UniProtKB - Q969D9 (TSLP_HUMAN)
Thymic stromal lymphopoietin
TSLP
Functioni
Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells.
3 PublicationsMay act as an antimicrobial peptide in the oral cavity and on the skin.
1 PublicationGO - Molecular functioni
- cytokine activity Source: UniProtKB
- interleukin-7 receptor binding Source: UniProtKB
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- defense response to fungus Source: UniProtKB
- defense response to Gram-negative bacterium Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of chemokine (C-C motif) ligand 1 production Source: UniProtKB
- positive regulation of chemokine production Source: UniProtKB
- positive regulation of cytokine-mediated signaling pathway Source: UniProtKB
- positive regulation of granulocyte colony-stimulating factor production Source: UniProtKB
- positive regulation of inflammatory response Source: UniProtKB
- positive regulation of interleukin-10 production Source: UniProtKB
- positive regulation of interleukin-13 production Source: UniProtKB
- positive regulation of interleukin-5 production Source: UniProtKB
- positive regulation of interleukin-6 production Source: UniProtKB
- positive regulation of mast cell activation Source: UniProtKB
- positive regulation of receptor signaling pathway via STAT Source: UniProtKB
- positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Keywordsi
Molecular function | Cytokine |
Enzyme and pathway databases
PathwayCommonsi | Q969D9 |
Reactomei | R-HSA-1266695, Interleukin-7 signaling |
SignaLinki | Q969D9 |
SIGNORi | Q969D9 |
Names & Taxonomyi
Protein namesi | Recommended name: Thymic stromal lymphopoietin |
Gene namesi | Name:TSLP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30743, TSLP |
MIMi | 607003, gene |
neXtProti | NX_Q969D9 |
VEuPathDBi | HostDB:ENSG00000145777 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 85480 |
OpenTargetsi | ENSG00000145777 |
PharmGKBi | PA162407159 |
Miscellaneous databases
Pharosi | Q969D9, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3712931 |
Genetic variation databases
BioMutai | TSLP |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000300873 | 29 – 159 | Thymic stromal lymphopoietinAdd BLAST | 131 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 110 | By similarity | ||
Glycosylationi | 64 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 69 ↔ 75 | By similarity | ||
Disulfide bondi | 90 ↔ 137 | By similarity | ||
Glycosylationi | 119 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q969D9 |
PaxDbi | Q969D9 |
PRIDEi | Q969D9 |
PTM databases
GlyGeni | Q969D9, 2 sites |
PhosphoSitePlusi | Q969D9 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000145777, Expressed in epithelial cell of pancreas and 135 other tissues |
ExpressionAtlasi | Q969D9, baseline and differential |
Genevisiblei | Q969D9, HS |
Organism-specific databases
HPAi | ENSG00000145777, Tissue enhanced (liver, urinary bladder) |
Interactioni
Subunit structurei
Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.
By similarityGO - Molecular functioni
- cytokine activity Source: UniProtKB
- interleukin-7 receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 124555, 4 interactors |
IntActi | Q969D9, 2 interactors |
STRINGi | 9606.ENSP00000339804 |
Miscellaneous databases
RNActi | Q969D9, protein |
Structurei
Secondary structure
3D structure databases
SASBDBi | Q969D9 |
SMRi | Q969D9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TEM0, Eukaryota |
GeneTreei | ENSGT00390000012541 |
HOGENOMi | CLU_2885173_0_0_1 |
InParanoidi | Q969D9 |
OMAi | NPTPRCA |
OrthoDBi | 1389326at2759 |
PhylomeDBi | Q969D9 |
TreeFami | TF338216 |
Family and domain databases
Gene3Di | 1.20.1250.90, 1 hit |
InterProi | View protein in InterPro IPR029189, TSLP IPR038329, TSLP_sf |
PANTHERi | PTHR38003, PTHR38003, 1 hit |
Pfami | View protein in Pfam PF15216, TSLP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFPFALLYVL SVSFRKIFIL QLVGLVLTYD FTNCDFEKIK AAYLSTISKD
60 70 80 90 100
LITYMSGTKS TEFNNTVSCS NRPHCLTEIQ SLTFNPTAGC ASLAKEMFAM
110 120 130 140 150
KTKAALAIWC PGYSETQINA TQAMKKRRKR KVTTNKCLEQ VSQLQGLWRR
FNRPLLKQQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DG43 | A0A0C4DG43_HUMAN | Thymic stromal lymphopoietin | TSLP | 159 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 – 11 | MFPFALLYVLS → MKCLGQSKKEE in AAH40592 (PubMed:15372022).CuratedAdd BLAST | 11 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057462 | 1 – 96 | Missing in isoform 2. 1 PublicationAdd BLAST | 96 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY037115 mRNA Translation: AAK67490.1 AF338732 mRNA Translation: AAK60617.1 AC008572 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49038.1 BC016720 mRNA Translation: AAH16720.1 Different initiation. BC022894 mRNA Translation: AAH22894.1 Different initiation. BC040592 mRNA Translation: AAH40592.1 |
CCDSi | CCDS4101.1 [Q969D9-1] |
RefSeqi | NP_149024.1, NM_033035.4 [Q969D9-1] NP_612561.2, NM_138551.4 [Q969D9-2] XP_011542000.1, XM_011543698.1 [Q969D9-2] |
Genome annotation databases
Ensembli | ENST00000344895; ENSP00000339804; ENSG00000145777 ENST00000379706; ENSP00000427827; ENSG00000145777 [Q969D9-2] |
GeneIDi | 85480 |
KEGGi | hsa:85480 |
MANE-Selecti | ENST00000344895.4; ENSP00000339804.3; NM_033035.5; NP_149024.1 |
UCSCi | uc003kpb.3, human [Q969D9-1] uc031skq.1, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY037115 mRNA Translation: AAK67490.1 AF338732 mRNA Translation: AAK60617.1 AC008572 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49038.1 BC016720 mRNA Translation: AAH16720.1 Different initiation. BC022894 mRNA Translation: AAH22894.1 Different initiation. BC040592 mRNA Translation: AAH40592.1 |
CCDSi | CCDS4101.1 [Q969D9-1] |
RefSeqi | NP_149024.1, NM_033035.4 [Q969D9-1] NP_612561.2, NM_138551.4 [Q969D9-2] XP_011542000.1, XM_011543698.1 [Q969D9-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5J11 | X-ray | 2.56 | A | 36-159 | [»] | |
5J12 | X-ray | 3.55 | A | 1-159 | [»] | |
5J13 | X-ray | 2.30 | A | 29-159 | [»] | |
SASBDBi | Q969D9 | |||||
SMRi | Q969D9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124555, 4 interactors |
IntActi | Q969D9, 2 interactors |
STRINGi | 9606.ENSP00000339804 |
Chemistry databases
ChEMBLi | CHEMBL3712931 |
PTM databases
GlyGeni | Q969D9, 2 sites |
PhosphoSitePlusi | Q969D9 |
Genetic variation databases
BioMutai | TSLP |
Proteomic databases
MassIVEi | Q969D9 |
PaxDbi | Q969D9 |
PRIDEi | Q969D9 |
Protocols and materials databases
ABCDi | Q969D9, 5 sequenced antibodies |
Antibodypediai | 25309, 841 antibodies from 41 providers |
DNASUi | 85480 |
Genome annotation databases
Ensembli | ENST00000344895; ENSP00000339804; ENSG00000145777 ENST00000379706; ENSP00000427827; ENSG00000145777 [Q969D9-2] |
GeneIDi | 85480 |
KEGGi | hsa:85480 |
MANE-Selecti | ENST00000344895.4; ENSP00000339804.3; NM_033035.5; NP_149024.1 |
UCSCi | uc003kpb.3, human [Q969D9-1] uc031skq.1, human |
Organism-specific databases
CTDi | 85480 |
DisGeNETi | 85480 |
GeneCardsi | TSLP |
HGNCi | HGNC:30743, TSLP |
HPAi | ENSG00000145777, Tissue enhanced (liver, urinary bladder) |
MIMi | 607003, gene |
neXtProti | NX_Q969D9 |
OpenTargetsi | ENSG00000145777 |
PharmGKBi | PA162407159 |
VEuPathDBi | HostDB:ENSG00000145777 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TEM0, Eukaryota |
GeneTreei | ENSGT00390000012541 |
HOGENOMi | CLU_2885173_0_0_1 |
InParanoidi | Q969D9 |
OMAi | NPTPRCA |
OrthoDBi | 1389326at2759 |
PhylomeDBi | Q969D9 |
TreeFami | TF338216 |
Enzyme and pathway databases
PathwayCommonsi | Q969D9 |
Reactomei | R-HSA-1266695, Interleukin-7 signaling |
SignaLinki | Q969D9 |
SIGNORi | Q969D9 |
Miscellaneous databases
BioGRID-ORCSi | 85480, 7 hits in 1035 CRISPR screens |
GeneWikii | Thymic_stromal_lymphopoietin |
GenomeRNAii | 85480 |
Pharosi | Q969D9, Tbio |
PROi | PR:Q969D9 |
RNActi | Q969D9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145777, Expressed in epithelial cell of pancreas and 135 other tissues |
ExpressionAtlasi | Q969D9, baseline and differential |
Genevisiblei | Q969D9, HS |
Family and domain databases
Gene3Di | 1.20.1250.90, 1 hit |
InterProi | View protein in InterPro IPR029189, TSLP IPR038329, TSLP_sf |
PANTHERi | PTHR38003, PTHR38003, 1 hit |
Pfami | View protein in Pfam PF15216, TSLP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TSLP_HUMAN | |
Accessioni | Q969D9Primary (citable) accession number: Q969D9 Secondary accession number(s): G3XAM8, Q8IW99, Q96AU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references