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Entry version 132 (29 Sep 2021)
Sequence version 3 (02 Jun 2021)
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Protein

Nipped-B-like protein scc-2

Gene

scc-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the loading of the cohesin complex on to meiotic chromosomes (PubMed:21856158).

Forms a heterodimeric complex (also known as cohesin loading complex) with mau-2/SCC4 which mediates the loading of the cohesin complex onto chromatin (By similarity).

Plays an essential role in cell division during embryonic development (PubMed:15146185, PubMed:16802858).

Promotes normal chromosome organization during meiosis (PubMed:21856158).

Required for the assembly of the synaptonemal complex between homologous chromosomes to promote sister chromatid cohesion during meiosis (PubMed:21856158).

Required for chromosome segregation during mitosis and meiosis (PubMed:16802858).

Plays a role in DNA double-strand break (DSB) repair during meiotic recombination and promotes the assembly of the 9-1-1 cell-cycle checkpoint response complex which is required for inducing apoptosis in response to DNA damage, at DNA damage sites (PubMed:21856158).

By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2470946, Cohesin Loading onto Chromatin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nipped-B-like protein scc-2Curated
Alternative name(s):
Prion-like-(Q/N-rich) domain-bearing protein 85
SCC2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:scc-21 Publication
Synonyms:pqn-85Imported
ORF Names:Y43H11AL.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
Y43H11AL.3a ; CE53800 ; WBGene00004166 ; scc-2
Y43H11AL.3b ; CE50846 ; WBGene00004166 ; scc-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown results in 100% embryonic lethality (PubMed:15146185, PubMed:16802858). Any survivors display a paralyzed uncoordinated phenotype, body morphology defects and sometimes a vulval defect (PubMed:15146185). RNAi-mediated knockdown results in chromosome segregation defects in early embryos with lagging chromosomes at the anaphase phase of mitosis (PubMed:16802858). RNAi-mediated knockdown results in cytological defects in the pachytene and diakinesis phases of meiosis in the germline (PubMed:21856158). RNAi-mediated knockdown abolishes loading of cohesin complex components smc-1, smc-3 and rec-8 onto the to the axial element of meiotic chromosomes in the germline, however these subunits do accumulate in the mitotic nuclei and the meiotic S phase nuclei that precede the start of meiotic prophase (PubMed:21856158). RNAi-mediated knockdown results in defective DNA double-strand break repair during meiosis resulting in an accumulation of rad-51-positive recombination intermediates and elongated rad-51-positive recombination structures in the mid and late pachytene region of the germline (PubMed:21856158). There is an increase in apoptosis in response to the accumulation of recombination intermediates, but only in the presence of smc-1, indicative of a defective DNA damage response (PubMed:21856158).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi112H → Y in fq1; cytological defects in the pachytene and diakinesis phases of meiotic prophase in the germline. Abolishes loading of cohesin complex components smc-1, smc-3 and rec-8 onto the to the axial element of meiotic chromosomes in the germline, however these subunits do accumulate in the mitotic nuclei and the meiotic S phase nuclei that precede the start of meiotic prophase. Abrogates assembly of the synaptonemal complex between homologous chromosomes. Does not affect the loading of condensin and the smc-5/6 complex onto meiotic chromosomes. Defective DNA double-strand break repair during meiosis resulting in an accumulation of rad-51-positive recombination intermediates and elongated rad-51-positive recombination structures in the mid and late pachytene region of the germline. No increase in apoptosis in response to the accumulation of recombination intermediates, indicative of a defective DNA damage response. Furthermore, hus-1, a component of the 9-1-1 cell-cycle checkpoint response complex which is required for inducing apoptosis in response to DNA damage, does not accumulate on the recombination intermediates. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002185981 – 2176Nipped-B-like protein scc-2Add BLAST2176

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q95XZ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q95XZ5

