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Protein

Peroxidase 9

Gene

PER9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei81Transition state stabilizerPROSITE-ProRule annotation1
Active sitei85Proton acceptorPROSITE-ProRule annotation1
Metal bindingi86Calcium 1PROSITE-ProRule annotation1
Metal bindingi89Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi91Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi93Calcium 1PROSITE-ProRule annotation1
Metal bindingi95Calcium 1PROSITE-ProRule annotation1
Binding sitei182Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi212Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi213Calcium 2PROSITE-ProRule annotation1
Metal bindingi264Calcium 2PROSITE-ProRule annotation1
Metal bindingi267Calcium 2PROSITE-ProRule annotation1
Metal bindingi272Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G44970-MONOMER

Protein family/group databases

PeroxiBasei85 AtPrx09

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 9 (EC:1.11.1.7)
Short name:
Atperox P9
Alternative name(s):
ATP18a
Gene namesi
Name:PER9
Synonyms:P9
Ordered Locus Names:At1g44970
ORF Names:F27F5.6, T22C22.24
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G44970
TAIRilocus:2028280 AT1G44970

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002367524 – 346Peroxidase 9Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 134PROSITE-ProRule annotation
Disulfide bondi87 ↔ 92PROSITE-ProRule annotation
Disulfide bondi140 ↔ 342PROSITE-ProRule annotation
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi219 ↔ 251PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96512
PRIDEiQ96512

Expressioni

Gene expression databases

ExpressionAtlasiQ96512 baseline and differential
GenevisibleiQ96512 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G44970.1

Structurei

3D structure databases

ProteinModelPortaliQ96512
SMRiQ96512
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIDC Eukaryota
ENOG410YFB5 LUCA
HOGENOMiHOG000237557
InParanoidiQ96512
KOiK00430
OMAiCVTFKQR
OrthoDBiEOG09360EN5
PhylomeDBiQ96512

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96512-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAISKLIPTL VLFVLFSFDV SVAHPGLGFG WGSNSPIGGS FYSNLYPQFY
60 70 80 90 100
QFSCPQADEI VMTVLEKAIA KEPRMAASLL RLHFHDCFVQ GCDASILLDD
110 120 130 140 150
SATIRSEKNA GPNKNSVRGF QVIDEIKAKL EQACPQTVSC ADILALAARG
160 170 180 190 200
STILSGGPSW ELPLGRRDSR TASLNGANTN IPAPNSTIQN LLTMFQRKGL
210 220 230 240 250
NEEDLVSLSG GHTIGVARCT TFKQRLYNQN GNNQPDETLE RSYYYGLRSI
260 270 280 290 300
CPPTGGDNNI SPLDLASPAR FDNTYFKLLL WGKGLLTSDE VLLTGNVGKT
310 320 330 340
GALVKAYAED ERLFFQQFAK SMVNMGNIQP LTGFNGEIRK SCHVIN
Length:346
Mass (Da):37,741
Last modified:February 1, 1997 - v1
Checksum:i47EFD6297469A065
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269A → S in AAM63684 (Ref. 5) Curated1
Sequence conflicti290E → Q in AAM63684 (Ref. 5) Curated1
Sequence conflicti302A → S in AAM63684 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98804 mRNA Translation: CAA67336.1
AC007915 Genomic DNA Translation: AAF69153.1
AC020576 Genomic DNA Translation: AAF78280.1
CP002684 Genomic DNA Translation: AEE32069.1
BT008612 mRNA Translation: AAP40436.1
AY086626 mRNA Translation: AAM63684.1
RefSeqiNP_175117.1, NM_103577.4
UniGeneiAt.140

Genome annotation databases

EnsemblPlantsiAT1G44970.1; AT1G44970.1; AT1G44970
GeneIDi841062
GrameneiAT1G44970.1; AT1G44970.1; AT1G44970
KEGGiath:AT1G44970

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98804 mRNA Translation: CAA67336.1
AC007915 Genomic DNA Translation: AAF69153.1
AC020576 Genomic DNA Translation: AAF78280.1
CP002684 Genomic DNA Translation: AEE32069.1
BT008612 mRNA Translation: AAP40436.1
AY086626 mRNA Translation: AAM63684.1
RefSeqiNP_175117.1, NM_103577.4
UniGeneiAt.140

3D structure databases

ProteinModelPortaliQ96512
SMRiQ96512
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G44970.1

Protein family/group databases

PeroxiBasei85 AtPrx09

Proteomic databases

PaxDbiQ96512
PRIDEiQ96512

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G44970.1; AT1G44970.1; AT1G44970
GeneIDi841062
GrameneiAT1G44970.1; AT1G44970.1; AT1G44970
KEGGiath:AT1G44970

Organism-specific databases

AraportiAT1G44970
TAIRilocus:2028280 AT1G44970

Phylogenomic databases

eggNOGiENOG410IIDC Eukaryota
ENOG410YFB5 LUCA
HOGENOMiHOG000237557
InParanoidiQ96512
KOiK00430
OMAiCVTFKQR
OrthoDBiEOG09360EN5
PhylomeDBiQ96512

Enzyme and pathway databases

BioCyciARA:AT1G44970-MONOMER

Miscellaneous databases

PROiPR:Q96512

Gene expression databases

ExpressionAtlasiQ96512 baseline and differential
GenevisibleiQ96512 AT

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER9_ARATH
AccessioniPrimary (citable) accession number: Q96512
Secondary accession number(s): Q9LPD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: February 1, 1997
Last modified: October 10, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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