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Entry version 143 (13 Feb 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Interleukin-22 receptor subunit alpha-2

Gene

IL22RA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Isoform 1 may play a role in establishing and maintaining successful pregnancy.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei99Critical for IL22-bindingBy similarity1
Sitei151Critical for IL22-bindingBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8854691 Interleukin-20 family signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q969J5

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q969J5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-22 receptor subunit alpha-2
Short name:
IL-22 receptor subunit alpha-2
Short name:
IL-22R-alpha-2
Short name:
IL-22RA2
Alternative name(s):
Cytokine receptor class-II member 10
Cytokine receptor family 2 member 10
Short name:
CRF2-10
Cytokine receptor family type 2, soluble 1
Short name:
CRF2-S1
Interleukin-22-binding protein
Short name:
IL-22BP
Short name:
IL22BP
ZcytoR16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL22RA2
ORF Names:UNQ5793/PRO19598/PRO19822
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164485.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14901 IL22RA2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606648 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969J5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
116379

Open Targets

More...
OpenTargetsi
ENSG00000164485

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134983729

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL22RA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
61213728

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001101622 – 263Interleukin-22 receptor subunit alpha-2Add BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi238 ↔ 2591 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969J5

PRoteomics IDEntifications database

More...
PRIDEi
Q969J5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75775
75776 [Q969J5-2]
75777 [Q969J5-3]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969J5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164485 Expressed in 33 organ(s), highest expression level in epithelium of nasopharynx

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q969J5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034906
HPA030582

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125503, 3 interactors

Database of interacting proteins

More...
DIPi
DIP-46036N

Protein interaction database and analysis system

More...
IntActi
Q969J5, 3 interactors

Molecular INTeraction database

More...
MINTi
Q969J5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296980

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3G9VX-ray2.76A/C21-263[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q969J5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q969J5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q969J5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 68Fibronectin type-III 1Add BLAST43
Domaini100 – 161Fibronectin type-III 2Add BLAST62
Domaini162 – 263Fibronectin type-III 3Add BLAST102

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVX1 Eukaryota
ENOG410YNE2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161124

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082681

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052067

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969J5

KEGG Orthology (KO)

More...
KOi
K05139

Identification of Orthologs from Complete Genome Data

More...
OMAi
VQYKMYG

Database of Orthologous Groups

More...
OrthoDBi
1078220at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969J5

TreeFam database of animal gene trees

More...
TreeFami
TF332537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q969J5-1) [UniParc]FASTAAdd to basket
Also known as: Long, CRF2-10L, CRF2-s1-long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMPKHCFLGF LISFFLTGVA GTQSTHESLK PQRVQFQSRN FHNILQWQPG
60 70 80 90 100
RALTGNSSVY FVQYKIMFSC SMKSSHQKPS GCWQHISCNF PGCRTLAKYG
110 120 130 140 150
QRQWKNKEDC WGTQELSCDL TSETSDIQEP YYGRVRAASA GSYSEWSMTP
160 170 180 190 200
RFTPWWETKI DPPVMNITQV NGSLLVILHA PNLPYRYQKE KNVSIEDYYE
210 220 230 240 250
LLYRVFIINN SLEKEQKVYE GAHRAVEIEA LTPHSSYCVV AEIYQPMLDR
260
RSQRSEERCV EIP
Length:263
Mass (Da):30,550
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC96ECEC5D78AC79B
GO
Isoform 2 (identifier: Q969J5-2) [UniParc]FASTAAdd to basket
Also known as: Short, CRF2-10, CRF2-s1-short

The sequence of this isoform differs from the canonical sequence as follows:
     67-98: Missing.

Show »
Length:231
Mass (Da):26,980
Checksum:i24A6912BFF75100F
GO
Isoform 3 (identifier: Q969J5-3) [UniParc]FASTAAdd to basket
Also known as: CRF2-10S

The sequence of this isoform differs from the canonical sequence as follows:
     67-98: Missing.
     158-162: TKIDP → RAKGL
     163-263: Missing.

