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Entry version 157 (07 Apr 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Cadherin-related hmr-1

Gene

hmr-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cadherins are calcium-dependent cell adhesion proteins (PubMed:25938815, PubMed:25850673). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:25938815, PubMed:25850673). Required for adherens junction assembly and connecting adherens junctions to the cytoskeleton (PubMed:26412237).3 Publications
Isoform a is required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567, PubMed:12847081). Required for proper localization of other junctional components, such as hmp-1, hmp-2, jac-1 and pac-1 (PubMed:9531567, PubMed:25938815). Recruitment of pac-1 is required to establish cell polarity, independent of its role in cell adhesion (PubMed:25938815). Required for primodial germ cell ingression and adherence to endodermal cells during gastrulation (PubMed:20515680, PubMed:22675206).5 Publications
Isoform b is involved in axonal guidance in a subset of motor neurons.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion, Differentiation, Neurogenesis
LigandCalcium

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q967F4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin-related hmr-1
Alternative name(s):
Protein Hammerhead
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hmr-1
ORF Names:W02B9.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
W02B9.1a ; CE46853 ; WBGene00001980 ; hmr-1
W02B9.1b ; CE30357 ; WBGene00001980 ; hmr-1
W02B9.1c ; CE42574 ; WBGene00001980 ; hmr-1
W02B9.1d ; CE46949 ; WBGene00001980 ; hmr-1
W02B9.1e ; CE47071 ; WBGene00001980 ; hmr-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 2779ExtracellularSequence analysisAdd BLAST2760
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2780 – 2800HelicalSequence analysisAdd BLAST21
Topological domaini2801 – 2920CytoplasmicSequence analysisAdd BLAST120

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethal (PubMed:20689042, PubMed:25850673). Hammerhead phenotype characterized by morphogenetic defects before the start of body elongation, due to improper closure of hypodermis (PubMed:9531567, PubMed:25850673). Humpback phenotype with embryos containing dorsal humps (PubMed:20689042). Embryos also exhibit defective actin structures including loss of actin at cell-cell junctions and detached thick actin bundles called circumferential filament bundles that insert at right angles to junctional actin (PubMed:20689042). RNAi-mediated knockdown results in ingression defects in primordial germ cells (PubMed:22675206).4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2845K → R: No obvious phenotype. 1 Publication1
Mutagenesisi2874K → R: No obvious phenotype. No sumoylation; when associated with R-2882 and R-2884. 1 Publication1
Mutagenesisi2882K → R: No sumoylation; when associated with R-2874 and R-2884. 1 Publication1
Mutagenesisi2884K → R: No sumoylation; when associated with R-2874 and R-2882. 1 Publication1
Mutagenesisi2909S → A: Results in no phosphorylation at S-2909, T-2912, S-2915 and S-2918. Retains ability to bind to hmp-2. 1 Publication1
Mutagenesisi2912T → A: Results in no phosphorylation at S-2915 and S-2918. Upon phosphorylation by kin-19, there is increased binding to hmp-2. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000026864620 – 2920Cadherin-related hmr-1Add BLAST2901

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi508N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi658N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi685N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi715N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi826N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1646N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1935N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2224N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2232N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2250 ↔ 2261By similarity
Disulfide bondi2255 ↔ 2270By similarity
Disulfide bondi2272 ↔ 2282By similarity
Glycosylationi2307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2332N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2452 ↔ 2478By similarity
Disulfide bondi2501 ↔ 2515By similarity
Disulfide bondi2517 ↔ 2526By similarity
Glycosylationi2623N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2839Phosphoserine1 Publication1
Modified residuei2909Phosphoserine1 Publication1
Modified residuei2912Phosphothreonine1 Publication1
Modified residuei2915Phosphoserine1 Publication1
Modified residuei2918Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at T-2912 increases the binding affinity for hmp-2.1 Publication
Sumoylated. Sumoylation prevents accumulation at adherens junctions and decreases the binding affinity for hmp-2.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q967F4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q967F4

