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Entry version 159 (16 Oct 2019)
Sequence version 2 (03 Nov 2009)
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Protein

Insulin-like receptor

Gene

daf-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage (PubMed:9252323, PubMed:9790527, PubMed:11743719, PubMed:24332851, PubMed:28853436, PubMed:21334311). Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1 (PubMed:11274053). Required for germline progenitor proliferation during larval development (PubMed:22278922). Required for the response to environmental stimuli such as food, pheromone, and temperature (PubMed:24332851). Negatively regulates resistance to UV and oxidative stress (PubMed:24332851). Role in immune function and pathogen resistance (PubMed:18782349). Negatively regulates autophagy (PubMed:22560223). Regulates daf-18/PTEN protein levels (PubMed:23995781).10 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Autophosphorylation activates the kinase activity (By similarity). Interaction with shc-1 may inhibit its activity (PubMed:18832074).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1282ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1388Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1252 – 1260ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processCarbohydrate metabolism, Immunity, Innate immunity
LigandATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-109704 PI3K Cascade
R-CEL-1257604 PIP3 activates AKT signaling
R-CEL-1433557 Signaling by SCF-KIT
R-CEL-1433559 Regulation of KIT signaling
R-CEL-186763 Downstream signal transduction
R-CEL-186797 Signaling by PDGF
R-CEL-5673001 RAF/MAP kinase cascade
R-CEL-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-CEL-9607240 FLT3 Signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q968Y9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin-like receptorBy similarity (EC:2.7.10.1)
Short name:
IRBy similarity
Alternative name(s):
Abnormal dauer formation protein 21 Publication
Cleaved into the following 2 chains:
Insulin-like receptor subunit alphaBy similarity
Insulin-like receptor subunit betaBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:daf-2Imported
ORF Names:Y55D5A.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
Y55D5A.5a ; CE46852 ; WBGene00000898 ; daf-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini970 – 1183ExtracellularSequence analysisAdd BLAST214
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1184 – 1204HelicalSequence analysisAdd BLAST21
Topological domaini1205 – 1846CytoplasmicSequence analysisAdd BLAST642

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Accumulation of fat, pigmented intestine, increased lifespan, increased dauer formation and increased resistance to pathogens. Severe loss of function mutants display recessive early embryonic lethality (PubMed:9252323, PubMed:9790527, PubMed:11274053, PubMed:18782349, PubMed:18245374). RNAi-mediated knockdown in germline, hypodermis, intestine or in muscles causes increased lifespan (PubMed:24332851, PubMed:28853436). RNAi-mediated knockdown in a ncl-1 mutant (e1942) background reduces the increased longevity of the daf-2 single mutant, and reduces the increased ribosomal protein synthesis in the ncl-1 single mutant (e1942) (PubMed:28853436). RNAi-mediated knockdown in adults causes an increase in lgg-1 positive autophagic vesicles (PubMed:22560223). RNAi-mediated knockdown results in an increase in the number of muscle arm extensions (PubMed:18436204).9 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi146C → Y: Embronically lethal. 1 Publication1
Mutagenesisi383G → E in m41; temperature-sensitive. No visible change in dauer formation and adult lifepspan at 15 degrees Celsius, but undergoes dauer formation at 25 degrees Celsius and has increased lifespan. Slight decrease in NaCl avoidance behavior after exposure to NaCl under starvation conditions. Normal number of muscle membrane extensions. 3 Publications1
Mutagenesisi401C → Y: Dauer formation; when associated with L-470. 1 Publication1
Mutagenesisi469C → S: Dauer formation above 20 degrees Celsius. 1 Publication1
Mutagenesisi470P → L: Dauer formation; when associated with Y-401. 1 Publication1
Mutagenesisi547G → S in m596; increases the number of muscle membrane extensions during larval development. 1 Publication1
Mutagenesisi573S → L: Dauer formation above 25 degrees Celsius. 1 Publication1
Mutagenesisi580A → T: Dauer formation above 26 degrees Celsius. 1 Publication1
Mutagenesisi648D → N: Dauer formation above 25 degrees Celsius. 1 Publication1
Mutagenesisi1045C → Y in m577; normal number of muscle membrane extensions. 1 Publication1
Mutagenesisi1374D → N in sa219; dauer formation above 20 degrees Celsius. Normal NaCl avoidance behavior after exposure to NaCl under starvation conditions. 2 Publications1
Mutagenesisi1434P → L in e1391; dauer formation above 20 degrees Celsius and increased lifespan. Increases the number of muscle membrane extensions during larval development. 3 Publications1
Mutagenesisi1465P → S in e1370; extended lifespan. Accumulates fat and undergoes dauer formation above 25 degrees Celsius. Pigmented intestine and increased resistance to bacterial pathogens, UV, high temperature and paraquat treatment. Reduced number of germline progenitors during larval development and proliferation of germline stem cells. Fails to avoid NaCl after exposure to NaCl under starvation conditions. Increases the number of muscle membrane extensions during larval development. Overextension of PML neuron axons. Reduces nucleoli size in hypodermal and pharyngeal muscle cells. 13 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – ?Sequence analysis
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000386619? – 966Insulin-like receptor subunit alphaSequence analysis
ChainiPRO_0000386620970 – 1846Insulin-like receptor subunit betaSequence analysisAdd BLAST877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi371 ↔ 386By similarity
Disulfide bondi393 ↔ 401By similarity
Disulfide bondi397 ↔ 410By similarity
Disulfide bondi413 ↔ 422By similarity
Disulfide bondi426 ↔ 438By similarity
Glycosylationi453N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi469 ↔ 483By similarity
Disulfide bondi486 ↔ 490By similarity
Glycosylationi518N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi615 ↔ 646By similarity
Glycosylationi652N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi671N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi696N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi706InterchainBy similarity
Glycosylationi1017N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1047N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1078N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1087N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1093N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q968Y9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q968Y9

