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UniProtKB - Q96287 (KSG8_ARATH)
Protein
Shaggy-related protein kinase theta
Gene
ASK8
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
May mediate extracellular signals to regulate transcription in differentiating cells.
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 167 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 263 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 144 – 152 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- kinase activity Source: TAIR
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: TAIR
- protein serine kinase activity Source: RHEA
GO - Biological processi
- protein autophosphorylation Source: TAIR
- response to brassinosteroid Source: TAIR
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.26, 399 |
Names & Taxonomyi
Protein namesi | Recommended name: Shaggy-related protein kinase theta (EC:2.7.11.1)Alternative name(s): ASK-theta Shaggy-related protein kinase 32 Short name: AtSK32 |
Gene namesi | Name:ASK8 Synonyms:SK32 Ordered Locus Names:At4g00720Imported ORF Names:F6N23.11Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT4G00720 |
TAIRi | locus:2126993, AT4G00720 |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086223 | 1 – 472 | Shaggy-related protein kinase thetaAdd BLAST | 472 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 298 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Autophosphorylated mainly on threonine and serine residues.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q96287 |
PRIDEi | Q96287 |
ProteomicsDBi | 237105 |
PTM databases
iPTMneti | Q96287 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q96287, baseline and differential |
Genevisiblei | Q96287, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 13314, 5 interactors |
IntActi | Q96287, 3 interactors |
STRINGi | 3702.AT4G00720.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 138 – 423 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 286 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0658, Eukaryota |
HOGENOMi | CLU_000288_181_20_1 |
InParanoidi | Q96287 |
OMAi | KHYIRMN |
OrthoDBi | 990896at2759 |
PhylomeDBi | Q96287 |
Family and domain databases
CDDi | cd14137, STKc_GSK3, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR039192, STKc_GSK3 |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96287-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNVMRRLKSI ASGRTSISSD PGGDYALKRA KLDQENDNLC VDPMQVDQNS
60 70 80 90 100
SCFEMKADVL SQESVAGTSN VPAVSEKPVD DQLPDVMIEM KIRDERNANR
110 120 130 140 150
EDKDMETTVV NGSGTETGQV ITTTVGGRDG KPKQTISYMA QRVVGTGSFG
160 170 180 190 200
VVFQAKCLET GEQVAIKKVL QDKRYKNREL QIMRLQDHPN VVRLRHSFFS
210 220 230 240 250
TTDKDELYLN LVLEYVPETV YRASKHYTKM NQHMPIIFVQ LYTYQICRAL
260 270 280 290 300
NYLHRVVGVC HRDIKPQNLL VNPQTHQLKI CDFGSAKMLV PGEPNISYIC
310 320 330 340 350
SRYYRAPELI FGATEYTNAI DMWSGGCVMA ELLLGQPLFP GESGIDQLVE
360 370 380 390 400
IIKILGTPTR EEIRCMNPNY TEFKFPQIKA HPWHKIFHKR MPPEAVDLVS
410 420 430 440 450
RLLQYSPNLR CTALEACAHP FFDDLRDPNV SLPNGRALPP LFNFTAQELA
460 470
GASTELRQRL IPAHCQGTGS SS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y07822 mRNA Translation: CAA69156.1 AF058919 Genomic DNA Translation: AAC13616.1 AL161472 Genomic DNA Translation: CAB80881.1 CP002687 Genomic DNA Translation: AEE81925.1 AY062099 mRNA Translation: AAL32976.1 AY124881 mRNA Translation: AAM70590.1 |
PIRi | T01236 |
RefSeqi | NP_191981.1, NM_116297.4 |
Genome annotation databases
EnsemblPlantsi | AT4G00720.1; AT4G00720.1; AT4G00720 |
GeneIDi | 828023 |
Gramenei | AT4G00720.1; AT4G00720.1; AT4G00720 |
KEGGi | ath:AT4G00720 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y07822 mRNA Translation: CAA69156.1 AF058919 Genomic DNA Translation: AAC13616.1 AL161472 Genomic DNA Translation: CAB80881.1 CP002687 Genomic DNA Translation: AEE81925.1 AY062099 mRNA Translation: AAL32976.1 AY124881 mRNA Translation: AAM70590.1 |
PIRi | T01236 |
RefSeqi | NP_191981.1, NM_116297.4 |
3D structure databases
AlphaFoldDBi | Q96287 |
SMRi | Q96287 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 13314, 5 interactors |
IntActi | Q96287, 3 interactors |
STRINGi | 3702.AT4G00720.1 |
PTM databases
iPTMneti | Q96287 |
Proteomic databases
PaxDbi | Q96287 |
PRIDEi | Q96287 |
ProteomicsDBi | 237105 |
Genome annotation databases
EnsemblPlantsi | AT4G00720.1; AT4G00720.1; AT4G00720 |
GeneIDi | 828023 |
Gramenei | AT4G00720.1; AT4G00720.1; AT4G00720 |
KEGGi | ath:AT4G00720 |
Organism-specific databases
Araporti | AT4G00720 |
TAIRi | locus:2126993, AT4G00720 |
Phylogenomic databases
eggNOGi | KOG0658, Eukaryota |
HOGENOMi | CLU_000288_181_20_1 |
InParanoidi | Q96287 |
OMAi | KHYIRMN |
OrthoDBi | 990896at2759 |
PhylomeDBi | Q96287 |
Enzyme and pathway databases
BRENDAi | 2.7.11.26, 399 |
Miscellaneous databases
PROi | PR:Q96287 |
Gene expression databases
ExpressionAtlasi | Q96287, baseline and differential |
Genevisiblei | Q96287, AT |
Family and domain databases
CDDi | cd14137, STKc_GSK3, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR039192, STKc_GSK3 |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KSG8_ARATH | |
Accessioni | Q96287Primary (citable) accession number: Q96287 Secondary accession number(s): P93731 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | June 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 167 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families