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Protein

Genome polyprotein

Gene
N/A
Organism
Bovine viral diarrhea virus (strain CP7) (BVDV) (Mucosal disease virus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (By similarity).By similarity
P7 forms a leader sequence to properly orient NS2 in the membrane.By similarity
Uncleaved NS2-3 is required for production of infectious virus.
NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.
NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase.
NS4A is a cofactor for the NS3 protease activity.By similarity
RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.

Miscellaneous

BVDV is divided in two types: cytopathic and non-cytopathic. Both types of viruses can be found in animals suffering from mucosal disease, as a cytopathic BVDV can develop from a non-cytopathic virus within the infected animal by deletions, mutations or insertions. Both types express uncleaved NS2-3, but cytopathic strains also express NS3.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites. EC:3.4.21.113

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei49For N-terminal protease activityPROSITE-ProRule annotation1
Active sitei69For N-terminal protease activityPROSITE-ProRule annotation1
Active sitei1456For cysteine protease NS2 activityPROSITE-ProRule annotation1 Publication1
Active sitei1470For cysteine protease NS2 activityPROSITE-ProRule annotation1 Publication1
Active sitei1521For cysteine protease NS2 activityPROSITE-ProRule annotation1 Publication1
Active sitei1667Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation1
Active sitei1704Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation1
Active sitei1761Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Ion channel, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Thiol protease, Transferase, Viral ion channel
Biological processActivation of host autophagy by virus, Clathrin-mediated endocytosis of virus by host, Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Ion transport, Transport, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Viral RNA replication, Virus endocytosis by host, Virus entry into host cell
LigandATP-binding, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.53.1.5 the hepatitis c virus p7 viroporin cation-selective channel (hcv-p7) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 13 chains:
N-terminal protease (EC:3.4.22.-)
Short name:
N-pro
Alternative name(s):
Autoprotease p20
Alternative name(s):
gp44/48
Alternative name(s):
gp33
Alternative name(s):
gp55
Alternative name(s):
Non-structural protein 2
Alternative name(s):
Non-structural protein 3
Alternative name(s):
NS5B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBovine viral diarrhea virus (strain CP7) (BVDV) (Mucosal disease virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri268305 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageFlaviviridaePestivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBos taurus (Bovine) [TaxID: 9913]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000173611 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000007618 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

E(rns) glycoprotein :
Cysteine protease NS2 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1144 – 1164HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1189 – 1209HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1217 – 1237HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1247 – 1267HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1281 – 1301HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1369 – 1389HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1577 – 1597HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane, Virion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi438E → A: Almost no effect on membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi446Q → A: Almost no effect on membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi455G → A: Almost no effect on membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi460L → A: Reduced membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi461E → A: Greatly reduced membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi462S → A: Almost no effect on membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi465Q → A: Almost no effect on membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi469K → A: Almost no effect on membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi471T → A: Almost no effect on membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi473W → A: Reduced membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi476R → A: Almost no effect on membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi478L → A: Reduced membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi481L → A: Reduced membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi486E → A: Greatly reduced membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi487N → A: Almost no effect on membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi489S → A: Almost no effect on membrane association of E(rns) glycoprotein. 1 Publication1
Mutagenesisi492W → A: Reduced membrane association of E(rns) glycoprotein. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3937

