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Protein

Semaphorin-2A

Gene

mab-20

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. May also be involved in axon guidance.4 Publications

GO - Molecular functioni

  • semaphorin receptor binding Source: WormBase

GO - Biological processi

  • axonal fasciculation Source: WormBase
  • axon guidance Source: WormBase
  • embryonic body morphogenesis Source: WormBase
  • morphogenesis of embryonic epithelium Source: WormBase
  • nematode male tail mating organ morphogenesis Source: WormBase
  • nematode male tail tip morphogenesis Source: WormBase
  • regulation of actin cytoskeleton organization Source: WormBase
  • regulation of axon guidance Source: UniProtKB
  • regulation of cell adhesion Source: WormBase
  • regulation of cell migration Source: WormBase
  • semaphorin-plexin signaling pathway Source: WormBase

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

ReactomeiR-CEL-416700 Other semaphorin interactions
R-CEL-5173214 O-glycosylation of TSR domain-containing proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-2A
Short name:
Sema-2a
Alternative name(s):
Protein male abnormal 20
Gene namesi
Name:mab-20
ORF Names:Y71G12B.20
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY71G12B.20a ; CE22926 ; WBGene00003111 ; mab-20
Y71G12B.20b ; CE33246 ; WBGene00003111 ; mab-20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Worms have defects both in early embryonic morphogenesis and in postembryonic male tail morphogenesis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000024854720 – 658Semaphorin-2AAdd BLAST639

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi87 ↔ 97PROSITE-ProRule annotation
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi252 ↔ 360PROSITE-ProRule annotation
Glycosylationi275N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi276 ↔ 320PROSITE-ProRule annotation
Disulfide bondi479 ↔ 494PROSITE-ProRule annotation
Disulfide bondi488 ↔ 503PROSITE-ProRule annotation
Glycosylationi653N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ95XP4
PaxDbiQ95XP4
PeptideAtlasiQ95XP4
PRIDEiQ95XP4

PTM databases

iPTMnetiQ95XP4

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiWBGene00003111
ExpressionAtlasiQ95XP4 baseline

Interactioni

Subunit structurei

Interacts with plx-2.1 Publication

GO - Molecular functioni

  • semaphorin receptor binding Source: WormBase

Protein-protein interaction databases

IntActiQ95XP4, 1 interactor
STRINGi6239.Y71G12B.20a

Structurei

3D structure databases

ProteinModelPortaliQ95XP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 476SemaPROSITE-ProRule annotationAdd BLAST457
Domaini478 – 527PSIAdd BLAST50
Domaini556 – 592Ig-likeAdd BLAST37

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000119134
HOGENOMiHOG000154283
InParanoidiQ95XP4
OMAiWAYNIND
OrthoDBiEOG091G0QST
PhylomeDBiQ95XP4

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q95XP4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRNFLVFSVI FIAYNSCEAA NIQADNTFAD PNIGEFRELL IDPKAGALFV
60 70 80 90 100
GSEGAIFRLW AYNINDTGEN VFAKKQLVLS ESEESECRST ASDERLCRPS
110 120 130 140 150
TRFLAFTNNL DSIYVCSSVG MRPEIRVLDS LSLRDQQEPR TEIGICVVDP
160 170 180 190 200
TFNFTAVVVD SGNPEDATSV YSGIRTGMGG ENHLIYRPPL TKNGKQLHAS
210 220 230 240 250
IRTIYSDNKW LNEPQFVGSF DVGQHVFFFF REIAHDNSFG ERIVHSRVAR
260 270 280 290 300
VCKKDIGGRN VLRQVWTSFV KARLNCSVSA NFPFYFDHIQ SVKRVDKHGE
310 320 330 340 350
TYFYATFSTS ETAFTSSAIC MFQLSSINHL LDTGLLMEET ANGQFSVTAD
360 370 380 390 400
EIPAHRPGTC SQNSHSISDT DLHFAKTHLL VSDSISGGTP ILPLRDHVFT
410 420 430 440 450
HIVVDQLPNQ NVIFAFDSAN RRVWKISHWK EGNEWKSNLI EEKSLKIAAS
460 470 480 490 500
RINDVALLPA EFFFVTSGAG VSQFSVARCS EQPSCALCSL DPYCSWNAVN
510 520 530 540 550
SKCSLKTKTN EKSVGWISSS WAGRISPECS AVEKLTVKDV YLGDGLRLVG
560 570 580 590 600
AKNGVWQKDG RSVESGQRHV VTRNGELVVL DAQLEDAGTY ECLRDNIILV
610 620 630 640 650
RARIVVHENC ARPTSVAEYR SCQREWCKKA DAYKAALNIW SDSNKKNVQC

KANTSSAH
Length:658
Mass (Da):73,328
Last modified:December 1, 2001 - v1
Checksum:iF2AE83F7667D4F6E
GO
Isoform b (identifier: Q95XP4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-174: DATSVYSGI → GKQVRSIDK
     175-658: Missing.

Show »
Length:174
Mass (Da):19,373
Checksum:i1AF01FA3B5FEF043
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87C → Y in AAF60253 (PubMed:10648234).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020310166 – 174DATSVYSGI → GKQVRSIDK in isoform b. Curated9
Alternative sequenceiVSP_020311175 – 658Missing in isoform b. CuratedAdd BLAST484

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216968 mRNA Translation: AAF60253.2
FO080942 Genomic DNA Translation: CCD67974.1
FO080942 Genomic DNA Translation: CCD67975.1
RefSeqiNP_001021820.1, NM_001026649.3 [Q95XP4-2]
NP_490875.1, NM_058474.4 [Q95XP4-1]
UniGeneiCel.39551
Cel.7500

Genome annotation databases

EnsemblMetazoaiY71G12B.20a; Y71G12B.20a; WBGene00003111 [Q95XP4-1]
GeneIDi171727
KEGGicel:CELE_Y71G12B.20
UCSCiY71G12B.20a c. elegans [Q95XP4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSEM2A_CAEEL
AccessioniPrimary (citable) accession number: Q95XP4
Secondary accession number(s): Q86LT8, Q9NI38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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