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Entry version 108 (18 Sep 2019)
Sequence version 1 (01 Feb 1997)
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Protein

Genome polyprotein

Gene

ORF1

Organism
European brown hare syndrome virus (strain GD) (Ha/LV/EBHSV/GD/1989/FR) (EBHSV-GD)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NTPase presumably plays a role in replication.By similarity
Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity).By similarity
3C-like protease processes the polyprotein: 3CLpro-RdRp (p72) is first released by autocleavage, then all other proteins are cleaved.By similarity
RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).PROSITE-ProRule annotation
Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).By similarity

Miscellaneous

Two different RNAs lead the expression of the capsid protein. One arises from the cleavage of the polyprotein translated from the genomic RNA and the other from the translation of a subgenomic RNA derived from the (-)RNA template. Capsid protein expressed from the subgenomic mRNA is produced in much larger amounts than the cleaved one (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.PROSITE-ProRule annotation EC:3.4.22.66

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1128For 3CLpro activityPROSITE-ProRule annotation1
Active sitei1145For 3CLpro activityPROSITE-ProRule annotation1
Active sitei1205For 3CLpro activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C24.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Alternative name(s):
p254
Cleaved into the following 11 chains:
NTPase (EC:3.6.1.15)
Alternative name(s):
2C-like protein
P2C
p37
Alternative name(s):
VPg
p13
3C-like protease (EC:3.4.22.66)
Short name:
3CLpro
Alternative name(s):
Calicivirin
Thiol protease P3C
p15
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
3Dpol
p58
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:ORF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEuropean brown hare syndrome virus (strain GD) (Ha/LV/EBHSV/GD/1989/FR) (EBHSV-GD)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri316979 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaCaliciviridaeLagovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiLepus europaeus (European hare) [TaxID: 9983]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003419861 – 2334Genome polyproteinAdd BLAST2334
ChainiPRO_00000369861 – 138Protein p16By similarityAdd BLAST138
ChainiPRO_0000036987139 – 334Protein p23By similarityAdd BLAST196
ChainiPRO_0000036988335 – 711NTPaseBy similarityAdd BLAST377
ChainiPRO_0000341987712 – 1108Precursor p41Add BLAST397
ChainiPRO_0000036989712 – 986Protein p29By similarityAdd BLAST275
ChainiPRO_0000341988712 – 929Protein p23/2Add BLAST218
ChainiPRO_0000341989930 – 1101Protein p18Add BLAST172
ChainiPRO_0000036990987 – 1101Viral genome-linked proteinBy similarityAdd BLAST115
ChainiPRO_00000369911102 – 12443C-like proteaseBy similarityAdd BLAST143
ChainiPRO_00000369921245 – 1760RNA-directed RNA polymeraseBy similarityAdd BLAST516
ChainiPRO_00000369941761 – 2334Capsid protein VP60By similarityAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1007O-(5'-phospho-RNA)-tyrosineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1577 ↔ 1584By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages by its own cysteine protease yield mature proteins. The protease cleaves itself from the nascent polyprotein autocatalytically. Precursor p41 can be cleaved by viral 3CLpro into protein p19 and VPg, or cleaved by host protease into protein p23/2 and protein p18 (By similarity).By similarity
VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the polyadenylated genomic and subgenomic RNAs. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei138 – 139Cleavage; by 3CLproBy similarity2
Sitei334 – 335Cleavage; by 3CLproBy similarity2
Sitei711 – 712Cleavage; by 3CLproBy similarity2
Sitei929 – 930Cleavage; by hostBy similarity2
Sitei986 – 987Cleavage; by 3CLproBy similarity2
Sitei1101 – 1102Cleavage; by 3CLproBy similarity2
Sitei1244 – 1245Cleavage; by 3CLproBy similarity2
Sitei1760 – 1761Cleavage; by 3CLproBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Disulfide bond, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q96725

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to histo-blood group antigens at surface of target cells.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96725

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini487 – 647SF3 helicasePROSITE-ProRule annotationAdd BLAST161
Domaini1102 – 1237Peptidase C24PROSITE-ProRule annotationAdd BLAST136
Domaini1488 – 1612RdRp catalyticPROSITE-ProRule annotationAdd BLAST125

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00205 rhv_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004005 Calicivirus_coat
IPR004004 Helic/Pol/Pept_Calicivir-typ
IPR000605 Helicase_SF3_ssDNA/RNA_vir
IPR014759 Helicase_SF3_ssRNA_vir
IPR027417 P-loop_NTPase
IPR000317 Peptidase_C24
IPR009003 Peptidase_S1_PA
IPR033703 Rhv-like
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
IPR029053 Viral_coat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00915 Calici_coat, 1 hit
PF03510 Peptidase_C24, 1 hit
PF00680 RdRP_1, 1 hit
PF00910 RNA_helicase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00916 2CENDOPTASE
PR00918 CALICVIRUSNS

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51894 CV_3CL_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit
PS51218 SF3_HELICASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket
Isoform Genome polyprotein (identifier: Q96725-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVASRPCGV ATSVLPAKKP LSFFTDLVGK TPPRCIRAPH TLAWPVFADL
60 70 80 90 100
DNEEESPEIC RKCGKYANGF GVFDLTDLGD VCLCSIRPQR HVGGPCCLCN
110 120 130 140 150
KQYIRACGRY CARVLKHYKA FNKVIPCLHS RQVKPVFEGE VEDLFVELGA
160 170 180 190 200
PTRMNFTEAE LASQGASIMD RFVDLVEPCL STEDSNFLDN ICSDASIRKR
210 220 230 240 250
LEDEYDVDMI AAARARKDFA KTLKLALQDR ERKPDKWYSK LGCITTKGRQ
260 270 280 290 300
WAKKVVHGAK KLSDPLKTLA AILLVALHNC VAVDTTTMLS HFKPVNLLAI
310 320 330 340 350
LLDWTNDLPG FLTTLIRFME LYGVVQSTVN LVVDAIKSFW DRVMCATERC
360 370 380 390 400
CDLLKRLFDK FEDSVPTGPT AGCLIFMSFV FSVIVGYLPN NSVISTFMKG
410 420 430 440 450
AGKLTTFAGV IGAIRTLWIT INQHMVAKDI TSIQEKVMAV VKMANEAATL
460 470 480 490 500
NQLEIVSVLC SELESTLTNR CTLPSYNQHM GVLNAAQKVV ADIHTLVLGK
510 520 530 540 550
INMTKQRPQP VAVVFKGAPG IGKTYLVHRL AKDLGCPHPS NINFGLDHFD
560 570 580 590 600
SYTGEDVAIA DEFNTSGDER WVELFIQMVN TNPCPLNCDK VENKNKVFSS
610 620 630 640 650
KYLLCTTNSS MVLNATHPRA TAFYRRVIIV DVRNKAVEGW QSTRHGSKPG
660 670 680 690 700
KHCYTKDMSH LTFQVYPHNM PAPGFVFVGE KLVKSQVAPR ELKYNELLDM
710 720 730 740 750
IKNEHPDANF EGATKHEFVY PDVQYEQALL MWKQYFLMYG CTARLAKVFV
760 770 780 790 800
DDIPYNQVHV ARKSDPRSPG AVHHECELKY IWRMVPHFAL GCVNMTNQLG
810 820 830 840 850
TDLTQSQLDR ITCGVEGITV TTVDNILPFH SQNTLINPSF LKLIWALRRH
860 870 880 890 900
LRGLRGITQV ATFIWKVMCN PVCAYDTLIR TLTGAATFSE DPVTTTIVCP
910 920 930 940 950
NCTIQIHTCG GLLVRYSGDP APVASDNVDR GNQGIDCLTN PNLIAGFSWR
960 970 980 990 1000
QIADLFSTVM TSLCNNHLVN LATMAAIGAV ATKALQGVKG KTKRGRGARI
1010 1020 1030 1040 1050
NLGNDEYDEW QQMRREFNNA HDMTAEEFLE LRNRAAMGSD DADAIKFRSW
1060 1070 1080 1090 1100
WTNRQLRQDE AHVTVVGKGG VRNEVIRTRV RNAPKGPRTL DDGGFYDNDY
1110 1120 1130 1140 1150
EGLPGYLRFN GSGWMIHIGN GMYLSNTHTA RSSCSEIVTC SPTTDLCLVK
1160 1170 1180 1190 1200
AEPIRSVAQI AEGTPVRDWK RASITTYGLK KTFSDSTKID VLAYDGPTQT
1210 1220 1230 1240 1250
THGDCGLPLF DEAGKVVAIH TGKLLGFSKM CTLIDCTITK GVYENTDLFC
1260 1270 1280 1290 1300
GDPIDYRGLV AFRVAGVEPR PPVSGTRYAK VPGVPEEYHT GYRPANLGRG
1310 1320 1330 1340 1350
DPDSHCTLMN IAVKNLQVYQ QEPKLTKVDT FIERAAADVL GFLRFLTKGE
1360 1370 1380 1390 1400
RQMNLNFSAA FNVLDLSTSC GPFVPGKKID HVKDGKLDEV LSKHLYKCWS
1410 1420 1430 1440 1450
VANSGKALHH VYACGLKDEL RPLDKVKEGK KRLLWGCNVG VALCAAAVFH
1460 1470 1480 1490 1500
NLCFKLKTVA RFGPIAVGID MTSRDVDVMI TQLTSKAGDF LCLDYSKWDS
1510 1520 1530 1540 1550
TMSPCVVRLA IDILADCCEQ TELTKSVVLT LKSLPMTVLD AMIVPTKRGL
1560 1570 1580 1590 1600
PSGMPFTSVI NSICHWLLWS AAVYKACDEI GLFCSNLYED APFFVYGDDG
1610 1620 1630 1640 1650
VYAMTPMMVS LLPAILDNLR DYGLSPTAAD KTEFIDVCPL KDISFLKRKF
1660 1670 1680 1690 1700
VMSELGWLSQ LDRSSILRQL EWTKTAKRHM CIEECSELDK DERGVQLEEL
1710 1720 1730 1740 1750
QIHAAAHGEE FFELVKKELR RQQAFTRFSV FDYQTARKTL GDRKRIVSVV
1760 1770 1780 1790 1800
PDDSFVNVME GKPRADAPGT ATTASVPGTT TDGMDPGVVA STDVVTADNV
1810 1820 1830 1840 1850
AASVATAGIG GPPQQASPQE SWRVNFFYND VFTWSVTDAP GSILYTVQHS
1860 1870 1880 1890 1900
PQNNPFTQVL SQMYAGWAGG MQFRFIVAGS GIFGGRLVCA IIPPGIQIQP
1910 1920 1930 1940 1950
GLEVRQFPHV VIDARSLEPV TITMPDLRPE MYHPTGNPGL VPTLVVSVYN
1960 1970 1980 1990 2000
NLINPFGGTT SAIQVTVETR PSEDFEFVLI RAPSSKTVDS VNPSWLLTTP
2010 2020 2030 2040 2050
VLTGAGSDNR WGAPIVGLQP VPGGFSTSNR HWNMNGETYG WSSPRFDDID
2060 2070 2080 2090 2100
HPSGNVSYPS GSATNTIETW YANAGTATTN PISNIAPDGF PDMGAIPFSG
2110 2120 2130 2140 2150
TTIPTGAWVG FGQVWNASNG TPYVGTVQAY ELGFANGAPS SIRPVTTTTG
2160 2170 2180 2190 2200
AQLVAKSIYG VAIAQNQTSA GIIFLSKGMV STPGVAATTY TPQPSAIVTT
2210 2220 2230 2240 2250
PGTPVAAPIG KNTPIMFSAV VRRTGDVNAG PGSANGTQYG VGSQPLSVTL
2260 2270 2280 2290 2300
GLSLTNYSSA LQPGQFFVWQ LNFASGFMEV GMNTDGYFYA GTGAYSGMID
2310 2320 2330
LTDLIDVRPV GVRPNTSTLV FNLAGVATTG YSYV
Note: Produced from the genomic RNA.
Length:2,334
Mass (Da):255,925
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3865CFA2457C0FB6
GO
Isoform Subgenomic capsid protein VP60 (identifier: Q96725-2) [UniParc]FASTAAdd to basket
Also known as: VP1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1758: Missing.

Note: Produced from the subgenomic RNA.
Show »
Length:576
Mass (Da):60,081
Checksum:i037C5471E67A732C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0343771 – 1758Missing in isoform Subgenomic capsid protein VP60. CuratedAdd BLAST1758

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z69620 Genomic RNA Translation: CAA93445.1
Z32526 Genomic RNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_068828.1, NC_002615.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
912265

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:912265

Keywords - Coding sequence diversityi

Alternative promoter usage

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69620 Genomic RNA Translation: CAA93445.1
Z32526 Genomic RNA No translation available.
RefSeqiNP_068828.1, NC_002615.1

3D structure databases

SMRiQ96725
ModBaseiSearch...

Protein family/group databases

MEROPSiC24.001

Proteomic databases

PRIDEiQ96725

Genome annotation databases

GeneIDi912265
KEGGivg:912265

Family and domain databases

CDDicd00205 rhv_like, 1 hit
Gene3Di2.60.120.20, 1 hit
InterProiView protein in InterPro
IPR004005 Calicivirus_coat
IPR004004 Helic/Pol/Pept_Calicivir-typ
IPR000605 Helicase_SF3_ssDNA/RNA_vir
IPR014759 Helicase_SF3_ssRNA_vir
IPR027417 P-loop_NTPase
IPR000317 Peptidase_C24
IPR009003 Peptidase_S1_PA
IPR033703 Rhv-like
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
IPR029053 Viral_coat
PfamiView protein in Pfam
PF00915 Calici_coat, 1 hit
PF03510 Peptidase_C24, 1 hit
PF00680 RdRP_1, 1 hit
PF00910 RNA_helicase, 1 hit
PRINTSiPR00916 2CENDOPTASE
PR00918 CALICVIRUSNS
SUPFAMiSSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51894 CV_3CL_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit
PS51218 SF3_HELICASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_EBHSG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96725
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: February 1, 1997
Last modified: September 18, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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