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Protein

Peroxidase 16

Gene

PER16

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei61Transition state stabilizerPROSITE-ProRule annotation1
Active sitei65Proton acceptorPROSITE-ProRule annotation1
Metal bindingi66Calcium 1PROSITE-ProRule annotation1
Metal bindingi69Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi71Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi73Calcium 1PROSITE-ProRule annotation1
Metal bindingi75Calcium 1PROSITE-ProRule annotation1
Binding sitei161Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi191Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi192Calcium 2PROSITE-ProRule annotation1
Metal bindingi243Calcium 2PROSITE-ProRule annotation1
Metal bindingi246Calcium 2PROSITE-ProRule annotation1
Metal bindingi251Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G18980-MONOMER

Protein family/group databases

PeroxiBasei97 AtPrx16

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 16 (EC:1.11.1.7)
Short name:
Atperox P16
Alternative name(s):
ATP22a
Gene namesi
Name:PER16
Synonyms:P16
Ordered Locus Names:At2g18980
ORF Names:F19F24.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G18980
TAIRilocus:2044485 AT2G18980

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002368224 – 323Peroxidase 16Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 113PROSITE-ProRule annotation
Disulfide bondi67 ↔ 72PROSITE-ProRule annotation
Disulfide bondi119 ↔ 319PROSITE-ProRule annotation
Disulfide bondi198 ↔ 230PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96518
PRIDEiQ96518

Expressioni

Tissue specificityi

Expressed in the whole plant, but preferentially in roots and leaves.1 Publication

Gene expression databases

ExpressionAtlasiQ96518 baseline and differential
GenevisibleiQ96518 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G18980.1

Structurei

3D structure databases

ProteinModelPortaliQ96518
SMRiQ96518
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJYG Eukaryota
ENOG4111S7R LUCA
HOGENOMiHOG000237556
InParanoidiQ96518
KOiK00430
OMAiMFANSEA
OrthoDBiEOG09360FB9
PhylomeDBiQ96518

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96518-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNQSSFSIV ALLLIFFSSS VFAQLQTNFY RKSCPNVETI VRNAVRQKFQ
60 70 80 90 100
QTFVTAPATL RLFFHDCFVR GCDASILLAS PSEKDHPDDK SLAGDGFDTV
110 120 130 140 150
AKAKQALDRD PNCRNKVSCA DILALATRDV VVLTGGPNYP VELGRRDGRL
160 170 180 190 200
STVASVQHSL PQPSFKLDQL NTMFARHGLS QTDMIALSGA HTIGFAHCGK
210 220 230 240 250
FSKRIYNFSP KRPIDPTLNI RYALQLRQMC PIRVDLRIAI NMDPTSPNTF
260 270 280 290 300
DNAYFKNLQK GMGLFTSDQV LFSDERSRST VNSFASSEAT FRQAFISAIT
310 320
KLGRVGVKTG NAGEIRRDCS RVN
Length:323
Mass (Da):35,832
Last modified:November 1, 1998 - v2
Checksum:i43880AD393482989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003673 Genomic DNA Translation: AAC09031.1
CP002685 Genomic DNA Translation: AEC06835.1
BT003082 mRNA Translation: AAO23647.1
Y08781 mRNA Translation: CAA70034.1
PIRiT01626
RefSeqiNP_179488.1, NM_127455.4
UniGeneiAt.86

Genome annotation databases

EnsemblPlantsiAT2G18980.1; AT2G18980.1; AT2G18980
GeneIDi816415
GrameneiAT2G18980.1; AT2G18980.1; AT2G18980
KEGGiath:AT2G18980

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003673 Genomic DNA Translation: AAC09031.1
CP002685 Genomic DNA Translation: AEC06835.1
BT003082 mRNA Translation: AAO23647.1
Y08781 mRNA Translation: CAA70034.1
PIRiT01626
RefSeqiNP_179488.1, NM_127455.4
UniGeneiAt.86

3D structure databases

ProteinModelPortaliQ96518
SMRiQ96518
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G18980.1

Protein family/group databases

PeroxiBasei97 AtPrx16

Proteomic databases

PaxDbiQ96518
PRIDEiQ96518

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G18980.1; AT2G18980.1; AT2G18980
GeneIDi816415
GrameneiAT2G18980.1; AT2G18980.1; AT2G18980
KEGGiath:AT2G18980

Organism-specific databases

AraportiAT2G18980
TAIRilocus:2044485 AT2G18980

Phylogenomic databases

eggNOGiENOG410IJYG Eukaryota
ENOG4111S7R LUCA
HOGENOMiHOG000237556
InParanoidiQ96518
KOiK00430
OMAiMFANSEA
OrthoDBiEOG09360FB9
PhylomeDBiQ96518

Enzyme and pathway databases

BioCyciARA:AT2G18980-MONOMER

Miscellaneous databases

PROiPR:Q96518

Gene expression databases

ExpressionAtlasiQ96518 baseline and differential
GenevisibleiQ96518 AT

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER16_ARATH
AccessioniPrimary (citable) accession number: Q96518
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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