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Protein

Zinc finger protein with KRAB and SCAN domains 4

Gene

ZKSCAN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the transcriptional activation of MDM2 and EP300 genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri320 – 342C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 4
Alternative name(s):
P373c6.1
Zinc finger protein 307
Zinc finger protein 427
Gene namesi
Name:ZKSCAN4
Synonyms:ZNF307, ZNF427
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000187626.8
HGNCiHGNC:13854 ZKSCAN4
MIMi611643 gene
neXtProtiNX_Q969J2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi387032
OpenTargetsiENSG00000187626
PharmGKBiPA162409784

Polymorphism and mutation databases

BioMutaiZKSCAN4
DMDMi23396993

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475251 – 545Zinc finger protein with KRAB and SCAN domains 4Add BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ969J2
MaxQBiQ969J2
PaxDbiQ969J2
PeptideAtlasiQ969J2
PRIDEiQ969J2
ProteomicsDBi75772

PTM databases

iPTMnetiQ969J2
PhosphoSitePlusiQ969J2

Expressioni

Tissue specificityi

Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000187626 Expressed in 170 organ(s), highest expression level in sperm
CleanExiHS_ZKSCAN4
ExpressionAtlasiQ969J2 baseline and differential
GenevisibleiQ969J2 HS

Organism-specific databases

HPAiHPA009637

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi132179, 34 interactors
IntActiQ969J2, 22 interactors
STRINGi9606.ENSP00000366509

Structurei

3D structure databases

ProteinModelPortaliQ969J2
SMRiQ969J2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 135SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini221 – 317KRABPROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri320 – 342C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ969J2
KOiK09229
OMAiCREDAMV
OrthoDBiEOG091G040B
PhylomeDBiQ969J2
TreeFamiTF350830

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequencei

Sequence statusi: Complete.

Q969J2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAREPRKNAA LDAQSAEDQT GLLTVKVEKE EASALTAEVR APCSPARGPE
60 70 80 90 100
RSRQRFRGFR YPEAAGPREA LSRLRELCGQ WLQPEMHSKE QILELLVLEQ
110 120 130 140 150
FLTILPGNLQ SWVREQHPES GEEVVVLLEY LERQLDEPAP QVPVGDQGQE
160 170 180 190 200
LLCCKMALLT QTQGSQSSQC QPMKALFKHE SLGSQPLHDR VLQVPGLAQG
210 220 230 240 250
GCCREDAMVA SRLTPGSQGL LKMEDVALTL TPGWTQLDSS QVNLYRDEKQ
260 270 280 290 300
ENHSSLVSLG GEIQTKSRDL PPVKKLPEKE HGKICHLRED IAQIPTHAEA
310 320 330 340 350
GEQEGRLQRK QKNAIGSRRH YCHECGKSFA QSSGLTKHRR IHTGEKPYEC
360 370 380 390 400
EDCGKTFIGS SALVIHQRVH TGEKPYECEE CGKVFSHSSN LIKHQRTHTG
410 420 430 440 450
EKPYECDDCG KTFSQSCSLL EHHKIHTGEK PYQCNMCGKA FRRNSHLLRH
460 470 480 490 500
QRIHGDKNVQ NPEHGESWES QGRTESQWEN TEAPVSYKCN ECERSFTRNR
510 520 530 540
SLIEHQKIHT GEKPYQCDTC GKGFTRTSYL VQHQRSHVGK KTLSQ
Length:545
Mass (Da):61,579
Last modified:December 1, 2001 - v1
Checksum:iCCFB6B5D976926ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05995133S → F. Corresponds to variant dbSNP:rs9986596Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY781778 mRNA Translation: AAV41023.1
AK315783 mRNA Translation: BAG38129.1
AL022393 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03142.1
BC014031 mRNA Translation: AAH14031.1
CCDSiCCDS4647.1
RefSeqiNP_061983.2, NM_019110.4
XP_005249152.1, XM_005249095.3
UniGeneiHs.44720
Hs.739171

Genome annotation databases

EnsembliENST00000377294; ENSP00000366509; ENSG00000187626
GeneIDi387032
KEGGihsa:387032
UCSCiuc003nks.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY781778 mRNA Translation: AAV41023.1
AK315783 mRNA Translation: BAG38129.1
AL022393 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03142.1
BC014031 mRNA Translation: AAH14031.1
CCDSiCCDS4647.1
RefSeqiNP_061983.2, NM_019110.4
XP_005249152.1, XM_005249095.3
UniGeneiHs.44720
Hs.739171

3D structure databases

ProteinModelPortaliQ969J2
SMRiQ969J2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132179, 34 interactors
IntActiQ969J2, 22 interactors
STRINGi9606.ENSP00000366509

PTM databases

iPTMnetiQ969J2
PhosphoSitePlusiQ969J2

Polymorphism and mutation databases

BioMutaiZKSCAN4
DMDMi23396993

Proteomic databases

EPDiQ969J2
MaxQBiQ969J2
PaxDbiQ969J2
PeptideAtlasiQ969J2
PRIDEiQ969J2
ProteomicsDBi75772

Protocols and materials databases

DNASUi387032
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377294; ENSP00000366509; ENSG00000187626
GeneIDi387032
KEGGihsa:387032
UCSCiuc003nks.2 human

Organism-specific databases

CTDi387032
DisGeNETi387032
EuPathDBiHostDB:ENSG00000187626.8
GeneCardsiZKSCAN4
HGNCiHGNC:13854 ZKSCAN4
HPAiHPA009637
MIMi611643 gene
neXtProtiNX_Q969J2
OpenTargetsiENSG00000187626
PharmGKBiPA162409784
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ969J2
KOiK09229
OMAiCREDAMV
OrthoDBiEOG091G040B
PhylomeDBiQ969J2
TreeFamiTF350830

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii387032
PROiPR:Q969J2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187626 Expressed in 170 organ(s), highest expression level in sperm
CleanExiHS_ZKSCAN4
ExpressionAtlasiQ969J2 baseline and differential
GenevisibleiQ969J2 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZKSC4_HUMAN
AccessioniPrimary (citable) accession number: Q969J2
Secondary accession number(s): B2RE32, Q5U7L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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