UniProtKB - Q966X9 (CHAG_TRYCR)
Protein
Chagasin
Gene
cha
Organism
Trypanosoma cruzi
Status
Functioni
Tight-binding and reversible inhibitor of papain-like cysteine proteases.1 Publication
GO - Molecular functioni
- cysteine-type endopeptidase inhibitor activity Source: CACAO
Keywordsi
Molecular function | Protease inhibitor, Thiol protease inhibitor |
Protein family/group databases
MEROPSi | I42.001 |
Names & Taxonomyi
Protein namesi | Recommended name: Chagasin |
Gene namesi | Name:cha |
Organismi | Trypanosoma cruzi |
Taxonomic identifieri | 5693 [NCBI] |
Taxonomic lineagei | Eukaryota › Discoba › Euglenozoa › Kinetoplastea › Metakinetoplastina › Trypanosomatida › Trypanosomatidae › Trypanosoma › Schizotrypanum |
Subcellular locationi
- Flagellar pocket 1 Publication
- Cytoplasmic vesicle 1 Publication
- Cell surface 1 Publication Note: Flagellar pocket and cytoplasmic vesicles of trypomastigotes and to the cell surface of amastigotes.
GO - Cellular componenti
- cell surface Source: CACAO
- ciliary pocket Source: CACAO
- cytoplasmic vesicle Source: CACAO
Keywords - Cellular componenti
Cytoplasmic vesiclePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218291 | 1 – 110 | ChagasinAdd BLAST | 110 |
Proteomic databases
PRIDEi | Q966X9 |
Interactioni
Binary interactionsi
Q966X9
With | #Exp. | IntAct |
---|---|---|
Q9NBD4 from Plasmodium falciparum. | 2 | EBI-15637083,EBI-15637102 |
Protein-protein interaction databases
DIPi | DIP-29312N |
IntActi | Q966X9, 1 interactor |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q966X9 |
SMRi | Q966X9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q966X9 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 29 – 33 | NPTTG motif | 5 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 2.60.40.2020, 1 hit |
InterProi | View protein in InterPro IPR036331, Chagasin-like_sf IPR018990, Prot_inh_I42_chagasin |
Pfami | View protein in Pfam PF09394, Inhibitor_I42, 1 hit |
SUPFAMi | SSF141066, SSF141066, 1 hit |
i Sequence
Sequence statusi: Complete.
Q966X9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHKVTKAHN GATLTVAVGE LVEIQLPSNP TTGFAWYFEG GTKESPNESM
60 70 80 90 100
FTVENKYFPP DSKLLGAGGT EHFHVTVKAA GTHAVNLTYM RPWTGPSHDS
110
ERFTVYLKAN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ299433 mRNA Translation: CAC39242.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ299433 mRNA Translation: CAC39242.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FO8 | NMR | - | A | 2-110 | [»] | |
2H7W | X-ray | 1.70 | A/B | 1-110 | [»] | |
2NNR | X-ray | 1.70 | A/B | 1-110 | [»] | |
2NQD | X-ray | 1.75 | A | 2-110 | [»] | |
2OUL | X-ray | 2.20 | B | 1-110 | [»] | |
3CBJ | X-ray | 1.80 | B | 1-110 | [»] | |
3CBK | X-ray | 2.67 | B | 1-110 | [»] | |
3E1Z | X-ray | 1.86 | A | 1-110 | [»] | |
BMRBi | Q966X9 | |||||
SMRi | Q966X9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-29312N |
IntActi | Q966X9, 1 interactor |
Protein family/group databases
MEROPSi | I42.001 |
Proteomic databases
PRIDEi | Q966X9 |
Miscellaneous databases
EvolutionaryTracei | Q966X9 |
Family and domain databases
Gene3Di | 2.60.40.2020, 1 hit |
InterProi | View protein in InterPro IPR036331, Chagasin-like_sf IPR018990, Prot_inh_I42_chagasin |
Pfami | View protein in Pfam PF09394, Inhibitor_I42, 1 hit |
SUPFAMi | SSF141066, SSF141066, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CHAG_TRYCR | |
Accessioni | Q966X9Primary (citable) accession number: Q966X9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families