Thymic stromal lymphopoietin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells."
    Reche P.A., Soumelis V., Gorman D.M., Clifford T., Liu M.-R., Travis M., Zurawski S.M., Johnston J., Liu Y.-J., Spits H., de Waal Malefyt R., Kastelein R.A., Bazan J.F.
    J. Immunol. 167:336-343(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, FUNCTION (ISOFORM 1).
• interleukin-7 receptor binding Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.2

    "Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation."
    Quentmeier H., Drexler H.G., Fleckenstein D., Zaborski M., Armstrong A., Sims J.E., Lyman S.D.
    Leukemia 15:1286-1292(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION (ISOFORM 1), TISSUE SPECIFICITY.

GO - Biological processⁱ

• antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide."
    Bjerkan L., Schreurs O., Engen S.A., Jahnsen F.L., Baekkevold E.S., Blix I.J., Schenck K.
    Mucosal Immunol. 8:49-56(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 2), FUNCTION (ISOFORM 2).
• defense response to fungus Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide."
    Bjerkan L., Schreurs O., Engen S.A., Jahnsen F.L., Baekkevold E.S., Blix I.J., Schenck K.
    Mucosal Immunol. 8:49-56(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 2), FUNCTION (ISOFORM 2).
• defense response to Gram-negative bacterium Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide."
    Bjerkan L., Schreurs O., Engen S.A., Jahnsen F.L., Baekkevold E.S., Blix I.J., Schenck K.
    Mucosal Immunol. 8:49-56(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 2), FUNCTION (ISOFORM 2).
• interleukin-7-mediated signaling pathway Source: Reactome
• negative regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • Ref.2

    "Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation."
    Quentmeier H., Drexler H.G., Fleckenstein D., Zaborski M., Armstrong A., Sims J.E., Lyman S.D.
    Leukemia 15:1286-1292(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION (ISOFORM 1), TISSUE SPECIFICITY.
• positive regulation of cell population proliferation Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells."
    Reche P.A., Soumelis V., Gorman D.M., Clifford T., Liu M.-R., Travis M., Zurawski S.M., Johnston J., Liu Y.-J., Spits H., de Waal Malefyt R., Kastelein R.A., Bazan J.F.
    J. Immunol. 167:336-343(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, FUNCTION (ISOFORM 1).
• positive regulation of chemokine (C-C motif) ligand 1 production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
    Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G.
    J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ALLERGIC INFLAMMATION (ISOFORM 1), INDUCTION.
• positive regulation of chemokine production Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells."
    Reche P.A., Soumelis V., Gorman D.M., Clifford T., Liu M.-R., Travis M., Zurawski S.M., Johnston J., Liu Y.-J., Spits H., de Waal Malefyt R., Kastelein R.A., Bazan J.F.
    J. Immunol. 167:336-343(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, FUNCTION (ISOFORM 1).
• positive regulation of cytokine-mediated signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells."
    Reche P.A., Soumelis V., Gorman D.M., Clifford T., Liu M.-R., Travis M., Zurawski S.M., Johnston J., Liu Y.-J., Spits H., de Waal Malefyt R., Kastelein R.A., Bazan J.F.
    J. Immunol. 167:336-343(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, FUNCTION (ISOFORM 1).
• positive regulation of granulocyte colony-stimulating factor production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
    Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G.
    J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ALLERGIC INFLAMMATION (ISOFORM 1), INDUCTION.
• positive regulation of inflammatory response Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
    Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G.
    J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ALLERGIC INFLAMMATION (ISOFORM 1), INDUCTION.
• positive regulation of interleukin-10 production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
    Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G.
    J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ALLERGIC INFLAMMATION (ISOFORM 1), INDUCTION.
• positive regulation of interleukin-13 production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
    Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G.
    J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ALLERGIC INFLAMMATION (ISOFORM 1), INDUCTION.
• positive regulation of interleukin-5 production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
    Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G.
    J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ALLERGIC INFLAMMATION (ISOFORM 1), INDUCTION.
• positive regulation of interleukin-5 secretion Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
    Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G.
    J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ALLERGIC INFLAMMATION (ISOFORM 1), INDUCTION.
• positive regulation of interleukin-6 production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
    Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G.
    J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ALLERGIC INFLAMMATION (ISOFORM 1), INDUCTION.
• positive regulation of mast cell activation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
    Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G.
    J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ALLERGIC INFLAMMATION (ISOFORM 1), INDUCTION.
• positive regulation of receptor signaling pathway via STAT Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide."
    Bjerkan L., Schreurs O., Engen S.A., Jahnsen F.L., Baekkevold E.S., Blix I.J., Schenck K.
    Mucosal Immunol. 8:49-56(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORM 2), FUNCTION (ISOFORM 2).
  • Ref.1

    "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells."
    Reche P.A., Soumelis V., Gorman D.M., Clifford T., Liu M.-R., Travis M., Zurawski S.M., Johnston J., Liu Y.-J., Spits H., de Waal Malefyt R., Kastelein R.A., Bazan J.F.
    J. Immunol. 167:336-343(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, FUNCTION (ISOFORM 1).
• positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKBInferred from direct assayⁱ
  • Ref.2

    "Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation."
    Quentmeier H., Drexler H.G., Fleckenstein D., Zaborski M., Armstrong A., Sims J.E., Lyman S.D.
    Leukemia 15:1286-1292(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION (ISOFORM 1), TISSUE SPECIFICITY.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• cytokine activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells."
    Reche P.A., Soumelis V., Gorman D.M., Clifford T., Liu M.-R., Travis M., Zurawski S.M., Johnston J., Liu Y.-J., Spits H., de Waal Malefyt R., Kastelein R.A., Bazan J.F.
    J. Immunol. 167:336-343(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, FUNCTION (ISOFORM 1).
• interleukin-7 receptor binding Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.2

    "Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation."
    Quentmeier H., Drexler H.G., Fleckenstein D., Zaborski M., Armstrong A., Sims J.E., Lyman S.D.
    Leukemia 15:1286-1292(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION (ISOFORM 1), TISSUE SPECIFICITY.

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MFPFALLYVL SVSFRKIFIL QLVGLVLTYD FTNCDFEKIK AAYLSTISKD 
        60         70         80         90        100
LITYMSGTKS TEFNNTVSCS NRPHCLTEIQ SLTFNPTAGC ASLAKEMFAM 
       110        120        130        140        150
KTKAALAIWC PGYSETQINA TQAMKKRRKR KVTTNKCLEQ VSQLQGLWRR 

FNRPLLKQQ                                              

        10         20         30         40         50
MFAMKTKAAL AIWCPGYSET QINATQAMKK RRKRKVTTNK CLEQVSQLQG 
        60 
LWRRFNRPLL KQQ                                         

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
2. Human chromosome 5
   Human chromosome 5: entries, gene names and cross-references to MIM
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references