UniProtKB - Q969F0 (FATE1_HUMAN)
Protein
Fetal and adult testis-expressed transcript protein
Gene
FATE1
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca2+ transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).1 Publication1 Publication
GO - Molecular functioni
- identical protein binding Source: IntAct
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of mitochondrial calcium ion concentration Source: UniProtKB
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q969F0 |
Names & Taxonomyi
Protein namesi | Recommended name: Fetal and adult testis-expressed transcript proteinAlternative name(s): Cancer/testis antigen 43 Short name: CT43 Tumor antigen BJ-HCC-2 |
Gene namesi | Name:FATE1 Synonyms:FATE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000147378.11 |
HGNCi | HGNC:24683, FATE1 |
MIMi | 300450, gene |
neXtProti | NX_Q969F0 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein Curated; Cytoplasmic side 1 Publication
Mitochondrion
- Mitochondrion 2 Publications
- Mitochondrion outer membrane 1 Publication
Note: Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: LIFEdb
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- mitochondria-associated endoplasmic reticulum membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 163 – 181 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 151 | L → D: Impairs association with mitochondria. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 89885 |
OpenTargetsi | ENSG00000147378 |
PharmGKBi | PA134875203 |
Miscellaneous databases
Pharosi | Q969F0, Tbio |
Polymorphism and mutation databases
BioMutai | FATE1 |
DMDMi | 37078481 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087200 | 1 – 183 | Fetal and adult testis-expressed transcript proteinAdd BLAST | 183 |
Proteomic databases
MassIVEi | Q969F0 |
PaxDbi | Q969F0 |
PeptideAtlasi | Q969F0 |
PRIDEi | Q969F0 |
ProteomicsDBi | 75746 |
Expressioni
Tissue specificityi
Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919).2 Publications
Gene expression databases
Bgeei | ENSG00000147378, Expressed in right testis and 100 other tissues |
ExpressionAtlasi | Q969F0, baseline and differential |
Genevisiblei | Q969F0, HS |
Organism-specific databases
HPAi | ENSG00000147378, Tissue enriched (testis) |
Interactioni
Subunit structurei
Binary interactionsi
Q969F0
GO - Molecular functioni
- identical protein binding Source: IntAct
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 124636, 112 interactors |
IntActi | Q969F0, 101 interactors |
MINTi | Q969F0 |
STRINGi | 9606.ENSP00000359375 |
Miscellaneous databases
RNActi | Q969F0, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SRT6, Eukaryota |
GeneTreei | ENSGT00390000006832 |
HOGENOMi | CLU_129363_0_0_1 |
InParanoidi | Q969F0 |
OMAi | QNMRFHY |
OrthoDBi | 1420413at2759 |
PhylomeDBi | Q969F0 |
TreeFami | TF338514 |
Family and domain databases
InterProi | View protein in InterPro IPR039153, FATE1 IPR039433, Mff-like_dom |
PANTHERi | PTHR21128, PTHR21128, 1 hit |
Pfami | View protein in Pfam PF05644, Miff, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q969F0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGGPPNTKA EMEMSLAEEL NHGRQGENQE HLVIAEMMEL GSRSRGASQK
60 70 80 90 100
KQKLEQKAAG SASAKRVWNM TATRPKKMGS QLPKPRMLRE SGHGDAHLQE
110 120 130 140 150
YAGNFQGIRF HYDRNPGTDA VAQTSLEEFN VLEMEVMRRQ LYAVNRRLRA
160 170 180
LEEQGATWRH RETLIIAVLV SASIANLWLW MNQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C1I5 | H7C1I5_HUMAN | Fetal and adult testis-expressed tr... | FATE1 | 80 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016917 | 10 | A → V Common polymorphism; 16% of the population; infertile and fertile individuals. 1 PublicationCorresponds to variant dbSNP:rs3810715Ensembl. | 1 | |
Natural variantiVAR_016918 | 34 | I → T in fertile and infertile individuals. 1 Publication | 1 | |
Natural variantiVAR_016919 | 125 | S → R in fertile and infertile individuals. 1 PublicationCorresponds to variant dbSNP:rs141497002Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF249872 mRNA Translation: AAK69024.1 AY101182 mRNA Translation: AAM48744.1 AK057369 mRNA Translation: BAB71454.1 BC022064 mRNA Translation: AAH22064.1 |
CCDSi | CCDS14700.1 |
RefSeqi | NP_149076.1, NM_033085.2 |
Genome annotation databases
Ensembli | ENST00000370350; ENSP00000359375; ENSG00000147378 |
GeneIDi | 89885 |
KEGGi | hsa:89885 |
UCSCi | uc004fex.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF249872 mRNA Translation: AAK69024.1 AY101182 mRNA Translation: AAM48744.1 AK057369 mRNA Translation: BAB71454.1 BC022064 mRNA Translation: AAH22064.1 |
CCDSi | CCDS14700.1 |
RefSeqi | NP_149076.1, NM_033085.2 |
3D structure databases
SMRi | Q969F0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124636, 112 interactors |
IntActi | Q969F0, 101 interactors |
MINTi | Q969F0 |
STRINGi | 9606.ENSP00000359375 |
Polymorphism and mutation databases
BioMutai | FATE1 |
DMDMi | 37078481 |
Proteomic databases
MassIVEi | Q969F0 |
PaxDbi | Q969F0 |
PeptideAtlasi | Q969F0 |
PRIDEi | Q969F0 |
ProteomicsDBi | 75746 |
Protocols and materials databases
Antibodypediai | 30697, 280 antibodies |
DNASUi | 89885 |
Genome annotation databases
Ensembli | ENST00000370350; ENSP00000359375; ENSG00000147378 |
GeneIDi | 89885 |
KEGGi | hsa:89885 |
UCSCi | uc004fex.4, human |
Organism-specific databases
CTDi | 89885 |
DisGeNETi | 89885 |
EuPathDBi | HostDB:ENSG00000147378.11 |
GeneCardsi | FATE1 |
HGNCi | HGNC:24683, FATE1 |
HPAi | ENSG00000147378, Tissue enriched (testis) |
MIMi | 300450, gene |
neXtProti | NX_Q969F0 |
OpenTargetsi | ENSG00000147378 |
PharmGKBi | PA134875203 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SRT6, Eukaryota |
GeneTreei | ENSGT00390000006832 |
HOGENOMi | CLU_129363_0_0_1 |
InParanoidi | Q969F0 |
OMAi | QNMRFHY |
OrthoDBi | 1420413at2759 |
PhylomeDBi | Q969F0 |
TreeFami | TF338514 |
Enzyme and pathway databases
PathwayCommonsi | Q969F0 |
Miscellaneous databases
BioGRID-ORCSi | 89885, 3 hits in 470 CRISPR screens |
ChiTaRSi | FATE1, human |
GeneWikii | FATE1 |
GenomeRNAii | 89885 |
Pharosi | Q969F0, Tbio |
PROi | PR:Q969F0 |
RNActi | Q969F0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147378, Expressed in right testis and 100 other tissues |
ExpressionAtlasi | Q969F0, baseline and differential |
Genevisiblei | Q969F0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039153, FATE1 IPR039433, Mff-like_dom |
PANTHERi | PTHR21128, PTHR21128, 1 hit |
Pfami | View protein in Pfam PF05644, Miff, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FATE1_HUMAN | |
Accessioni | Q969F0Primary (citable) accession number: Q969F0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations