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Protein

5'-AMP-activated protein kinase catalytic subunit alpha-2

Gene

aak-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals (PubMed:15574588). Role in motility and response to oxidative stress (PubMed:18408008, PubMed:24763318). Involved in the establishment of germline stem cell (GSC) quiescence during dauer development (PubMed:15574588, PubMed:20110331). Plays a role in axon regrowth after axotomy in PLM neurons (PubMed:24431434). Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress (PubMed:26439621). Plays a role in the regulation of flp-7 secretion from ASI neurons (PubMed:28128367). Keeps the CREB-regulated transcription coactivator 1 homolog crtc-1 inactive which in turn inhibits flp-7 secretion (PubMed:28128367). Following serotonin signaling, derepresses crtc-1 which stimulates flp-7 secretion and subsequent body fat loss (PubMed:28128367).7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by phosphorylation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei116ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei210Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi93 – 101ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • AMP-activated protein kinase activity Source: WormBase
  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1632852 Macroautophagy
R-CEL-163680 AMPK inhibits chREBP transcriptional activation activity
R-CEL-200425 Import of palmitoyl-CoA into the mitochondrial matrix
R-CEL-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-CEL-5628897 TP53 Regulates Metabolic Genes

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q95ZQ4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC:2.7.11.1)
Short name:
AMPK subunit alpha-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aak-2
ORF Names:T01C8.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
T01C8.1a ; CE31222 ; WBGene00020142 ; aak-2
T01C8.1b ; CE31223 ; WBGene00020142 ; aak-2
T01C8.1c ; CE07458 ; WBGene00020142 ; aak-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Shortened life-span (PubMed:15574588, PubMed:18408008). Temperature-dependent hypersensitivity to stress, slow body bending, abnormal modulation of head oscillation (PubMed:15574588, PubMed:18408008). Reduced survival following oxidative stress induced by the superoxide paraquat (PubMed:24763318). Reduced survival as a result of hyperosmotic stress induced by NaCl (PubMed:26439621). Double knockout with aak-1 results in reduced glycogen accumulation (PubMed:26439621).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000855991 – 6265'-AMP-activated protein kinase catalytic subunit alpha-2Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei243Phosphothreonine; by par-42 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Thr-243 in response to oxidative stress and during dauer development.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q95ZQ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q95ZQ4

PeptideAtlas

More...
PeptideAtlasi
Q95ZQ4

PRoteomics IDEntifications database

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PRIDEi
Q95ZQ4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q95ZQ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the pharynx, the ventral cord, neurons including the hermaphrodite-specific neuron, body wall muscles, the vulva, the excretory canal, and weakly in the intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00020142 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer that binds four cAMP molecules.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
aakb-2Q9NAH74EBI-326514,EBI-2417663

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
46610, 8 interactors

Database of interacting proteins

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DIPi
DIP-25170N

Protein interaction database and analysis system

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IntActi
Q95ZQ4, 7 interactors

STRING: functional protein association networks

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STRINGi
6239.T01C8.1b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q95ZQ4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q95ZQ4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini87 – 339Protein kinasePROSITE-ProRule annotationAdd BLAST253

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0586 Eukaryota
ENOG410XNQ0 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000167424

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233016

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q95ZQ4

KEGG Orthology (KO)

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KOi
K07198

Identification of Orthologs from Complete Genome Data

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OMAi
TMHIPPG

Database of Orthologous Groups

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OrthoDBi
EOG091G03TG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q95ZQ4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032270 AMPK_C
IPR028375 KA1/Ssp2_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16579 AdenylateSensor, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform b1 Publication (identifier: Q95ZQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSHQDRDRD RKEDGGGDGT EMKSKSRSQP SGLNRVKNLS RKLSAKSRKE
60 70 80 90 100
RKDRDSTDNS SKMSSPGGET STKQQQELKA QIKIGHYILK ETLGVGTFGK
110 120 130 140 150
VKVGIHETTQ YKVAVKILNR QKIKSLDVVG KIRREIQNLS LFRHPHIIRL
160 170 180 190 200
YQVISTPSDI FMIMEHVSGG ELFDYIVKHG RLKTAEARRF FQQIISGVDY
210 220 230 240 250
CHRHMVVHRD LKPENLLLDE QNNVKIADFG LSNIMTDGDF LRTSCGSPNY
260 270 280 290 300
AAPEVISGKL YAGPEVDVWS CGVILYALLC GTLPFDDEHV PSLFRKIKSG
310 320 330 340 350
VFPTPDFLER PIVNLLHHML CVDPMKRATI KDVIAHEWFQ KDLPNYLFPP
360 370 380 390 400
INESEASIVD IEAVREVTEF QRYHVAEEEV TSALLGDDPH HHLSIAYNLI
410 420 430 440 450
VDNKRIADET AKLSIEEFYQ VTPNKGPGPV HRHPERIAAS VSSKITPTLD
460 470 480 490 500
NTEASGANRN KRAKWHLGIR SQSRPEDIMF EVFRAMKQLD MEWKVLNPYH
510 520 530 540 550
VIVRRKPDAP AADPPKMSLQ LYQVDQRSYL LDFKSLADEE SGSASASSSR
560 570 580 590 600
HASMSMPQKP AGIRGTRTSS MPQAMSMEAS IEKMEVHDFS DMSCDVTPPP
610 620
SPGGAKLSQT MQFFEICAAL IGTLAR
Note: No experimental confirmation available.Curated
Length:626
Mass (Da):70,443
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1401DB1286D8624
GO
Isoform a1 Publication (identifier: Q95ZQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     370-371: Missing.

