CAVIN3

Functionⁱ

Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

protein kinase C binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

circadian regulation of gene expression Source: UniProtKB
cortical actin cytoskeleton organization Source: Ensembl
negative regulation of fermentation Source: Ensembl
negative regulation of protein kinase B signaling Source: Ensembl
positive regulation of ERK1 and ERK2 cascade Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Biological rhythms

Biological process

Biological rhythms

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Caveolae-associated protein 3Imported Alternative name(s): Cavin-3 Protein kinase C delta-binding protein Serum deprivation response factor-related gene product that binds to C-kinase Short name: hSRBC
Gene namesⁱ	Name:CAVIN3Imported Synonyms:PRKCDBP, SRBC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170955.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9400 CAVIN3
neXtProtⁱ	NX_Q969G5

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	112464
Open Targets More...OpenTargetsⁱ	ENSG00000170955
PharmGKBⁱ	PA33764

Polymorphism and mutation databases

BioMutaⁱ	PRKCDBP
DMDMⁱ	317373527

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000331412	1 – 261	Caveolae-associated protein 3Add BLAST		261

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	62	PhosphoserineCombined sources	1
Modified residueⁱ	70	PhosphoserineCombined sources	1
Cross-linkⁱ	128	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	165	PhosphoserineCombined sources	1
Modified residueⁱ	166	PhosphoserineCombined sources	1
Modified residueⁱ	173	PhosphoserineBy similarity	1

Post-translational modificationⁱ

In vitro, phosphorylated by PRKCD.

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q969G5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q969G5
PaxDbⁱ	Q969G5
PeptideAtlas More...PeptideAtlasⁱ	Q969G5
PRIDEⁱ	Q969G5
ProteomicsDBⁱ	75756

PTM databases

iPTMnetⁱ	Q969G5
PhosphoSitePlusⁱ	Q969G5

Expressionⁱ

Tissue specificityⁱ

Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Strongly expressed in mammary and epithelial cells.2 Publications

Inductionⁱ

Down-regulated in breast and lung cancer cell lines.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000170955
CleanExⁱ	HS_PRKCDBP
ExpressionAtlasⁱ	Q969G5 baseline and differential
Genevisibleⁱ	Q969G5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055136 HPA073327

HPAⁱ

HPA055136
HPA073327

Interactionⁱ

Subunit structureⁱ

Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2. Interacts with CAVIN1 (By similarity). Interacts (via leucine-zipper domain) with CAV1 in a cholesterol-sensitive manner (PubMed:19262564). Interacts with EPS15L1 (PubMed:19262564).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CAV1	Q03135	11	EBI-3893101,EBI-603614
CAVIN1	Q6NZI2	10	EBI-3893101,EBI-2559016
EPS15L1	Q9UBC2	2	EBI-3893101,EBI-2556746
MRFAP1L1	Q96HT8	5	EBI-3893101,EBI-748896

Show more details

GO - Molecular functionⁱ

protein kinase C binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	125187, 51 interactors
Database of interacting proteins More...DIPⁱ	DIP-60484N
IntActⁱ	Q969G5, 45 interactors
Molecular INTeraction database More...MINTⁱ	Q969G5
STRINGⁱ	9606.ENSP00000307292

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q969G5
SMRⁱ	Q969G5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 84	Interaction with CAVIN1By similarityAdd BLAST	84
Regionⁱ	20 – 78	Leucine-zipper1 PublicationAdd BLAST	59
Regionⁱ	135 – 203	Interaction with CAV1By similarityAdd BLAST	69

Domainⁱ

The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1.1 Publication

Sequence similaritiesⁱ

Belongs to the CAVIN family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IVVG Eukaryota ENOG4111EFW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063058
HOGENOMⁱ	HOG000115686
HOVERGENⁱ	HBG108288
InParanoidⁱ	Q969G5
PhylomeDBⁱ	Q969G5
TreeFamⁱ	TF331031

Family and domain databases

InterProⁱ	View protein in InterPro IPR033300 CAVIN3 IPR026752 Cavin_fam
PANTHERⁱ	PTHR15240 PTHR15240, 1 hit PTHR15240:SF2 PTHR15240:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15237 PTRF_SDPR, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q969G5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRESALERGP VPEAPAGGPV HAVTVVTLLE KLASMLETLR ERQGGLARRQ 
        60         70         80         90        100
GGLAGSVRRI QSGLGALSRS HDTTSNTLAQ LLAKAERVSS HANAAQERAV 
       110        120        130        140        150
RRAAQVQRLE ANHGLLVARG KLHVLLFKEE GEVPASAFQK APEPLGPADQ 
       160        170        180        190        200
SELGPEQLEA EVGESSDEEP VESRAQRLRR TGLQKVQSLR RALSGRKGPA 
       210        220        230        240        250
APPPTPVKPP RLGPGRSAEA QPEAQPALEP TLEPEPPQDT EEDPGRPGAA 
       260 
EEALLQMESV A

