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Entry version 113 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Ectopic P granules protein 2

Gene

epg-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in autophagy (PubMed:20550938, PubMed:24140420, PubMed:24374177).

Thought to act as an adapter protein that brings PGL granules to autophagic structures containing lgg-1 (PubMed:20550938).

Association with other adapters such as sepa-1 is required for the accumulation and degradation of germ cell specific P-granules by autophagy in somatic cells (PubMed:24140420, PubMed:28806108).

This ensures exclusive localization of the P-granules in germ cells (PubMed:24140420, PubMed:28806108).

May also play a role in the removal of sepa-1 from somatic cells (PubMed:28806108).

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ectopic P granules protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:epg-2Imported
ORF Names:Y39G10AR.10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
Y39G10AR.10 ; CE26989 ; WBGene00021468 ; epg-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No colocalization of P-granule components with lgg-1 (PubMed:20550938). Furthermore, there is an accumulation of pgl-3 positive P-granules in somatic cells of embryos (PubMed:28806108). RNAi-mediated knockdown results in increased lgg-2-positive autophagosomes following fertilization and at later embryonic stages (PubMed:24374177).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi59 – 64KTYSTL → ATASTA: Impairs the interaction with lgg-1. 1 Publication6
Mutagenesisi381 – 385DFKIL → KAKIA: Abolishes the interaction with lgg-1. 1 Publication5
Mutagenesisi683 – 687EWEMV → KAKMA: Impairs the interaction with lgg-1. 1 Publication5
Mutagenesisi684 – 686WEM → FVE: Impairs the interaction with lgg-1. Abolishes the interaction with lgg-2. 1 Publication3
Mutagenesisi684W → A: Abolishes the interaction with lgg-1. 1 Publication1
Mutagenesisi684W → F: Abolishes the interaction with lgg-2, but not with lgg-1. 1 Publication1
Mutagenesisi685E → K: Abolishes the interaction with lgg-1. 1 Publication1
Mutagenesisi687V → A: Abolishes the interaction with lgg-1. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004047071 – 690Ectopic P granules protein 2Add BLAST690

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q95XR4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q95XR4

PeptideAtlas

More...
PeptideAtlasi
Q95XR4

PRoteomics IDEntifications database

More...
PRIDEi
Q95XR4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Aggregates of epg-2 peak in abundance at the 100 cell stage then decrease until they are very few at the comma stage (PubMed:20550938, PubMed:28806108). Absent from the 200 stage onwards (PubMed:24140420, PubMed:28806108).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00021468, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with sepa-1 (PubMed:24140420, PubMed:28806108).

Interacts (via the LIR motifs) with lgg-1 and lgg-2 (PubMed:26687600). Shows strong interaction with lgg-1 and weak interaction with lgg-2 (PubMed:26687600).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
37273, 8 interactors

Database of interacting proteins

More...
DIPi
DIP-27321N

Protein interaction database and analysis system

More...
IntActi
Q95XR4, 4 interactors

STRING: functional protein association networks

More...
STRINGi
6239.Y39G10AR.10

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q95XR4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni381 – 385Required for interaction with lgg-11 Publication5
Regioni666 – 690DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili20 – 181Sequence analysisAdd BLAST162
Coiled coili359 – 409Sequence analysisAdd BLAST51
Coiled coili458 – 494Sequence analysisAdd BLAST37
Coiled coili560 – 643Sequence analysisAdd BLAST84

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi61 – 64LIR 11 Publication4
Motifi684 – 687LIR 21 Publication4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi666 – 681Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LIR motifs (LC3-interacting region) are required for its interaction with lgg-1 and lgg-2.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502THXW, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_430982_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q95XR4

Identification of Orthologs from Complete Genome Data

More...
OMAi
AINQEMI

Database of Orthologous Groups

More...
OrthoDBi
1749076at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q95XR4

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q95XR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSANRTVTVF SSSAEDQEPI ELAEDSLQNL DKMLAEEKEE HQLLKDEVVL
60 70 80 90 100
LRKENVEAKT YSTLLEIMLD EAEEKASSAQ ETTSEENNLK ILNRDLVAEN
110 120 130 140 150
LELKEMKEEL RKIWLSDSKK FQEALTRISD ENTKLQKDCH ELESIRQCAQ
160 170 180 190 200
FALDNCNEEL EKTQTENEEH ESRIETLERE VCEKDIAMKD IVERKDEISL
210 220 230 240 250
QLELQTKEFT SALNDLMYGR EDTLKQIHQM KENWKVKQNE FEVEITKLKS
260 270 280 290 300
QNDYFDSERL QLTDRIRALL NELSDVRLEL GSTRLAMKEK AEVTEAVTSF
310 320 330 340 350
NKDLRDKLED EIARLGECLQ FRKDEHEQDE AVIAHLEEQL KLGSDKAAAF
360 370 380 390 400
SSEHSDTIEL LRESETELME LRMENYDLKE DFKILKEEKE DVNRTCECLR
410 420 430 440 450
EQLSTTIQER DIEKGQMQSE MDAKMVAVHQ QYAKQIDNMK YNHMLAINQE
460 470 480 490 500
LIKGQMALES GKKKHANEIL TVRNELEQSN AAHQSLRDQC SLLLSSEDDL
510 520 530 540 550
RTAHLALESK MTLVSEECIA LRVSRANAQK EIGNLTEHHK LEVALLEDAK
560 570 580 590 600
SGIQQRLHYA TIEIEQLKKI NEVTQAQFKK ETDEKNAEIN EFQAAMVSMK
610 620 630 640 650
QQYNVLGNHC RVLTSQGISD RTTIDKLQET IREHTELAIE TKRIHDAEIV
660 670 680 690
QLNDAHKKLV DNLGVEELDE EPKASTESEE KAEWEMVDEE
Length:690
Mass (Da):79,973
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40730553023C5BAE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO081209 Genomic DNA Translation: CCD69908.1

NCBI Reference Sequences

More...
RefSeqi
NP_490955.1, NM_058554.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y39G10AR.10.1; Y39G10AR.10.1; WBGene00021468

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
171787

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y39G10AR.10

UCSC genome browser

More...
UCSCi
Y39G10AR.10, c. elegans

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081209 Genomic DNA Translation: CCD69908.1
RefSeqiNP_490955.1, NM_058554.4

3D structure databases

SMRiQ95XR4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi37273, 8 interactors
DIPiDIP-27321N
IntActiQ95XR4, 4 interactors
STRINGi6239.Y39G10AR.10

Proteomic databases

EPDiQ95XR4
PaxDbiQ95XR4
PeptideAtlasiQ95XR4
PRIDEiQ95XR4

Genome annotation databases

EnsemblMetazoaiY39G10AR.10.1; Y39G10AR.10.1; WBGene00021468
GeneIDi171787
KEGGicel:CELE_Y39G10AR.10
UCSCiY39G10AR.10, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
171787
WormBaseiY39G10AR.10 ; CE26989 ; WBGene00021468 ; epg-2

Phylogenomic databases

eggNOGiENOG502THXW, Eukaryota
HOGENOMiCLU_430982_0_0_1
InParanoidiQ95XR4
OMAiAINQEMI
OrthoDBi1749076at2759
PhylomeDBiQ95XR4

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q95XR4

Gene expression databases

BgeeiWBGene00021468, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEPG2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95XR4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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