Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-22 receptor subunit alpha-2

Gene

IL22RA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Isoform 1 may play a role in establishing and maintaining successful pregnancy.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei99Critical for IL22-bindingBy similarity1
Sitei151Critical for IL22-bindingBy similarity1

GO - Molecular functioni

  • interleukin-22 binding Source: UniProtKB
  • interleukin-22 receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ969J5
SIGNORiQ969J5

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22 receptor subunit alpha-2
Short name:
IL-22 receptor subunit alpha-2
Short name:
IL-22R-alpha-2
Short name:
IL-22RA2
Alternative name(s):
Cytokine receptor class-II member 10
Cytokine receptor family 2 member 10
Short name:
CRF2-10
Cytokine receptor family type 2, soluble 1
Short name:
CRF2-S1
Interleukin-22-binding protein
Short name:
IL-22BP
Short name:
IL22BP
ZcytoR16
Gene namesi
Name:IL22RA2
ORF Names:UNQ5793/PRO19598/PRO19822
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000164485.14
HGNCiHGNC:14901 IL22RA2
MIMi606648 gene
neXtProtiNX_Q969J5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi116379
OpenTargetsiENSG00000164485
PharmGKBiPA134983729

Polymorphism and mutation databases

BioMutaiIL22RA2
DMDMi61213728

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001101622 – 263Interleukin-22 receptor subunit alpha-2Add BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi238 ↔ 2591 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ969J5
PRIDEiQ969J5
ProteomicsDBi75775
75776 [Q969J5-2]
75777 [Q969J5-3]

PTM databases

PhosphoSitePlusiQ969J5

Expressioni

Tissue specificityi

Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.3 Publications

Gene expression databases

BgeeiENSG00000164485
CleanExiHS_IL22RA2
GenevisibleiQ969J5 HS

Organism-specific databases

HPAiCAB034906
HPA030582

Interactioni

GO - Molecular functioni

  • interleukin-22 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125503, 3 interactors
IntActiQ969J5, 3 interactors
MINTiQ969J5
STRINGi9606.ENSP00000296980

Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 39Combined sources8
Beta strandi42 – 48Combined sources7
Beta strandi59 – 66Combined sources8
Beta strandi105 – 113Combined sources9
Beta strandi116 – 119Combined sources4
Helixi122 – 124Combined sources3
Beta strandi131 – 139Combined sources9
Helixi154 – 157Combined sources4
Beta strandi164 – 166Combined sources3
Beta strandi177 – 179Combined sources3
Helixi184 – 187Combined sources4
Helixi195 – 198Combined sources4
Beta strandi202 – 207Combined sources6
Beta strandi216 – 223Combined sources8
Beta strandi239 – 245Combined sources7
Turni246 – 249Combined sources4

3D structure databases

ProteinModelPortaliQ969J5
SMRiQ969J5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ969J5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 68Fibronectin type-III 1Add BLAST43
Domaini100 – 161Fibronectin type-III 2Add BLAST62
Domaini162 – 263Fibronectin type-III 3Add BLAST102

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVX1 Eukaryota
ENOG410YNE2 LUCA
GeneTreeiENSGT00530000063352
HOGENOMiHOG000082681
HOVERGENiHBG052067
InParanoidiQ969J5
KOiK05139
OMAiPYYGRVR
OrthoDBiEOG091G068P
PhylomeDBiQ969J5
TreeFamiTF332537

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
PfamiView protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 3 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969J5-1) [UniParc]FASTAAdd to basket
Also known as: Long, CRF2-10L, CRF2-s1-long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMPKHCFLGF LISFFLTGVA GTQSTHESLK PQRVQFQSRN FHNILQWQPG
60 70 80 90 100
RALTGNSSVY FVQYKIMFSC SMKSSHQKPS GCWQHISCNF PGCRTLAKYG
110 120 130 140 150
QRQWKNKEDC WGTQELSCDL TSETSDIQEP YYGRVRAASA GSYSEWSMTP
160 170 180 190 200
RFTPWWETKI DPPVMNITQV NGSLLVILHA PNLPYRYQKE KNVSIEDYYE
210 220 230 240 250
LLYRVFIINN SLEKEQKVYE GAHRAVEIEA LTPHSSYCVV AEIYQPMLDR
260
RSQRSEERCV EIP
Length:263
Mass (Da):30,550
Last modified:December 1, 2001 - v1
Checksum:iC96ECEC5D78AC79B
GO
Isoform 2 (identifier: Q969J5-2) [UniParc]FASTAAdd to basket
Also known as: Short, CRF2-10, CRF2-s1-short

The sequence of this isoform differs from the canonical sequence as follows:
     67-98: Missing.

Show »
Length:231
Mass (Da):26,980
Checksum:i24A6912BFF75100F
GO
Isoform 3 (identifier: Q969J5-3) [UniParc]FASTAAdd to basket
Also known as: CRF2-10S

The sequence of this isoform differs from the canonical sequence as follows:
     67-98: Missing.
     158-162: TKIDP → RAKGL
     163-263: Missing.

Show »
Length:130
Mass (Da):15,128
Checksum:iA165814C641F5E5B
GO

Sequence cautioni

The sequence AAQ89097 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02149316L → P1 PublicationCorresponds to variant dbSNP:rs28385692Ensembl.1
Natural variantiVAR_021494190E → K1 PublicationCorresponds to variant dbSNP:rs28362173Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01310567 – 98Missing in isoform 2 and isoform 3. 6 PublicationsAdd BLAST32
Alternative sequenceiVSP_013106158 – 162TKIDP → RAKGL in isoform 3. 1 Publication5
Alternative sequenceiVSP_013107163 – 263Missing in isoform 3. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313161 mRNA Translation: CAC85634.1
AJ313162 mRNA Translation: CAC85635.1
AY040566 mRNA Translation: AAK85714.1
AY040567 mRNA Translation: AAK85715.1
AY040568 mRNA Translation: AAK85716.1
AJ297262 mRNA Translation: CAC83097.1
AY044429 mRNA Translation: AAK91775.1
AY358111 mRNA Translation: AAQ88478.1
AY358737 mRNA Translation: AAQ89097.1 Different initiation.
AY779023 Genomic DNA Translation: AAV31775.1
AL050337 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47933.1
BC125167 mRNA Translation: AAI25168.1
BC125168 mRNA Translation: AAI25169.1
CCDSiCCDS5182.1 [Q969J5-1]
CCDS5183.1 [Q969J5-2]
CCDS5184.1 [Q969J5-3]
RefSeqiNP_443194.1, NM_052962.2 [Q969J5-1]
NP_851826.1, NM_181309.1 [Q969J5-2]
NP_851827.1, NM_181310.1 [Q969J5-3]
UniGeneiHs.126891

Genome annotation databases

EnsembliENST00000296980; ENSP00000296980; ENSG00000164485 [Q969J5-1]
ENST00000339602; ENSP00000340920; ENSG00000164485 [Q969J5-3]
ENST00000349184; ENSP00000296979; ENSG00000164485 [Q969J5-2]
GeneIDi116379
KEGGihsa:116379
UCSCiuc003qhl.4 human [Q969J5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiI22R2_HUMAN
AccessioniPrimary (citable) accession number: Q969J5
Secondary accession number(s): Q08AH7
, Q6UWM1, Q96A41, Q96QR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health