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Entry version 86 (12 Aug 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Mushroom body large-type Kenyon cell-specific protein 1

Gene

Mblk-1

Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator which binds to the consensus sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in higher-order sensory processing.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi610 – 630H-T-H motifPROSITE-ProRule annotationAdd BLAST21
DNA bindingi1062 – 1082H-T-H motifPROSITE-ProRule annotationAdd BLAST21

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mushroom body large-type Kenyon cell-specific protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mblk-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiApis mellifera (Honeybee)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7460 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005203 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi444S → A: Loss of phosphorylation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002389161 – 1598Mushroom body large-type Kenyon cell-specific protein 1Add BLAST1598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei444Phosphoserine; by MAPK1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q95YM8

PRoteomics IDEntifications database

More...
PRIDEi
Q95YM8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q95YM8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Large-type Kenyon cells of mushroom body.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Curated1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7460.GB50048-PA

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q95YM8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini582 – 634HTH psq-type 1PROSITE-ProRule annotationAdd BLAST53
Domaini1034 – 1086HTH psq-type 2PROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi106 – 120Poly-ThrAdd BLAST15
Compositional biasi147 – 150Poly-His4
Compositional biasi164 – 177Poly-GlnAdd BLAST14
Compositional biasi284 – 290Poly-Glu7
Compositional biasi447 – 455Poly-Ser9
Compositional biasi564 – 574Poly-AlaAdd BLAST11
Compositional biasi656 – 677Poly-ThrAdd BLAST22
Compositional biasi769 – 772Poly-Ala4
Compositional biasi823 – 855Poly-GlnAdd BLAST33
Compositional biasi1108 – 1112Poly-Ala5
Compositional biasi1209 – 1235Poly-GlnAdd BLAST27
Compositional biasi1309 – 1312Poly-Gln4
Compositional biasi1448 – 1466Poly-GlnAdd BLAST19
Compositional biasi1501 – 1547Poly-GlnAdd BLAST47
Compositional biasi1578 – 1584Poly-Gln7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The second H-T-H motif is necessary for transcriptional activation.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4565, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q95YM8

KEGG Orthology (KO)

More...
KOi
K20015

Database of Orthologous Groups

More...
OrthoDBi
596515at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q95YM8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR007889, HTH_Psq

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05225, HTH_psq, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50960, HTH_PSQ, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q95YM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADCPYARCI QERRHIRREL LRWTKNMVFV VGLERVAEEL MGRRRWKQYQ
60 70 80 90 100
DTLYSGTRSS ESLTAQAHHR LYPAFSSSCD PVPGNLEQIG SRPLHPPASS
110 120 130 140 150
TSLPATITTT TTTTTTTTAT AAATATTTAT GLIKQETLQR HHHLQNHHHH
160 170 180 190 200
LQSTAVQDHH RPYQQQQQQQ QRQQQRQEER RLRPDEIKVE VGEDEFANGG
210 220 230 240 250
AARDESKAGS TDASTPATVT TTGATTTLPA ASATGTGPAT PSAVVATSNA
260 270 280 290 300
TAAMTTGTTT IPTRRLRKRR QNDGEGADDR DDDEENEEEE DGRGQSEAEK
310 320 330 340 350
RLKLDEDADG AVSPLRREKD RGSREYPTSN ATDTDGTKER TEEVALDRTP
360 370 380 390 400
VTQGLLRVKK EEELQEAPSC GGGPTILTTP GLDSDGIRLP CREVEAAATA
410 420 430 440 450
RNVVAPFLIG SRRTSPPPED WKPLDKCYFC LDGKLPHDDQ PPLSPQSDSS
460 470 480 490 500
SSSRSAESPM SVQVDPMAAS VVAAALTGTY PTLLPQWCLP PREAPLVGVQ
510 520 530 540 550
PHQDSATPAD QPLDLSAKPK NSQDNNISLL EQQKIPLRMT AGIDPKSIFN
560 570 580 590 600
SGYRPKPRMS GPVAAVAAAA VAAAGVGGVP VVGAGGGRRA YTEEELQAAL
610 620 630 640 650
RDIQSGKLGT RRAAVIYGIP RSTLRNKVYK LAMERERDAS LSSTHSHPHE
660 670 680 690 700
PGAPATTITT ITTTTTTTTT TTTTTTTPNT TQNASATTPP PQVDEVDDKE
710 720 730 740 750
LSGAEEEKEV EKALLKPLLS LEDLVRFSTL EGSGGDSLRT LLQRGQETGA
760 770 780 790 800
EWPGLEHANI GPYIQKMIAA AAPFKGMETQ DYRIPEVMRR LMSEDKRLSK
810 820 830 840 850
SVNGDQSQPP HQQLHHHQST HPQAQAQAQP QQQQQQQQQQ PQQQQQQQQQ
860 870 880 890 900
QQQQQRGPMT NDDFNPNIEE EASDSAQGRA ILKIPSYKPA STPGCSSKNG
910 920 930 940 950
EPTSAAFAQG FATAASSPGL LERASPAFSG TSSPTNSLVG KTVAVNFRDV
960 970 980 990 1000
IAKSISVKFQ EGQTVSGGGM GGCQPGGVVQ SQQPIMTDPS PFKRGRYTPP
1010 1020 1030 1040 1050
QPANAQQGQA QAQAKPQSQE ANKPKPATGG KGTRPKRGKY RNYDRDSLVE
1060 1070 1080 1090 1100
AVRAVQRGEM SVHRAGSYYG VPHSTLEYKV KERHLMRPRK RDQKQSDDKT
1110 1120 1130 1140 1150
KETSTVTAAA AATNIRPGTA DNKPQLKPQK PFTSPGGIPG PNGIKMPSFM
1160 1170 1180 1190 1200
EGMPHLPFTP FNFWNPPPFM PSPFMAGAPN VPTILPEQYF ATSRIRGLQE
1210 1220 1230 1240 1250
QQRNAAMVQQ QQQQQQQQQQ QQQQQQQQQQ QQQHQARERE GVGAGIAETS
1260 1270 1280 1290 1300
AGTSNSRGAA QMSKVPRDVS EGIYDGSGAN GSFLDNLIRS SLETGIPRDQ
1310 1320 1330 1340 1350
RAMTEARNQQ QQASSQQQIP ESMRSKALID QLCRNSRRTP VPRLAQDSSE
1360 1370 1380 1390 1400
DESYRGPSAS GGRPVPERPE RVPTVDLSPS PSDRGRNDDG SDRLTSPPTP
1410 1420 1430 1440 1450
LSISRAGSRD EDSTRDSTKL DRSSREREVH NGGQQEDRDR KTLTSAPQQP
1460 1470 1480 1490 1500
QQQQQQQQQQ QQQQQQLNHY PDLHNLYAVP TDKKSACDSK LIVDHSSQKT
1510 1520 1530 1540 1550
QQQQPQQQQQ QQQQQQPQQQ SQQPQQQQPQ PQQQQQQQQQ QQPQQQQKEY
1560 1570 1580 1590
GAVSGLVVQL QRGYNSGNNR SGEQANSQQQ QQQQSGEPVI GMEDSVEQ
Length:1,598
Mass (Da):174,929
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5475BDD3ACB1EEF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB047034 mRNA Translation: BAB64310.1

NCBI Reference Sequences

More...
RefSeqi
NP_001011629.1, NM_001011629.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
408521

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ame:408521

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047034 mRNA Translation: BAB64310.1
RefSeqiNP_001011629.1, NM_001011629.1

3D structure databases

SMRiQ95YM8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7460.GB50048-PA

PTM databases

iPTMnetiQ95YM8

Proteomic databases

PaxDbiQ95YM8
PRIDEiQ95YM8

Genome annotation databases

GeneIDi408521
KEGGiame:408521

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
408521

Phylogenomic databases

eggNOGiKOG4565, Eukaryota
InParanoidiQ95YM8
KOiK20015
OrthoDBi596515at2759
PhylomeDBiQ95YM8

Family and domain databases

InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR007889, HTH_Psq
PfamiView protein in Pfam
PF05225, HTH_psq, 2 hits
SUPFAMiSSF46689, SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS50960, HTH_PSQ, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBLK1_APIME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95YM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: August 12, 2020
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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