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000380111 – 168N-terminal proteaseBy similarityAdd BLAST168
ChainiPRO_0000038012169 – 270Capsid protein CBy similarityAdd BLAST102
ChainiPRO_0000038013271 – 497E(rns) glycoproteinBy similarityAdd BLAST227
ChainiPRO_0000038014498 – 659Envelope glycoprotein E1By similarityAdd BLAST162
ChainiPRO_0000038015660 – 1066Envelope glycoprotein E2By similarityAdd BLAST407
ChainiPRO_00000380161067 – 1136p7Add BLAST70
ChainiPRO_00000380171137 – 2281Non-structural protein 2-3By similarityAdd BLAST1145
ChainiPRO_00000380181137 – 1598Cysteine protease NS2PROSITE-ProRule annotationAdd BLAST462
ChainiPRO_00000380191599 – 2281Serine protease NS3By similarityAdd BLAST683
ChainiPRO_00000380202282 – 2345Non-structural protein 4AAdd BLAST64
ChainiPRO_00000380212346 – 2692Non-structural protein 4BAdd BLAST347
ChainiPRO_00000380222693 – 3188Non-structural protein 5AAdd BLAST496
ChainiPRO_00000380233189 – 3907RNA-directed RNA polymeraseAdd BLAST719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi272N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi281N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi335N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi365N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi487N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi597N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi809N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi878N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi922N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi990N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1366N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1428N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1460N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1722N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi2143N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi2226N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi2503N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi2691N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi2900N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi3697N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi3802N-linked (GlcNAc...) asparagine; by hostSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The E(rns) glycoprotein is heavily glycosylated.By similarity
The viral RNA of pestiviruses is expressed as a single polyprotein which undergoes post-translational proteolytic processing resulting in the production of at least eleven individual proteins. The N-terminal protease cleaves itself from the nascent polyprotein autocatalytically and thereby generates the N-terminus of the adjacent viral capsid protein C (By similarity).By similarity
Cleavage between E2 and p7 is partial.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei168 – 169Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei270 – 271Cleavage; by host signal peptidaseBy similarity2
Sitei497 – 498CleavageBy similarity2
Sitei659 – 660Cleavage; by host signal peptidaseBy similarity2
Sitei1066 – 1067Cleavage; by host signal peptidase; partial2
Sitei1136 – 1137Cleavage; by host signal peptidaseBy similarity2
Sitei1598 – 1599Cleavage; by NS2; in cytopathic strainsBy similarity2
Sitei2281 – 2282Cleavage; by serine protease NS32
Sitei2345 – 2346Cleavage; by serine protease NS32
Sitei2692 – 2693Cleavage; by serine protease NS32
Sitei3188 – 3189Cleavage; by serine protease NS32

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q96662

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q96662

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The E(rns) glycoprotein is found as a homodimer; disulfide-linked. The E1 and E2 envelope glycoproteins form disulfide-linked homodimers as well as heterodimers.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q96662, 1 interactor

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q96662

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13907
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96662

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96662

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96662

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 168Peptidase C53PROSITE-ProRule annotationAdd BLAST168
Domaini1450 – 1598Peptidase C74PROSITE-ProRule annotationAdd BLAST149
Domaini1599 – 1772Peptidase S31PROSITE-ProRule annotationAdd BLAST174
Domaini1811 – 1969Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST159
Domaini1987 – 2152Helicase C-terminalPROSITE-ProRule annotationAdd BLAST166
Domaini3527 – 3650RdRp catalyticPROSITE-ProRule annotationAdd BLAST124

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1432 – 1435Poly-Glu4
Compositional biasi3268 – 3271Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pestivirus polyprotein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
VOG09000032

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.730.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR021824 Capsid-C_pestivirus
IPR011492 DEAD_Flavivir
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR022120 NS2
IPR030399 NS2_C74
IPR027417 P-loop_NTPase
IPR008751 Peptidase_C53
IPR032521 Pestivirus_E2
IPR000280 Pestivirus_NS3_S31
IPR007094 RNA-dir_pol_PSvirus
IPR002166 RNA_pol_HCV
IPR036430 RNase_T2-like_sf
IPR033130 RNase_T2_His_AS_2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11889 DUF3409, 1 hit
PF07652 Flavi_DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF05550 Peptidase_C53, 1 hit
PF12387 Peptidase_C74, 1 hit
PF05578 Peptidase_S31, 1 hit
PF16329 Pestivirus_E2, 1 hit
PF00998 RdRP_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00729 CDVENDOPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF55895 SSF55895, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51692 PESTIVIRUS_NS2_PRO, 1 hit
PS51535 PESTIVIRUS_NS3PRO, 1 hit
PS51876 PV_NPRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit
PS00531 RNASE_T2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q96662-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELITNELLY KTYKQKPAGV EEPVYDQAGN PLFGERGVIH PQSTLKLPHK
60 70 80 90 100
RGEREVPTNL ASLPKRGDCR SGNSKGPVSG IYLKPGPLFY QDYKGPVYHR
110 120 130 140 150
APLEFFEEAS MCETTKRIGR VTGSDSRLYH IYVCIDGCII VKSATKDRQK
160 170 180 190 200
VLKWVHNKLN CPLWVSSCSD TKDEGVVRKK QQKPDRLEKG RMKITPKESE
210 220 230 240 250
KDSKTKPPDA TIVVDGVKYQ VKKKGKVKSK NTQDGLYHNK NKPQESRKKL
260 270 280 290 300
EKALLAWAII ALVFFQVTMG ENITQWNLQD NGTEGIQRAM FQRGVNRSLH
310 320 330 340 350
GIWPEKICTG VPSHLATDTE LKAIHGMMDA SEKTNYTCCR LQRHEWNKHG
360 370 380 390 400
WCNWYNIEPW ILLMNKTQAN LTEGQPLREC AVTCRYDRDS DLNVVTQARD
410 420 430 440 450
SPTPLTGCKK GKNFSFAGIL VQGPCNFEIA VSDVLFKEHD CTSVIQDTAH
460 470 480 490 500
YLVDGMTNSL ESARQGTAKL TTWLGRQLGI LGKKLENKSK TWFGAYAASP
510 520 530 540 550
YCEVERKLGY IWYTKNCTPA CLPRNTKIIG PGRFDTNAED GKILHEMGGH
560 570 580 590 600
LSEVLLLSVV VLSDFAPETA SVIYLILHFS IPQGHTDIQD CDKNQLNLTV
610 620 630 640 650
ELTTAEVIPG SVWNLGKYVC VRPDWWPYET ATVLVIEEVG QVIKVVLRAL
660 670 680 690 700
KDLTRIWTAA TTTAFLVCLV KVVRGQVLQG ILWLMLITGA QGYPDCKPGF
710 720 730 740 750
SYAIAKNDEI GPLGATGLTT QWYEYSDGMR LQDSVVEVWC KNGEIKYLIR
760 770 780 790 800
CGREARYLAV LHTRALPTSV VFEKIFDGKE QEDIVEMDDN FEFGLCPCDA
810 820 830 840 850
RPLIRGKFNT TLLNGPAFQM VCPIGWTGTV SCTLANKDTL ATIVVRTYKR
860 870 880 890 900
VRPFPYRQDC VTQKTIGEDL YDCALGGNWT CVPGDALRYV AGPVESCEWC
910 920 930 940 950
GYKFLKSEGL PHFPIGKCRL KNESGYRQVD ETSCNRNGVA IVPSGTVKCK
960 970 980 990 1000
IGDTVVQVIA MDDKLGPMPC KPHEIISSEG PVEKTACTFN YTRTLKNKYF
1010 1020 1030 1040 1050
EPRDNYFQQY MLKGEYQYWF DLEITDHHRD YFAESLLVIV VALLGGRYVL
1060 1070 1080 1090 1100
WLLVTYMILS EQMASGVQYG AGEIVMMGNL LTHDSVEVVT YFLLLYLLLR
1110 1120 1130 1140 1150
EENTKKWVIL IYHIIVMHPL KSVTVILLMV GGMAKAEPGA QGYLEQVDLS
1160 1170 1180 1190 1200
FTMITIIVIG LVIARRDPTV VPLVTIVAAL KITGLGFGPG VDAAMAVLTL
1210 1220 1230 1240 1250
TLLMTSYVTD YFRYKRWIQC ILSLVAGVFL IRTLKHLGEL KTPELTIPNW
1260 1270 1280 1290 1300
RPLTFILLYL TSATVVTRWK IDIAGIFLQG APILLMIATL WADFLTLVLI
1310 1320 1330 1340 1350
LPTYELAKLY YLKNVKTDVE KSWGVPYPDP QTLGGLDYRT IDSVYDVDES
1360 1370 1380 1390 1400
GEGVYLFPSR QKKNKNISIL LPLIRATLIS CISSKWQMVY MAYLTLDFMY
1410 1420 1430 1440 1450
YMHRKVIEEI SGSTNVMSRV IAALIELNWS MEEEESKGLK KFFILSGRLR
1460 1470 1480 1490 1500
NLIIKHKVRN QTVASWYGEE EVYGMPKVVT IIRACTLNKN KHCIICTVCE
1510 1520 1530 1540 1550
ARKWKGGNCP KCGRHGKPII CGMTLADFEE RHYKRIFIRE GNFEGPFRQE
1560 1570 1580 1590 1600
YNGFVQYTAR GQLFLRNLPI LATKVKMIMV GNLGEEIGDL EHLGWILRGP
1610 1620 1630 1640 1650
