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UniProtKB - Q96303 (PHT14_ARATH)
Protein
Inorganic phosphate transporter 1-4
Gene
PHT1-4
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
High-affinity transporter for external inorganic phosphate. Acts as a H+:phosphate symporter in both low- and high-Pi conditions. Confers sensitivity to arsenate.
3 PublicationsMiscellaneous
Although related to the sugar transporter family, it does not transport sugars.
GO - Molecular functioni
- inorganic phosphate transmembrane transporter activity Source: TAIR
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- phosphate ion transport Source: UniProtKB-KW
Keywordsi
Biological process | Phosphate transport, Symport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Inorganic phosphate transporter 1-4Short name: AtPht1;4 Alternative name(s): H(+)/Pi cotransporter |
Gene namesi | Name:PHT1-4 Synonyms:PHT4, PT2 Ordered Locus Names:At2g38940 ORF Names:T7F6.11 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G38940 |
TAIRi | locus:2064895, AT2G38940 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication1 Publication; Multi-pass membrane protein 1 Publication
Golgi apparatus
- Golgi apparatus Source: TAIR
Plasma Membrane
- plasma membrane Source: TAIR
Vacuole
- vacuole Source: TAIR
Other locations
- integral component of membrane Source: UniProtKB-KW
- plasmodesma Source: TAIR
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 24 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 25 – 45 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 46 – 70 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 71 – 91 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 92 – 99 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 131 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 132 – 152 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 153 – 161 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 162 – 182 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 183 – 211 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 212 – 232 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 233 – 293 | CytoplasmicSequence analysisAdd BLAST | 61 | |
Transmembranei | 294 – 314 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 315 – 349 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 350 – 370 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 371 – 372 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 373 – 393 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 394 – 403 | ExtracellularSequence analysis | 10 | |
Transmembranei | 404 – 424 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 425 – 442 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 443 – 463 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 464 – 484 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 485 – 505 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 506 – 534 | CytoplasmicSequence analysisAdd BLAST | 29 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050471 | 1 – 534 | Inorganic phosphate transporter 1-4Add BLAST | 534 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 524 | PhosphoserineCombined sources | 1 | |
Modified residuei | 528 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q96303 |
ProteomicsDBi | 234664 |
PTM databases
iPTMneti | Q96303 |
Expressioni
Tissue specificityi
Mostly expressed in roots, in tissues connecting the lateral roots to the primary root. Also present in flowers, in senescing anther filaments and in the abscission zone at the base of siliques. Expressed in hydathodes and axillary buds, and in some senescing leaves. After Pi starvation, localized in all cells of undifferentiated root segments, including root tips and root hairs, and in the epidermis, cortex and stellar regions of mature root segments.5 Publications
Inductioni
In roots by phosphate starvation. Repressed by the Pi analog phosphite (Phi).6 Publications
Gene expression databases
ExpressionAtlasi | Q96303, baseline and differential |
Genevisiblei | Q96303, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 3818, 7 interactors |
STRINGi | 3702.AT2G38940.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 512 – 534 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. phosphate:H(+) symporter (TC 2.A.1.9) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0252, Eukaryota |
HOGENOMi | CLU_001265_46_14_1 |
InParanoidi | Q96303 |
OMAi | WFFLDLA |
OrthoDBi | 762280at2759 |
PhylomeDBi | Q96303 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004738, Phos_permease |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00887, 2A0109, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96303-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAREQLQVLN ALDVAKTQWY HFTAIIIAGM GFFTDAYDLF CISLVTKLLG
60 70 80 90 100
RIYYHVEGAQ KPGTLPPNVA AAVNGVAFCG TLAGQLFFGW LGDKLGRKKV
110 120 130 140 150
YGMTLMVMVL CSIASGLSFG HEPKAVMATL CFFRFWLGFG IGGDYPLSAT
160 170 180 190 200
IMSEYANKKT RGAFVSAVFA MQGFGIMAGG IFAIIISSAF EAKFPSPAYA
210 220 230 240 250
DDALGSTIPQ ADLVWRIILM AGAIPAAMTY YSRSKMPETA RYTALVAKDA
260 270 280 290 300
KQAASDMSKV LQVEIEPEQQ KLEEISKEKS KAFGLFSKEF MSRHGLHLLG
310 320 330 340 350
TTSTWFLLDI AFYSQNLFQK DIFSAIGWIP PAQSMNAIQE VFKIARAQTL
360 370 380 390 400
IALCSTVPGY WFTVAFIDVI GRFAIQMMGF FFMTVFMFAL AIPYNHWTHK
410 420 430 440 450
ENRIGFVIMY SLTFFFANFG PNATTFVVPA EIFPARFRST CHGISAASGK
460 470 480 490 500
LGAMVGAFGF LYLAQNPDKD KTDAGYPPGI GVRNSLIVLG VVNFLGILFT
510 520 530
FLVPESKGKS LEEMSGENED NENSNNDSRT VPIV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62331 mRNA Translation: AAB17266.1 AF022872 Genomic DNA Translation: AAB88291.1 AB016166 Genomic DNA Translation: BAA34398.1 AC005770 Genomic DNA Translation: AAC79607.1 CP002685 Genomic DNA Translation: AEC09615.1 |
PIRi | C84811 |
RefSeqi | NP_181428.1, NM_129452.4 |
Genome annotation databases
EnsemblPlantsi | AT2G38940.1; AT2G38940.1; AT2G38940 |
GeneIDi | 818479 |
Gramenei | AT2G38940.1; AT2G38940.1; AT2G38940 |
KEGGi | ath:AT2G38940 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62331 mRNA Translation: AAB17266.1 AF022872 Genomic DNA Translation: AAB88291.1 AB016166 Genomic DNA Translation: BAA34398.1 AC005770 Genomic DNA Translation: AAC79607.1 CP002685 Genomic DNA Translation: AEC09615.1 |
PIRi | C84811 |
RefSeqi | NP_181428.1, NM_129452.4 |
3D structure databases
SMRi | Q96303 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 3818, 7 interactors |
STRINGi | 3702.AT2G38940.1 |
PTM databases
iPTMneti | Q96303 |
Proteomic databases
PaxDbi | Q96303 |
ProteomicsDBi | 234664 |
Genome annotation databases
EnsemblPlantsi | AT2G38940.1; AT2G38940.1; AT2G38940 |
GeneIDi | 818479 |
Gramenei | AT2G38940.1; AT2G38940.1; AT2G38940 |
KEGGi | ath:AT2G38940 |
Organism-specific databases
Araporti | AT2G38940 |
TAIRi | locus:2064895, AT2G38940 |
Phylogenomic databases
eggNOGi | KOG0252, Eukaryota |
HOGENOMi | CLU_001265_46_14_1 |
InParanoidi | Q96303 |
OMAi | WFFLDLA |
OrthoDBi | 762280at2759 |
PhylomeDBi | Q96303 |
Miscellaneous databases
PROi | PR:Q96303 |
Gene expression databases
ExpressionAtlasi | Q96303, baseline and differential |
Genevisiblei | Q96303, AT |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004738, Phos_permease |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00887, 2A0109, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PHT14_ARATH | |
Accessioni | Q96303Primary (citable) accession number: Q96303 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families