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Protein

Liver-expressed antimicrobial peptide 2

Gene

LEAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has an antimicrobial activity.1 Publication

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • antimicrobial humoral response Source: Reactome
  • defense response to bacterium Source: UniProtKB-KW
  • defense response to fungus Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
Liver-expressed antimicrobial peptide 2
Short name:
LEAP-2
Gene namesi
Name:LEAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164406.7
HGNCiHGNC:29571 LEAP2
MIMi611373 gene
neXtProtiNX_Q969E1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi116842
OpenTargetsiENSG00000164406
PharmGKBiPA162393840

Polymorphism and mutation databases

BioMutaiLEAP2
DMDMi20138667

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000001735523 – 37Add BLAST15
ChainiPRO_000001735638 – 77Liver-expressed antimicrobial peptide 2Add BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 65
Disulfide bondi60 ↔ 70

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ969E1
PeptideAtlasiQ969E1
PRIDEiQ969E1
ProteomicsDBi75739

PTM databases

iPTMnetiQ969E1
PhosphoSitePlusiQ969E1

Expressioni

Gene expression databases

BgeeiENSG00000164406
CleanExiHS_LEAP2
GenevisibleiQ969E1 HS

Interactioni

Protein-protein interaction databases

BioGridi125535, 5 interactors

Structurei

Secondary structure

177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi46 – 48Combined sources3
Helixi57 – 59Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L1QNMR-A38-77[»]
ProteinModelPortaliQ969E1
SMRiQ969E1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ969E1

Family & Domainsi

Sequence similaritiesi

Belongs to the LEAP2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7PZ Eukaryota
ENOG410Y6EA LUCA
GeneTreeiENSGT00390000013467
HOGENOMiHOG000037938
HOVERGENiHBG052319
InParanoidiQ969E1
OMAiTMLRSME
OrthoDBiEOG091G13A9
PhylomeDBiQ969E1
TreeFamiTF336274

Family and domain databases

InterProiView protein in InterPro
IPR009955 LEAP-2
PANTHERiPTHR21007 PTHR21007, 1 hit
PfamiView protein in Pfam
PF07359 LEAP-2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWHLKLCAVL MIFLLLLGQI DGSPIPEVSS AKRRPRRMTP FWRGVSLRPI
60 70
GASCRDDSEC ITRLCRKRRC SLSVAQE
Length:77
Mass (Da):8,814
Last modified:December 1, 2001 - v1
Checksum:iFD1C300B0F42E4C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306405 mRNA Translation: CAC51306.1
AJ409064 Genomic DNA Translation: CAC51515.1
AJ409065 mRNA Translation: CAC51516.1
CH471062 Genomic DNA Translation: EAW62306.1
CH471062 Genomic DNA Translation: EAW62307.1
BC070199 mRNA Translation: AAH70199.1
CCDSiCCDS4163.1
RefSeqiNP_443203.1, NM_052971.2
UniGeneiHs.337588

Genome annotation databases

EnsembliENST00000296877; ENSP00000296877; ENSG00000164406
GeneIDi116842
KEGGihsa:116842
UCSCiuc003kyc.4 human

Similar proteinsi

Entry informationi

Entry nameiLEAP2_HUMAN
AccessioniPrimary (citable) accession number: Q969E1
Secondary accession number(s): D3DQ91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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