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Protein

F-box/WD repeat-containing protein 7

Gene

FBXW7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:22748924, PubMed:17434132, PubMed:26976582, PubMed:28727686). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:29149593, PubMed:25775507, PubMed:28007894, PubMed:26976582, PubMed:28727686). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593).By similarity1 Publication14 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cyclin binding Source: ParkinsonsUK-UCL
  • identical protein binding Source: IntAct
  • phosphothreonine residue binding Source: UniProtKB
  • protein binding, bridging Source: ParkinsonsUK-UCL
  • ubiquitin binding Source: GO_Central
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
  • ubiquitin-protein transferase activator activity Source: ParkinsonsUK-UCL
  • ubiquitin-protein transferase activity Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8951664 Neddylation
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q969H0

SIGNOR Signaling Network Open Resource

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SIGNORi
Q969H0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box/WD repeat-containing protein 7Curated
Alternative name(s):
Archipelago homolog1 Publication
Short name:
hAgo1 Publication
F-box and WD-40 domain-containing protein 7Curated
F-box protein FBX301 Publication
SEL-101 Publication
hCdc41 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXW7Imported
Synonyms:FBW7Imported, FBX30Imported, SEL10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000109670.13

Human Gene Nomenclature Database

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HGNCi
HGNC:16712 FBXW7

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606278 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q969H0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi159S → A: Does not affect interaction with PIN1. 1 Publication1
Mutagenesisi205T → A: Impaired interaction with PIN1. 1 Publication1
Mutagenesisi252 – 257ALDELI → DDDEDD: Prevents homodimerization. 1 Publication6
Mutagenesisi349S → A: Does not affect interaction with PIN1. 1 Publication1
Mutagenesisi372S → A: Does not affect interaction with PIN1. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
55294

Open Targets

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OpenTargetsi
ENSG00000109670

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28054

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FBXW7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
44887885

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000509941 – 707F-box/WD repeat-containing protein 7Add BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei205Phosphothreonine1 Publication1
Modified residuei227Phosphoserine; by SGK11 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Thr-205 promotes interaction with PIN1, leading to disrupt FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation (PubMed:22608923).1 Publication
Ubiquitinated: autoubiquitinates following phosphorylation at Thr-205 and subsequent interaction with PIN1. Ubiquitination leads to its proteasomal degradation (PubMed:22608923).1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q969H0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q969H0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q969H0

PeptideAtlas

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PeptideAtlasi
Q969H0

PRoteomics IDEntifications database

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PRIDEi
Q969H0

ProteomicsDB human proteome resource

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ProteomicsDBi
75759
75760 [Q969H0-2]
75762 [Q969H0-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969H0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q969H0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is widely expressed. Isoform 3 is expressed in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000109670 Expressed in 239 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

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CleanExi
HS_FBXW7

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q969H0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q969H0 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB013793
CAB029987

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; homodimerization plays a role in substrate binding and/or ubiquitination and degradation (PubMed:22608923, PubMed:17434132, PubMed:28007894). Component of the SCF(FBXW7) complex consisting of CUL1, RBX1, SKP1 and FBXW7 (PubMed:11565034, PubMed:15103331, PubMed:22748924, PubMed:28007894, PubMed:26976582, PubMed:28727686). Interacts (via F-box domain) with SKP1 (PubMed:11585921, PubMed:17434132, PubMed:28007894, PubMed:26976582, PubMed:28727686). Interacts (via F-box domain) with pseudophosphatase STYX; the interaction is direct and prevents FBXW7 interaction with SKP1 (PubMed:28007894). Interacts with cyclin-E (CCNE1 or CCNE2) (PubMed:11565034, PubMed:17434132). Interacts with PSEN1 (PubMed:12354302). Forms a trimeric complex with NOTCH1 and SGK1 (PubMed:21147854). Interacts with NOTCH1 intracellular domain/NICD and NOTCH4 intracellular domain/NICD (PubMed:11585921). Interacts with NOTCH2 intracellular domain (N2ICD) (PubMed:29149593). Interacts with MYC (when phosphorylated) (PubMed:17873522, PubMed:25775507, PubMed:28007894). Interacts with USP28, leading to counteract ubiquitination of MYC (PubMed:17873522). Interacts with JUN (PubMed:14739463, PubMed:22608923). Found in a complex with JUN and PRR7 (PubMed:27458189). Interacts with JUN and PRR7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (PubMed:27458189). Interacts (when phosphorylated at Thr-205) with PIN1, leading to disrupt FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation (PubMed:22608923). Interacts with UBE2QL1 (PubMed:24000165). Interacts with FAM83D; promotes FBXW7 degradation (PubMed:24344117). Interacts with MYCN; FBXW7 competes with AURKA for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN (PubMed:27837025). Interacts with STOML1 (PubMed:23082202). Interacts with NFE2L1 (By similarity). Interacts with USP36, leading to counteract ubiquitination of MYC (PubMed:25775507).By similarity18 Publications
(Microbial infection) Interacts (via WD repeats) with SV40 large T antigen (via CPD region).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120581, 329 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q969H0

Database of interacting proteins

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DIPi
DIP-27613N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q969H0

Protein interaction database and analysis system

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IntActi
Q969H0, 49 interactors

Molecular INTeraction database

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MINTi
Q969H0

STRING: functional protein association networks

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STRINGi
9606.ENSP00000281708

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1707
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q969H0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q969H0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q969H0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini278 – 324F-boxPROSITE-ProRule annotationAdd BLAST47
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati378 – 418WD 1Add BLAST41
Repeati420 – 456WD 2Add BLAST37
Repeati459 – 498WD 3Add BLAST40
Repeati500 – 536WD 4Add BLAST37
Repeati539 – 578WD 5Add BLAST40
Repeati580 – 618WD 6Add BLAST39
Repeati622 – 659WD 7Add BLAST38

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WD repeats mediate interaction with substrates of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.1 Publication
The F-box domain mediates interaction with SKP1.2 Publications

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0274 Eukaryota
ENOG410XRWX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154986

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051596

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q969H0

KEGG Orthology (KO)

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KOi
K10260

Identification of Orthologs from Complete Genome Data

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OMAi
MTWKNLC

Database of Orthologous Groups

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OrthoDBi
EOG091G04EW

Database for complete collections of gene phylogenies

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PhylomeDBi
Q969H0

TreeFam database of animal gene trees

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TreeFami
TF101074

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF12937 F-box-like, 1 hit
PF00400 WD40, 7 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00256 FBOX, 1 hit
SM00320 WD40, 8 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 5 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969H0-1) [UniParc]FASTAAdd to basket
Also known as: Archipelago alpha, FBW7alpha2 Publications, 110K, common

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE
60 70 80 90 100
EHTARNGEVV GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE
110 120 130 140 150
DEEHAGEQDE EDEEEEEMDQ ESDDFDQSDD SSREDEHTHT NSVTNSSSIV
160 170 180 190 200
DLPVHQLSSP FYTKTTKMKR KLDHGSEVRS FSLGKKPCKV SEYTSTTGLV
210 220 230 240 250
PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM FQSWSGPEKL
260 270 280 290 300
LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD
310 320 330 340 350
LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP
360 370 380 390 400
WKSAYIRQHR IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD
410 420 430 440 450
NTLKVWSAVT GKCLRTLVGH TGGVWSSQMR DNIIISGSTD RTLKVWNAET
460 470 480 490 500
GECIHTLYGH TSTVRCMHLH EKRVVSGSRD ATLRVWDIET GQCLHVLMGH
510 520 530 540 550
VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH TNRVYSLQFD
560 570 580 590 600
GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD
610 620 630 640 650
STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD
660 670 680 690 700
LKTGEFIRNL VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL

DFDVDMK
Length:707
Mass (Da):79,663
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4A357F76DFD8203
GO
Isoform 2 (identifier: Q969H0-2) [UniParc]FASTAAdd to basket
Also known as: Archipelago beta, FBW7beta1 Publication, 69K

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     81-166: NNRFISVDED...LSSPFYTKTT → MCVPRSGLIL...FYGTLKMIFY

Show »
Length:627
Mass (Da):70,324
Checksum:i3D4107C053381BED
GO
Isoform 3 (identifier: Q969H0-4) [UniParc]FASTAAdd to basket
Also known as: Archipelago gamma, FBW7gamma2 Publications, Hippocampal

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     119-167: DQESDDFDQS...SSPFYTKTTK → MSKPGKPTLN...AQGLPFCRRR

Show »
Length:589
Mass (Da):66,120
Checksum:i2AFB6E8A36E6E8DE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z2C8B7Z2C8_HUMAN
F-box/WD repeat-containing protein ...
FBXW7
531Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3U4S4R3U4_HUMAN
F-box/WD repeat-containing protein ...
FBXW7
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G0Z2K0G0Z2K0_HUMAN
F-box and WD repeat domain containi...
FBXW7
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3N3S4R3N3_HUMAN
F-box/WD repeat-containing protein ...
FBXW7
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91986 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti344P → L in AAH37320 (PubMed:15489334).Curated1
Sequence conflicti377K → N in AAH37320 (PubMed:15489334).Curated1
Sequence conflicti508Q → R in AAH37320 (PubMed:15489334).Curated1
Isoform 2 (identifier: Q969H0-2)
Sequence conflicti7G → V in AAH37320 (PubMed:15489334).1
Sequence conflicti50L → I in BAA91986 (PubMed:14702039).1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017812115E → K. Corresponds to variant dbSNP:rs6816935Ensembl.1
Natural variantiVAR_033030117E → K in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs991177157Ensembl.1
Natural variantiVAR_017813133R → G. Corresponds to variant dbSNP:rs6842544EnsemblClinVar.1
Natural variantiVAR_017814144T → R. Corresponds to variant dbSNP:rs7660281Ensembl.1
Natural variantiVAR_017815465R → C in an acute lymphoblastic leukemia cell line; loss of interaction with substrate; does not affect interaction with SKP1 or STYX. 2 PublicationsCorresponds to variant dbSNP:rs867384286Ensembl.1
Natural variantiVAR_035880465R → H in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_017816505R → L in an ovarian cancer cell line. 2 PublicationsCorresponds to variant dbSNP:rs1057519896Ensembl.1
Natural variantiVAR_035881582S → L in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_017817668S → G. Corresponds to variant dbSNP:rs7679116Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0094821 – 118Missing in isoform 3. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_0094831 – 80Missing in isoform 2. 2 PublicationsAdd BLAST80
Alternative sequenceiVSP_00948481 – 166NNRFI…YTKTT → MCVPRSGLILSCICLYCGVL LPVLLPNLPFLTCLSMSTLE SVTYLPEKGLYCQRLPSSRT HGGTESLKGKNTENMGFYGT LKMIFY in isoform 2. 2 PublicationsAdd BLAST86
Alternative sequenceiVSP_009485119 – 167DQESD…TKTTK → MSKPGKPTLNHGLVPVDLKS AKEPLPHQTVMKIFSISIIA QGLPFCRRR in isoform 3. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY033553 mRNA Translation: AAK57547.1
AF383178 mRNA Translation: AAK60269.1
AF411971 mRNA Translation: AAL06290.1
AF411972 mRNA Translation: AAL06291.1
AY049984 mRNA Translation: AAL07271.1
AY008274 mRNA Translation: AAG16640.1
CR749305 mRNA Translation: CAH18160.1
BC037320 mRNA Translation: AAH37320.1
BC117244 mRNA Translation: AAI17245.1
BC117246 mRNA Translation: AAI17247.1
BC143944 mRNA Translation: AAI43945.1
AK001933 mRNA Translation: BAA91986.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34078.1 [Q969H0-4]
CCDS3777.1 [Q969H0-1]
CCDS3778.1 [Q969H0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001013433.1, NM_001013415.1 [Q969H0-4]
NP_060785.2, NM_018315.4 [Q969H0-2]
NP_361014.1, NM_033632.3 [Q969H0-1]
XP_011530385.1, XM_011532083.1
XP_011530386.1, XM_011532084.1 [Q969H0-1]
XP_011530387.1, XM_011532085.1 [Q969H0-1]
XP_016863851.1, XM_017008362.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.561245
Hs.717081

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263981; ENSP00000263981; ENSG00000109670 [Q969H0-2]
ENST00000281708; ENSP00000281708; ENSG00000109670 [Q969H0-1]
ENST00000296555; ENSP00000296555; ENSG00000109670 [Q969H0-4]
ENST00000393956; ENSP00000377528; ENSG00000109670 [Q969H0-2]
ENST00000603548; ENSP00000474725; ENSG00000109670 [Q969H0-1]
ENST00000603841; ENSP00000474971; ENSG00000109670 [Q969H0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55294

