UniProtKB - Q969H6 (POP5_HUMAN)
Ribonuclease P/MRP protein subunit POP5
POP5
Functioni
Miscellaneous
Catalytic activityi
- Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.2 Publications EC:3.1.26.5
GO - Molecular functioni
- ribonuclease P activity Source: UniProtKB-EC
- ribonuclease P RNA binding Source: UniProtKB
GO - Biological processi
- rRNA processing Source: GO_Central
- tRNA 5'-leader removal Source: UniProtKB
- tRNA processing Source: GO_Central
Keywordsi
Molecular function | Hydrolase, RNA-binding |
Biological process | rRNA processing, tRNA processing |
Enzyme and pathway databases
PathwayCommonsi | Q969H6 |
Reactomei | R-HSA-6784531, tRNA processing in the nucleus |
Names & Taxonomyi
Protein namesi | Recommended name: Ribonuclease P/MRP protein subunit POP5 (EC:3.1.26.52 Publications)Short name: hPop5 |
Gene namesi | Name:POP5 ORF Names:AD-008, HSPC004, x0003 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17689, POP5 |
MIMi | 609992, gene |
neXtProti | NX_Q969H6 |
VEuPathDBi | HostDB:ENSG00000167272.10 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- nucleolar ribonuclease P complex Source: GO_Central
- nucleolus Source: UniProtKB
- nucleoplasm Source: Reactome
Other locations
- multimeric ribonuclease P complex Source: UniProtKB
- ribonuclease MRP complex Source: FlyBase
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51367 |
OpenTargetsi | ENSG00000167272 |
PharmGKBi | PA128394660 |
Miscellaneous databases
Pharosi | Q969H6, Tbio |
Genetic variation databases
BioMutai | POP5 |
DMDMi | 74731042 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239007 | 1 – 163 | Ribonuclease P/MRP protein subunit POP5Add BLAST | 163 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 154 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q969H6 |
jPOSTi | Q969H6 |
MassIVEi | Q969H6 |
MaxQBi | Q969H6 |
PaxDbi | Q969H6 |
PeptideAtlasi | Q969H6 |
PRIDEi | Q969H6 |
ProteomicsDBi | 75765 [Q969H6-1] 75766 [Q969H6-2] |
PTM databases
iPTMneti | Q969H6 |
PhosphoSitePlusi | Q969H6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167272, Expressed in right adrenal gland and 233 other tissues |
Genevisiblei | Q969H6, HS |
Organism-specific databases
HPAi | ENSG00000167272, Low tissue specificity |
Interactioni
Subunit structurei
Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:11413139, PubMed:15096576, PubMed:16723659, PubMed:30454648). RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:11413139, PubMed:15096576, PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:11413139, PubMed:15096576, PubMed:16723659).
4 PublicationsBinary interactionsi
Hide detailsQ969H6
Protein-protein interaction databases
BioGRIDi | 119502, 29 interactors |
CORUMi | Q969H6 |
IntActi | Q969H6, 20 interactors |
MINTi | Q969H6 |
STRINGi | 9606.ENSP00000350098 |
Miscellaneous databases
RNActi | Q969H6, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4639, Eukaryota |
GeneTreei | ENSGT00390000012331 |
HOGENOMi | CLU_2132628_0_0_1 |
InParanoidi | Q969H6 |
OMAi | FLDRAMG |
OrthoDBi | 1492689at2759 |
PhylomeDBi | Q969H6 |
TreeFami | TF317496 |
Family and domain databases
Gene3Di | 3.30.70.3250, 1 hit |
InterProi | View protein in InterPro IPR016819, RNase_P/MRP_POP5 IPR002759, RNase_P/MRP_subunit IPR038085, Rnp2-like_sf |
Pfami | View protein in Pfam PF01900, RNase_P_Rpp14, 1 hit |
PIRSFi | PIRSF023803, Ribonuclease_P_prd, 1 hit |
SUPFAMi | SSF160350, SSF160350, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVRFKHRYLL CELVSDDPRC RLSLDDRVLS SLVRDTIARV HGTFGAAACS
60 70 80 90 100
IGFAVRYLNA YTGIVLLRCR KEFYQLVWSA LPFITYLENK GHRYPCFFNT
110 120 130 140 150
LHVGGTIRTC QKFLIQYNRR QLLILLQNCT DEGEREAIQK SVTRSCLLEE
160
EEESGEEAAE AME
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 – 48 | AA → P in AAF17213 (PubMed:10931946).Curated | 2 | |
Sequence conflicti | 47 – 48 | AA → P in AAD20966 (PubMed:11042152).Curated | 2 | |
Sequence conflicti | 99 | N → D in BAD96926 (Ref. 5) Curated | 1 | |
