UniProtKB - Q969E2 (SCAM4_HUMAN)
Protein
Secretory carrier-associated membrane protein 4
Gene
SCAMP4
Organism
Homo sapiens (Human)
Status
Functioni
Probably involved in membrane protein trafficking.By similarity
GO - Biological processi
- protein transport Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q969E2 |
Protein family/group databases
TCDBi | 8.A.103.1.4, the secretory carrier-associated membrane protein (scamp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Secretory carrier-associated membrane protein 4Short name: Secretory carrier membrane protein 4 |
Gene namesi | Name:SCAMP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000227500.9 |
HGNCi | HGNC:30385, SCAMP4 |
MIMi | 613764, gene |
neXtProti | NX_Q969E2 |
Subcellular locationi
Other locations
Endosome
- recycling endosome membrane Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi membrane Source: GO_Central
- trans-Golgi network membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 39 | CytoplasmicSequence analysisAdd BLAST | 39 | |
Transmembranei | 40 – 60 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 61 – 81 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 105 – 125 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 229 | CytoplasmicSequence analysisAdd BLAST | 60 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 113178 |
OpenTargetsi | ENSG00000227500 |
PharmGKBi | PA134983341 |
Miscellaneous databases
Pharosi | Q969E2, Tdark |
Polymorphism and mutation databases
BioMutai | SCAMP4 |
DMDMi | 47117277 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191259 | 1 – 229 | Secretory carrier-associated membrane protein 4Add BLAST | 229 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 194 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q969E2 |
jPOSTi | Q969E2 |
MassIVEi | Q969E2 |
MaxQBi | Q969E2 |
PaxDbi | Q969E2 |
PeptideAtlasi | Q969E2 |
PRIDEi | Q969E2 |
ProteomicsDBi | 75740 [Q969E2-1] 75741 [Q969E2-2] 75742 [Q969E2-3] |
PTM databases
iPTMneti | Q969E2 |
PhosphoSitePlusi | Q969E2 |
SwissPalmi | Q969E2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000227500, Expressed in right uterine tube and 187 other tissues |
ExpressionAtlasi | Q969E2, baseline and differential |
Genevisiblei | Q969E2, HS |
Organism-specific databases
HPAi | ENSG00000227500, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ969E2
Protein-protein interaction databases
BioGRIDi | 125230, 24 interactors |
IntActi | Q969E2, 25 interactors |
MINTi | Q969E2 |
STRINGi | 9606.ENSP00000316007 |
Miscellaneous databases
RNActi | Q969E2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the SCAMP family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3088, Eukaryota |
GeneTreei | ENSGT00940000162150 |
HOGENOMi | CLU_066546_1_0_1 |
InParanoidi | Q969E2 |
OMAi | IMFSMSA |
PhylomeDBi | Q969E2 |
TreeFami | TF313797 |
Family and domain databases
InterProi | View protein in InterPro IPR007273, SCAMP |
PANTHERi | PTHR10687, PTHR10687, 1 hit |
Pfami | View protein in Pfam PF04144, SCAMP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q969E2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSEKENNFPP LPKFIPVKPC FYQNFSDEIP VEHQVLVKRI YRLWMFYCAT
60 70 80 90 100
LGVNLIACLA WWIGGGSGTN FGLAFVWLLL FTPCGYVCWF RPVYKAFRAD
110 120 130 140 150
SSFNFMAFFF IFGAQFVLTV IQAIGFSGWG ACGWLSAIGF FQYSPGAAVV
160 170 180 190 200
MLLPAIMFSV SAAMMAIAIM KVHRIYRGAG GSFQKAQTEW NTGTWRNPPS
210 220
REAQYNNFSG NSLPEYPTVP SYPGSGQWP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JWM2 | C9JWM2_HUMAN | Secretory carrier-associated membra... | SCAMP4 | 123 | Annotation score: | ||
A0A087WVT5 | A0A087WVT5_HUMAN | Secretory carrier-associated membra... | SCAMP4 | 140 | Annotation score: | ||
K7EJJ4 | K7EJJ4_HUMAN | Secretory carrier-associated membra... | SCAMP4 | 57 | Annotation score: | ||
A0A087WU01 | A0A087WU01_HUMAN | Secretory carrier-associated membra... | SCAMP4 | 22 | Annotation score: | ||
