Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein cortex

Gene

cort

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C) (PubMed:17251266, PubMed:18020708). Required for the completion of meiosis in oocytes (PubMed:11252055, PubMed:10683177, PubMed:10924478, PubMed:17251266, PubMed:18020708). Activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis (PubMed:17251266, PubMed:18020708). Promotes the ubiquitination and degradation of CycA early in meiosis I and the degradation of CycB and CycB3 after egg activation (PubMed:18020708). Promotes degradation of mtrm at the oocyte-to-embryo transition (PubMed:24019759).6 Publications

GO - Molecular functioni

GO - Biological processi

  • anaphase-promoting complex-dependent catabolic process Source: FlyBase
  • cellularization Source: FlyBase
  • egg activation Source: FlyBase
  • female meiosis I Source: FlyBase
  • female meiosis II Source: FlyBase
  • female meiotic nuclear division Source: UniProtKB
  • homologous chromosome segregation Source: FlyBase
  • oogenesis Source: UniProtKB-KW
  • pole cell formation Source: FlyBase
  • positive regulation of anaphase-promoting complex-dependent catabolic process Source: FlyBase
  • positive regulation of ubiquitin protein ligase activity Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Meiosis, Oogenesis

Enzyme and pathway databases

SignaLinkiQ960N3

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cortex1 Publication
Gene namesi
Name:cort1 Publication
ORF Names:CG11330
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000351 cort

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi303Y → C in QW55; abnormal arrest in female meiosis. 1 Publication1
Mutagenesisi424 – 432RGTLFLMWN → AGTAFLMWA: Prevents degradation following egg activation. 1 Publication9
Mutagenesisi431 – 483Missing in RH65; abnormal arrest in female meiosis. 1 PublicationAdd BLAST53

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509411 – 483Protein cortexAdd BLAST483

Post-translational modificationi

Probably ubiquitinated: degraded following egg activation by the anaphase promoting complex/cyclosome (APC/C).1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ960N3
PRIDEiQ960N3

Expressioni

Tissue specificityi

Highly expressed in ovaries. Expressed in nurse cells from stage 6 to stage 12 egg chambers. As oocyte matures, it is transferred from the nurse cells to the oocyte.1 Publication

Developmental stagei

Undetectable in early stage 1-8 egg chambers and present at very low levels in stages 9-10B egg chambers. Strongly increases in stage 12-13 egg chambers and remains high in mature stage 14 oocytes (PubMed:18020708). Protein levels drop dramatically by the time meiosis is completed in unfertilized eggs (at protein level) (PubMed:18020708).1 Publication

Inductioni

Transcription is activated by grauzone (grau), which binds to its promoter region.2 Publications

Gene expression databases

BgeeiFBgn0000351
ExpressionAtlasiQ960N3 baseline and differential
GenevisibleiQ960N3 DM

Interactioni

Subunit structurei

Interacts with anaphase promoting complex/cyclosome (APC/C) subunits Cdc16 and Cdc27 (PubMed:18020708). Interacts with mtrm (PubMed:24019759).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
mtrmQ239733EBI-3423056,EBI-166563

Protein-protein interaction databases

BioGridi60090, 9 interactors
DIPiDIP-60666N
ELMiQ960N3
IntActiQ960N3, 8 interactors
STRINGi7227.FBpp0078949

Structurei

3D structure databases

ProteinModelPortaliQ960N3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati158 – 195WD 1Add BLAST38
Repeati196 – 237WD 2Add BLAST42
Repeati245 – 284WD 3Add BLAST40
Repeati287 – 326WD 4Add BLAST40
Repeati421 – 460WD 5Add BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi424 – 432D-box1 Publication9

Sequence similaritiesi

Belongs to the WD repeat CORT family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IMNW Eukaryota
ENOG4112CYB LUCA
InParanoidiQ960N3
OMAiSYWRQSG
OrthoDBiEOG091G0A9L
PhylomeDBiQ960N3

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR033010 Cdc20/Fizzy
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19918 PTHR19918, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q960N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVEMSVCDS PNKNSKLDKK SLTPFKKVRR KNWKQEAAYK SDTSKGQEVS
60 70 80 90 100
YVGERFIPNR FERENIEFNL KYIGKRKERD ILETGVTLTA SYWRQSGFIS
110 120 130 140 150
NINRTFGIGE RRLFQFSSQQ GTRSRVVDND SADSDWPCNP RARPYAIQNA
160 170 180 190 200
THEMPGICSP VDYNMMDWSS GGMVAMSSGQ DVMLWRNLDE STMVFSVESP
210 220 230 240 250
TSLKYSPDGK HLAIGCMDRN YPVLDLWEVR SPTEFLVSYR KLFFKSMGYI
260 270 280 290 300
SCIEWSHDGK EVICGTQCGV IIVLAMPTLN TLMQLREHRH TVKKMKFAPT
310 320 330 340 350
HKYFASSDTD GKIFIFDAVL KVRLLKLDGR SIVFDWHPWT GEDLAVAERS
360 370 380 390 400
PASIFIFNIP RRQFVASYRR RDDRIVIKTL TYSKITGELL VNVIRRDDAD
410 420 430 440 450
LAVCEILVLA SLNRVVDLMS HQDRGTLFLM WNPDGTKIAT GGLDDTFSLW
460 470 480
NFFPTYKREA ILRKQEQKAK DKCSSLSLYK GIR
Length:483
Mass (Da):55,575
Last modified:April 23, 2003 - v2
Checksum:i007DD0190DE06735
GO

Sequence cautioni

The sequence AAK93390 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033478 mRNA Translation: AAK54464.1
AE014134 Genomic DNA Translation: AAF52421.1
AY051966 mRNA Translation: AAK93390.1 Different initiation.
RefSeqiNP_001260144.1, NM_001273215.1
NP_523494.1, NM_078770.2
UniGeneiDm.12510

Genome annotation databases

EnsemblMetazoaiFBtr0079320; FBpp0078949; FBgn0000351
FBtr0333350; FBpp0305542; FBgn0000351
GeneIDi33937
KEGGidme:Dmel_CG11330
UCSCiCG11330-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiCORT_DROME
AccessioniPrimary (citable) accession number: Q960N3
Secondary accession number(s): Q9VMA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: May 23, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health