Sequence conflicti | 102 | H → R in BAD96926 (Ref. 5) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042733 | 55 – 104 | Missing in isoform 2. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ306296 mRNA Translation: CAC59822.1 AF117232 mRNA Translation: AAF17213.1 AF070660 mRNA Translation: AAD20966.1 AK303144 mRNA Translation: BAG64248.1 AK223206 mRNA Translation: BAD96926.1 AC063943 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW98206.1 BC012505 mRNA Translation: AAH12505.1 |
CCDSi | CCDS9202.1 [Q969H6-1] CCDS9203.1 [Q969H6-2] |
RefSeqi | NP_057002.2, NM_015918.3 [Q969H6-1] NP_937845.1, NM_198202.1 [Q969H6-2] |
Genome annotation databases
Ensembli | ENST00000341039; ENSP00000341791; ENSG00000167272 [Q969H6-2] ENST00000357500; ENSP00000350098; ENSG00000167272 [Q969H6-1] |
GeneIDi | 51367 |
KEGGi | hsa:51367 |
UCSCi | uc001tys.3, human [Q969H6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ306296 mRNA Translation: CAC59822.1 AF117232 mRNA Translation: AAF17213.1 AF070660 mRNA Translation: AAD20966.1 AK303144 mRNA Translation: BAG64248.1 AK223206 mRNA Translation: BAD96926.1 AC063943 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW98206.1 BC012505 mRNA Translation: AAH12505.1 |
CCDSi | CCDS9202.1 [Q969H6-1] CCDS9203.1 [Q969H6-2] |
RefSeqi | NP_057002.2, NM_015918.3 [Q969H6-1] NP_937845.1, NM_198202.1 [Q969H6-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6AHR | electron microscopy | 3.92 | E | 1-163 | [»] | |
6AHU | electron microscopy | 3.66 | E | 1-163 | [»] | |
SMRi | Q969H6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119502, 29 interactors |
CORUMi | Q969H6 |
IntActi | Q969H6, 20 interactors |
MINTi | Q969H6 |
STRINGi | 9606.ENSP00000350098 |
PTM databases
iPTMneti | Q969H6 |
PhosphoSitePlusi | Q969H6 |
Genetic variation databases
BioMutai | POP5 |
DMDMi | 74731042 |
Proteomic databases
EPDi | Q969H6 |
jPOSTi | Q969H6 |
MassIVEi | Q969H6 |
MaxQBi | Q969H6 |
PaxDbi | Q969H6 |
PeptideAtlasi | Q969H6 |
PRIDEi | Q969H6 |
ProteomicsDBi | 75765 [Q969H6-1] 75766 [Q969H6-2] |
Protocols and materials databases
Antibodypediai | 45552, 46 antibodies |
Genome annotation databases
Ensembli | ENST00000341039; ENSP00000341791; ENSG00000167272 [Q969H6-2] ENST00000357500; ENSP00000350098; ENSG00000167272 [Q969H6-1] |
GeneIDi | 51367 |
KEGGi | hsa:51367 |
UCSCi | uc001tys.3, human [Q969H6-1] |
Organism-specific databases
CTDi | 51367 |
DisGeNETi | 51367 |
GeneCardsi | POP5 |
HGNCi | HGNC:17689, POP5 |
HPAi | ENSG00000167272, Low tissue specificity |
MIMi | 609992, gene |
neXtProti | NX_Q969H6 |
OpenTargetsi | ENSG00000167272 |
PharmGKBi | PA128394660 |
VEuPathDBi | HostDB:ENSG00000167272.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4639, Eukaryota |
GeneTreei | ENSGT00390000012331 |
HOGENOMi | CLU_2132628_0_0_1 |
InParanoidi | Q969H6 |
OMAi | FLDRAMG |
OrthoDBi | 1492689at2759 |
PhylomeDBi | Q969H6 |
TreeFami | TF317496 |
Enzyme and pathway databases
PathwayCommonsi | Q969H6 |
Reactomei | R-HSA-6784531, tRNA processing in the nucleus |
Miscellaneous databases
BioGRID-ORCSi | 51367, 728 hits in 879 CRISPR screens |
ChiTaRSi | POP5, human |
GeneWikii | POP5 |
GenomeRNAii | 51367 |
Pharosi | Q969H6, Tbio |
PROi | PR:Q969H6 |
RNActi | Q969H6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167272, Expressed in right adrenal gland and 233 other tissues |
Genevisiblei | Q969H6, HS |
Family and domain databases
Gene3Di | 3.30.70.3250, 1 hit |
InterProi | View protein in InterPro IPR016819, RNase_P/MRP_POP5 IPR002759, RNase_P/MRP_subunit IPR038085, Rnp2-like_sf |
Pfami | View protein in Pfam PF01900, RNase_P_Rpp14, 1 hit |
PIRSFi | PIRSF023803, Ribonuclease_P_prd, 1 hit |
SUPFAMi | SSF160350, SSF160350, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | POP5_HUMAN | |
Accessioni | Q969H6Primary (citable) accession number: Q969H6 Secondary accession number(s): A6NL80, Q53FS5, Q9Y2Q6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families