PeptideAtlas

More...
PeptideAtlasi
Q967F4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q967F4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform b is neuron-specific (PubMed:11790304). Isoform a is located in epidermal cells (at protein level) (PubMed:9531567).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform a is present in all embryonic blastomeres at early stages of development (PubMed:9531567, PubMed:25938815). Expressed throughout gastrulation and in primordial germ cells (PubMed:22675206).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001980, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer in solution (PubMed:20689042). Isoform a is a component of a core catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2; the complex localizes to adherens junctions (PubMed:20689042, PubMed:25850673). Isoform a interacts with hmp-2; the interaction is direct (PubMed:10952315, PubMed:20689042, PubMed:25850673, PubMed:26412237). Isoform a interacts (via intracellular domain) with jac-1 (PubMed:12847081, PubMed:25938815).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
38416, 10 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-499, Catenin-Cadherin complex

Database of interacting proteins

More...
DIPi
DIP-56285N

Protein interaction database and analysis system

More...
IntActi
Q967F4, 10 interactors

STRING: functional protein association networks

More...
STRINGi
6239.W02B9.1b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12920
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q967F4

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini322 – 422Cadherin 1PROSITE-ProRule annotationAdd BLAST101
Domaini425 – 530Cadherin 2PROSITE-ProRule annotationAdd BLAST106
Domaini531 – 642Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini643 – 747Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini749 – 865Cadherin 5PROSITE-ProRule annotationAdd BLAST117
Domaini871 – 979Cadherin 6PROSITE-ProRule annotationAdd BLAST109
Domaini980 – 1093Cadherin 7PROSITE-ProRule annotationAdd BLAST114
Domaini1097 – 1211Cadherin 8PROSITE-ProRule annotationAdd BLAST115
Domaini1212 – 1335Cadherin 9PROSITE-ProRule annotationAdd BLAST124
Domaini1336 – 1436Cadherin 10PROSITE-ProRule annotationAdd BLAST101
Domaini1438 – 1546Cadherin 11PROSITE-ProRule annotationAdd BLAST109
Domaini1548 – 1661Cadherin 12PROSITE-ProRule annotationAdd BLAST114
Domaini1662 – 1772Cadherin 13PROSITE-ProRule annotationAdd BLAST111
Domaini1772 – 1874Cadherin 14PROSITE-ProRule annotationAdd BLAST103
Domaini2246 – 2283EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini2284 – 2478Laminin G-likePROSITE-ProRule annotationAdd BLAST195
Domaini2492 – 2527EGF-like 2PROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic domain is necessary for binding to jac-1.1 Publication

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000168029

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000347_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q967F4

Identification of Orthologs from Complete Genome Data

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OMAi
HLSCSSY

Database of Orthologous Groups

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OrthoDBi
6237at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q967F4