PeptideAtlas

More...
PeptideAtlasi
Q95XZ5

PRoteomics IDEntifications database

More...
PRIDEi
Q95XZ5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q95XZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004166, Expressed in multi-cellular organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q95XZ5, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May heterodimerize with mau-2/SCC4 to form the cohesin loading complex.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
38788, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q95XZ5, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.Y43H11AL.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q95XZ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1280 – 1312HEAT 1Add BLAST33
Repeati1320 – 1351HEAT 2Add BLAST32
Repeati1353 – 1388HEAT 3Add BLAST36
Repeati1393 – 1426HEAT 4Add BLAST34
Repeati1692 – 1723HEAT 5Add BLAST32
Repeati1803 – 1834HEAT 6Add BLAST32
Repeati1840 – 1871HEAT 7Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni150 – 170DisorderedSequence analysisAdd BLAST21
Regioni464 – 483DisorderedSequence analysisAdd BLAST20
Regioni495 – 514DisorderedSequence analysisAdd BLAST20
Regioni523 – 551DisorderedSequence analysisAdd BLAST29
Regioni585 – 615DisorderedSequence analysisAdd BLAST31
Regioni669 – 708DisorderedSequence analysisAdd BLAST40
Regioni2149 – 2176DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi534 – 551Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi586 – 615Basic and acidic residuesSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SCC2/Nipped-B family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1020, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010427

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000763_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q95XZ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
SANFKDR

Database of Orthologous Groups

More...
OrthoDBi
608077at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q95XZ5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR026003, Cohesin_HEAT
IPR024986, Nipped-B_C
IPR033031, SCC2/Nipped-B

