UniProtKB - Q969H8 (MYDGF_HUMAN)
Protein
Myeloid-derived growth factor
Gene
MYDGF
Organism
Homo sapiens (Human)
Status
Functioni
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).By similarity1 Publication
Caution
Was originally thought to signal lymphoid cells to proliferate via thymic shared antigen 1 (PubMed:11714798). This work was later retracted (PubMed:12538725).2 Publications
It has been reported that MYDGF is secreted into blood plasma and localized to the endoplasmic reticulum-Golgi intermediate compartment (PubMed:17362502, PubMed:25581518). However, another report shows resident localization to the endoplasmic reticulum and Golgi apparatus and secretion when the two most C-terminal residues of the RTEL motif are abolished (PubMed:29954947).3 Publications
GO - Biological processi
- angiogenesis Source: UniProtKB-KW
- apoptotic process Source: UniProtKB-KW
- IRE1-mediated unfolded protein response Source: Reactome
- negative regulation of apoptotic process Source: UniProtKB
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of endothelial cell proliferation Source: UniProtKB
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of protein kinase B signaling Source: UniProtKB
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
Keywordsi
Biological process | Angiogenesis, Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q969H8 |
Reactomei | R-HSA-381038, XBP1(S) activates chaperone genes |
Names & Taxonomyi
Protein namesi | Recommended name: Myeloid-derived growth factor1 PublicationImportedShort name: MYDGF1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000074842.7 |
HGNCi | HGNC:16948, MYDGF |
MIMi | 606746, gene |
neXtProti | NX_Q969H8 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Golgi apparatus
- Golgi apparatus 1 Publication
Extracellular region or secreted
- Secreted 2 Publications
Other locations
- Endoplasmic reticulum-Golgi intermediate compartment 1 Publication
Note: The C-terminal RTEL motif may provide retention in the endoplasmic reticulum.2 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular space Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Other locations
- endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 172 – 173 | Missing : Increased secretion. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 56005 |
OpenTargetsi | ENSG00000074842 |
PharmGKBi | PA29827 |
Miscellaneous databases
Pharosi | Q969H8, Tbio |
Polymorphism and mutation databases
BioMutai | MYDGF |
DMDMi | 61221730 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | 1 PublicationAdd BLAST | 31 | |
ChainiPRO_0000021008 | 32 – 173 | Myeloid-derived growth factorAdd BLAST | 142 |
Proteomic databases
EPDi | Q969H8 |
jPOSTi | Q969H8 |
MassIVEi | Q969H8 |
MaxQBi | Q969H8 |
PaxDbi | Q969H8 |
PeptideAtlasi | Q969H8 |
PRIDEi | Q969H8 |
ProteomicsDBi | 75767 |
TopDownProteomicsi | Q969H8 |
2D gel databases
UCD-2DPAGEi | Q969H8 |
PTM databases
iPTMneti | Q969H8 |
MetOSitei | Q969H8 |
PhosphoSitePlusi | Q969H8 |
SwissPalmi | Q969H8 |
Expressioni
Tissue specificityi
Expressed in eosinophils (at protein level) (PubMed:29954947). Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).3 Publications
Inductioni
Up-regulated in response to myocardial infarction (MI).1 Publication
Gene expression databases
Bgeei | ENSG00000074842, Expressed in stromal cell of endometrium and 241 other tissues |
ExpressionAtlasi | Q969H8, baseline and differential |
Genevisiblei | Q969H8, HS |
Organism-specific databases
HPAi | ENSG00000074842, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ969H8
Protein-protein interaction databases
BioGRIDi | 121028, 21 interactors |
IntActi | Q969H8, 21 interactors |
STRINGi | 9606.ENSP00000262947 |
Miscellaneous databases
RNActi | Q969H8, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q969H8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the MYDGF family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RZK9, Eukaryota |
GeneTreei | ENSGT00390000000777 |
HOGENOMi | CLU_132160_0_0_1 |
InParanoidi | Q969H8 |
OMAi | TQFKAEL |
OrthoDBi | 1577767at2759 |
PhylomeDBi | Q969H8 |
TreeFami | TF332795 |
Family and domain databases
InterProi | View protein in InterPro IPR018887, MYDGF |
PANTHERi | PTHR31230, PTHR31230, 1 hit |
Pfami | View protein in Pfam PF10572, UPF0556, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q969H8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPSGGWNG VGASLWAALL LGAVALRPAE AVSEPTTVAF DVRPGGVVHS