Show »
Length:624
Mass (Da):70,168
Checksum:i3BF9F9610BA95DB7
GO
Isoform c1 Publication (identifier: Q95ZQ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     370-371: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:562
Mass (Da):63,103
Checksum:iAA34A96C5BBCAFBD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0519401 – 62Missing in isoform c. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_051941370 – 371Missing in isoform a and isoform c. 2 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY347273 mRNA Translation: AAR06928.1
FO081053 Genomic DNA Translation: CCD68833.1
FO081053 Genomic DNA Translation: CCD68834.1
FO081053 Genomic DNA Translation: CCD68835.1

Protein sequence database of the Protein Information Resource

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PIRi
T29858

NCBI Reference Sequences

More...
RefSeqi
NP_001024868.1, NM_001029697.3 [Q95ZQ4-3]
NP_510710.2, NM_078309.4 [Q95ZQ4-1]
NP_510711.2, NM_078310.5 [Q95ZQ4-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Cel.17479

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T01C8.1a; T01C8.1a; WBGene00020142 [Q95ZQ4-2]
T01C8.1b; T01C8.1b; WBGene00020142 [Q95ZQ4-1]
T01C8.1c.1; T01C8.1c.1; WBGene00020142 [Q95ZQ4-3]
T01C8.1c.2; T01C8.1c.2; WBGene00020142 [Q95ZQ4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
181727

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_T01C8.1

UCSC genome browser

More...
UCSCi
T01C8.1c.1 c. elegans [Q95ZQ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY347273 mRNA Translation: AAR06928.1
FO081053 Genomic DNA Translation: CCD68833.1
FO081053 Genomic DNA Translation: CCD68834.1
FO081053 Genomic DNA Translation: CCD68835.1
PIRiT29858
RefSeqiNP_001024868.1, NM_001029697.3 [Q95ZQ4-3]
NP_510710.2, NM_078309.4 [Q95ZQ4-1]
NP_510711.2, NM_078310.5 [Q95ZQ4-2]
UniGeneiCel.17479

3D structure databases

ProteinModelPortaliQ95ZQ4
SMRiQ95ZQ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46610, 8 interactors
DIPiDIP-25170N
IntActiQ95ZQ4, 7 interactors
STRINGi6239.T01C8.1b

PTM databases

iPTMnetiQ95ZQ4

Proteomic databases

EPDiQ95ZQ4
PaxDbiQ95ZQ4
PeptideAtlasiQ95ZQ4
PRIDEiQ95ZQ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT01C8.1a; T01C8.1a; WBGene00020142 [Q95ZQ4-2]
T01C8.1b; T01C8.1b; WBGene00020142 [Q95ZQ4-1]
T01C8.1c.1; T01C8.1c.1; WBGene00020142 [Q95ZQ4-3]
T01C8.1c.2; T01C8.1c.2; WBGene00020142 [Q95ZQ4-3]
GeneIDi181727
KEGGicel:CELE_T01C8.1
UCSCiT01C8.1c.1 c. elegans [Q95ZQ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181727
WormBaseiT01C8.1a ; CE31222 ; WBGene00020142 ; aak-2
T01C8.1b ; CE31223 ; WBGene00020142 ; aak-2
T01C8.1c ; CE07458 ; WBGene00020142 ; aak-2

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
GeneTreeiENSGT00940000167424
HOGENOMiHOG000233016
InParanoidiQ95ZQ4
KOiK07198
OMAiTMHIPPG
OrthoDBiEOG091G03TG
PhylomeDBiQ95ZQ4

Enzyme and pathway databases

ReactomeiR-CEL-1632852 Macroautophagy
R-CEL-163680 AMPK inhibits chREBP transcriptional activation activity
R-CEL-200425 Import of palmitoyl-CoA into the mitochondrial matrix
R-CEL-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-CEL-5628897 TP53 Regulates Metabolic Genes
SignaLinkiQ95ZQ4

Miscellaneous databases

Protein Ontology

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PROi
PR:Q95ZQ4

Gene expression databases

BgeeiWBGene00020142 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

InterProiView protein in InterPro
IPR032270 AMPK_C
IPR028375 KA1/Ssp2_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF16579 AdenylateSensor, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAAPK2_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95ZQ4
Secondary accession number(s): Q22068, Q86FL6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2002
Last modified: December 5, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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