PeptideAtlas

More...
PeptideAtlasi
Q968Y9

PRoteomics IDEntifications database

More...
PRIDEi
Q968Y9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q968Y9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000898 Expressed in 5 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q968Y9 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain (By similarity).

Interacts (via cytoplasmic domain) with shc-1 (PID domain) (PubMed:18832074).

Interacts (via kinase domain) with daf-18 (via C-terminus) (PubMed:23995781).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
40655, 165 interactors

STRING: functional protein association networks

More...
STRINGi
6239.Y55D5A.5a

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini775 – 869Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST95
Domaini969 – 1067Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini1077 – 1179Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST103
Domaini1246 – 1528Protein kinasePROSITE-ProRule annotationAdd BLAST283

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4258 Eukaryota
COG0515 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170078

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000151241

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q968Y9

KEGG Orthology (KO)

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KOi
K04527

Database for complete collections of gene phylogenies

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PhylomeDBi
Q968Y9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits
cd00064 FU, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 3 hits
3.80.20.20, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00757 Furin-like, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF01030 Recep_L_domain, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q968Y9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRMNIVRCR RRHKILENLE EENLGPSCSS TTSTTAATEA LGTTTEDMRL
60 70 80 90 100
KQQRSSSRAT EHDIVDGNHH DDEHITMRRL RLVKNSRTRR RTTPDSSMDC
110 120 130 140 150
YEENPPSQKT SINYSWISKK SSMTSLMLLL LFAFVQPCAS IVEKRCGPID
160 170 180 190 200
IRNRPWDIKP QWSKLGDPNE KDLAGQRMVN CTVVEGSLTI SFVLKHKTKA
210 220 230 240 250
QEEMHRSLQP RYSQDEFITF PHLREITGTL LVFETEGLVD LRKIFPNLRV
260 270 280 290 300
IGGRSLIQHY ALIIYRNPDL EIGLDKLSVI RNGGVRIIDN RKLCYTKTID
310 320 330 340 350
WKHLITSSIN DVVVDNAAEY AVTETGLMCP RGACEEDKGE SKCHYLEEKN
360 370 380 390 400
QEQGVERVQS CWSNTTCQKS CAYDRLLPTK EIGPGCDANG DRCHDQCVGG
410 420 430 440 450
CERVNDATAC HACKNVYHKG KCIEKCDAHL YLLLQRRCVT REQCLQLNPV
460 470 480 490 500
LSNKTVPIKA TAGLCSDKCP DGYQINPDDH RECRKCVGKC EIVCEINHVI
510 520 530 540 550
DTFPKAQAIR LCNIIDGNLT IEIRGKQDSG MASELKDIFA NIHTITGYLL
560 570 580 590 600
VRQSSPFISL NMFRNLRRIE AKSLFRNLYA ITVFENPNLK KLFDSTTDLT
610 620 630 640 650
LDRGTVSIAN NKMLCFKYIK QLMSKLNIPL DPIDQSEGTN GEKAICEDMA
660 670 680 690 700
INVSITAVNA DSVFFSWPSF NITDIDQRKF LGYELFFKEV PRIDENMTIE
710 720 730 740 750
