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Entry version 131 (12 Aug 2020)
Sequence version 1 (01 Feb 1997)
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Protein

Guanosine nucleotide diphosphate dissociation inhibitor 1

Gene

GDI1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanosine nucleotide diphosphate dissociation inhibitor 1
Short name:
AtGDI1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GDI1
Ordered Locus Names:At2g44100
ORF Names:F6E13.23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G44100

The Arabidopsis Information Resource

More...
TAIRi
locus:2051839, AT2G44100

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004258071 – 445Guanosine nucleotide diphosphate dissociation inhibitor 1Add BLAST445

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96254

PRoteomics IDEntifications database

More...
PRIDEi
Q96254

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
221918 [Q96254-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96254

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q96254

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots, rosette leaves, stems, floral buds and siliques.2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96254, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96254, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the GDP-bound form of RABA5C (via C-terminus).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4352, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q96254, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT2G44100.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96254

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1439, Eukaryota

KEGG Orthology (KO)

More...
KOi
K17255

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFLGHAV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96254

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.50.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036188, FAD/NAD-bd_sf
IPR018203, GDP_dissociation_inhibitor
IPR000806, RabGDI

The PANTHER Classification System

More...
PANTHERi
PTHR11787, PTHR11787, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00996, GDI, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00892, RABGDI
PR00891, RABGDIREP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905, SSF51905, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96254-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEEYEVIVL GTGLKECILS GLLSVDGLKV LHMDRNDYYG GESTSLNLNQ
60 70 80 90 100
LWKKFRGEEK APAHLGSSRD YNVDMMPKFM MANGKLVRVL IHTDVTKYLS
110 120 130 140 150
FKAVDGSYVF VQGKVQKVPA TPMEALKSPL MGIFEKRRAG KFFSYVQEYD
160 170 180 190 200
EKDPKTHDGM DLRRVTTKDL IAKFGLKEDT IDFIGHAVAL HCNDNHLHQP
210 220 230 240 250
AYDTVMRMKL YAESLARFQG GSPYIYPLYG LGELPQAFAR LSAVYGGTYM
260 270 280 290 300
LNKPECKVEF DEEGKVSGVT SEGETAKCKK VVCDPSYLTN KVRKIGRVAR
310 320 330 340 350
AIAIMSHPIP NTNDSQSVQV ILPQKQLGRK SDMYVFCCSY SHNVAPKGKF
360 370 380 390 400
IAFVSTDAET DNPQTELQPG IDLLGPVDEL FFDIYDRYEP VNEPTLDNCF
410 420 430 440
ISTSYDATTH FDTTVVDVLN MYKLITGKEL DLSVDLNAAS AAEEE
Length:445
Mass (Da):49,819
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i228451B5A55C7545
GO
Isoform 2 (identifier: Q96254-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-431: ELD → VMF
     432-445: Missing.

Show »
Length:431
Mass (Da):48,439
Checksum:i6AB42AB1FA25554A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti233E → K in AAL38263 (PubMed:14593172).Curated1
Sequence conflicti338C → F in AAM64484 (Ref. 8) Curated1
Sequence conflicti430L → P in AAL38263 (PubMed:14593172).Curated1
Sequence conflicti438A → P in CAA69258 (PubMed:9091322).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053854429 – 431ELD → VMF in isoform 2. 1 Publication3
Alternative sequenceiVSP_053855432 – 445Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D83531 mRNA Translation: BAA11944.1
Y07961 mRNA Translation: CAA69258.1
AC004005 Genomic DNA Translation: AAC23429.1
CP002685 Genomic DNA Translation: AEC10374.1
CP002685 Genomic DNA Translation: AEC10375.1
AF361801 mRNA Translation: AAK32814.1
AY050418 mRNA Translation: AAK91434.1
AY065087 mRNA Translation: AAL38263.1
AY113036 mRNA Translation: AAM47344.1
AK316933 mRNA Translation: BAH19638.1
AK226690 mRNA Translation: BAE98797.1
AK227643 mRNA Translation: BAE99631.1
AY086920 mRNA Translation: AAM64484.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T00690

NCBI Reference Sequences

More...
RefSeqi
NP_001078054.1, NM_001084585.2 [Q96254-2]
NP_181938.1, NM_129973.3 [Q96254-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G44100.1; AT2G44100.1; AT2G44100 [Q96254-1]
AT2G44100.2; AT2G44100.2; AT2G44100 [Q96254-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
819016

Gramene; a comparative resource for plants

More...
Gramenei
AT2G44100.1; AT2G44100.1; AT2G44100 [Q96254-1]
AT2G44100.2; AT2G44100.2; AT2G44100 [Q96254-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G44100

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83531 mRNA Translation: BAA11944.1
Y07961 mRNA Translation: CAA69258.1
AC004005 Genomic DNA Translation: AAC23429.1
CP002685 Genomic DNA Translation: AEC10374.1
CP002685 Genomic DNA Translation: AEC10375.1
AF361801 mRNA Translation: AAK32814.1
AY050418 mRNA Translation: AAK91434.1
AY065087 mRNA Translation: AAL38263.1
AY113036 mRNA Translation: AAM47344.1
AK316933 mRNA Translation: BAH19638.1
AK226690 mRNA Translation: BAE98797.1
AK227643 mRNA Translation: BAE99631.1
AY086920 mRNA Translation: AAM64484.1
PIRiT00690
RefSeqiNP_001078054.1, NM_001084585.2 [Q96254-2]
NP_181938.1, NM_129973.3 [Q96254-1]

3D structure databases

SMRiQ96254
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4352, 4 interactors
IntActiQ96254, 1 interactor
STRINGi3702.AT2G44100.1

PTM databases

iPTMnetiQ96254
MetOSiteiQ96254

Proteomic databases

PaxDbiQ96254
PRIDEiQ96254
ProteomicsDBi221918 [Q96254-1]

Genome annotation databases

EnsemblPlantsiAT2G44100.1; AT2G44100.1; AT2G44100 [Q96254-1]
AT2G44100.2; AT2G44100.2; AT2G44100 [Q96254-2]
GeneIDi819016
GrameneiAT2G44100.1; AT2G44100.1; AT2G44100 [Q96254-1]
AT2G44100.2; AT2G44100.2; AT2G44100 [Q96254-2]
KEGGiath:AT2G44100

Organism-specific databases

AraportiAT2G44100
TAIRilocus:2051839, AT2G44100

Phylogenomic databases

eggNOGiKOG1439, Eukaryota
KOiK17255
OMAiDFLGHAV
PhylomeDBiQ96254

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q96254

Gene expression databases

ExpressionAtlasiQ96254, baseline and differential
GenevisibleiQ96254, AT

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188, FAD/NAD-bd_sf
IPR018203, GDP_dissociation_inhibitor
IPR000806, RabGDI
PANTHERiPTHR11787, PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996, GDI, 1 hit
PRINTSiPR00892, RABGDI
PR00891, RABGDIREP
SUPFAMiSSF51905, SSF51905, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGDI1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96254
Secondary accession number(s): B9DFX1
, Q8LBY8, Q8VZB4, Q96284
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: February 1, 1997
Last modified: August 12, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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