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Entry version 138 (29 Sep 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Transcription elongation factor A protein-like 3

Gene

TCEAL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • WW domain binding Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q969E4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription elongation factor A protein-like 3
Short name:
TCEA-like protein 3
Alternative name(s):
Transcription elongation factor S-II protein-like 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCEAL3
ORF Names:MSTP072
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28247, TCEAL3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969E4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000196507

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000196507

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394737

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q969E4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TCEAL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762641

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002392071 – 200Transcription elongation factor A protein-like 3Add BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30PhosphoserineCombined sources1
Modified residuei65PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q969E4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q969E4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q969E4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q969E4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969E4

PeptideAtlas

More...
PeptideAtlasi
Q969E4

PRoteomics IDEntifications database

More...
PRIDEi
Q969E4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75744

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q969E4, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969E4

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q969E4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969E4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196507, Expressed in substantia nigra and 217 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969E4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000196507, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124427, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q969E4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361711

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q969E4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q969E4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 200DisorderedSequence analysisAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi18 – 33Acidic residuesSequence analysisAdd BLAST16
Compositional biasi34 – 54Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi61 – 78Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi93 – 162Basic and acidic residuesSequence analysisAdd BLAST70

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RKY0, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183164

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_078412_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969E4

Identification of Orthologs from Complete Genome Data

More...
OMAi
RINNFYW

Database of Orthologous Groups

More...
OrthoDBi
1432394at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969E4

TreeFam database of animal gene trees

More...
TreeFami
TF336871

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021156, TF_A-like/BEX

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04538, BEX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q969E4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKPYNKNEG NLENEGKPED EVEPDDEGKS DEEEKPDVEG KTECEGKRED
60 70 80 90 100
EGEPGDEGQL EDEGSQEKQG RSEGEGKPQG EGKPASQAKP ESQPRAAEKR
110 120 130 140 150
PAEDYVPRKA KRKTDRGTDD SPKDSQEDLQ ERHLSSEEMM RECGDVSRAQ
160 170 180 190 200
EELRKKQKMG GFHWMQRDVQ DPFAPRGQRG VRGVRGGGRG QRGLHDIPYL
Length:200
Mass (Da):22,502
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8F18B86A1A8F484
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05982987Q → E. Corresponds to variant dbSNP:rs12009847Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF163263 mRNA Translation: AAQ13592.1
AK098494 mRNA Translation: BAC05318.1
Z73965 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54703.1
CH471190 Genomic DNA Translation: EAW54704.1
BC007622 mRNA Translation: AAH07622.1
BC008703 mRNA Translation: AAH08703.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14511.1

NCBI Reference Sequences

More...
RefSeqi
NP_001006934.1, NM_001006933.1
NP_116315.1, NM_032926.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000243286; ENSP00000243286; ENSG00000196507
ENST00000372627; ENSP00000361710; ENSG00000196507
ENST00000372628; ENSP00000361711; ENSG00000196507

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85012

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85012

UCSC genome browser

More...
UCSCi
uc004ekq.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163263 mRNA Translation: AAQ13592.1
AK098494 mRNA Translation: BAC05318.1
Z73965 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54703.1
CH471190 Genomic DNA Translation: EAW54704.1
BC007622 mRNA Translation: AAH07622.1
BC008703 mRNA Translation: AAH08703.1
CCDSiCCDS14511.1
RefSeqiNP_001006934.1, NM_001006933.1
NP_116315.1, NM_032926.2

3D structure databases

SMRiQ969E4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124427, 2 interactors
IntActiQ969E4, 1 interactor
STRINGi9606.ENSP00000361711

PTM databases

GlyGeniQ969E4, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ969E4
MetOSiteiQ969E4
PhosphoSitePlusiQ969E4

Genetic variation databases

BioMutaiTCEAL3
DMDMi74762641

Proteomic databases

EPDiQ969E4
jPOSTiQ969E4
MassIVEiQ969E4
MaxQBiQ969E4
PaxDbiQ969E4
PeptideAtlasiQ969E4
PRIDEiQ969E4
ProteomicsDBi75744

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
44291, 106 antibodies

The DNASU plasmid repository

More...
DNASUi
85012

Genome annotation databases

EnsembliENST00000243286; ENSP00000243286; ENSG00000196507
ENST00000372627; ENSP00000361710; ENSG00000196507
ENST00000372628; ENSP00000361711; ENSG00000196507
GeneIDi85012
KEGGihsa:85012
UCSCiuc004ekq.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85012

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TCEAL3
HGNCiHGNC:28247, TCEAL3
HPAiENSG00000196507, Low tissue specificity
neXtProtiNX_Q969E4
OpenTargetsiENSG00000196507
PharmGKBiPA128394737
VEuPathDBiHostDB:ENSG00000196507

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RKY0, Eukaryota
GeneTreeiENSGT00950000183164
HOGENOMiCLU_078412_1_0_1
InParanoidiQ969E4
OMAiRINNFYW
OrthoDBi1432394at2759
PhylomeDBiQ969E4
TreeFamiTF336871

Enzyme and pathway databases

PathwayCommonsiQ969E4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
85012, 42 hits in 565 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TCEAL3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85012
PharosiQ969E4, Tdark

Protein Ontology

More...
PROi
PR:Q969E4
RNActiQ969E4, protein

Gene expression databases

BgeeiENSG00000196507, Expressed in substantia nigra and 217 other tissues
GenevisibleiQ969E4, HS

Family and domain databases

InterProiView protein in InterPro
IPR021156, TF_A-like/BEX
PfamiView protein in Pfam
PF04538, BEX, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCAL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969E4
Secondary accession number(s): D3DXA4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: September 29, 2021
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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