EDRSACVDSW QSVFKQYYET SNGEPTPDIF MDIGPRERIR PNTLYAYYVA
760 770 780 790 800
TQMVLHAGAK NGVSKIGFVR TSYYTPDPPT LALAQVDSDA IHITWEAPLQ
810 820 830 840 850
PNGDLTHYTI MWRENEVSPY EEAEKFCTDA STPANRQHTK DPKETIVADK
860 870 880 890 900
PVDIPSSRTV APTLLTMMGH EDQQKTCAAT PGCCSCSAIE ESSEQNKKKR
910 920 930 940 950
PDPMSAIESS AFENKLLDEV LMPRDTMRVR RSIEDANRVS EELEKAENLG
960 970 980 990 1000
KAPKTLGGKK PLIHISKKKP SSSSTTSTPA PTIASMYALT RKPTTVPGTR
1010 1020 1030 1040 1050
IRLYEIYEPL PGSWAINVSA LALDNSYVIR NLKHYTLYAI SLSACQNMTV
1060 1070 1080 1090 1100
PGASCSISHR AGALKRTKHI TDIDKVLNET IEWRFMNNSQ QVNVTWDPPT
1110 1120 1130 1140 1150
EVNGGIFGYV VKLKSKVDGS IVMTRCVGAK RGYSTRNQGV LFQNLADGRY
1160 1170 1180 1190 1200
FVSVTATSVH GAGPEAESSD PIVVMTPGFF TVEIILGMLL VFLILMSIAG
1210 1220 1230 1240 1250
CIIYYYIQVR YGKKVKALSD FMQLNPEYCV DNKYNADDWE LRQDDVVLGQ
1260 1270 1280 1290 1300
QCGEGSFGKV YLGTGNNVVS LMGDRFGPCA IKINVDDPAS TENLNYLMEA
1310 1320 1330 1340 1350
NIMKNFKTNF IVKLYGVIST VQPAMVVMEM MDLGNLRDYL RSKREDEVFN
1360 1370 1380 1390 1400
ETDCNFFDII PRDKFHEWAA QICDGMAYLE SLKFCHRDLA ARNCMINRDE
1410 1420 1430 1440 1450
TVKIGDFGMA RDLFYHDYYK PSGKRMMPVR WMSPESLKDG KFDSKSDVWS
1460 1470 1480 1490 1500
FGVVLYEMVT LGAQPYIGLS NDEVLNYIGM ARKVIKKPEC CENYWYKVMK
1510 1520 1530 1540 1550
MCWRYSPRDR PTFLQLVHLL AAEASPEFRD LSFVLTDNQM ILDDSEALDL
1560 1570 1580 1590 1600
DDIDDTDMND QVVEVAPDVE NVEVQSDSER RNTDSIPLKQ FKTIPPINAT
1610 1620 1630 1640 1650
TSHSTISIDE TPMKAKQREG SLDEEYALMN HSGGPSDAEV RTYAGDGDYV
1660 1670 1680 1690 1700
ERDVRENDVP TRRNTGASTS SYTGGGPYCL TNRGGSNERG AGFGEAVRLT
1710 1720 1730 1740 1750
DGVGSGHLND DDYVEKEISS MDTRRSTGAS SSSYGVPQTN WSGNRGATYY
1760 1770 1780 1790 1800
TSKAQQAATA AAAAAAALQQ QQNGGRGDRL TQLPGTGHLQ STRGGQDGDY
1810 1820 1830 1840
IETEPKNYRN NGSPSRNGNS RDIFNGRSAF GENEHLIEDN EHHPLV
Length:1,846
Mass (Da):207,124
Last modified:November 3, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i230B28322FF0F126
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0K3AUY1A0A0K3AUY1_CAEEL
Receptor protein-tyrosine kinase
daf-2 CELE_Y55D5A.5, Y55D5A.5
1,928Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ARZ1A0A0K3ARZ1_CAEEL
Receptor protein-tyrosine kinase
daf-2 CELE_Y55D5A.5, Y55D5A.5
1,770Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AXA0A0A0K3AXA0_CAEEL
Receptor protein-tyrosine kinase
daf-2 CELE_Y55D5A.5, Y55D5A.5
1,799Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AUA1A0A0K3AUA1_CAEEL
Uncharacterized protein
daf-2 CELE_Y55D5A.5, Y55D5A.5
1,036Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ARE8A0A0K3ARE8_CAEEL
Protein kinase domain-containing pr...
daf-2 CELE_Y55D5A.5, Y55D5A.5
672Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti838H → R in AAC47715 (PubMed:9252323).Curated1
Sequence conflicti1313K → Q in AAC47715 (PubMed:9252323).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF012437 mRNA Translation: AAC47715.1
BX284603 Genomic DNA Translation: CCD72201.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T42047

NCBI Reference Sequences

More...
RefSeqi
NP_497650.4, NM_065249.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y55D5A.5a.1; Y55D5A.5a.1; WBGene00000898
Y55D5A.5a.2; Y55D5A.5a.2; WBGene00000898

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175410

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y55D5A.5

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012437 mRNA Translation: AAC47715.1
BX284603 Genomic DNA Translation: CCD72201.2
PIRiT42047
RefSeqiNP_497650.4, NM_065249.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi40655, 165 interactors
STRINGi6239.Y55D5A.5a

PTM databases

iPTMnetiQ968Y9

Proteomic databases

EPDiQ968Y9
PaxDbiQ968Y9
PeptideAtlasiQ968Y9
PRIDEiQ968Y9

Genome annotation databases

EnsemblMetazoaiY55D5A.5a.1; Y55D5A.5a.1; WBGene00000898
Y55D5A.5a.2; Y55D5A.5a.2; WBGene00000898
GeneIDi175410
KEGGicel:CELE_Y55D5A.5

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175410
WormBaseiY55D5A.5a ; CE46852 ; WBGene00000898 ; daf-2

Phylogenomic databases

eggNOGiKOG4258 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00940000170078
HOGENOMiHOG000151241
InParanoidiQ968Y9
KOiK04527
PhylomeDBiQ968Y9

Enzyme and pathway databases

ReactomeiR-CEL-109704 PI3K Cascade
R-CEL-1257604 PIP3 activates AKT signaling
R-CEL-1433557 Signaling by SCF-KIT
R-CEL-1433559 Regulation of KIT signaling
R-CEL-186763 Downstream signal transduction
R-CEL-186797 Signaling by PDGF
R-CEL-5673001 RAF/MAP kinase cascade
R-CEL-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-CEL-9607240 FLT3 Signaling
SignaLinkiQ968Y9

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q968Y9

Gene expression databases

BgeeiWBGene00000898 Expressed in 5 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiQ968Y9 baseline and differential

Family and domain databases

CDDicd00063 FN3, 2 hits
cd00064 FU, 1 hit
Gene3Di2.60.40.10, 3 hits
3.80.20.20, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF00757 Furin-like, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF01030 Recep_L_domain, 2 hits
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINSR_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q968Y9
Secondary accession number(s): B5QS63, O16131
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: October 16, 2019
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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