Length:261

Mass (Da):27,701

Last modified:January 11, 2011 - v3

Checksum:ⁱE806A01DA992C53B

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_042851	8	R → P3 PublicationsCorresponds to variant dbSNP:rs2682123Ensembl.	1
Natural variantⁱVAR_042852	104	A → T. Corresponds to variant dbSNP:rs10839551Ensembl.	1
Natural variantⁱVAR_042853	158	L → P. Corresponds to variant dbSNP:rs1051992Ensembl.	1
Natural variantⁱVAR_042854	255	L → F. Corresponds to variant dbSNP:rs12294600Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF339881 mRNA Translation: AAK97572.1 AF408198 Genomic DNA Translation: AAK97528.1 AC068733 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68733.1 BC011585 mRNA Translation: AAH11585.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7762.1
NCBI Reference Sequences More...RefSeqⁱ	NP_659477.2, NM_145040.2
UniGeneⁱ	Hs.434044

Genome annotation databases

Ensemblⁱ	ENST00000303927; ENSP00000307292; ENSG00000170955
GeneIDⁱ	112464
KEGGⁱ	hsa:112464
UCSC genome browser More...UCSCⁱ	uc001mcu.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q969G5	UPI0000492F02		GORGO		266
UPI00020AA39C		NOMLE		266
Protein kinase C delta-binding protein		MACMU		263
Caveolae associated protein 3		SAIBB		263
Caveolae associated protein 3		PAPAN		263
+34

Protein	Similar proteins		Species	Score	Length
Q969G5	UPI0000492F02		GORGO		266
UPI00020AA39C		NOMLE		266
Caveolae associated protein 3		CHLSB		263
Caveolae associated protein 3		CERAT		263
Caveolae associated protein 3		RHIRO		263
+37

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF339881 mRNA Translation: AAK97572.1 AF408198 Genomic DNA Translation: AAK97528.1 AC068733 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68733.1 BC011585 mRNA Translation: AAH11585.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7762.1
NCBI Reference Sequences More...RefSeqⁱ	NP_659477.2, NM_145040.2
UniGeneⁱ	Hs.434044

3D structure databases

ProteinModelPortalⁱ	Q969G5
SMRⁱ	Q969G5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125187, 51 interactors
Database of interacting proteins More...DIPⁱ	DIP-60484N
IntActⁱ	Q969G5, 45 interactors
Molecular INTeraction database More...MINTⁱ	Q969G5
STRINGⁱ	9606.ENSP00000307292

PTM databases

iPTMnetⁱ	Q969G5
PhosphoSitePlusⁱ	Q969G5

Polymorphism and mutation databases

BioMutaⁱ	PRKCDBP
DMDMⁱ	317373527

Proteomic databases

EPDⁱ	Q969G5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q969G5
PaxDbⁱ	Q969G5
PeptideAtlas More...PeptideAtlasⁱ	Q969G5
PRIDEⁱ	Q969G5
ProteomicsDBⁱ	75756

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	112464
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000303927; ENSP00000307292; ENSG00000170955
GeneIDⁱ	112464
KEGGⁱ	hsa:112464
UCSC genome browser More...UCSCⁱ	uc001mcu.2 human

Organism-specific databases

CTDⁱ	112464
DisGeNET More...DisGeNETⁱ	112464
EuPathDBⁱ	HostDB:ENSG00000170955.9
GeneCardsⁱ	CAVIN3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9400 CAVIN3
Human Protein Atlas More...HPAⁱ	HPA055136 HPA073327
neXtProtⁱ	NX_Q969G5
Open Targets More...OpenTargetsⁱ	ENSG00000170955
PharmGKBⁱ	PA33764
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVVG Eukaryota ENOG4111EFW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063058
HOGENOMⁱ	HOG000115686
HOVERGENⁱ	HBG108288
InParanoidⁱ	Q969G5
PhylomeDBⁱ	Q969G5
TreeFamⁱ	TF331031

Miscellaneous databases

ChiTaRSⁱ	PRKCDBP human
GenomeRNAiⁱ	112464
Protein Ontology More...PROⁱ	PR:Q969G5

Gene expression databases

Bgeeⁱ	ENSG00000170955
CleanExⁱ	HS_PRKCDBP
ExpressionAtlasⁱ	Q969G5 baseline and differential
Genevisibleⁱ	Q969G5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033300 CAVIN3 IPR026752 Cavin_fam
PANTHERⁱ	PTHR15240 PTHR15240, 1 hit PTHR15240:SF2 PTHR15240:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15237 PTRF_SDPR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAVN3_HUMAN
Accessionⁱ	Q969G5Primary (citable) accession number: Q969G5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
	Last sequence update:	January 11, 2011
	Last modified:	July 18, 2018
	This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q969G5 (CAVN3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Caveolae-associated protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

Cytosol

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