The PANTHER Classification System

More...
PANTHERi
PTHR21704, PTHR21704, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12765, Cohesin_HEAT, 1 hit
PF12830, Nipped-B_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q95XZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPNNLQNSL NGTGNPNFQP VQTNAGGFGH QMAQTGAAAA AAATGQYNPM
60 70 80 90 100
LLQQQYLNFG FGMNYNNQLF DFQAQQQQQQ QYLMQQQQQQ QQLHHQQQQQ
110 120 130 140 150
HQNIAQPQAQ HHQMNMFTQH QMLQLMQQQQ QQQQQQPVQQ IQRQQPIAQP
160 170 180 190 200
IPQHTIPPST SNQFQQQIQS AASSIFDSSV ISSHQKLYEE QCRQIEKERK
210 220 230 240 250
EQEERKRKQE LEEQRKRNEE LKRLRIAEEK RLLEEQQRLR EQMERERLAE
260 270 280 290 300
IKRLEEAARL EDERRIAADI EAQKQAMLQK MQAEQNKHIA EVERQRSELE
310 320 330 340 350
ERFARVSQPM TLVGTHFLPN FLDMIPFPYE SMVDSTLPQV FDMERDSAIL
360 370 380 390 400
ESCDPQMVAT ISNILNATNI DDIITRMDKL RPDDKETNDL FLDKLPPIIQ
410 420 430 440 450
AVVNYNTSAL DVDSHNDMEL LENEDVMMTE DITRTTAPST SSSSYNNHHQ
460 470 480 490 500
NSIVMMTSSS VSMSEATQSS SVTMNHHDVD EEGPAPISIE KRRQMMSVGK
510 520 530 540 550
APKAGGGGGQ NQRKKRDMVE NLYDSLTDNF VPTDTGRRGR RRGRGSDDDE
560 570 580 590 600
DELLQRDLKL IEEMEKGVKL PASVTGFTTT EEDVQHFFGS QKKRRKEDRI
610 620 630 640 650
RKDRSPTPED VIESRDAEWQ ERLRLKMERE KSRKADEESQ NAWSLQALAD
660 670 680 690 700
NETFTRFCQT VDGVLEQGDS LDTELKMPKN KKRRSGGDHH HKGDENSDES
710 720 730 740 750
DEEEEMDEID PDLRIELYIL EELRRGSARL RENHALQAVG ADKLLKLVAM
760 770 780 790 800
LDRNIRDAIS ADNQRLLVPC DDDVDVGDVL EKEICEERVK RASDAAVVAL
810 820 830 840 850
NIMSSHRMHK QVIIEDVIDR CVGLTRLLLI HLIYPASDSI YKSVNSKKKD
860 870 880 890 900
RAPEEARRRK KAGVCTRDKF SEYIYERITE AIGLLAVLVK SESMTDTSVH
910 920 930 940 950
NVASVALTPF FVANVGSLQI TAMLLASNIF SRAEDSLRFS MITDLLSSLH
960 970 980 990 1000
RAPQFTQKNS NNGYSLPDGS WISTTTALFI QLVQSTIKIP KFKKHADEDE
1010 1020 1030 1040 1050
LAKRSKKEEA MVKEGFLKAS KVTNAFLNGF LAKCSQKGNK MDGEEDYRIL
1060 1070 1080 1090 1100
FSNFLQELLS ALYSPEWPAA EMILTALGSL LVKNFRSKSS DMTIRQASLD
1110 1120 1130 1140 1150
YLGNITAKLR KDQKEAIAGE RRLDAVVKKS FLLLSDKGVE DYESVDISNL
1160 1170 1180 1190 1200
KQNDKLKVLE TSLIDYLVIT NSSDIIVYAC NFYVGEWYKE VAEDLESARS
1210 1220 1230 1240 1250
KLKQTVDTNE SEKDVKKAER KYEKIQYRGA EMKVFLSKIL DKKEIKRRLE
1260 1270 1280 1290 1300
KSNKVKMLDS DAFWAVKFLA QSREFTHSFD TYLKHIVFGA GSETIVALRS
1310 1320 1330 1340 1350
KALKCLSSII EADSSVLILE DVQQAVHTRM VDSHAQVRES AVELIGRFVL
1360 1370 1380 1390 1400
YDEEYVRKYY SQIAERILDT GVAVRKRVIR IMREICEKFP TFEMIPDMLA
1410 1420 1430 1440 1450
RMIRRVTDEE GVKKLVFETF TTLWFQPVDT RIYTNAVATK VTTMCSVAQH
1460 1470 1480 1490 1500
CIKDAMSDYL EQLILHIVKN GQEGSGMSVA VKQIIDSLVD HILNLEQHKS
1510 1520 1530 1540 1550
SENVSEVELM RRKEQEEKYM AYLSTLAVFS KIRPLLLTSH VEVLLPYLTF
1560 1570 1580 1590 1600
SGAKTNAENQ VTKEMIGMLE RVIPLVPFPS NIVLDSIDEN LCKVIMFNGM
1610 1620 1630 1640 1650
ALVVSAVSCV ASIYKKFKRG ATKTIDVFST YLKHLEVIKR NFDSNPRYDL
1660 1670 1680 1690 1700
DPKLFPILSR SIFTLGVLSR YFQFEEFVKE DPTEEKVEAL KEKVFITLEF
1710 1720 1730 1740 1750
FSRYHKGGLR QKALTAMGHF CAQHSTYLTK RQLTNTYLEI LNAANSPQQQ
1760 1770 1780 1790 1800
QQRILVLQNL EMFLQCEEQK LAASHDKWDE NKEAQNLKEM ELSGSGLGSS
1810 1820 1830 1840 1850
VIQKYWKAVL ESYVDADIQL RRAAVQVVWL TLNQGLVTPG ASIPTLIAMT
1860 1870 1880 1890 1900
TDPVDVIRNR IDILLKEIDS KYSGMVQSKA MQGVRLSYKL HLKLRMLQQE
1910 1920 1930 1940 1950
KFVRGFRFCD FHLNTLPNAL PEKTHDGMAV LSGLYQSLRT NRQQRRSFLQ
1960 1970 1980 1990 2000
SMVKLFSEEF SHDKPQLMEY IFIADNLAMF PYQMIDEPLY VMRQIDQNIA
2010 2020 2030 2040 2050
QTGQSLLVQY KLQLRMQESE DEDIVFLDEN MMSRLSQLGQ IETFHQLFLD
2060 2070 2080 2090 2100
SQVPSLLLYV RTFLMQLYGF NETKVAEYQP SEAAKVYEKA VTRRNIHMFK
2110 2120 2130 2140 2150
PITALEALNF PFEWGSFQHT AFLAEKICSF RKMLLSLDQV EEVEVSNTIT
2160 2170
AANDDYDEEE DGGEDSRGPI MEQMEH
Length:2,176
Mass (Da):249,784
Last modified:June 2, 2021 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB58B2406273EA9D
GO
Isoform bImported (identifier: Q95XZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1761: Missing.

Show »
Length:415
Mass (Da):48,010
Checksum:iA500C440931121DE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0610561 – 1761Missing in isoform b. CuratedAdd BLAST1761

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD71490.2
BX284602 Genomic DNA Translation: CTQ86543.1

NCBI Reference Sequences

More...
RefSeqi
NP_001300604.1, NM_001313675.1 [Q95XZ5-2]
NP_493687.2, NM_061286.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y43H11AL.3a.1; Y43H11AL.3a.1; WBGene00004166
Y43H11AL.3b.1; Y43H11AL.3b.1; WBGene00004166 [Q95XZ5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
173410

UCSC genome browser

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UCSCi
Y43H11AL.3, c. elegans [Q95XZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD71490.2
BX284602 Genomic DNA Translation: CTQ86543.1
RefSeqiNP_001300604.1, NM_001313675.1 [Q95XZ5-2]
NP_493687.2, NM_061286.3

3D structure databases

SMRiQ95XZ5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi38788, 3 interactors
IntActiQ95XZ5, 2 interactors
STRINGi6239.Y43H11AL.3

PTM databases

iPTMnetiQ95XZ5

Proteomic databases

EPDiQ95XZ5
PaxDbiQ95XZ5
PeptideAtlasiQ95XZ5
PRIDEiQ95XZ5

Genome annotation databases

EnsemblMetazoaiY43H11AL.3a.1; Y43H11AL.3a.1; WBGene00004166
Y43H11AL.3b.1; Y43H11AL.3b.1; WBGene00004166 [Q95XZ5-2]
GeneIDi173410
UCSCiY43H11AL.3, c. elegans [Q95XZ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
173410
WormBaseiY43H11AL.3a ; CE53800 ; WBGene00004166 ; scc-2
Y43H11AL.3b ; CE50846 ; WBGene00004166 ; scc-2

Phylogenomic databases

eggNOGiKOG1020, Eukaryota
GeneTreeiENSGT00390000010427
HOGENOMiCLU_000763_1_1_1
InParanoidiQ95XZ5
OMAiSANFKDR
OrthoDBi608077at2759
PhylomeDBiQ95XZ5

Enzyme and pathway databases

ReactomeiR-CEL-2470946, Cohesin Loading onto Chromatin

Miscellaneous databases

Protein Ontology

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PROi
PR:Q95XZ5

Gene expression databases

BgeeiWBGene00004166, Expressed in multi-cellular organism and 5 other tissues
ExpressionAtlasiQ95XZ5, baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR026003, Cohesin_HEAT
IPR024986, Nipped-B_C
IPR033031, SCC2/Nipped-B
PANTHERiPTHR21704, PTHR21704, 2 hits
PfamiView protein in Pfam
PF12765, Cohesin_HEAT, 1 hit
PF12830, Nipped-B_C, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNIPBL_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95XZ5
Secondary accession number(s): A0A0K3AU30
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 2, 2021
Last modified: September 29, 2021
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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