60 70 80 90 100
FSHNVGPGDK YTCMFTYASQ GGTNEQWQMS LGTSEDHQHF TCTIWRPQGK
110 120 130 140 150
SYLYFTQFKA EVRGAEIEYA MAYSKAAFER ESDVPLKTEE FEVTKTAVAH
160 170
RPGAFKAELS KLVIVAKASR TEL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QYN0 | M0QYN0_HUMAN | Myeloid-derived growth factor | MYDGF | 189 | Annotation score: | ||
M0QXF7 | M0QXF7_HUMAN | Myeloid-derived growth factor | MYDGF | 84 | Annotation score: |
Sequence cautioni
The sequence AAC27824 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC33800 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060183 | 12 | G → R. Corresponds to variant dbSNP:rs2270090Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005594 Genomic DNA Translation: AAC33800.1 Sequence problems. AC005339 Genomic DNA Translation: AAC27824.1 Sequence problems. CH471139 Genomic DNA Translation: EAW69202.1 CH471139 Genomic DNA Translation: EAW69203.1 BC003639 mRNA Translation: AAH03639.2 BC010129 mRNA Translation: AAH10129.1 BC014655 mRNA Translation: AAH14655.1 AL365373 mRNA Translation: CAB96947.1 AL365374 mRNA Translation: CAB96948.1 |
CCDSi | CCDS12133.1 |
RefSeqi | NP_061980.1, NM_019107.3 |
Genome annotation databases
Ensembli | ENST00000262947; ENSP00000262947; ENSG00000074842 |
GeneIDi | 56005 |
KEGGi | hsa:56005 |
UCSCi | uc002may.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005594 Genomic DNA Translation: AAC33800.1 Sequence problems. AC005339 Genomic DNA Translation: AAC27824.1 Sequence problems. CH471139 Genomic DNA Translation: EAW69202.1 CH471139 Genomic DNA Translation: EAW69203.1 BC003639 mRNA Translation: AAH03639.2 BC010129 mRNA Translation: AAH10129.1 BC014655 mRNA Translation: AAH14655.1 AL365373 mRNA Translation: CAB96947.1 AL365374 mRNA Translation: CAB96948.1 |
CCDSi | CCDS12133.1 |
RefSeqi | NP_061980.1, NM_019107.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6O6W | NMR | - | A | 32-173 | [»] | |
6SVK | X-ray | 1.60 | A/B | 32-173 | [»] | |
6SVL | X-ray | 1.58 | C/F/J/N/Q/R | 32-173 | [»] | |
SMRi | Q969H8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121028, 21 interactors |
IntActi | Q969H8, 21 interactors |
STRINGi | 9606.ENSP00000262947 |
PTM databases
iPTMneti | Q969H8 |
MetOSitei | Q969H8 |
PhosphoSitePlusi | Q969H8 |
SwissPalmi | Q969H8 |
Polymorphism and mutation databases
BioMutai | MYDGF |
DMDMi | 61221730 |
2D gel databases
UCD-2DPAGEi | Q969H8 |
Proteomic databases
EPDi | Q969H8 |
jPOSTi | Q969H8 |
MassIVEi | Q969H8 |
MaxQBi | Q969H8 |
PaxDbi | Q969H8 |
PeptideAtlasi | Q969H8 |
PRIDEi | Q969H8 |
ProteomicsDBi | 75767 |
TopDownProteomicsi | Q969H8 |
Protocols and materials databases
ABCDi | Q969H8, 1 sequenced antibody |
Antibodypediai | 23698, 227 antibodies |
Genome annotation databases
Ensembli | ENST00000262947; ENSP00000262947; ENSG00000074842 |
GeneIDi | 56005 |
KEGGi | hsa:56005 |
UCSCi | uc002may.4, human |
Organism-specific databases
CTDi | 56005 |
DisGeNETi | 56005 |
EuPathDBi | HostDB:ENSG00000074842.7 |
GeneCardsi | MYDGF |
HGNCi | HGNC:16948, MYDGF |
HPAi | ENSG00000074842, Low tissue specificity |
MIMi | 606746, gene |
neXtProti | NX_Q969H8 |
OpenTargetsi | ENSG00000074842 |
PharmGKBi | PA29827 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZK9, Eukaryota |
GeneTreei | ENSGT00390000000777 |
HOGENOMi | CLU_132160_0_0_1 |
InParanoidi | Q969H8 |
OMAi | TQFKAEL |
OrthoDBi | 1577767at2759 |
PhylomeDBi | Q969H8 |
TreeFami | TF332795 |
Enzyme and pathway databases
PathwayCommonsi | Q969H8 |
Reactomei | R-HSA-381038, XBP1(S) activates chaperone genes |
Miscellaneous databases
BioGRID-ORCSi | 56005, 3 hits in 843 CRISPR screens |
ChiTaRSi | MYDGF, human |
GenomeRNAii | 56005 |
Pharosi | Q969H8, Tbio |
PROi | PR:Q969H8 |
RNActi | Q969H8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000074842, Expressed in stromal cell of endometrium and 241 other tissues |
ExpressionAtlasi | Q969H8, baseline and differential |
Genevisiblei | Q969H8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018887, MYDGF |
PANTHERi | PTHR31230, PTHR31230, 1 hit |
Pfami | View protein in Pfam PF10572, UPF0556, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYDGF_HUMAN | |
Accessioni | Q969H8Primary (citable) accession number: Q969H8 Secondary accession number(s): D6W628 Q9NP69 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations