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Protein

Urocortin-3

Gene

UCN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-373080 Class B/2 (Secretin family receptors)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Urocortin-3
Alternative name(s):
Stresscopin
Urocortin III
Short name:
Ucn III
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UCN3
Synonyms:SPC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000178473.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17781 UCN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605901 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969E3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114131

Open Targets

More...
OpenTargetsi
ENSG00000178473

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA130413153

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UCN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452853

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000624522 – 118Add BLAST97
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000006246120 – 157Urocortin-3Add BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei157Isoleucine amideSequence analysis1

Keywords - PTMi

Amidation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969E3

PeptideAtlas

More...
PeptideAtlasi
Q969E3

PRoteomics IDEntifications database

More...
PRIDEi
Q969E3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75743

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969E3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969E3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178473 Expressed in 34 organ(s), highest expression level in adenohypophysis

CleanEx database of gene expression profiles

More...
CleanExi
HS_UCN3

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969E3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038281

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125284, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369798

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMHNMR-A120-157[»]
3N93X-ray2.50C142-157[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q969E3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q969E3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q969E3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZ00 Eukaryota
ENOG410YJR9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160568

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230495

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG036243

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969E3

KEGG Orthology (KO)

More...
KOi
K05257

Identification of Orthologs from Complete Genome Data

More...
OMAi
KFYKAKP

Database of Orthologous Groups

More...
OrthoDBi
1568003at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969E3

TreeFam database of animal gene trees

More...
TreeFami
TF330723

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000187 CRF
IPR024270 Urocortin_II/III

The PANTHER Classification System

More...
PANTHERi
PTHR17575 PTHR17575, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00473 CRF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q969E3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMPVHFLLL LLLLLGGPRT GLPHKFYKAK PIFSCLNTAL SEAEKGQWED
60 70 80 90 100
ASLLSKRSFH YLRSRDASSG EEEEGKEKKT FPISGARGGA RGTRYRYVSQ
110 120 130 140 150
AQPRGKPRQD TAKSPHRTKF TLSLDVPTNI MNLLFNIAKA KNLRAQAAAN
160
AHLMAQIGRK K
Length:161
Mass (Da):17,961
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB83B3D8D30879911
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06041077E → K. Corresponds to variant dbSNP:rs12768730Ensembl.1
Natural variantiVAR_06041191R → G3 PublicationsCorresponds to variant dbSNP:rs10904481Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF361943 Genomic DNA Translation: AAK67317.1
AY026949 mRNA Translation: AAK11729.1
AL683826 Genomic DNA No translation available.
BC069530 mRNA Translation: AAH69530.1
BC100867 mRNA Translation: AAI00868.1
BC100868 mRNA Translation: AAI00869.1
BC100869 mRNA Translation: AAI00870.1
BC100870 mRNA Translation: AAI00871.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7065.1

NCBI Reference Sequences

More...
RefSeqi
NP_444277.2, NM_053049.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.511775
Hs.680475

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380433; ENSP00000369798; ENSG00000178473

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114131

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114131

UCSC genome browser

More...
UCSCi
uc001ihx.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361943 Genomic DNA Translation: AAK67317.1
AY026949 mRNA Translation: AAK11729.1
AL683826 Genomic DNA No translation available.
BC069530 mRNA Translation: AAH69530.1
BC100867 mRNA Translation: AAI00868.1
BC100868 mRNA Translation: AAI00869.1
BC100869 mRNA Translation: AAI00870.1
BC100870 mRNA Translation: AAI00871.1
CCDSiCCDS7065.1
RefSeqiNP_444277.2, NM_053049.3
UniGeneiHs.511775
Hs.680475

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMHNMR-A120-157[»]
3N93X-ray2.50C142-157[»]
ProteinModelPortaliQ969E3
SMRiQ969E3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125284, 16 interactors
STRINGi9606.ENSP00000369798

PTM databases

iPTMnetiQ969E3
PhosphoSitePlusiQ969E3

Polymorphism and mutation databases

BioMutaiUCN3
DMDMi296452853

Proteomic databases

PaxDbiQ969E3
PeptideAtlasiQ969E3
PRIDEiQ969E3
ProteomicsDBi75743

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
114131
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380433; ENSP00000369798; ENSG00000178473
GeneIDi114131
KEGGihsa:114131
UCSCiuc001ihx.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114131
DisGeNETi114131
EuPathDBiHostDB:ENSG00000178473.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UCN3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0035360
HGNCiHGNC:17781 UCN3
HPAiHPA038281
MIMi605901 gene
neXtProtiNX_Q969E3
OpenTargetsiENSG00000178473
PharmGKBiPA130413153

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZ00 Eukaryota
ENOG410YJR9 LUCA
GeneTreeiENSGT00940000160568
HOGENOMiHOG000230495
HOVERGENiHBG036243
InParanoidiQ969E3
KOiK05257
OMAiKFYKAKP
OrthoDBi1568003at2759
PhylomeDBiQ969E3
TreeFamiTF330723

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)

Miscellaneous databases

EvolutionaryTraceiQ969E3

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
UCN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114131

Protein Ontology

More...
PROi
PR:Q969E3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000178473 Expressed in 34 organ(s), highest expression level in adenohypophysis
CleanExiHS_UCN3
GenevisibleiQ969E3 HS

Family and domain databases

InterProiView protein in InterPro
IPR000187 CRF
IPR024270 Urocortin_II/III
PANTHERiPTHR17575 PTHR17575, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUCN3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969E3
Secondary accession number(s): Q496H2, Q5SR91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 18, 2010
Last modified: January 16, 2019
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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