
MINTi | Q969K4 |
STRINGi | 9606.ENSP00000232744 |
Miscellaneous databases
RNActi | Q969K4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 1 – 31 | ANK 1Sequence analysisAdd BLAST | 31 | |
Repeati | 35 – 64 | ANK 2Sequence analysisAdd BLAST | 30 | |
Domaini | 115 – 182 | BTB 1PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 272 – 346 | BTB 2PROSITE-ProRule annotationAdd BLAST | 75 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 451 – 477 | Sequence analysisAdd BLAST | 27 |
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0511, Eukaryota |
GeneTreei | ENSGT00390000017131 |
HOGENOMi | CLU_022885_0_0_1 |
InParanoidi | Q969K4 |
OMAi | LCGHYEL |
OrthoDBi | 871743at2759 |
PhylomeDBi | Q969K4 |
TreeFami | TF329194 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00651, BTB, 2 hits |
SMARTi | View protein in SMART SM00248, ANK, 2 hits SM00225, BTB, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF54695, SSF54695, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50097, BTB, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 22 Publications (identifier: Q969K4-1) [UniParc]FASTAAdd to basket
Also known as: BPOZ-21 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDTSDLFASC RKGDVGRVRY LLEQRDVEVN VRDKWDSTPL YYACLCGHEE
60 70 80 90 100
LVLYLLANGA RCEANTFDGE RCLYGALSDP IRRALRDYKQ VTASCRRRDY
110 120 130 140 150
YDDFLQRLLE QGIHSDVVFV VHGKPFRVHR CVLGARSAYF ANMLDTKWKG
160 170 180 190 200
KSVVVLRHPL INPVAFGALL QYLYTGRLDI GVEHVSDCER LAKQCQLWDL
210 220 230 240 250
LSDLEAKCEK VSEFVASKPG TCVKVLTIEP PPADPRLRED MALLADCALP
260 270 280 290 300
PELRGDLWEL PFPCPDGFNS CPDICFRVAG CSFLCHKAFF CGRSDYFRAL
310 320 330 340 350
LDDHFRESEE PATSGGPPAV TLHGISPDVF THVLYYMYSD HTELSPEAAY
360 370 380 390 400
DVLSVADMYL LPGLKRLCGR SLAQMLDEDT VVGVWRVAKL FRLARLEDQC
410 420 430 440 450
TEYMAKVIEK LVEREDFVEA VKEEAAAVAA RQETDSIPLV DDIRFHVAST
460 470
VQTYSAIEEA QQRLRALEDL LVSIGLDC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C4W8 | H7C4W8_HUMAN | Ankyrin repeat and BTB/POZ domain-c... | ABTB1 | 141 | Annotation score: | ||
F2Z3F5 | F2Z3F5_HUMAN | Ankyrin repeat and BTB/POZ domain-c... | ABTB1 | 57 | Annotation score: |
Sequence cautioni
The sequence AAQ04661 differs from that shown. Reason: Frameshift.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052148 | 1 – 142 | Missing in isoform 1. 2 PublicationsAdd BLAST | 142 | |
Alternative sequenceiVSP_052149 | 1 – 40 | MDTSD…DSTPL → MWAECGTCWSSETWR in isoform 3. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_052150 | 24 – 50 | Missing in isoform 4. 1 PublicationAdd BLAST | 27 | |
Alternative sequenceiVSP_052151 | 87 – 196 | DYKQV…AKQCQ → LCGHEE in isoform 4. 1 PublicationAdd BLAST | 110 | |
Alternative sequenceiVSP_052152 | 255 – 287 | Missing in isoform 4. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_052153 | 468 – 478 | EDLLVSIGLDC → LETSMCMRLCAALLPAPCTL RASWGVRGAQWGFSSLHEPG DPRGGSIWDEPPPPNAQASP QDPGGGHHSGKPGVGVGFGL STFLLQIPPTHPSPKSSPLA LA in isoform 4. 1 PublicationAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB053324 mRNA Translation: BAB55648.1 AB053325 mRNA Translation: BAB55649.1 AB053326 mRNA Translation: BAB55650.1 AF447886 mRNA Translation: AAQ04661.1 Frameshift. AK130594 mRNA Translation: BAC85392.1 CH471052 Genomic DNA Translation: EAW79333.1 CH471052 Genomic DNA Translation: EAW79334.1 BC011858 mRNA Translation: AAH11858.1 AF297986 mRNA Translation: AAK57478.1 |
CCDSi | CCDS3045.1 [Q969K4-1] CCDS46901.1 [Q969K4-2] |
PIRi | JC7326 |