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR000233, Cadherin_cytoplasmic-dom
IPR013320, ConA-like_dom_sf
IPR018247, EF_Hand_1_Ca_BS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR001791, Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028, Cadherin, 8 hits
PF01049, Cadherin_C, 1 hit
PF02210, Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112, CA, 13 hits
SM00181, EGF, 2 hits
SM00282, LamG, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49313, SSF49313, 13 hits
SSF49899, SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00232, CADHERIN_1, 8 hits
PS50268, CADHERIN_2, 15 hits
PS00018, EF_HAND_1, 1 hit
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS50025, LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform b (identifier: Q967F4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWNILLILL ISNLDEVLAK TLLKLPSNAP PGWLISDLQF QNLIGDSEIA
60 70 80 90 100
TLQPSIFSTN FEVEDGYRII TNTTVTQFHG ELFELFLNVK EQNFQRLVTL
110 120 130 140 150
HVYVDPRGTS QQPATFLSTV YHATVYTSQQ PGSTVVFSKP ITVRNRKNFV
160 170 180 190 200
ISPISKIDKI SKYSSPFSVM TRGKSVDIVM MKQKLEEDDI TRHVIFLGAF
210 220 230 240 250
TEKTGEMIAQ TKVIIDVIDS GDVHFLLKSK KSIAKFASAI PANSTVFDVE
260 270 280 290 300
KRNLSEPLLF HLEEPSRFFK IDQFSGRVST VLPVGYGTYH IHVVARNQKK
310 320 330 340 350
QRSDAWLEIS VKKEQKLEPM TSSRSRRHLD DIVFRIPENT TMEDIEKKDM
360 370 380 390 400
KIPLFAGETI GEINVAKEWL KIDDDGKIHL LKPLNYEKTS SIIATVPING
410 420 430 440 450
LQSTRTQTIR IHVADIDEPP SFVNSPLPML AVVPLNPTIG RIVYQFVARD
460 470 480 490 500
EHGDGDSNVL YKTIDVIPAG SFIVDPKSGV VRTGWSKYER GDTYRISAQA
510 520 530 540 550
MDLSPSDNTT SQLSEVAILE ILADERPPQF AKQEYEVTVS EDNLVDYSVV
560 570 580 590 600
DVKAQSFRSF EDGRSKGPIT YSLEGDTPED ETKWFRIDPS TGIIHLTRLL
610 620 630 640 650
DFDDPALPKL HKLKVTARED NRESHVDLTI RIDDVNDNVP TFTRPLYTAQ
660 670 680 690 700
VREDIPLNQT ILKVTAVDKD TGDNSRITYS VDNHNFSINS NGEISAKVRL
710 720 730 740 750
DADQLNERHF VYRFNVTARD HGEPVSLSSS AMIHIRTENT NDESAVFLPT
760 770 780 790 800
SQYTAFVAED AQGGTPVIQI QARDADRDEV TYSFMDKNGR STQKMNLFSI
810 820 830 840 850
DEHTGLVKLR HGVSAADLAE AENPINLTVI VQDDGSCCVY PSKTHTSYAT
860 870 880 890 900
LLIGIEDVNN NKPEFPDCAK YSDIAKIMEG TYKTDPPTIV KVEATDDDSS
910 920 930 940 950
ANGDIVYSLY YTQSESRKAF VIDRQTGVLT PSPHVVFDRE TRPREDVTVK
960 970 980 990 1000
ATDRGDRPLI GFCQFSVEVV DINDNSPQFE RPSYETSVSR FEAVGTSVIT
1010 1020 1030 1040 1050
VFAFDNDAAH NAEITYSLEI DTTAGEEHQN DLDFFELVNR RSGEITLIKP
1060 1070 1080 1090 1100
IPMKTQKFIF NVIADDNGIP EALQSSAQVT LNVLDKQQKA PKWQTSPDCK
1110 1120 1130 1140 1150
PGITVDENVE LNKVILRCRA VSSGDSRNSD VIYKLTASGG PGNKAESKFR
1160 1170 1180 1190 1200
QFNKFENGNE WVEVVIMEGL DYEQVNNYTL TLTATDMTSR VASTKTFVVE
1210 1220 1230 1240 1250
VRDVNDVVPQ FTVDLFTGTI DEEMTPNEHL EKTNGKPIVT VKAIDTDSDG
1260 1270 1280 1290 1300
PQNEVHYRIV GEANGEETKH FRIDELTGEI FPNEKFDREK IDMYILTVEA
1310 1320 1330 1340 1350
SDRSVSALPG ANGPNKDNVK VQIVINDVND NAPSFEEQKY IGRVKESEGE
1360 1370 1380 1390 1400
GHDVITIKAH DLDKHSNLRY HLIGAGGGRI PFGVRTDSGT IFVKEPLDFE
1410 1420 1430 1440 1450
ASDQYHLVLI ASDGRHNATT NVYIHIEDVN DNAPQFEQQK YATTVIEEDV
1460 1470 1480 1490 1500
DIPKVLFNVH ATDADQDEKS SRIVYRLEGQ GADEVFRIGK YSGTIELVKA
1510 1520 1530 1540 1550
LDRDPPAGVP SWNFVVQAID DDGNGLVGYA DVQVNVRDIN DNSPIFPERL
1560 1570 1580 1590 1600
FGYIEENREP IHSDGVYFMD VQARDFDDPT TENANIEYGI VRNKLINGES
1610 1620 1630 1640 1650
VFRIDQNTGK IFAMRSLDRE ISSEREFIIE VRANDRGVPS REGFANVTIK
1660 1670 1680 1690 1700
VTDMNDNAPF FEKTRYEGSV EETAPIGAAV MSFSAFDADE EAKDNVFTYQ
1710 1720 1730 1740 1750
LSEESDYFYV TTDKDSKQSS VGVLRVKQPL DYEDVTQRDG FHLGIRVSDG
1760 1770 1780 1790 1800
RHDAEAAVHV ALVDRNDHAP HIHGATEHRV REDVPRGTSI GRYTATDRDA
1810 1820 1830 1840 1850
GDTARFRINR QSDPKRQFTI DQDGTLRVAH TLDREDIAVY NLIIEAYDNS
1860 1870 1880 1890 1900
NNIGRQMVAV YLQDVNDNGP EPYTVPRPCI FRENTPVNQL GTCEIRATDR
1910 1920 1930 1940 1950
DTAEFGPPFT MEVSPSFKYS QYLNVIFNAN GDGGNGSMTI TPLQEFDREA
1960 1970 1980 1990 2000
PVPGKILEIP LILADRAGRR NEASVHVIIG DLNDNTMHDG RMTIHVNSYL
2010 2020 2030 2040 2050
GRLKETVIGR VYVDDADDWD LGDKTFSWKD SRPGFELSDK GSITMAGEMA
2060 2070 2080 2090 2100
AGTYTMSANV HDNARDEDAV GYVTVIVNAV PQIAFDNQGS VQLLIAEETP
2110 2120 2130 2140 2150
LQLPDDFIRA DSNGQSLMDT FKQEMTAYMG GDVTVDVFSV QVGIATLQTR
2160 2170 2180 2190 2200
DVPVLNVRFN ARGSTYRDTA QLNGLIAAHR ADLQRKLNVE IVGVGIDMCK
2210 2220 2230 2240 2250
FTQCDAGCQT LNSADYDGIV VSANSTVIVG VNATSRDDCT CPVWRAPPAC
2260 2270 2280 2290 2300
QHSLCHNDGV CHNTNPGFFC ECRNDGLKGA RCQGTTRSFG GNGFAWYKPM
2310 2320 2330 2340 2350
PACTSLNISF SFMTTQSDAL LFYNGPLETL RNDTHIEYSD YIFIQLRGGR
2360 2370 2380 2390 2400
ISLEVSMNGQ SRSSLEVAST ALNDGTWHDI SVNQEGKRVE LVVDNCRFLG
2410 2420 2430 2440 2450
AGADDSSCRA ELYTPDDDER LNIVTPVQIG GLAPLSGQDY PQTIPRAGLN
2460 2470 2480 2490 2500
GCVRNLNVNG DQYDLATPAF EQNSEKGCRL WGATCDSNSV DSLNHCIHGD
2510 2520 2530 2540 2550
CFADVQGSGA MVAKCVCDPG WGGARCERRM EWIQFAQGAF IEYSPRIAFP
2560 2570 2580 2590 2600
EQVSDIELLF ISGKVNGAPA ELSFGTDSQQ SYVSTNLESG QNGVTAAGKF
2610 2620 2630 2640 2650
DIGTGGRRAR QELRVSEVLL KENASYWLQF TRNPTRASLS IDNAYTVSTQ
2660 2670 2680 2690 2700
LDKGEPFSLQ VNQITLGTQG QNKGFQGCIG TYRWSKQNLP LKRGGAMDEN
2710 2720 2730 2740 2750
EESIVSISNM AGVQDGCDLR ITCADLPAGY CGGSFVCVDF WKGPFCTCND
2760 2770 2780 2790 2800
GANAILGDDG QVVGCGETLA VSKLGISSPA IILILVSLAL LILLVMMMVV
2810 2820 2830 2840 2850
YTRRSPGAFE NVRPEEMNRD NLRQYGVEGG GEADNDQYSM AGLRKPVMPL
2860 2870 2880 2890 2900
DTGMGPAIGG HPPHYPPRGM APPKDDHELN SKIKDLETDQ NAAPYDELRI
2910 2920
YDDERDNISV VTLESIESAQ
Length:2,920
Mass (Da):323,914
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E0D4C8FD24694FB
GO
Isoform a (identifier: Q967F4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1651: Missing.
     1652-1805: TDMNDNAPFF...TDRDAGDTAR → MQKRRCTWHS...DPSNPMYNFS

Show »
Length:1,269
Mass (Da):138,910
Checksum:i4EB6E41F25D8ED56
GO
Isoform c (identifier: Q967F4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1747: Missing.
     1748-1805: SDGRHDAEAA...TDRDAGDTAR → MANFWLFSLH...KKKKKKKKKK

Show »
Length:1,173
Mass (Da):128,592
Checksum:i659345A53CE5FBEB
GO
Isoform d (identifier: Q967F4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1856: Missing.

Show »
Length:1,064
Mass (Da):115,740
Checksum:iF65682546EF95939
GO
Isoform e (identifier: Q967F4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1986: Missing.

Show »
Length:934
Mass (Da):101,431
Checksum:i4F9BB2314088B702
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB94553 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0441521 – 1986Missing in isoform e. CuratedAdd BLAST1986
Alternative sequenceiVSP_0441511 – 1856Missing in isoform d. CuratedAdd BLAST1856
Alternative sequenceiVSP_0441501 – 1747Missing in isoform c. CuratedAdd BLAST1747
Alternative sequenceiVSP_0219781 – 1651Missing in isoform a. 1 PublicationAdd BLAST1651
Alternative sequenceiVSP_0219791652 – 1805TDMND…GDTAR → MQKRRCTWHSSIATTTRHTF TEPQNTESERTCHVEQALDD TRQRIGMPETRQGRSSRGNC VIFGSSKRLWVTLLGFCFVL STLIGGAEAFTDLSLPFGLE PSVAKSRFSSLVGGVRARDI HVFVMKNISEDTPVGTVLET FKAHDPSNPMYNFS in isoform a. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_0441531748 – 1805SDGRH…GDTAR → MANFWLFSLHPKLTRWVIRW ICEGEASPLPLLILIYNGNN KCNGVKKKKKKKKKKKKK in isoform c. CuratedAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF016854 mRNA Translation: AAB94553.1 Different initiation.
AJ307058 mRNA Translation: CAC38842.1
Z82064 Genomic DNA Translation: CAB61036.2
Z82064, AL032638, Z82093 Genomic DNA Translation: CAD27611.1
Z82064 Genomic DNA Translation: CAQ48404.1
Z82064 Genomic DNA Translation: CCF23411.1
Z82064 Genomic DNA Translation: CCF23412.1

NCBI Reference Sequences

More...
RefSeqi
NP_001021649.2, NM_001026478.3
NP_001021650.1, NM_001026479.2 [Q967F4-1]
NP_001129794.1, NM_001136322.1
NP_001251561.1, NM_001264632.1 [Q967F4-4]
NP_001251562.1, NM_001264633.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
W02B9.1a.1; W02B9.1a.1; WBGene00001980 [Q967F4-2]
W02B9.1a.2; W02B9.1a.2; WBGene00001980 [Q967F4-2]
W02B9.1a.3; W02B9.1a.3; WBGene00001980 [Q967F4-2]
W02B9.1b.1; W02B9.1b.1; WBGene00001980 [Q967F4-1]
W02B9.1b.2; W02B9.1b.2; WBGene00001980 [Q967F4-1]
W02B9.1c.1; W02B9.1c.1; WBGene00001980 [Q967F4-3]
W02B9.1c.2; W02B9.1c.2; WBGene00001980 [Q967F4-3]
W02B9.1d.1; W02B9.1d.1; WBGene00001980 [Q967F4-4]
W02B9.1d.2; W02B9.1d.2; WBGene00001980 [Q967F4-4]
W02B9.1e.1; W02B9.1e.1; WBGene00001980 [Q967F4-5]
W02B9.1e.2; W02B9.1e.2; WBGene00001980 [Q967F4-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
173007

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_W02B9.1

UCSC genome browser

More...
UCSCi
W02B9.1b, c. elegans [Q967F4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016854 mRNA Translation: AAB94553.1 Different initiation.
AJ307058 mRNA Translation: CAC38842.1
Z82064 Genomic DNA Translation: CAB61036.2
Z82064, AL032638, Z82093 Genomic DNA Translation: CAD27611.1
Z82064 Genomic DNA Translation: CAQ48404.1
Z82064 Genomic DNA Translation: CCF23411.1
Z82064 Genomic DNA Translation: CCF23412.1
RefSeqiNP_001021649.2, NM_001026478.3
NP_001021650.1, NM_001026479.2 [Q967F4-1]
NP_001129794.1, NM_001136322.1
NP_001251561.1, NM_001264632.1 [Q967F4-4]
NP_001251562.1, NM_001264633.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4R10X-ray2.30B2841-2920[»]
4R11X-ray2.79B/D/F2841-2920[»]
SMRiQ967F4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi38416, 10 interactors
ComplexPortaliCPX-499, Catenin-Cadherin complex
DIPiDIP-56285N
IntActiQ967F4, 10 interactors
STRINGi6239.W02B9.1b

PTM databases

iPTMnetiQ967F4

Proteomic databases

EPDiQ967F4
PaxDbiQ967F4
PeptideAtlasiQ967F4

Genome annotation databases

EnsemblMetazoaiW02B9.1a.1; W02B9.1a.1; WBGene00001980 [Q967F4-2]
W02B9.1a.2; W02B9.1a.2; WBGene00001980 [Q967F4-2]
W02B9.1a.3; W02B9.1a.3; WBGene00001980 [Q967F4-2]
W02B9.1b.1; W02B9.1b.1; WBGene00001980 [Q967F4-1]
W02B9.1b.2; W02B9.1b.2; WBGene00001980 [Q967F4-1]
W02B9.1c.1; W02B9.1c.1; WBGene00001980 [Q967F4-3]
W02B9.1c.2; W02B9.1c.2; WBGene00001980 [Q967F4-3]
W02B9.1d.1; W02B9.1d.1; WBGene00001980 [Q967F4-4]
W02B9.1d.2; W02B9.1d.2; WBGene00001980 [Q967F4-4]
W02B9.1e.1; W02B9.1e.1; WBGene00001980 [Q967F4-5]
W02B9.1e.2; W02B9.1e.2; WBGene00001980 [Q967F4-5]
GeneIDi173007
KEGGicel:CELE_W02B9.1
UCSCiW02B9.1b, c. elegans [Q967F4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
173007
WormBaseiW02B9.1a ; CE46853 ; WBGene00001980 ; hmr-1
W02B9.1b ; CE30357 ; WBGene00001980 ; hmr-1
W02B9.1c ; CE42574 ; WBGene00001980 ; hmr-1
W02B9.1d ; CE46949 ; WBGene00001980 ; hmr-1
W02B9.1e ; CE47071 ; WBGene00001980 ; hmr-1

Phylogenomic databases

eggNOGiKOG3594, Eukaryota
GeneTreeiENSGT00940000168029
HOGENOMiCLU_000347_1_0_1
InParanoidiQ967F4
OMAiHLSCSSY
OrthoDBi6237at2759
PhylomeDBiQ967F4

Enzyme and pathway databases

SignaLinkiQ967F4

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q967F4

Gene expression databases

BgeeiWBGene00001980, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR000233, Cadherin_cytoplasmic-dom
IPR013320, ConA-like_dom_sf
IPR018247, EF_Hand_1_Ca_BS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR001791, Laminin_G
PfamiView protein in Pfam
PF00028, Cadherin, 8 hits
PF01049, Cadherin_C, 1 hit
PF02210, Laminin_G_2, 1 hit
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 13 hits
SM00181, EGF, 2 hits
SM00282, LamG, 1 hit
SUPFAMiSSF49313, SSF49313, 13 hits
SSF49899, SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00232, CADHERIN_1, 8 hits
PS50268, CADHERIN_2, 15 hits
PS00018, EF_HAND_1, 1 hit
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS50025, LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMR1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q967F4
Secondary accession number(s): B2MZC5
, H2FLJ9, H2FLK0, O44327
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: April 7, 2021
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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