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Entry version 172 (12 Aug 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Zinc finger protein with KRAB and SCAN domains 4

Gene

ZKSCAN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the transcriptional activation of MDM2 and EP300 genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri320 – 342C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q969J2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 4
Alternative name(s):
P373c6.1
Zinc finger protein 307
Zinc finger protein 427
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZKSCAN4
Synonyms:ZNF307, ZNF427
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187626.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13854, ZKSCAN4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611643, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969J2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
387032

Open Targets

More...
OpenTargetsi
ENSG00000187626

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162409784

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q969J2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZKSCAN4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23396993

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475251 – 545Zinc finger protein with KRAB and SCAN domains 4Add BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q969J2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q969J2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q969J2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q969J2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969J2

PeptideAtlas

More...
PeptideAtlasi
Q969J2

PRoteomics IDEntifications database

More...
PRIDEi
Q969J2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75772

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969J2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969J2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187626, Expressed in sperm and 185 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q969J2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969J2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000187626, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
132179, 40 interactors

Protein interaction database and analysis system

More...
IntActi
Q969J2, 37 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366509

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q969J2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q969J2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 135SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini221 – 317KRABPROSITE-ProRule annotationAdd BLAST97

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri320 – 342C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159644

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_49_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969J2

KEGG Orthology (KO)

More...
KOi
K09229

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHCREDA

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969J2

TreeFam database of animal gene trees

More...
TreeFami
TF350830

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit
cd07936, SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q969J2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAREPRKNAA LDAQSAEDQT GLLTVKVEKE EASALTAEVR APCSPARGPE
60 70 80 90 100
RSRQRFRGFR YPEAAGPREA LSRLRELCGQ WLQPEMHSKE QILELLVLEQ
110 120 130 140 150
FLTILPGNLQ SWVREQHPES GEEVVVLLEY LERQLDEPAP QVPVGDQGQE
160 170 180 190 200
LLCCKMALLT QTQGSQSSQC QPMKALFKHE SLGSQPLHDR VLQVPGLAQG
210 220 230 240 250
GCCREDAMVA SRLTPGSQGL LKMEDVALTL TPGWTQLDSS QVNLYRDEKQ
260 270 280 290 300
ENHSSLVSLG GEIQTKSRDL PPVKKLPEKE HGKICHLRED IAQIPTHAEA
310 320 330 340 350
GEQEGRLQRK QKNAIGSRRH YCHECGKSFA QSSGLTKHRR IHTGEKPYEC
360 370 380 390 400
EDCGKTFIGS SALVIHQRVH TGEKPYECEE CGKVFSHSSN LIKHQRTHTG
410 420 430 440 450
EKPYECDDCG KTFSQSCSLL EHHKIHTGEK PYQCNMCGKA FRRNSHLLRH
460 470 480 490 500
QRIHGDKNVQ NPEHGESWES QGRTESQWEN TEAPVSYKCN ECERSFTRNR
510 520 530 540
SLIEHQKIHT GEKPYQCDTC GKGFTRTSYL VQHQRSHVGK KTLSQ
Length:545
Mass (Da):61,579
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCFB6B5D976926ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05995133S → F. Corresponds to variant dbSNP:rs9986596Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY781778 mRNA Translation: AAV41023.1
AK315783 mRNA Translation: BAG38129.1
AL022393 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03142.1
BC014031 mRNA Translation: AAH14031.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4647.1

NCBI Reference Sequences

More...
RefSeqi
NP_061983.2, NM_019110.4
XP_005249152.1, XM_005249095.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377294; ENSP00000366509; ENSG00000187626

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
387032

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:387032

UCSC genome browser

More...
UCSCi
uc003nks.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY781778 mRNA Translation: AAV41023.1
AK315783 mRNA Translation: BAG38129.1
AL022393 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03142.1
BC014031 mRNA Translation: AAH14031.1
CCDSiCCDS4647.1
RefSeqiNP_061983.2, NM_019110.4
XP_005249152.1, XM_005249095.3

3D structure databases

SMRiQ969J2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi132179, 40 interactors
IntActiQ969J2, 37 interactors
STRINGi9606.ENSP00000366509

PTM databases

iPTMnetiQ969J2
PhosphoSitePlusiQ969J2

Polymorphism and mutation databases

BioMutaiZKSCAN4
DMDMi23396993

Proteomic databases

EPDiQ969J2
jPOSTiQ969J2
MassIVEiQ969J2
MaxQBiQ969J2
PaxDbiQ969J2
PeptideAtlasiQ969J2
PRIDEiQ969J2
ProteomicsDBi75772

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q969J2, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
11231, 235 antibodies

The DNASU plasmid repository

More...
DNASUi
387032

Genome annotation databases

EnsembliENST00000377294; ENSP00000366509; ENSG00000187626
GeneIDi387032
KEGGihsa:387032
UCSCiuc003nks.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
387032
DisGeNETi387032
EuPathDBiHostDB:ENSG00000187626.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZKSCAN4
HGNCiHGNC:13854, ZKSCAN4
HPAiENSG00000187626, Low tissue specificity
MIMi611643, gene
neXtProtiNX_Q969J2
OpenTargetsiENSG00000187626
PharmGKBiPA162409784

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000159644
HOGENOMiCLU_002678_49_4_1
InParanoidiQ969J2
KOiK09229
OMAiGHCREDA
OrthoDBi1318335at2759
PhylomeDBiQ969J2
TreeFamiTF350830

Enzyme and pathway databases

PathwayCommonsiQ969J2
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
387032, 3 hits in 890 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
387032
PharosiQ969J2, Tdark

Protein Ontology

More...
PROi
PR:Q969J2
RNActiQ969J2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187626, Expressed in sperm and 185 other tissues
ExpressionAtlasiQ969J2, baseline and differential
GenevisibleiQ969J2, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
cd07936, SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 7 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZKSC4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969J2
Secondary accession number(s): B2RE32, Q5U7L4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: August 12, 2020
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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