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Protein

Urocortin-3

Gene

UCN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-3
Alternative name(s):
Stresscopin
Urocortin III
Short name:
Ucn III
Gene namesi
Name:UCN3
Synonyms:SPC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000178473.6
HGNCiHGNC:17781 UCN3
MIMi605901 gene
neXtProtiNX_Q969E3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi114131
OpenTargetsiENSG00000178473
PharmGKBiPA130413153

Polymorphism and mutation databases

BioMutaiUCN3
DMDMi296452853

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000000624522 – 118Add BLAST97
ChainiPRO_0000006246120 – 157Urocortin-3Add BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei157Isoleucine amideSequence analysis1

Keywords - PTMi

Amidation

Proteomic databases

PaxDbiQ969E3
PeptideAtlasiQ969E3
PRIDEiQ969E3
ProteomicsDBi75743

PTM databases

iPTMnetiQ969E3
PhosphoSitePlusiQ969E3

Expressioni

Gene expression databases

BgeeiENSG00000178473 Expressed in 34 organ(s), highest expression level in adenohypophysis
CleanExiHS_UCN3
GenevisibleiQ969E3 HS

Organism-specific databases

HPAiHPA038281

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125284, 16 interactors
STRINGi9606.ENSP00000369798

Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ969E3
SMRiQ969E3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ969E3

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ00 Eukaryota
ENOG410YJR9 LUCA
GeneTreeiENSGT00390000001251
HOGENOMiHOG000230495
HOVERGENiHBG036243
InParanoidiQ969E3
KOiK05257
OMAiKFYKAKP
OrthoDBiEOG091G10Y0
PhylomeDBiQ969E3
TreeFamiTF330723

Family and domain databases

InterProiView protein in InterPro
IPR000187 CRF
IPR024270 Urocortin_II/III
PANTHERiPTHR17575 PTHR17575, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969E3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMPVHFLLL LLLLLGGPRT GLPHKFYKAK PIFSCLNTAL SEAEKGQWED
60 70 80 90 100
ASLLSKRSFH YLRSRDASSG EEEEGKEKKT FPISGARGGA RGTRYRYVSQ
110 120 130 140 150
AQPRGKPRQD TAKSPHRTKF TLSLDVPTNI MNLLFNIAKA KNLRAQAAAN
160
AHLMAQIGRK K
Length:161
Mass (Da):17,961
Last modified:May 18, 2010 - v2
Checksum:iB83B3D8D30879911
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06041077E → K. Corresponds to variant dbSNP:rs12768730Ensembl.1
Natural variantiVAR_06041191R → G3 PublicationsCorresponds to variant dbSNP:rs10904481Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361943 Genomic DNA Translation: AAK67317.1
AY026949 mRNA Translation: AAK11729.1
AL683826 Genomic DNA No translation available.
BC069530 mRNA Translation: AAH69530.1
BC100867 mRNA Translation: AAI00868.1
BC100868 mRNA Translation: AAI00869.1
BC100869 mRNA Translation: AAI00870.1
BC100870 mRNA Translation: AAI00871.1
CCDSiCCDS7065.1
RefSeqiNP_444277.2, NM_053049.3
UniGeneiHs.511775
Hs.680475

Genome annotation databases

EnsembliENST00000380433; ENSP00000369798; ENSG00000178473
GeneIDi114131
KEGGihsa:114131
UCSCiuc001ihx.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361943 Genomic DNA Translation: AAK67317.1
AY026949 mRNA Translation: AAK11729.1
AL683826 Genomic DNA No translation available.
BC069530 mRNA Translation: AAH69530.1
BC100867 mRNA Translation: AAI00868.1
BC100868 mRNA Translation: AAI00869.1
BC100869 mRNA Translation: AAI00870.1
BC100870 mRNA Translation: AAI00871.1
CCDSiCCDS7065.1
RefSeqiNP_444277.2, NM_053049.3
UniGeneiHs.511775
Hs.680475

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMHNMR-A120-157[»]
3N93X-ray2.50C142-157[»]
ProteinModelPortaliQ969E3
SMRiQ969E3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125284, 16 interactors
STRINGi9606.ENSP00000369798

PTM databases

iPTMnetiQ969E3
PhosphoSitePlusiQ969E3

Polymorphism and mutation databases

BioMutaiUCN3
DMDMi296452853

Proteomic databases

PaxDbiQ969E3
PeptideAtlasiQ969E3
PRIDEiQ969E3
ProteomicsDBi75743

Protocols and materials databases

DNASUi114131
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380433; ENSP00000369798; ENSG00000178473
GeneIDi114131
KEGGihsa:114131
UCSCiuc001ihx.2 human

Organism-specific databases

CTDi114131
DisGeNETi114131
EuPathDBiHostDB:ENSG00000178473.6
GeneCardsiUCN3
H-InvDBiHIX0035360
HGNCiHGNC:17781 UCN3
HPAiHPA038281
MIMi605901 gene
neXtProtiNX_Q969E3
OpenTargetsiENSG00000178473
PharmGKBiPA130413153
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ00 Eukaryota
ENOG410YJR9 LUCA
GeneTreeiENSGT00390000001251
HOGENOMiHOG000230495
HOVERGENiHBG036243
InParanoidiQ969E3
KOiK05257
OMAiKFYKAKP
OrthoDBiEOG091G10Y0
PhylomeDBiQ969E3
TreeFamiTF330723

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)

Miscellaneous databases

EvolutionaryTraceiQ969E3
GeneWikiiUCN3
GenomeRNAii114131
PROiPR:Q969E3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178473 Expressed in 34 organ(s), highest expression level in adenohypophysis
CleanExiHS_UCN3
GenevisibleiQ969E3 HS

Family and domain databases

InterProiView protein in InterPro
IPR000187 CRF
IPR024270 Urocortin_II/III
PANTHERiPTHR17575 PTHR17575, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUCN3_HUMAN
AccessioniPrimary (citable) accession number: Q969E3
Secondary accession number(s): Q496H2, Q5SR91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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