Show »
Length:130
Mass (Da):15,128
Checksum:iA165814C641F5E5B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ89097 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02149316L → P1 PublicationCorresponds to variant dbSNP:rs28385692Ensembl.1
Natural variantiVAR_021494190E → K1 PublicationCorresponds to variant dbSNP:rs28362173Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01310567 – 98Missing in isoform 2 and isoform 3. 6 PublicationsAdd BLAST32
Alternative sequenceiVSP_013106158 – 162TKIDP → RAKGL in isoform 3. 1 Publication5
Alternative sequenceiVSP_013107163 – 263Missing in isoform 3. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ313161 mRNA Translation: CAC85634.1
AJ313162 mRNA Translation: CAC85635.1
AY040566 mRNA Translation: AAK85714.1
AY040567 mRNA Translation: AAK85715.1
AY040568 mRNA Translation: AAK85716.1
AJ297262 mRNA Translation: CAC83097.1
AY044429 mRNA Translation: AAK91775.1
AY358111 mRNA Translation: AAQ88478.1
AY358737 mRNA Translation: AAQ89097.1 Different initiation.
AY779023 Genomic DNA Translation: AAV31775.1
AL050337 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47933.1
BC125167 mRNA Translation: AAI25168.1
BC125168 mRNA Translation: AAI25169.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5182.1 [Q969J5-1]
CCDS5183.1 [Q969J5-2]
CCDS5184.1 [Q969J5-3]

NCBI Reference Sequences

More...
RefSeqi
NP_443194.1, NM_052962.2 [Q969J5-1]
NP_851826.1, NM_181309.1 [Q969J5-2]
NP_851827.1, NM_181310.1 [Q969J5-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.126891

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296980; ENSP00000296980; ENSG00000164485 [Q969J5-1]
ENST00000339602; ENSP00000340920; ENSG00000164485 [Q969J5-3]
ENST00000349184; ENSP00000296979; ENSG00000164485 [Q969J5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
116379

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:116379

UCSC genome browser

More...
UCSCi
uc003qhl.4 human [Q969J5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313161 mRNA Translation: CAC85634.1
AJ313162 mRNA Translation: CAC85635.1
AY040566 mRNA Translation: AAK85714.1
AY040567 mRNA Translation: AAK85715.1
AY040568 mRNA Translation: AAK85716.1
AJ297262 mRNA Translation: CAC83097.1
AY044429 mRNA Translation: AAK91775.1
AY358111 mRNA Translation: AAQ88478.1
AY358737 mRNA Translation: AAQ89097.1 Different initiation.
AY779023 Genomic DNA Translation: AAV31775.1
AL050337 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47933.1
BC125167 mRNA Translation: AAI25168.1
BC125168 mRNA Translation: AAI25169.1
CCDSiCCDS5182.1 [Q969J5-1]
CCDS5183.1 [Q969J5-2]
CCDS5184.1 [Q969J5-3]
RefSeqiNP_443194.1, NM_052962.2 [Q969J5-1]
NP_851826.1, NM_181309.1 [Q969J5-2]
NP_851827.1, NM_181310.1 [Q969J5-3]
UniGeneiHs.126891

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3G9VX-ray2.76A/C21-263[»]
ProteinModelPortaliQ969J5
SMRiQ969J5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125503, 3 interactors
DIPiDIP-46036N
IntActiQ969J5, 3 interactors
MINTiQ969J5
STRINGi9606.ENSP00000296980

PTM databases

PhosphoSitePlusiQ969J5

Polymorphism and mutation databases

BioMutaiIL22RA2
DMDMi61213728

Proteomic databases

PaxDbiQ969J5
PRIDEiQ969J5
ProteomicsDBi75775
75776 [Q969J5-2]
75777 [Q969J5-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296980; ENSP00000296980; ENSG00000164485 [Q969J5-1]
ENST00000339602; ENSP00000340920; ENSG00000164485 [Q969J5-3]
ENST00000349184; ENSP00000296979; ENSG00000164485 [Q969J5-2]
GeneIDi116379
KEGGihsa:116379
UCSCiuc003qhl.4 human [Q969J5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
116379
DisGeNETi116379
EuPathDBiHostDB:ENSG00000164485.14

GeneCards: human genes, protein and diseases

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GeneCardsi
IL22RA2
HGNCiHGNC:14901 IL22RA2
HPAiCAB034906
HPA030582
MIMi606648 gene
neXtProtiNX_Q969J5
OpenTargetsiENSG00000164485
PharmGKBiPA134983729

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IVX1 Eukaryota
ENOG410YNE2 LUCA
GeneTreeiENSGT00940000161124
HOGENOMiHOG000082681
HOVERGENiHBG052067
InParanoidiQ969J5
KOiK05139
OMAiVQYKMYG
OrthoDBi1078220at2759
PhylomeDBiQ969J5
TreeFamiTF332537

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ969J5
SIGNORiQ969J5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IL22RA2 human
EvolutionaryTraceiQ969J5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
116379

Protein Ontology

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PROi
PR:Q969J5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000164485 Expressed in 33 organ(s), highest expression level in epithelium of nasopharynx
GenevisibleiQ969J5 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
PfamiView protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI22R2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969J5
Secondary accession number(s): Q08AH7
, Q6UWM1, Q96A41, Q96QR0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: February 13, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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