UniProtKB - Q969E1 (LEAP2_HUMAN)
Protein
Liver-expressed antimicrobial peptide 2
Gene
LEAP2
Organism
Homo sapiens (Human)
Status
Functioni
Has an antimicrobial activity.1 Publication
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- antimicrobial humoral response Source: Reactome
- defense response to bacterium Source: UniProtKB-KW
- defense response to fungus Source: UniProtKB
Keywordsi
Molecular function | Antibiotic, Antimicrobial |
Enzyme and pathway databases
PathwayCommonsi | Q969E1 |
Reactomei | R-HSA-6803157, Antimicrobial peptides |
Names & Taxonomyi
Protein namesi | Recommended name: Liver-expressed antimicrobial peptide 2Short name: LEAP-2 |
Gene namesi | Name:LEAP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29571, LEAP2 |
MIMi | 611373, gene |
neXtProti | NX_Q969E1 |
VEuPathDBi | HostDB:ENSG00000164406.7 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 116842 |
OpenTargetsi | ENSG00000164406 |
PharmGKBi | PA162393840 |
Miscellaneous databases
Pharosi | Q969E1, Tbio |
Genetic variation databases
BioMutai | LEAP2 |
DMDMi | 20138667 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
PropeptideiPRO_0000017355 | 23 – 37 | Add BLAST | 15 | |
ChainiPRO_0000017356 | 38 – 77 | Liver-expressed antimicrobial peptide 2Add BLAST | 40 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 54 ↔ 65 | |||
Disulfide bondi | 60 ↔ 70 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondProteomic databases
jPOSTi | Q969E1 |
MassIVEi | Q969E1 |
PaxDbi | Q969E1 |
PeptideAtlasi | Q969E1 |
PRIDEi | Q969E1 |
ProteomicsDBi | 75739 |
PTM databases
iPTMneti | Q969E1 |
PhosphoSitePlusi | Q969E1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164406, Expressed in liver and 182 other tissues |
Genevisiblei | Q969E1, HS |
Organism-specific databases
HPAi | ENSG00000164406, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 125535, 5 interactors |
STRINGi | 9606.ENSP00000296877 |
Miscellaneous databases
RNActi | Q969E1, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q969E1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q969E1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the LEAP2 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SD5B, Eukaryota |
GeneTreei | ENSGT00390000013467 |
HOGENOMi | CLU_178163_0_0_1 |
InParanoidi | Q969E1 |
OMAi | LCRKNRC |
OrthoDBi | 1622785at2759 |
PhylomeDBi | Q969E1 |
TreeFami | TF336274 |
Family and domain databases
InterProi | View protein in InterPro IPR009955, LEAP-2 |
PANTHERi | PTHR21007, PTHR21007, 1 hit |
Pfami | View protein in Pfam PF07359, LEAP-2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q969E1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWHLKLCAVL MIFLLLLGQI DGSPIPEVSS AKRRPRRMTP FWRGVSLRPI
60 70
GASCRDDSEC ITRLCRKRRC SLSVAQE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ306405 mRNA Translation: CAC51306.1 AJ409064 Genomic DNA Translation: CAC51515.1 AJ409065 mRNA Translation: CAC51516.1 CH471062 Genomic DNA Translation: EAW62306.1 CH471062 Genomic DNA Translation: EAW62307.1 BC070199 mRNA Translation: AAH70199.1 |
CCDSi | CCDS4163.1 |
RefSeqi | NP_443203.1, NM_052971.2 |
Genome annotation databases
Ensembli | ENST00000296877; ENSP00000296877; ENSG00000164406 |
GeneIDi | 116842 |
KEGGi | hsa:116842 |
UCSCi | uc003kyc.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ306405 mRNA Translation: CAC51306.1 AJ409064 Genomic DNA Translation: CAC51515.1 AJ409065 mRNA Translation: CAC51516.1 CH471062 Genomic DNA Translation: EAW62306.1 CH471062 Genomic DNA Translation: EAW62307.1 BC070199 mRNA Translation: AAH70199.1 |
CCDSi | CCDS4163.1 |
RefSeqi | NP_443203.1, NM_052971.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2L1Q | NMR | - | A | 38-77 | [»] | |
SMRi | Q969E1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125535, 5 interactors |
STRINGi | 9606.ENSP00000296877 |
PTM databases
iPTMneti | Q969E1 |
PhosphoSitePlusi | Q969E1 |
Genetic variation databases
BioMutai | LEAP2 |
DMDMi | 20138667 |
Proteomic databases
jPOSTi | Q969E1 |
MassIVEi | Q969E1 |
PaxDbi | Q969E1 |
PeptideAtlasi | Q969E1 |
PRIDEi | Q969E1 |
ProteomicsDBi | 75739 |
Protocols and materials databases
Antibodypediai | 26190, 31 antibodies |
Genome annotation databases
Ensembli | ENST00000296877; ENSP00000296877; ENSG00000164406 |
GeneIDi | 116842 |
KEGGi | hsa:116842 |
UCSCi | uc003kyc.4, human |
Organism-specific databases
CTDi | 116842 |
DisGeNETi | 116842 |
GeneCardsi | LEAP2 |
HGNCi | HGNC:29571, LEAP2 |
HPAi | ENSG00000164406, Tissue enriched (liver) |
MIMi | 611373, gene |
neXtProti | NX_Q969E1 |
OpenTargetsi | ENSG00000164406 |
PharmGKBi | PA162393840 |
VEuPathDBi | HostDB:ENSG00000164406.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SD5B, Eukaryota |
GeneTreei | ENSGT00390000013467 |
HOGENOMi | CLU_178163_0_0_1 |
InParanoidi | Q969E1 |
OMAi | LCRKNRC |
OrthoDBi | 1622785at2759 |
PhylomeDBi | Q969E1 |
TreeFami | TF336274 |
Enzyme and pathway databases
PathwayCommonsi | Q969E1 |
Reactomei | R-HSA-6803157, Antimicrobial peptides |
Miscellaneous databases
BioGRID-ORCSi | 116842, 2 hits in 855 CRISPR screens |
EvolutionaryTracei | Q969E1 |
GenomeRNAii | 116842 |
Pharosi | Q969E1, Tbio |
PROi | PR:Q969E1 |
RNActi | Q969E1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164406, Expressed in liver and 182 other tissues |
Genevisiblei | Q969E1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009955, LEAP-2 |
PANTHERi | PTHR21007, PTHR21007, 1 hit |
Pfami | View protein in Pfam PF07359, LEAP-2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LEAP2_HUMAN | |
Accessioni | Q969E1Primary (citable) accession number: Q969E1 Secondary accession number(s): D3DQ91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 5, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM