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Protein

Xylosyltransferase sqv-6

Gene

sqv-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis.1 Publication

Catalytic activityi

UDP-alpha-D-xylose + [protein]-L-serine = UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine.1 Publication

Cofactori

Pathwayi: chondroitin sulfate biosynthesis

This protein is involved in the pathway chondroitin sulfate biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway chondroitin sulfate biosynthesis and in Glycan metabolism.

Pathwayi: heparan sulfate biosynthesis

This protein is involved in the pathway heparan sulfate biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway heparan sulfate biosynthesis and in Glycan metabolism.

GO - Molecular functioni

  • acetylglucosaminyltransferase activity Source: InterPro
  • protein xylosyltransferase activity Source: WormBase

GO - Biological processi

  • chondroitin sulfate biosynthetic process Source: WormBase
  • heparan sulfate proteoglycan biosynthetic process Source: UniProtKB-UniPathway
  • heparin biosynthetic process Source: WormBase
  • morphogenesis of an epithelium Source: WormBase
  • oviposition Source: WormBase
  • reproduction Source: WormBase
  • UDP-D-xylose metabolic process Source: WormBase
  • vulval development Source: WormBase

Keywordsi

Molecular functionDevelopmental protein, Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.2.26 1045
ReactomeiR-CEL-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
SignaLinkiQ965Q8
UniPathwayiUPA00755
UPA00756

Protein family/group databases

CAZyiGT14 Glycosyltransferase Family 14

Names & Taxonomyi

Protein namesi
Recommended name:
Xylosyltransferase sqv-6 (EC:2.4.2.261 Publication)
Alternative name(s):
Peptide O-xylosyltransferase
Squashed vulva protein 6
Gene namesi
Name:sqv-6
ORF Names:Y50D4C.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiY50D4C.4a ; CE35919 ; WBGene00005024 ; sqv-6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini33 – 806LumenalSequence analysisAdd BLAST774

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Worms are infertile because of the failure of the progeny of homozygous mutants to initiate cytokinesis and because of the failure to form an extracellular space between the egg and the eggshell.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001914131 – 806Xylosyltransferase sqv-6Add BLAST806

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi614N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi655N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi719N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ965Q8
PaxDbiQ965Q8
PeptideAtlasiQ965Q8

PTM databases

iPTMnetiQ965Q8

Expressioni

Gene expression databases

BgeeiWBGene00005024
ExpressionAtlasiQ965Q8 baseline

Interactioni

Protein-protein interaction databases

STRINGi6239.Y50D4C.4

Structurei

3D structure databases

ProteinModelPortaliQ965Q8
SMRiQ965Q8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 205WSCPROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0799 Eukaryota
KOG4157 Eukaryota
ENOG410XQ7M LUCA
GeneTreeiENSGT00760000119183
InParanoidiQ965Q8
KOiK00771
OMAiTYFARKF
OrthoDBiEOG091G020K
PhylomeDBiQ965Q8

Family and domain databases

InterProiView protein in InterPro
IPR003406 Glyco_trans_14
IPR002889 WSC_carb-bd
PfamiView protein in Pfam
PF02485 Branch, 1 hit
PF01822 WSC, 1 hit
SMARTiView protein in SMART
SM00321 WSC, 1 hit
PROSITEiView protein in PROSITE
PS51212 WSC, 1 hit

Sequencei

Sequence statusi: Complete.

Q965Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFNGTTKYR DYAIVISLFF LLNVYLLYNT AQHTQVGNSK HISSDSGEKT
60 70 80 90 100
SNPLPSCEIT DDLAKSAISR AITPSCKAKL QLEACQLKNG TFTINFPENQ
110 120 130 140 150
CPNHDSRLID QRIGCFLDKK EARVLTEFEY KLPKSNGKAT CRKHCYKAGF
160 170 180 190 200
LYFGLEFGHE CFCGNDVSNA TAVDDVECRA YKCPGNENSE EFCGGFNAVE
210 220 230 240 250
IFRTGFRSKV NHRKPTYLPP SSDSIKNPVK ILFLLQLNGR NERQVKRFLK
260 270 280 290 300
SIYLPHHYYY IHVDARQNYM FSEMQKVADF LDNIHITERR FSTIWGGASL
310 320 330 340 350
LQMFLQVIRD SMKIEKFKDW DYIINFSESD FPILPISDFE RLITVNNGKS
360 370 380 390 400
FLASHGYNTG KFIQKQGFEY VFSECDNRMF RIGKREFPQN LRIDGGSDWV
410 420 430 440 450
GIHRNLAEFS ISDEELPRKL RKTYESILLP LESFYHTLAF NSEFCDDLLM
460 470 480 490 500
SNLRLTNWYR KQGCRCASLK PIVDWCGCSP LVFREETMKK FELQKAISKP
510 520 530 540 550
TYFARKFDSM VDIDSIEAAE MQSISPEKLQ LNHPTYHFAF ANIFKTGIDE
560 570 580 590 600
QKLHFESLAN FALKSTETRA KFRKVLRIDA LRAHHNALIE IVMKIETTDG
610 620 630 640 650
ATFEFLIHRL SHVNLTENEE KLVEHGYLLR AVSFGTKFEW KEELCREYMG
660 670 680 690 700
FVTDNDTLHT RLQWHPTEHV KKVGDKTSPE MIFKYRKGDE LIEQTVVKPY
710 720 730 740 750
DSVFGGQFDS WNVGKKLSNL TTCSNFFVDI ISPSSPDDAP PLATLHFPVY
760 770 780 790 800
TDQNAHCHVD YLRQFFKIAD FCTSGDACKE KIWSTSYPDP KSDIFVGYDE

DTQTLI
Length:806
Mass (Da):93,115
Last modified:March 1, 2004 - v3
Checksum:i6EF779BEA4B570CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY241928 mRNA Translation: AAO85277.1
AJ496235 mRNA Translation: CAD42732.1
FO081564 Genomic DNA Translation: CCD72442.1
RefSeqiNP_503359.2, NM_070958.3
UniGeneiCel.1679

Genome annotation databases

EnsemblMetazoaiY50D4C.4a.1; Y50D4C.4a.1; WBGene00005024
Y50D4C.4a.2; Y50D4C.4a.2; WBGene00005024
GeneIDi190099
KEGGicel:CELE_Y50D4C.4
UCSCiY50D4C.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiXYLT_CAEEL
AccessioniPrimary (citable) accession number: Q965Q8
Secondary accession number(s): Q867S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2004
Last modified: May 23, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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