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Protein

Peroxidase 45

Gene

PER45

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei63Transition state stabilizerPROSITE-ProRule annotation1
Active sitei67Proton acceptorPROSITE-ProRule annotation1
Metal bindingi68Calcium 1PROSITE-ProRule annotation1
Metal bindingi71Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi73Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi75Calcium 1PROSITE-ProRule annotation1
Metal bindingi77Calcium 1PROSITE-ProRule annotation1
Binding sitei163Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi193Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi194Calcium 2PROSITE-ProRule annotation1
Metal bindingi245Calcium 2PROSITE-ProRule annotation1
Metal bindingi248Calcium 2PROSITE-ProRule annotation1
Metal bindingi253Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G30170-MONOMER

Protein family/group databases

PeroxiBasei211 AtPrx45

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 45 (EC:1.11.1.7)
Short name:
Atperox P45
Alternative name(s):
ATP8a
Gene namesi
Name:PER45
Synonyms:P45
Ordered Locus Names:At4g30170
ORF Names:F9N11.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G30170
TAIRilocus:2128921 AT4G30170

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002371126 – 325Peroxidase 45Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 115PROSITE-ProRule annotation
Disulfide bondi69 ↔ 74PROSITE-ProRule annotation
Disulfide bondi121 ↔ 321PROSITE-ProRule annotation
Disulfide bondi200 ↔ 232PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96522
PRIDEiQ96522

Expressioni

Tissue specificityi

Slightly expressed in roots.1 Publication

Inductioni

Up-regulated transiently by a cold treatment. Induced by methyl jasmonate, a plant defense-related signaling molecule.2 Publications

Gene expression databases

ExpressionAtlasiQ96522 baseline and differential
GenevisibleiQ96522 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G30170.1

Structurei

3D structure databases

ProteinModelPortaliQ96522
SMRiQ96522
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJYG Eukaryota
ENOG4111S7R LUCA
HOGENOMiHOG000237556
InParanoidiQ96522
KOiK00430
OMAiPRKFDNG
OrthoDBiEOG09360FB9
PhylomeDBiQ96522

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96522-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKNTSQTIF SNFFLLLLLS SCVSAQLRTG FYQNSCPNVE TIVRNAVRQK
60 70 80 90 100
FQQTFVTAPA TLRLFFHDCF VRGCDASIMI ASPSERDHPD DMSLAGDGFD
110 120 130 140 150
TVVKAKQAVD SNPNCRNKVS CADILALATR EVVVLTGGPS YPVELGRRDG
160 170 180 190 200
RISTKASVQS QLPQPEFNLN QLNGMFSRHG LSQTDMIALS GAHTIGFAHC
210 220 230 240 250
GKMSKRIYNF SPTTRIDPSI NRGYVVQLKQ MCPIGVDVRI AINMDPTSPR
260 270 280 290 300
TFDNAYFKNL QQGKGLFTSD QILFTDQRSR STVNSFANSE GAFRQAFITA
310 320
ITKLGRVGVL TGNAGEIRRD CSRVN
Length:325
Mass (Da):35,829
Last modified:February 1, 1997 - v1
Checksum:iF852C14BC2E846CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98855 mRNA Translation: CAA67361.1
AL109796 Genomic DNA Translation: CAB52461.1
AL161576 Genomic DNA Translation: CAB81010.1
CP002687 Genomic DNA Translation: AEE85729.1
AF370284 mRNA Translation: AAK44099.1
AY063051 mRNA Translation: AAL34225.1
AY085450 mRNA Translation: AAM62676.1
PIRiT14077
RefSeqiNP_194746.1, NM_119163.3
UniGeneiAt.24710
At.67068

Genome annotation databases

EnsemblPlantsiAT4G30170.1; AT4G30170.1; AT4G30170
GeneIDi829140
GrameneiAT4G30170.1; AT4G30170.1; AT4G30170
KEGGiath:AT4G30170

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98855 mRNA Translation: CAA67361.1
AL109796 Genomic DNA Translation: CAB52461.1
AL161576 Genomic DNA Translation: CAB81010.1
CP002687 Genomic DNA Translation: AEE85729.1
AF370284 mRNA Translation: AAK44099.1
AY063051 mRNA Translation: AAL34225.1
AY085450 mRNA Translation: AAM62676.1
PIRiT14077
RefSeqiNP_194746.1, NM_119163.3
UniGeneiAt.24710
At.67068

3D structure databases

ProteinModelPortaliQ96522
SMRiQ96522
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G30170.1

Protein family/group databases

PeroxiBasei211 AtPrx45

Proteomic databases

PaxDbiQ96522
PRIDEiQ96522

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G30170.1; AT4G30170.1; AT4G30170
GeneIDi829140
GrameneiAT4G30170.1; AT4G30170.1; AT4G30170
KEGGiath:AT4G30170

Organism-specific databases

AraportiAT4G30170
TAIRilocus:2128921 AT4G30170

Phylogenomic databases

eggNOGiENOG410IJYG Eukaryota
ENOG4111S7R LUCA
HOGENOMiHOG000237556
InParanoidiQ96522
KOiK00430
OMAiPRKFDNG
OrthoDBiEOG09360FB9
PhylomeDBiQ96522

Enzyme and pathway databases

BioCyciARA:AT4G30170-MONOMER

Miscellaneous databases

PROiPR:Q96522

Gene expression databases

ExpressionAtlasiQ96522 baseline and differential
GenevisibleiQ96522 AT

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER45_ARATH
AccessioniPrimary (citable) accession number: Q96522
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: February 1, 1997
Last modified: October 10, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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