A0A087WYP4 | A0A087WYP4_HUMAN | Secretory carrier-associated membra... | SCAMP4 | 35 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061783 | 49 | A → T. Corresponds to variant dbSNP:rs45562539Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026446 | 99 – 132 | Missing in isoform 2. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_026447 | 132 – 229 | CGWLS…SGQWP → G in isoform 3. 1 PublicationAdd BLAST | 98 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074586 mRNA Translation: BAC11075.1 AK074967 mRNA Translation: BAC11322.1 AK092056 mRNA Translation: BAC03797.1 BC011747 mRNA Translation: AAH11747.1 BC016509 mRNA Translation: AAH16509.1 BC062598 mRNA Translation: AAH62598.1 |
CCDSi | CCDS45903.1 [Q969E2-1] CCDS86689.1 [Q969E2-2] |
RefSeqi | NP_001316468.1, NM_001329539.1 NP_001316469.1, NM_001329540.1 [Q969E2-2] NP_524558.1, NM_079834.3 [Q969E2-1] |
Genome annotation databases
Ensembli | ENST00000316097; ENSP00000316007; ENSG00000227500 [Q969E2-1] ENST00000409472; ENSP00000386865; ENSG00000227500 [Q969E2-2] ENST00000621748; ENSP00000479083; ENSG00000227500 [Q969E2-1] |
GeneIDi | 113178 |
KEGGi | hsa:113178 |
UCSCi | uc002luj.5, human [Q969E2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074586 mRNA Translation: BAC11075.1 AK074967 mRNA Translation: BAC11322.1 AK092056 mRNA Translation: BAC03797.1 BC011747 mRNA Translation: AAH11747.1 BC016509 mRNA Translation: AAH16509.1 BC062598 mRNA Translation: AAH62598.1 |
CCDSi | CCDS45903.1 [Q969E2-1] CCDS86689.1 [Q969E2-2] |
RefSeqi | NP_001316468.1, NM_001329539.1 NP_001316469.1, NM_001329540.1 [Q969E2-2] NP_524558.1, NM_079834.3 [Q969E2-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125230, 24 interactors |
IntActi | Q969E2, 25 interactors |
MINTi | Q969E2 |
STRINGi | 9606.ENSP00000316007 |
Protein family/group databases
TCDBi | 8.A.103.1.4, the secretory carrier-associated membrane protein (scamp) family |
PTM databases
iPTMneti | Q969E2 |
PhosphoSitePlusi | Q969E2 |
SwissPalmi | Q969E2 |
Polymorphism and mutation databases
BioMutai | SCAMP4 |
DMDMi | 47117277 |
Proteomic databases
EPDi | Q969E2 |
jPOSTi | Q969E2 |
MassIVEi | Q969E2 |
MaxQBi | Q969E2 |
PaxDbi | Q969E2 |
PeptideAtlasi | Q969E2 |
PRIDEi | Q969E2 |
ProteomicsDBi | 75740 [Q969E2-1] 75741 [Q969E2-2] 75742 [Q969E2-3] |
Protocols and materials databases
Antibodypediai | 22844, 83 antibodies |
DNASUi | 113178 |
Genome annotation databases
Ensembli | ENST00000316097; ENSP00000316007; ENSG00000227500 [Q969E2-1] ENST00000409472; ENSP00000386865; ENSG00000227500 [Q969E2-2] ENST00000621748; ENSP00000479083; ENSG00000227500 [Q969E2-1] |
GeneIDi | 113178 |
KEGGi | hsa:113178 |
UCSCi | uc002luj.5, human [Q969E2-1] |
Organism-specific databases
CTDi | 113178 |
DisGeNETi | 113178 |
EuPathDBi | HostDB:ENSG00000227500.9 |
GeneCardsi | SCAMP4 |
HGNCi | HGNC:30385, SCAMP4 |
HPAi | ENSG00000227500, Low tissue specificity |
MIMi | 613764, gene |
neXtProti | NX_Q969E2 |
OpenTargetsi | ENSG00000227500 |
PharmGKBi | PA134983341 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3088, Eukaryota |
GeneTreei | ENSGT00940000162150 |
HOGENOMi | CLU_066546_1_0_1 |
InParanoidi | Q969E2 |
OMAi | IMFSMSA |
PhylomeDBi | Q969E2 |
TreeFami | TF313797 |
Enzyme and pathway databases
PathwayCommonsi | Q969E2 |
Miscellaneous databases
BioGRID-ORCSi | 113178, 6 hits in 842 CRISPR screens |
ChiTaRSi | SCAMP4, human |
GenomeRNAii | 113178 |
Pharosi | Q969E2, Tdark |
PROi | PR:Q969E2 |
RNActi | Q969E2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000227500, Expressed in right uterine tube and 187 other tissues |
ExpressionAtlasi | Q969E2, baseline and differential |
Genevisiblei | Q969E2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007273, SCAMP |
PANTHERi | PTHR10687, PTHR10687, 1 hit |
Pfami | View protein in Pfam PF04144, SCAMP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCAM4_HUMAN | |
Accessioni | Q969E2Primary (citable) accession number: Q969E2 Secondary accession number(s): Q8N2N1, Q8NAV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations