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Protein

60S ribosomal protein L7a

Gene

rpl-7A

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calmodulin binding Source: WormBase
  • RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-CEL-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-1799339 SRP-dependent cotranslational protein targeting to membrane
R-CEL-72689 Formation of a pool of free 40S subunits
R-CEL-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-CEL-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-CEL-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7a
Gene namesi
Name:rpl-7A
ORF Names:Y24D9A.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY24D9A.4a ; CE27398 ; WBGene00004419 ; rpl-7A
Y24D9A.4c ; CE30401 ; WBGene00004419 ; rpl-7A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001367562 – 26560S ribosomal protein L7aAdd BLAST264

Proteomic databases

EPDiQ966C6
PaxDbiQ966C6
PeptideAtlasiQ966C6
PRIDEiQ966C6

Expressioni

Gene expression databases

BgeeiWBGene00004419

Interactioni

Subunit structurei

Interacts with cmd-1 in the presence of Ca2+.1 Publication

GO - Molecular functioni

  • calmodulin binding Source: WormBase

Protein-protein interaction databases

BioGridi42335, 4 interactors
DIPiDIP-25472N
IntActiQ966C6, 4 interactors
STRINGi6239.Y24D9A.4a

Structurei

3D structure databases

ProteinModelPortaliQ966C6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eL8 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3166 Eukaryota
COG1358 LUCA
GeneTreeiENSGT00390000004753
HOGENOMiHOG000216644
InParanoidiQ966C6
KOiK02936
OMAiRQRSILY
OrthoDBiEOG091G0HPD
PhylomeDBiQ966C6

Family and domain databases

Gene3Di3.30.1330.210, 1 hit
InterProiView protein in InterPro
IPR029064 L30e-like
IPR001921 Ribosomal_L7A/L8
IPR038524 Ribosomal_L7A/L8_sf
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492 Ribosomal_L7Ae/L8/Nhp2
IPR004037 Ribosomal_L7Ae_CS
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00881 L7ARS6FAMILY
PR00882 RIBOSOMALL7A
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01082 RIBOSOMAL_L7AE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a1 Publication (identifier: Q966C6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSKKVIKKK VAAVPAHIRA QTQVQKEVKN PLFEKRARNF NIGQDIQPKK
60 70 80 90 100
DVTRFVKWPK YIRLQRQSAI LQKRLKVPPT INQFRTALDS QSARQAFKLL
110 120 130 140 150
DKYRPESTEA KKNRLRARAE ARAAGKKEEV TKRPNTVRHG VNTITRLVET
160 170 180 190 200
RRAQLVLIAH DVNPLEIVLH LPALCRKYNV PYAIIKGKAS LGTVVRRKTT
210 220 230 240 250
AAVALVDVNP EDKSALNKLV ETVNNNFSER HEEIRKHWGG GVMSAKSDAK
260
KLKIERARAR DLGKL
Note: No experimental confirmation available.Curated
Length:265
Mass (Da):30,174
Last modified:January 23, 2007 - v3
Checksum:iAC44C4420295D932
GO
Isoform c1 Publication (identifier: Q966C6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-128: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:245
Mass (Da):27,939
Checksum:i80EE5089D0992E85
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051845109 – 128Missing in isoform c. CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081479 Genomic DNA Translation: CCD71898.1
FO081479 Genomic DNA Translation: CCD71899.1
RefSeqiNP_741371.2, NM_171316.6 [Q966C6-1]
NP_741372.2, NM_171904.4 [Q966C6-2]
UniGeneiCel.9272

Genome annotation databases

EnsemblMetazoaiY24D9A.4a; Y24D9A.4a; WBGene00004419 [Q966C6-1]
GeneIDi177203
KEGGicel:CELE_Y24D9A.4
UCSCiY24D9A.4a c. elegans [Q966C6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRL7A_CAEEL
AccessioniPrimary (citable) accession number: Q966C6
Secondary accession number(s): Q8T875
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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