AVCKKITEHE KCHVNILDKL TAFFGVMPRG TTPRAPVRFP TALLKVRRGL
1660 1670 1680 1690 1700
ETGWAYTHQG GISSVDHVTA GKDLLVCDSM GRTRVVCQSN NKLTDETEYG
1710 1720 1730 1740 1750
VKTDSGCPDG ARCYVLNPEA VNISGSKGAV VHLQKTGGEF TCVTASGTPA
1760 1770 1780 1790 1800
FFDLKNLKGW SGLPIFEASS GRVVGRVKVG KNEESKPTKL MSGIQTVSKN
1810 1820 1830 1840 1850
TADLTEMVKK ITSMNRGDFR QITLATGAGK TTELPKAVIE EIGRHKRVLV
1860 1870 1880 1890 1900
LIPLRAAAES VYQYMRLKHP SISFNLRIGD MKEGDMATGI TYASYGYFCQ
1910 1920 1930 1940 1950
MPQPKLRAAM IEYSYIFLDE YHCATPEQLA VIGKIHRFSE SIRVVAMTAT
1960 1970 1980 1990 2000
PAGSVTTTGQ KHPIEEFIAP EVMKGEDLGS QFLDIAGLKI PVEEMKGNML
2010 2020 2030 2040 2050
VFVPTRNMAV EVAKKLKAKG YNSGYYYSGE DPANLRVVTS QSPYVVVATN
2060 2070 2080 2090 2100
AIESGVTLPD LDTVVDTGLK CEKRVRVSSK IPFIVTGLKR MAVTVGEQAQ
2110 2120 2130 2140 2150
RRGRVGRVKP GRYYRSQETA TGSKDYHYDL LQAQRYGIED GINVTKSFRE
2160 2170 2180 2190 2200
MNYDWSLYEE DSLLITQLEI LNNLLISEDL PAAVKNIMAR TDHPEPIQLA
2210 2220 2230 2240 2250
YNSYEVQVPV LFPKIRNGEV TDTYENYSFL NARKLGEDVP VYVYATEDED
2260 2270 2280 2290 2300
LAVDLLGLDW PDPGNQQVVE TGKALKQVVG LSSAENALLI ALFGYVGYQA
2310 2320 2330 2340 2350
LSKRHVPMIT DIYTIEDQRL EDTTHLQYAP NAIRTEGKET ELKELAVGDL
2360 2370 2380 2390 2400
DKIMGSISDY ASEGLNFVRS QAEKMRSAPA FKENVEAAKG YVQKFIDSLI
2410 2420 2430 2440 2450
ENKETIIRYG LWGTHTALYK SIAARLGHET AFATLVIKWL AFGGESVSDH
2460 2470 2480 2490 2500
MRQAAVDLVV YYVINKPSFP GDSETQQEGR RFVASLFISA LATYTYKTWN
2510 2520 2530 2540 2550
YNNLSKVVEP ALAYLPYATN ALKMFTPTRL ESVVILSTTI YKTYLSIRKG
2560 2570 2580 2590 2600
KSDGLLGTGI SAAMEILSQN PVSVGISVML GVGAIAAHNA IESSEQKRTL
2610 2620 2630 2640 2650
LMKVFVKNFL DQAATDELVK ENPEKIIMAL FEAVQTIGNP LRLIYHLYGV
2660 2670 2680 2690 2700
YYKGWEAKEL SERTAGRNLF TLIMFEAFEL LGMDSEGKIR NLSGNYVLDL
2710 2720 2730 2740 2750
IYSLHKQINR GLKKIVLGWA PAPFSCDWTP SDERIRLPTN NYLRVETKCP
2760 2770 2780 2790 2800
CGYEMKALRN VGGSLTKVEE KGPFLCRNRL GRGPVNYRVT KYYDDNLKEI
2810 2820 2830 2840 2850
KPVAKLEGFV DHYYKGVTAR IDYGRGKMLL ATDKWEVEHG VVTRLAKRYT
2860 2870 2880 2890 2900
GVGFKGAYLG DEPNHRDLVE RDCATITKNT VQFLKMKKGC AFTYDLTLSN
2910 2920 2930 2940 2950
LTRLIELVHK NNLEEKDIPA ATVTTWLAYT FVNEDIGTIK PVLGERVVTD
2960 2970 2980 2990 3000
PVVDVNLQPE VQVDTSEVGI TLVGRAALMT TGTTPVVEKT EPNADGGPSS
3010 3020 3030 3040 3050
IKIGLDEGRY PGPGLQDRTL TDEIHSRDER PFVLVLGSKN SMSNRAKTAR
3060 3070 3080 3090 3100
NINLYKGNNP REIRDLMAQG RMLVVALKDF NPELSELVDF KGTFLDREAL
3110 3120 3130 3140 3150
EALSLGRPKS KQVTTATVRE LLEQEVQVEI PSWFGAGDPV FLEVTLKGDR
3160 3170 3180 3190 3200
YHLVGDVDRV KDQAKELGAT DQTRIVKEVG ARTYTMKLSS WFLQATNKQM
3210 3220 3230 3240 3250
SLTPLFEELL LRCPPKIKSN KGHMASAYQL AQGNWEPLDC GVHLGTIPAR
3260 3270 3280 3290 3300
RVKIHPYEAY LKLKDLLEEE EKKPKCRDTV IREHNKWILK KVRHQGNLNT
3310 3320 3330 3340 3350
KKILNPGKLS EQLDREGHKR NIYNNQIGTI MTEAGSRLEK LPVVRAQTDT
3360 3370 3380 3390 3400
KSFHEAIRDK IDKNENQQSP GLHDKLLEIF HTIAQPSLRH TYSDVTWEQL
3410 3420 3430 3440 3450
EAGVNRKGAA GFLEKKNVGE VLDSEKHLVE QLIRDLKTGR KIRYYETAIP
3460 3470 3480 3490 3500
KNEKRDVSDD WQSGDLVDEK KPRVIQYPEA KTRLAITKVM YNWVKQQPVV
3510 3520 3530 3540 3550
IPGYEGKTPL FNIFNKVRKE WDLFNEPVAV SFDTKAWDTQ VTSRDLRLIG
3560 3570 3580 3590 3600
EIQKYYYRKE WHKFIDTITD HMVEVPVITA DGEVYIRNGQ RGSGQPDTSA
3610 3620 3630 3640 3650
GNSMLNVLTM MYAFCESTGV PYKSFNRVAR IHVCGDDGFL ITEKGLGLKF
3660 3670 3680 3690 3700
ANNGMQILHE AGKPQKITEG ERMKVAYRFE DIEFCSHTPV PVRWSDNTSS
3710 3720 3730 3740 3750
YMAGRDTAVI LSKMATRLDS SGERGTIAYE KAVAFSFLLM YSWNPLVRRI
3760 3770 3780 3790 3800
CLLVLSQQPE TTPSTQTTYY YKGDPIGAYK DVIGKNLCEL KRTGFEKLAN
3810 3820 3830 3840 3850
LNLSLSTLGI WSKHTSKRII QDCVTIGKEE GNWLVNADRL ISSKTGHLYI
3860 3870 3880 3890 3900
PDKGYTLQGK HYEQLQLQAR TSPVTGVGTE RYKLGPIVNL LLRRLRVLLM

AAVGASS
Length:3,907
Mass (Da):439,104
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E4B019FF8042410
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U63479 Genomic RNA Translation: AAC55984.1
AF220247 Genomic RNA Translation: AAG00378.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63479 Genomic RNA Translation: AAC55984.1
AF220247 Genomic RNA Translation: AAG00378.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AJJNMR-A2693-2720[»]
2AJMNMR-A2693-2720[»]
2AJNNMR-A2693-2720[»]
2AJONMR-A2693-2720[»]
2CJQX-ray2.60A3189-3907[»]
4DVKX-ray2.21A/B271-435[»]
4DVLX-ray2.75A/B271-435[»]
4DVNX-ray2.38A/B271-435[»]
4DW3X-ray2.35A/B271-435[»]
4DW4X-ray2.23A/B271-435[»]
4DW5X-ray2.21A/B271-435[»]
4DW7X-ray3.08A/B271-435[»]
4DWAX-ray3.01A/B271-435[»]
4DWCX-ray2.89A/B271-435[»]
ProteinModelPortaliQ96662
SMRiQ96662
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96662, 1 interactor

Chemistry databases

BindingDBiQ96662
ChEMBLiCHEMBL3937

Protein family/group databases

TCDBi1.A.53.1.5 the hepatitis c virus p7 viroporin cation-selective channel (hcv-p7) family

Proteomic databases

PRIDEiQ96662

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG09000032

Miscellaneous databases

EvolutionaryTraceiQ96662
PMAP-CutDBiQ96662

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.90.730.10, 1 hit
InterProiView protein in InterPro
IPR021824 Capsid-C_pestivirus
IPR011492 DEAD_Flavivir
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR022120 NS2
IPR030399 NS2_C74
IPR027417 P-loop_NTPase
IPR008751 Peptidase_C53
IPR032521 Pestivirus_E2
IPR000280 Pestivirus_NS3_S31
IPR007094 RNA-dir_pol_PSvirus
IPR002166 RNA_pol_HCV
IPR036430 RNase_T2-like_sf
IPR033130 RNase_T2_His_AS_2
PfamiView protein in Pfam
PF11889 DUF3409, 1 hit
PF07652 Flavi_DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF05550 Peptidase_C53, 1 hit
PF12387 Peptidase_C74, 1 hit
PF05578 Peptidase_S31, 1 hit
PF16329 Pestivirus_E2, 1 hit
PF00998 RdRP_3, 1 hit
PRINTSiPR00729 CDVENDOPTASE
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF55895 SSF55895, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51692 PESTIVIRUS_NS2_PRO, 1 hit
PS51535 PESTIVIRUS_NS3PRO, 1 hit
PS51876 PV_NPRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit
PS00531 RNASE_T2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_BVDVC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96662
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: February 1, 1997
Last modified: December 5, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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