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Entry version 162 (12 Aug 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Hepatocyte growth factor-regulated tyrosine kinase substrate

Gene

Hrs

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri158 – 218FYVE-typePROSITE-ProRule annotationCuratedAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin binding Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-182971, EGFR downregulation
R-DME-432720, Lysosome Vesicle Biogenesis
R-DME-8856825, Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828, Clathrin-mediated endocytosis
R-DME-917729, Endosomal Sorting Complex Required For Transport (ESCRT)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hepatocyte growth factor-regulated tyrosine kinase substrate
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hrs
ORF Names:CG2903
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0031450, Hrs

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000840701 – 760Hepatocyte growth factor-regulated tyrosine kinase substrateAdd BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei300Phosphoserine1 Publication1
Modified residuei302Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q960X8

PRoteomics IDEntifications database

More...
PRIDEi
Q960X8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q960X8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically throughout development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0031450, Expressed in digestive system element and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q960X8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q960X8, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; in vitro.

Interacts with ubiquitin.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
59683, 59 interactors

Database of interacting proteins

More...
DIPi
DIP-32844N

Protein interaction database and analysis system

More...
IntActi
Q960X8, 6 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088692

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1760
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q960X8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q960X8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 141VHSPROSITE-ProRule annotationCuratedAdd BLAST129
Domaini263 – 282UIMPROSITE-ProRule annotationAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi439 – 745Gln/Pro-richAdd BLAST307

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 218FYVE-typePROSITE-ProRule annotationCuratedAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1818, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158297

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013062_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q960X8

KEGG Orthology (KO)

More...
KOi
K12182

Identification of Orthologs from Complete Genome Data

More...
OMAi
PHSSCYS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q960X8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.90, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008942, ENTH_VHS
IPR024641, HRS_helical
IPR017073, Ubi-bd_Hrs_VPS27
IPR003903, UIM_dom
IPR002014, VHS_dom
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363, FYVE, 1 hit
PF12210, Hrs_helical, 1 hit
PF00790, VHS, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036956, Hrs_Vps27, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064, FYVE, 1 hit
SM00288, VHS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48464, SSF48464, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50330, UIM, 1 hit
PS50179, VHS, 1 hit
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: Q960X8-1) [UniParc]FASTAAdd to basket
Also known as: C

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRSSFDKNL ENATSHLRLE PDWPSILLIC DEINQKDVTP KNAFAAIKKK
60 70 80 90 100
MNSPNPHSSC YSLLVLESIV KNCGAPVHEE VFTKENCEMF SSFLESTPHE
110 120 130 140 150
NVRQKMLELV QTWAYAFRSS DKYQAIKDTM TILKAKGHTF PELREADAMF
160 170 180 190 200
TADTAPNWAD GRVCHRCRVE FTFTNRKHHC RNCGQVFCGQ CTAKQCPLPK
210 220 230 240 250
YGIEKEVRVC DGCFAALQRP TSGSGGAKSG PRPADSELPA EYLNSTLAQQ
260 270 280 290 300
VQTPARKTEQ ELKEEEELQL ALALSQSEAE QQKPKLQSLP PAAYRMQQRS
310 320 330 340 350
PSPEAPPEPK EYHQQPEEAT NPELAKYLNR SYWEQRKISE SSSMASPSAP
360 370 380 390 400
SPMPPTPQPQ QIMPLQVKSA DEVQIDEFAA NMRTQVEIFV NRMKSNSSRG
410 420 430 440 450
RSISNDSSVQ TLFMTLTSLH SQQLSYIKEM DDKRMWYEQL QDKLTQIKDS
460 470 480 490 500
RAALDQLRQE HVEKLRRIAE EQERQRQMQM AQKLDIMRKK KQEYLQYQRQ
510 520 530 540 550
LALQRIQEQE REMQLRQEQQ KAQYLMGQSA PPFPYMPPSA VPQHGSPSHQ
560 570 580 590 600
LNNVYNPYAA GVPGYLPQGP APAPNGHGQF QAIPPGMYNP AIQQPMPPNL
610 620 630 640 650
QPGGLMQQPA PPGNPQMMPP MPENQFANNP AAILQLPQQH SIAQPPQIPF
660 670 680 690 700
QPQPQQIPGQ QPQQIPGQQP QQIPGQQPQQ IPGQQPQQIP VQQPQPQPQM
710 720 730 740 750
GHVMLQQHQA PPAAQAPPVT EIANNQVQAV AAAPAPPQNE PGPAPVKAEE
760
PATAELISFD
Length:760
Mass (Da):85,415
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i993833378D094F2C
GO
Isoform A (identifier: Q960X8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MFRSSFDKNLENAT → MSSEEELSIEEESL
     15-127: Missing.

Show »
Length:647
Mass (Da):72,413
Checksum:i40A42C2796C736B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti471E → G in AAN71346 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0291681 – 14MFRSS…LENAT → MSSEEELSIEEESL in isoform A. CuratedAdd BLAST14
Alternative sequenceiVSP_02916915 – 127Missing in isoform A. CuratedAdd BLAST113

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY071846 mRNA Translation: AAL60055.1
AE014134 Genomic DNA Translation: AAF51221.2
AE014134 Genomic DNA Translation: AAF51222.1
AE014134 Genomic DNA Translation: AAN10412.2
AY051789 mRNA Translation: AAK93213.1
BT001591 mRNA Translation: AAN71346.1

NCBI Reference Sequences

More...
RefSeqi
NP_525099.3, NM_080360.5 [Q960X8-1]
NP_722830.2, NM_164496.1 [Q960X8-1]
NP_722831.1, NM_164497.1 [Q960X8-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089749; FBpp0088690; FBgn0031450 [Q960X8-2]
FBtr0089750; FBpp0088691; FBgn0031450 [Q960X8-1]
FBtr0089751; FBpp0088692; FBgn0031450 [Q960X8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33458

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG2903

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY071846 mRNA Translation: AAL60055.1
AE014134 Genomic DNA Translation: AAF51221.2
AE014134 Genomic DNA Translation: AAF51222.1
AE014134 Genomic DNA Translation: AAN10412.2
AY051789 mRNA Translation: AAK93213.1
BT001591 mRNA Translation: AAN71346.1
RefSeqiNP_525099.3, NM_080360.5 [Q960X8-1]
NP_722830.2, NM_164496.1 [Q960X8-1]
NP_722831.1, NM_164497.1 [Q960X8-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DVPX-ray2.00A1-219[»]
SMRiQ960X8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi59683, 59 interactors
DIPiDIP-32844N
IntActiQ960X8, 6 interactors
STRINGi7227.FBpp0088692

PTM databases

iPTMnetiQ960X8

Proteomic databases

PaxDbiQ960X8
PRIDEiQ960X8

Genome annotation databases

EnsemblMetazoaiFBtr0089749; FBpp0088690; FBgn0031450 [Q960X8-2]
FBtr0089750; FBpp0088691; FBgn0031450 [Q960X8-1]
FBtr0089751; FBpp0088692; FBgn0031450 [Q960X8-1]
GeneIDi33458
KEGGidme:Dmel_CG2903

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33458
FlyBaseiFBgn0031450, Hrs

Phylogenomic databases

eggNOGiKOG1818, Eukaryota
GeneTreeiENSGT00940000158297
HOGENOMiCLU_013062_0_0_1
InParanoidiQ960X8
KOiK12182
OMAiPHSSCYS
PhylomeDBiQ960X8

Enzyme and pathway databases

ReactomeiR-DME-182971, EGFR downregulation
R-DME-432720, Lysosome Vesicle Biogenesis
R-DME-8856825, Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828, Clathrin-mediated endocytosis
R-DME-917729, Endosomal Sorting Complex Required For Transport (ESCRT)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
33458, 0 hits in 1 CRISPR screen
EvolutionaryTraceiQ960X8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33458

Protein Ontology

More...
PROi
PR:Q960X8

Gene expression databases

BgeeiFBgn0031450, Expressed in digestive system element and 40 other tissues
ExpressionAtlasiQ960X8, baseline and differential
GenevisibleiQ960X8, DM

Family and domain databases

Gene3Di1.25.40.90, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR008942, ENTH_VHS
IPR024641, HRS_helical
IPR017073, Ubi-bd_Hrs_VPS27
IPR003903, UIM_dom
IPR002014, VHS_dom
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363, FYVE, 1 hit
PF12210, Hrs_helical, 1 hit
PF00790, VHS, 1 hit
PIRSFiPIRSF036956, Hrs_Vps27, 1 hit
SMARTiView protein in SMART
SM00064, FYVE, 1 hit
SM00288, VHS, 1 hit
SUPFAMiSSF48464, SSF48464, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50330, UIM, 1 hit
PS50179, VHS, 1 hit
PS50178, ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHRS_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q960X8
Secondary accession number(s): A4V018
, Q8IGU6, Q9VQF2, Q9VQF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: December 1, 2001
Last modified: August 12, 2020
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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