RefSeqi | NP_115937.1, NM_032548.3 [Q969K4-2] NP_742024.1, NM_172027.2 [Q969K4-1] XP_011511515.1, XM_011513213.1 [Q969K4-2] XP_016862776.1, XM_017007287.1 [Q969K4-2] |
Genome annotation databases
Ensembli | ENST00000232744; ENSP00000232744; ENSG00000114626 [Q969K4-1] ENST00000453791; ENSP00000412684; ENSG00000114626 [Q969K4-2] ENST00000468137; ENSP00000417366; ENSG00000114626 [Q969K4-2] |
GeneIDi | 80325 |
KEGGi | hsa:80325 |
UCSCi | uc003ejr.4, human [Q969K4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB053324 mRNA Translation: BAB55648.1 AB053325 mRNA Translation: BAB55649.1 AB053326 mRNA Translation: BAB55650.1 AF447886 mRNA Translation: AAQ04661.1 Frameshift. AK130594 mRNA Translation: BAC85392.1 CH471052 Genomic DNA Translation: EAW79333.1 CH471052 Genomic DNA Translation: EAW79334.1 BC011858 mRNA Translation: AAH11858.1 AF297986 mRNA Translation: AAK57478.1 |
CCDSi | CCDS3045.1 [Q969K4-1] CCDS46901.1 [Q969K4-2] |
PIRi | JC7326 |
RefSeqi | NP_115937.1, NM_032548.3 [Q969K4-2] NP_742024.1, NM_172027.2 [Q969K4-1] XP_011511515.1, XM_011513213.1 [Q969K4-2] XP_016862776.1, XM_017007287.1 [Q969K4-2] |
3D structure databases
SMRi | Q969K4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123237, 13 interactors |
IntActi | Q969K4, 12 interactors |
MINTi | Q969K4 |
STRINGi | 9606.ENSP00000232744 |
PTM databases
iPTMneti | Q969K4 |
PhosphoSitePlusi | Q969K4 |
Genetic variation databases
BioMutai | ABTB1 |
DMDMi | 74751721 |
Proteomic databases
jPOSTi | Q969K4 |
MassIVEi | Q969K4 |
PaxDbi | Q969K4 |
PeptideAtlasi | Q969K4 |
PRIDEi | Q969K4 |
ProteomicsDBi | 75781 [Q969K4-1] 75782 [Q969K4-2] 75783 [Q969K4-3] 75784 [Q969K4-4] |
Protocols and materials databases
Antibodypediai | 33153, 237 antibodies |
Genome annotation databases
Ensembli | ENST00000232744; ENSP00000232744; ENSG00000114626 [Q969K4-1] ENST00000453791; ENSP00000412684; ENSG00000114626 [Q969K4-2] ENST00000468137; ENSP00000417366; ENSG00000114626 [Q969K4-2] |
GeneIDi | 80325 |
KEGGi | hsa:80325 |
UCSCi | uc003ejr.4, human [Q969K4-1] |
Organism-specific databases
CTDi | 80325 |
DisGeNETi | 80325 |
GeneCardsi | ABTB1 |
HGNCi | HGNC:18275, ABTB1 |
HPAi | ENSG00000114626, Tissue enhanced (blood) |
MIMi | 608308, gene |
neXtProti | NX_Q969K4 |
OpenTargetsi | ENSG00000114626 |
PharmGKBi | PA24418 |
VEuPathDBi | HostDB:ENSG00000114626.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0511, Eukaryota |
GeneTreei | ENSGT00390000017131 |
HOGENOMi | CLU_022885_0_0_1 |
InParanoidi | Q969K4 |
OMAi | LCGHYEL |
OrthoDBi | 871743at2759 |
PhylomeDBi | Q969K4 |
TreeFami | TF329194 |
Enzyme and pathway databases
PathwayCommonsi | Q969K4 |
SIGNORi | Q969K4 |
Miscellaneous databases
BioGRID-ORCSi | 80325, 3 hits in 880 CRISPR screens |
ChiTaRSi | ABTB1, human |
GeneWikii | ABTB1 |
GenomeRNAii | 80325 |
Pharosi | Q969K4, Tbio |
PROi | PR:Q969K4 |
RNActi | Q969K4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114626, Expressed in prostate gland and 203 other tissues |
ExpressionAtlasi | Q969K4, baseline and differential |
Genevisiblei | Q969K4, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00651, BTB, 2 hits |
SMARTi | View protein in SMART SM00248, ANK, 2 hits SM00225, BTB, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF54695, SSF54695, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50097, BTB, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABTB1_HUMAN | |
Accessioni | Q969K4Primary (citable) accession number: Q969K4 Secondary accession number(s): D3DNB0 Q96S63 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot