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UniProtKB - Q969F0 (FATE1_HUMAN)

Entry version 144 (17 Jun 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Fetal and adult testis-expressed transcript protein

Gene

FATE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca2+ transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fetal and adult testis-expressed transcript protein
Alternative name(s):
Cancer/testis antigen 43
Short name:
CT43
Tumor antigen BJ-HCC-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FATE1
Synonyms:FATE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000147378.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:24683 FATE1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300450 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q969F0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei163 – 181HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi151L → D: Impairs association with mitochondria. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		89885

Open Targets

More...OpenTargetsi		ENSG00000147378

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134875203

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q969F0 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FATE1

Domain mapping of disease mutations (DMDM)

More...DMDMi		37078481

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000872001 – 183Fetal and adult testis-expressed transcript proteinAdd BLAST183

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q969F0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q969F0

PeptideAtlas

More...PeptideAtlasi		Q969F0

PRoteomics IDEntifications database

More...PRIDEi		Q969F0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75746

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000147378 Expressed in right testis and 80 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q969F0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q969F0 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000147378 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BIK and RNF183 (PubMed:26567849).

Interacts with IMMT/MIC60and EMD (PubMed:27402544).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q969F0
With#Exp.IntAct
AGTRAP [Q6RW13]3EBI-743099,EBI-741181
AGTRAP - isoform 2 [Q6RW13-2]3EBI-743099,EBI-11522760
APOL3 - isoform 2 [O95236-2]3EBI-743099,EBI-11976321
AQP9 [Q6FGT0]3EBI-743099,EBI-10249621
ASGR2 - isoform 3 [P07307-3]3EBI-743099,EBI-12808270
ATCAY [A0A0S2Z5Y8]3EBI-743099,EBI-16432496
BCL2L2 [Q92843]6EBI-743099,EBI-707714
BIK [Q13323]8EBI-743099,EBI-700794
BNIP2 [Q12982]6EBI-743099,EBI-752094
BNIP3 [Q12983]6EBI-743099,EBI-749464
BNIP3L [O60238]3EBI-743099,EBI-849893
BTN2A2 [Q8WVV5]3EBI-743099,EBI-8648738
C1QL4 [Q86Z23]3EBI-743099,EBI-12062109
CALN1 [Q9BXU9]3EBI-743099,EBI-12187137
CCDC155 [Q8N6L0]6EBI-743099,EBI-749265
CCDC70 [Q6NSX1]7EBI-743099,EBI-6873045
CD79A [P11912]6EBI-743099,EBI-7797864
CD83 [Q01151]3EBI-743099,EBI-2873723
CDC37 [Q16543]3EBI-743099,EBI-295634
CERS4 [Q9HA82]3EBI-743099,EBI-2622997
CREB3L3 [Q68CJ9]3EBI-743099,EBI-852194
CSF2RA [P15509]3EBI-743099,EBI-1763264
CTRL [P40313]3EBI-743099,EBI-7883667
CXCR1 [P25024]3EBI-743099,EBI-3905522
CXCR3 - isoform 3 [P49682-3]3EBI-743099,EBI-16432539
DCTN5 [Q9BTE1]3EBI-743099,EBI-747324
DNAJC30 [Q96LL9]3EBI-743099,EBI-8639143
EMD [P50402]10EBI-743099,EBI-489887
FAM177A1 - isoform 2 [Q8N128-2]3EBI-743099,EBI-12201693
FAM209A [Q5JX71]3EBI-743099,EBI-18304435
itself3EBI-743099,EBI-743099
FRMD8 [Q9BZ67]3EBI-743099,EBI-5773072
GIMAP5 [Q96F15]3EBI-743099,EBI-6166686
GINM1 [Q9NU53]3EBI-743099,EBI-12204961
GOSR2 [O14653]3EBI-743099,EBI-4401517
GPR25 [O00155]5EBI-743099,EBI-10178951
HSD17B13 [Q7Z5P4]3EBI-743099,EBI-18053395
INPP5K [Q9BT40]7EBI-743099,EBI-749162
KCNS2 [Q9ULS6]6EBI-743099,EBI-10323864
LNPEP [Q9UIQ6]3EBI-743099,EBI-2805360
LNPEP - isoform 2 [Q9UIQ6-2]3EBI-743099,EBI-12133176
LRRC25 [Q8N386]3EBI-743099,EBI-11304917
LY75 - isoform 3 [O60449-3]3EBI-743099,EBI-10186753
MARCHF2 [Q9P0N8]6EBI-743099,EBI-10317612
MARCHF3 [Q86UD3]3EBI-743099,EBI-2341065
MARCHF5 [Q9NX47]4EBI-743099,EBI-2341610
MARVELD2 [Q8N4S9]3EBI-743099,EBI-6875061
MFF - isoform 5 [Q9GZY8-5]3EBI-743099,EBI-11956541
MOSPD3 [O75425]3EBI-743099,EBI-12179105
MR1 [Q95460]3EBI-743099,EBI-10280401
MR1 - isoform 2 [Q95460-2]3EBI-743099,EBI-12201447
NDUFB11 [Q9NX14]6EBI-743099,EBI-1246182
NRG4 [Q8WWG1]7EBI-743099,EBI-8637292
NRSN1 [Q8IZ57]3EBI-743099,EBI-10264528
OTOP2 [Q7RTS6]4EBI-743099,EBI-7642372
PIN4 [Q9Y237]3EBI-743099,EBI-714599
PKMYT1 - isoform 2 [Q99640-2]3EBI-743099,EBI-12257782
PLP2 [Q04941]3EBI-743099,EBI-608347
PRRG2 [Q8TAS3]6EBI-743099,EBI-10272071
RBFA [Q8N0V3]3EBI-743099,EBI-3232108
RIC3 - isoform 4 [Q7Z5B4-5]3EBI-743099,EBI-12375429
RNF183 [Q96D59]4EBI-743099,EBI-743938
RPRM [Q9NS64]6EBI-743099,EBI-1052363
RTP2 [Q5QGT7]3EBI-743099,EBI-10244780
SCAMP5 [Q8TAC9]3EBI-743099,EBI-2695784
SEC22A [Q96IW7]6EBI-743099,EBI-8652744
SEC22C [Q9BRL7]6EBI-743099,EBI-10297029
SEC23A [Q15436]3EBI-743099,EBI-81088
SEC23B [Q15437]3EBI-743099,EBI-742673
SLC38A1 [Q9H2H9]6EBI-743099,EBI-9978441
SLC41A2 [Q96JW4]3EBI-743099,EBI-10290130
SLC7A1 [P30825]6EBI-743099,EBI-4289564
SLC7A14 [Q8TBB6]3EBI-743099,EBI-5235586
SMIM14 [Q96QK8]4EBI-743099,EBI-373430
SNAP47 [Q5SQN1]3EBI-743099,EBI-10244848
SSMEM1 [Q8WWF3]3EBI-743099,EBI-17280858
SYNDIG1 [Q9H7V2]6EBI-743099,EBI-726331
SYNE4 [Q8N205]5EBI-743099,EBI-7131783
SYNGR1 [O43759]3EBI-743099,EBI-6269521
SYNGR1 - isoform 1B [O43759-2]6EBI-743099,EBI-12187159
SYNPR [Q8TBG9]3EBI-743099,EBI-10273251
TIMMDC1 [Q9NPL8]4EBI-743099,EBI-6268651
TM4SF4 [P48230]3EBI-743099,EBI-8650934
TMEM11 [P17152]4EBI-743099,EBI-723946
TMEM179B [Q7Z7N9]3EBI-743099,EBI-11724423
TMEM201 - isoform 2 [Q5SNT2-2]3EBI-743099,EBI-11994282
TMEM74 [Q96NL1]3EBI-743099,EBI-10292091
TRAF3IP3 [Q9Y228]6EBI-743099,EBI-765817
UBE2I [Q7KZS0]3EBI-743099,EBI-10180829
UNC93B1 [Q9H1C4]3EBI-743099,EBI-4401271
USP20 [A0A024R8A9]3EBI-743099,EBI-14096082
USP20 [Q9Y2K6]3EBI-743099,EBI-2511991
VSIG4 [Q9Y279]3EBI-743099,EBI-903131
VSTM1 - isoform 3 [Q6UX27-3]3EBI-743099,EBI-12190699
YIPF4 [Q9BSR8]6EBI-743099,EBI-751253
ZCCHC12 [Q6PEW1]3EBI-743099,EBI-748373
ZFPL1 [O95159]3EBI-743099,EBI-718439
tax [P14079] from Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).3EBI-743099,EBI-9675698

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124636, 69 interactors

Protein interaction database and analysis system

More...IntActi		Q969F0, 101 interactors

Molecular INTeraction database

More...MINTi		Q969F0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359375

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q969F0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q969F0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J190 Eukaryota
ENOG410YXUY LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006832

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_129363_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q969F0

Identification of Orthologs from Complete Genome Data

More...OMAi		QNMRFHY

Database of Orthologous Groups

More...OrthoDBi		1420413at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q969F0

TreeFam database of animal gene trees

More...TreeFami		TF338514

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039153 FATE1
IPR039433 Mff-like_dom

The PANTHER Classification System

More...PANTHERi		PTHR21128 PTHR21128, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05644 Miff, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q969F0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGPPNTKA EMEMSLAEEL NHGRQGENQE HLVIAEMMEL GSRSRGASQK 
        60         70         80         90        100
KQKLEQKAAG SASAKRVWNM TATRPKKMGS QLPKPRMLRE SGHGDAHLQE 
       110        120        130        140        150
YAGNFQGIRF HYDRNPGTDA VAQTSLEEFN VLEMEVMRRQ LYAVNRRLRA 
       160        170        180 
LEEQGATWRH RETLIIAVLV SASIANLWLW MNQ
Length:183
Mass (Da):20,712
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3448EDCBCD148CB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1I5H7C1I5_HUMAN
Fetal and adult testis-expressed tr...
FATE1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01691710A → V Common polymorphism; 16% of the population; infertile and fertile individuals. 1 PublicationCorresponds to variant dbSNP:rs3810715Ensembl.1
Natural variantiVAR_01691834I → T in fertile and infertile individuals. 1 Publication1
Natural variantiVAR_016919125S → R in fertile and infertile individuals. 1 PublicationCorresponds to variant dbSNP:rs141497002Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF249872 mRNA Translation: AAK69024.1
AY101182 mRNA Translation: AAM48744.1
AK057369 mRNA Translation: BAB71454.1
BC022064 mRNA Translation: AAH22064.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14700.1

NCBI Reference Sequences

More...RefSeqi		NP_149076.1, NM_033085.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370350; ENSP00000359375; ENSG00000147378

Database of genes from NCBI RefSeq genomes

More...GeneIDi		89885

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:89885

UCSC genome browser

More...UCSCi		uc004fex.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249872 mRNA Translation: AAK69024.1
AY101182 mRNA Translation: AAM48744.1
AK057369 mRNA Translation: BAB71454.1
BC022064 mRNA Translation: AAH22064.1
CCDSiCCDS14700.1
RefSeqiNP_149076.1, NM_033085.2

3D structure databases

SMRiQ969F0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124636, 69 interactors
IntActiQ969F0, 101 interactors
MINTiQ969F0
STRINGi9606.ENSP00000359375

Polymorphism and mutation databases

BioMutaiFATE1
DMDMi37078481

Proteomic databases

MassIVEiQ969F0
PaxDbiQ969F0
PeptideAtlasiQ969F0
PRIDEiQ969F0
ProteomicsDBi75746

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30697 278 antibodies

The DNASU plasmid repository

More...DNASUi		89885

Genome annotation databases

EnsembliENST00000370350; ENSP00000359375; ENSG00000147378
GeneIDi89885
KEGGihsa:89885
UCSCiuc004fex.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		89885
DisGeNETi89885
EuPathDBiHostDB:ENSG00000147378.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		FATE1
HGNCiHGNC:24683 FATE1
HPAiENSG00000147378 Tissue enriched (testis)
MIMi300450 gene
neXtProtiNX_Q969F0
OpenTargetsiENSG00000147378
PharmGKBiPA134875203

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J190 Eukaryota
ENOG410YXUY LUCA
GeneTreeiENSGT00390000006832
HOGENOMiCLU_129363_0_0_1
InParanoidiQ969F0
OMAiQNMRFHY
OrthoDBi1420413at2759
PhylomeDBiQ969F0
TreeFamiTF338514

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		89885 2 hits in 414 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FATE1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FATE1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		89885
PharosiQ969F0 Tbio

Protein Ontology

More...PROi		PR:Q969F0
RNActiQ969F0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000147378 Expressed in right testis and 80 other tissues
ExpressionAtlasiQ969F0 baseline and differential
GenevisibleiQ969F0 HS

Family and domain databases

InterProiView protein in InterPro
IPR039153 FATE1
IPR039433 Mff-like_dom
PANTHERiPTHR21128 PTHR21128, 1 hit
PfamiView protein in Pfam
PF05644 Miff, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFATE1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969F0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 1, 2001
Last modified: June 17, 2020
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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