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UniProtKB - Q969H8 (MYDGF_HUMAN)

Entry version 150 (02 Dec 2020)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Myeloid-derived growth factor

Gene

MYDGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).By similarity1 Publication

Caution

Was originally thought to signal lymphoid cells to proliferate via thymic shared antigen 1 (PubMed:11714798). This work was later retracted (PubMed:12538725).2 Publications
It has been reported that MYDGF is secreted into blood plasma and localized to the endoplasmic reticulum-Golgi intermediate compartment (PubMed:17362502, PubMed:25581518). However, another report shows resident localization to the endoplasmic reticulum and Golgi apparatus and secretion when the two most C-terminal residues of the RTEL motif are abolished (PubMed:29954947).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis, Apoptosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q969H8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-381038, XBP1(S) activates chaperone genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myeloid-derived growth factor1 PublicationImported
Short name:
MYDGF1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYDGFImported
Synonyms:C19orf10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000074842.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:16948, MYDGF

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606746, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q969H8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi172 – 173Missing : Increased secretion. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		56005

Open Targets

More...OpenTargetsi		ENSG00000074842

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29827

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q969H8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MYDGF

Domain mapping of disease mutations (DMDM)

More...DMDMi		61221730

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 311 PublicationAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002100832 – 173Myeloid-derived growth factorAdd BLAST142

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q969H8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q969H8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q969H8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q969H8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q969H8

PeptideAtlas

More...PeptideAtlasi		Q969H8

PRoteomics IDEntifications database

More...PRIDEi		Q969H8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75767

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q969H8

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		Q969H8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q969H8

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q969H8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q969H8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q969H8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in eosinophils (at protein level) (PubMed:29954947). Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to myocardial infarction (MI).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000074842, Expressed in stromal cell of endometrium and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q969H8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q969H8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000074842, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121028, 21 interactors

Protein interaction database and analysis system

More...IntActi		Q969H8, 21 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262947

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q969H8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q969H8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYDGF family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RZK9, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000777

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_132160_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q969H8

Identification of Orthologs from Complete Genome Data

More...OMAi		TQFKAEL

Database of Orthologous Groups

More...OrthoDBi		1577767at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q969H8

TreeFam database of animal gene trees

More...TreeFami		TF332795

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018887, MYDGF

The PANTHER Classification System

More...PANTHERi		PTHR31230, PTHR31230, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10572, UPF0556, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q969H8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS 
        60         70         80         90        100
FSHNVGPGDK YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK 
       110        120        130        140        150
SYLYFTQFKA EVRGAEIEYA MAYSKAAFER ESDVPLKTEE FEVTKTAVAH 
       160        170 
RPGAFKAELS KLVIVAKASR TEL
Length:173
Mass (Da):18,795
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD8910DEFEA5E3FC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYN0M0QYN0_HUMAN
Myeloid-derived growth factor
MYDGF
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXF7M0QXF7_HUMAN
Myeloid-derived growth factor
MYDGF
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC27824 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC33800 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06018312G → R. Corresponds to variant dbSNP:rs2270090Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC005594 Genomic DNA Translation: AAC33800.1 Sequence problems.
AC005339 Genomic DNA Translation: AAC27824.1 Sequence problems.
CH471139 Genomic DNA Translation: EAW69202.1
CH471139 Genomic DNA Translation: EAW69203.1
BC003639 mRNA Translation: AAH03639.2
BC010129 mRNA Translation: AAH10129.1
BC014655 mRNA Translation: AAH14655.1
AL365373 mRNA Translation: CAB96947.1
AL365374 mRNA Translation: CAB96948.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12133.1

NCBI Reference Sequences

More...RefSeqi		NP_061980.1, NM_019107.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262947; ENSP00000262947; ENSG00000074842

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56005

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56005

UCSC genome browser

More...UCSCi		uc002may.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005594 Genomic DNA Translation: AAC33800.1 Sequence problems.
AC005339 Genomic DNA Translation: AAC27824.1 Sequence problems.
CH471139 Genomic DNA Translation: EAW69202.1
CH471139 Genomic DNA Translation: EAW69203.1
BC003639 mRNA Translation: AAH03639.2
BC010129 mRNA Translation: AAH10129.1
BC014655 mRNA Translation: AAH14655.1
AL365373 mRNA Translation: CAB96947.1
AL365374 mRNA Translation: CAB96948.1
CCDSiCCDS12133.1
RefSeqiNP_061980.1, NM_019107.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6O6WNMR-A32-173[»]
6SVKX-ray1.60A/B32-173[»]
6SVLX-ray1.58C/F/J/N/Q/R32-173[»]
SMRiQ969H8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121028, 21 interactors
IntActiQ969H8, 21 interactors
STRINGi9606.ENSP00000262947

PTM databases

iPTMnetiQ969H8
MetOSiteiQ969H8
PhosphoSitePlusiQ969H8
SwissPalmiQ969H8

Polymorphism and mutation databases

BioMutaiMYDGF
DMDMi61221730

2D gel databases

UCD-2DPAGEiQ969H8

Proteomic databases

EPDiQ969H8
jPOSTiQ969H8
MassIVEiQ969H8
MaxQBiQ969H8
PaxDbiQ969H8
PeptideAtlasiQ969H8
PRIDEiQ969H8
ProteomicsDBi75767
TopDownProteomicsiQ969H8

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q969H8, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23698, 227 antibodies

Genome annotation databases

EnsembliENST00000262947; ENSP00000262947; ENSG00000074842
GeneIDi56005
KEGGihsa:56005
UCSCiuc002may.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56005
DisGeNETi56005
EuPathDBiHostDB:ENSG00000074842.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		MYDGF
HGNCiHGNC:16948, MYDGF
HPAiENSG00000074842, Low tissue specificity
MIMi606746, gene
neXtProtiNX_Q969H8
OpenTargetsiENSG00000074842
PharmGKBiPA29827

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RZK9, Eukaryota
GeneTreeiENSGT00390000000777
HOGENOMiCLU_132160_0_0_1
InParanoidiQ969H8
OMAiTQFKAEL
OrthoDBi1577767at2759
PhylomeDBiQ969H8
TreeFamiTF332795

Enzyme and pathway databases

PathwayCommonsiQ969H8
ReactomeiR-HSA-381038, XBP1(S) activates chaperone genes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56005, 3 hits in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MYDGF, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56005
PharosiQ969H8, Tbio

Protein Ontology

More...PROi		PR:Q969H8
RNActiQ969H8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000074842, Expressed in stromal cell of endometrium and 241 other tissues
ExpressionAtlasiQ969H8, baseline and differential
GenevisibleiQ969H8, HS

Family and domain databases

InterProiView protein in InterPro
IPR018887, MYDGF
PANTHERiPTHR31230, PTHR31230, 1 hit
PfamiView protein in Pfam
PF10572, UPF0556, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYDGF_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969H8
Secondary accession number(s): D6W628
, O75256, O75272, Q9BTK7, Q9NP69
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: December 1, 2001
Last modified: December 2, 2020
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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