UniProtKB - Q969G5 (CAVN3_HUMAN)
Protein
Caveolae-associated protein 3
Gene
CAVIN3
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).By similarity1 Publication
GO - Molecular functioni
- protein kinase C binding Source: GO_Central
GO - Biological processi
- circadian regulation of gene expression Source: UniProtKB
Keywordsi
Biological process | Biological rhythms |
Enzyme and pathway databases
PathwayCommonsi | Q969G5 |
Names & Taxonomyi
Protein namesi | Recommended name: Caveolae-associated protein 3ImportedAlternative name(s): Cavin-3 Protein kinase C delta-binding protein Serum deprivation response factor-related gene product that binds to C-kinase Short name: hSRBC |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9400, CAVIN3 |
MIMi | 618303, gene |
neXtProti | NX_Q969G5 |
VEuPathDBi | HostDB:ENSG00000170955.9 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB-SubCell
Plasma Membrane
- caveola Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 112464 |
OpenTargetsi | ENSG00000170955 |
PharmGKBi | PA33764 |
Miscellaneous databases
Pharosi | Q969G5, Tbio |
Genetic variation databases
BioMutai | CAVIN3 |
DMDMi | 317373527 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331412 | 1 – 261 | Caveolae-associated protein 3Add BLAST | 261 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 62 | PhosphoserineCombined sources | 1 | |
Modified residuei | 70 | PhosphoserineCombined sources | 1 | |
Cross-linki | 128 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 165 | PhosphoserineCombined sources | 1 | |
Modified residuei | 166 | PhosphoserineCombined sources | 1 | |
Modified residuei | 173 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
In vitro, phosphorylated by PRKCD.
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q969G5 |
jPOSTi | Q969G5 |
MassIVEi | Q969G5 |
MaxQBi | Q969G5 |
PaxDbi | Q969G5 |
PeptideAtlasi | Q969G5 |
PRIDEi | Q969G5 |
ProteomicsDBi | 75756 |
PTM databases
iPTMneti | Q969G5 |
MetOSitei | Q969G5 |
PhosphoSitePlusi | Q969G5 |
Expressioni
Tissue specificityi
Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Strongly expressed in mammary and epithelial cells.2 Publications
Inductioni
Down-regulated in breast and lung cancer cell lines.1 Publication
Gene expression databases
Bgeei | ENSG00000170955, Expressed in tibial artery and 224 other tissues |
ExpressionAtlasi | Q969G5, baseline and differential |
Genevisiblei | Q969G5, HS |
Organism-specific databases
HPAi | ENSG00000170955, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4.
Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding.
Interacts with PER2.
Interacts with CAVIN1 (By similarity).
Interacts (via leucine-zipper domain) with CAV1 in a cholesterol-sensitive manner (PubMed:19262564).
Interacts with EPS15L1 (PubMed:19262564).
By similarity1 PublicationBinary interactionsi
Hide detailsQ969G5
GO - Molecular functioni
- protein kinase C binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 125187, 65 interactors |
DIPi | DIP-60484N |
IntActi | Q969G5, 49 interactors |
MINTi | Q969G5 |
STRINGi | 9606.ENSP00000307292 |
Miscellaneous databases
RNActi | Q969G5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 84 | Interaction with CAVIN1By similarityAdd BLAST | 84 | |
Regioni | 20 – 78 | Leucine-zipper1 PublicationAdd BLAST | 59 | |
Regioni | 135 – 203 | Interaction with CAV1By similarityAdd BLAST | 69 |
Domaini
The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1.1 Publication
Sequence similaritiesi
Belongs to the CAVIN family.Curated
Phylogenomic databases
eggNOGi | ENOG502QQCA, Eukaryota |
GeneTreei | ENSGT00950000182910 |
InParanoidi | Q969G5 |
OrthoDBi | 1532835at2759 |
PhylomeDBi | Q969G5 |
TreeFami | TF331031 |
Family and domain databases
InterProi | View protein in InterPro IPR033300, CAVIN3 IPR026752, Cavin_fam |
PANTHERi | PTHR15240, PTHR15240, 1 hit PTHR15240:SF2, PTHR15240:SF2, 1 hit |
Pfami | View protein in Pfam PF15237, PTRF_SDPR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q969G5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRESALERGP VPEAPAGGPV HAVTVVTLLE KLASMLETLR ERQGGLARRQ
60 70 80 90 100
GGLAGSVRRI QSGLGALSRS HDTTSNTLAQ LLAKAERVSS HANAAQERAV
110 120 130 140 150
RRAAQVQRLE ANHGLLVARG KLHVLLFKEE GEVPASAFQK APEPLGPADQ
160 170 180 190 200
SELGPEQLEA EVGESSDEEP VESRAQRLRR TGLQKVQSLR RALSGRKGPA
210 220 230 240 250
APPPTPVKPP RLGPGRSAEA QPEAQPALEP TLEPEPPQDT EEDPGRPGAA
260
EEALLQMESV A
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PIE3 | E9PIE3_HUMAN | Caveolae-associated protein 3 | CAVIN3 | 293 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042851 | 8 | R → P3 PublicationsCorresponds to variant dbSNP:rs2682123Ensembl. | 1 | |
Natural variantiVAR_042852 | 104 | A → T. Corresponds to variant dbSNP:rs10839551Ensembl. | 1 | |
Natural variantiVAR_042853 | 158 | L → P. Corresponds to variant dbSNP:rs1051992Ensembl. | 1 | |
Natural variantiVAR_042854 | 255 | L → F. Corresponds to variant dbSNP:rs12294600Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF339881 mRNA Translation: AAK97572.1 AF408198 Genomic DNA Translation: AAK97528.1 AC068733 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68733.1 BC011585 mRNA Translation: AAH11585.1 |
CCDSi | CCDS7762.1 |
RefSeqi | NP_659477.2, NM_145040.2 |
Genome annotation databases
Ensembli | ENST00000303927; ENSP00000307292; ENSG00000170955 |
GeneIDi | 112464 |
KEGGi | hsa:112464 |
UCSCi | uc001mcu.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF339881 mRNA Translation: AAK97572.1 AF408198 Genomic DNA Translation: AAK97528.1 AC068733 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68733.1 BC011585 mRNA Translation: AAH11585.1 |
CCDSi | CCDS7762.1 |
RefSeqi | NP_659477.2, NM_145040.2 |
3D structure databases
SMRi | Q969G5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125187, 65 interactors |
DIPi | DIP-60484N |
IntActi | Q969G5, 49 interactors |
MINTi | Q969G5 |
STRINGi | 9606.ENSP00000307292 |
PTM databases
iPTMneti | Q969G5 |
MetOSitei | Q969G5 |
PhosphoSitePlusi | Q969G5 |
Genetic variation databases
BioMutai | CAVIN3 |
DMDMi | 317373527 |
Proteomic databases
EPDi | Q969G5 |
jPOSTi | Q969G5 |
MassIVEi | Q969G5 |
MaxQBi | Q969G5 |
PaxDbi | Q969G5 |
PeptideAtlasi | Q969G5 |
PRIDEi | Q969G5 |
ProteomicsDBi | 75756 |
Protocols and materials databases
Antibodypediai | 23796, 199 antibodies |
DNASUi | 112464 |
Genome annotation databases
Ensembli | ENST00000303927; ENSP00000307292; ENSG00000170955 |
GeneIDi | 112464 |
KEGGi | hsa:112464 |
UCSCi | uc001mcu.2, human |
Organism-specific databases
CTDi | 112464 |
DisGeNETi | 112464 |
GeneCardsi | CAVIN3 |
HGNCi | HGNC:9400, CAVIN3 |
HPAi | ENSG00000170955, Tissue enhanced (testis) |
MIMi | 618303, gene |
neXtProti | NX_Q969G5 |
OpenTargetsi | ENSG00000170955 |
PharmGKBi | PA33764 |
VEuPathDBi | HostDB:ENSG00000170955.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQCA, Eukaryota |
GeneTreei | ENSGT00950000182910 |
InParanoidi | Q969G5 |
OrthoDBi | 1532835at2759 |
PhylomeDBi | Q969G5 |
TreeFami | TF331031 |
Enzyme and pathway databases
PathwayCommonsi | Q969G5 |
Miscellaneous databases
BioGRID-ORCSi | 112464, 4 hits in 874 CRISPR screens |
ChiTaRSi | PRKCDBP, human |
GenomeRNAii | 112464 |
Pharosi | Q969G5, Tbio |
PROi | PR:Q969G5 |
RNActi | Q969G5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170955, Expressed in tibial artery and 224 other tissues |
ExpressionAtlasi | Q969G5, baseline and differential |
Genevisiblei | Q969G5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033300, CAVIN3 IPR026752, Cavin_fam |
PANTHERi | PTHR15240, PTHR15240, 1 hit PTHR15240:SF2, PTHR15240:SF2, 1 hit |
Pfami | View protein in Pfam PF15237, PTRF_SDPR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAVN3_HUMAN | |
Accessioni | Q969G5Primary (citable) accession number: Q969G5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 10, 2021 | |
This is version 134 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families