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55294

UCSC genome browser

More...
UCSCi
uc003imq.4 human [Q969H0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033553 mRNA Translation: AAK57547.1
AF383178 mRNA Translation: AAK60269.1
AF411971 mRNA Translation: AAL06290.1
AF411972 mRNA Translation: AAL06291.1
AY049984 mRNA Translation: AAL07271.1
AY008274 mRNA Translation: AAG16640.1
CR749305 mRNA Translation: CAH18160.1
BC037320 mRNA Translation: AAH37320.1
BC117244 mRNA Translation: AAI17245.1
BC117246 mRNA Translation: AAI17247.1
BC143944 mRNA Translation: AAI43945.1
AK001933 mRNA Translation: BAA91986.1 Different initiation.
CCDSiCCDS34078.1 [Q969H0-4]
CCDS3777.1 [Q969H0-1]
CCDS3778.1 [Q969H0-2]
RefSeqiNP_001013433.1, NM_001013415.1 [Q969H0-4]
NP_060785.2, NM_018315.4 [Q969H0-2]
NP_361014.1, NM_033632.3 [Q969H0-1]
XP_011530385.1, XM_011532083.1
XP_011530386.1, XM_011532084.1 [Q969H0-1]
XP_011530387.1, XM_011532085.1 [Q969H0-1]
XP_016863851.1, XM_017008362.1
UniGeneiHs.561245
Hs.717081

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OVPX-ray2.90B263-707[»]
2OVQX-ray2.60B263-707[»]
2OVRX-ray2.50B263-707[»]
5IBKX-ray2.50B/E263-323[»]
5V4BX-ray2.60B263-706[»]
ProteinModelPortaliQ969H0
SMRiQ969H0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120581, 329 interactors
CORUMiQ969H0
DIPiDIP-27613N
ELMiQ969H0
IntActiQ969H0, 49 interactors
MINTiQ969H0
STRINGi9606.ENSP00000281708

PTM databases

iPTMnetiQ969H0
PhosphoSitePlusiQ969H0

Polymorphism and mutation databases

BioMutaiFBXW7
DMDMi44887885

Proteomic databases

EPDiQ969H0
MaxQBiQ969H0
PaxDbiQ969H0
PeptideAtlasiQ969H0
PRIDEiQ969H0
ProteomicsDBi75759
75760 [Q969H0-2]
75762 [Q969H0-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55294
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263981; ENSP00000263981; ENSG00000109670 [Q969H0-2]
ENST00000281708; ENSP00000281708; ENSG00000109670 [Q969H0-1]
ENST00000296555; ENSP00000296555; ENSG00000109670 [Q969H0-4]
ENST00000393956; ENSP00000377528; ENSG00000109670 [Q969H0-2]
ENST00000603548; ENSP00000474725; ENSG00000109670 [Q969H0-1]
ENST00000603841; ENSP00000474971; ENSG00000109670 [Q969H0-1]
GeneIDi55294
KEGGihsa:55294
UCSCiuc003imq.4 human [Q969H0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55294
DisGeNETi55294
EuPathDBiHostDB:ENSG00000109670.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FBXW7
HGNCiHGNC:16712 FBXW7
HPAiCAB013793
CAB029987
MIMi606278 gene
neXtProtiNX_Q969H0
OpenTargetsiENSG00000109670
PharmGKBiPA28054

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0274 Eukaryota
ENOG410XRWX LUCA
GeneTreeiENSGT00940000154986
HOVERGENiHBG051596
InParanoidiQ969H0
KOiK10260
OMAiMTWKNLC
OrthoDBiEOG091G04EW
PhylomeDBiQ969H0
TreeFamiTF101074

Enzyme and pathway databases

ReactomeiR-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8951664 Neddylation
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ969H0
SIGNORiQ969H0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FBXW7 human
EvolutionaryTraceiQ969H0

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FBXW7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55294

Protein Ontology

More...
PROi
PR:Q969H0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000109670 Expressed in 239 organ(s), highest expression level in corpus callosum
CleanExiHS_FBXW7
ExpressionAtlasiQ969H0 baseline and differential
GenevisibleiQ969H0 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 5 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBXW7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969H0
Secondary accession number(s): B7ZLP9
, Q68DR0, Q96A16, Q96LE0, Q96RI2, Q9NUX6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 1, 2001
Last modified: December 5, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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