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Entry version 179 (26 Feb 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Forkhead box protein O

Gene

foxo

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thor\d4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi95 – 201Fork-headPROSITE-ProRule annotationAdd BLAST107

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processCell cycle, Differentiation, Growth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-110478 Insulin signaling pathway
R-DME-1181150 Signaling by NODAL
R-DME-198693 AKT phosphorylates targets in the nucleus
R-DME-211163 AKT-mediated inactivation of FOXO1A
R-DME-5687128 MAPK6/MAPK4 signaling
R-DME-5689880 Ub-specific processing proteases
R-DME-9614399 Regulation of localization of FOXO transcription factors
R-DME-9617629 Regulation of FOXO transcriptional activity by acetylation
R-DME-9617828 FOXO-mediated transcription of cell cycle genes
R-DME-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q95V55

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Forkhead box protein O1 Publication
Short name:
dFOXO1 Publication
Alternative name(s):
Protein FKHR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:foxoImported
Synonyms:Afx
ORF Names:CG3143
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0038197 foxo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant foxo lacking Akt1 phosphorylation sites no longer responds to insulin inhibition, remains in the nucleus, and is constitutively active, inducing cell arrest.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi44T → A: Abolishes phosphorylation; when associated with A-190 and A-259. 1 Publication1
Mutagenesisi190S → A: Abolishes phosphorylation; when associated with A-44 and A-259. 1 Publication1
Mutagenesisi259S → A: Abolishes phosphorylation; when associated with A-44 and A-190. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003714361 – 613Forkhead box protein OAdd BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei44Phosphothreonine; by PKB/AKT11 Publication1
Modified residuei75Phosphoserine1 Publication1
Modified residuei190Phosphoserine; by PKB/AKT11 Publication1
Modified residuei259Phosphoserine; by PKB/AKT11 Publication1
Modified residuei262Phosphoserine1 Publication1
Modified residuei263Phosphoserine1 Publication1
Modified residuei268Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q95V55

PRoteomics IDEntifications database

More...
PRIDEi
Q95V55

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q95V55

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0038197 Expressed in tagma (Drosophila) and 44 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q95V55 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q95V55 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with melt.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q8I9J63EBI-500849,EBI-4288282

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
66786, 182 interactors

Protein interaction database and analysis system

More...
IntActi
Q95V55, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0293589

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q95V55

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi314 – 569Gln-richSequence analysisAdd BLAST256

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2294 Eukaryota
COG5025 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170843

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q95V55

KEGG Orthology (KO)

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KOi
K09408

Identification of Orthologs from Complete Genome Data

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OMAi
CLHNARD

Family and domain databases

Conserved Domains Database

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CDDi
cd00059 FH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001766 Fork_head_dom
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00250 Forkhead, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00053 FORKHEAD

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00339 FH, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform B1 Publication (identifier: Q95V55-1) [UniParc]FASTAAdd to basket
Also known as: C1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMDGYAQEWP RLTHTDNGLA MDQLGGDLPL DVGFEPQTRA RSNTWPCPRP
60 70 80 90 100
ENFVEPTDEL DSTKASNQQL APGDSQQAIQ NANAAKKNSS RRNAWGNLSY
110 120 130 140 150
ADLITHAIGS ATDKRLTLSQ IYEWMVQNVP YFKDKGDSNS SAGWKNSIRH
160 170 180 190 200
NLSLHNRFMR VQNEGTGKSS WWMLNPEAKP GKSVRRRAAS METSRYEKRR
210 220 230 240 250
GRAKKRVEAL RQAGVVGLND ATPSPSSSVS EGLDHFPESP LHSGGGFQLS
260 270 280 290 300
PDFRQRASSN ASSCGRLSPI RAQDLEPDWG FPVDYQNTTM TQAHAQALEE
310 320 330 340 350
LTGTMADELT LCNQQQQGFS AASGLPSQPP PPPYQPPQHQ QAQQQQQQQS
360 370 380 390 400
PYALNGPASG YNTLQPQSQC LLHRSLNCSC MHNARDGLSP NSVTTTMSPA
410 420 430 440 450
YPNSEPSSDS LNTYSNVVLD GPADTAALMV QQQQQQQQQQ QLSASLEGQC
460 470 480 490 500
LEVLNNEAQP IDEFNLENFP VGNLECNVEE LLQQEMSYGG LLDINIPLAT
510 520 530 540 550
VNTNLVNSSS GPLSISNISN LSNISSNSGS SLSLNQLQAQ LQQQQQQQQA
560 570 580 590 600
QQQQQAQQQQ QQHQQHQQQL LLNNNNNSSS SLELATQTAT TNLNARVQYS
610
QPSVVTSPPS WVH
Length:613
Mass (Da):67,413
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB472822ACA169BF9
GO
Isoform A1 Publication (identifier: Q95V55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-243: NSIRHNLSLH...DHFPESPLHS → SFAINALLSS...APQVTINCDD

Show »
Length:798
Mass (Da):87,696
Checksum:iD2FC95047EC055DD
GO
Isoform D1 Publication (identifier: Q95V55-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-304: NSIRHNLSLH...AQALEELTGT → DLQILQFFYI...CQFLRTPEPH
     305-613: Missing.

Show »
Length:304
Mass (Da):33,832
Checksum:i677D0D71F2B8EC54
GO
Isoform E1 Publication (identifier: Q95V55-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-447: NSIRHNLSLH...QQQQLSASLE → SFAINALLSS...CQFLRTPEPH
     448-613: Missing.

Show »
Length:448
Mass (Da):49,960
Checksum:i1642D86999B6C997
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KGN1A0A0B4KGN1_DROME
Forkhead box, sub-group O, isoform ...
foxo 3143, Afx, anon-WO0118547.374, cg3143, DFOXO
622Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A126GUT4A0A126GUT4_DROME
Forkhead box, sub-group O, isoform ...
foxo 3143, Afx, anon-WO0118547.374, cg3143, DFOXO
619Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL13947 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053039146 – 447NSIRH…SASLE → SFAINALLSSDRFSFCLHRS IPPLAVIKDQRLLKNSLRWL RRNRRRLFHLIPETLFFADS ALPANFSFFLRRLVVVRWFR GLADRWFGGSVARVFIIENS SSQSGDLAIEPVPKFYELST NQSECKWQSGMAVDKTWIIG GDPVSATCRDSVSPISRSNG PMKYAYLIRDDSVSWGSNEL HTSQSVAAQPLYEGPKRGHR QVILVDAQPGGQARQVCAPP CRFHGDVPVREAARQGQEAG GGTASGGRGGPQRCHALAQQ QRQRGAGSLSRESAPQWRWL PIIARFPATRLIQCQFLRTP EPH in isoform E. 1 PublicationAdd BLAST302
Alternative sequenceiVSP_053040146 – 304NSIRH…ELTGT → DLQILQFFYIQYISVFAKYI YLYVHICFSLVLVTELHTSQ SVAAQPLYEGPKRGHRQVIL VDAQPGGQARQVCAPPCRFH GDVPVREAARQGQEAGGGTA SGGRGGPQRCHALAQQQRQR GAGSLSRESAPQWRWLPIIA RFPATRLIQCQFLRTPEPH in isoform D. 1 PublicationAdd BLAST159
Alternative sequenceiVSP_053041146 – 243NSIRH…SPLHS → SFAINALLSSDRFSFCLHRS IPPLAVIKDQRLLKNSLRWL RRNRRRLFHLIPETLFFADS ALPANFSFFLRRLVVVRWFR GLADRWFGGSVARVFIIENS SSQSGDLAIEPVPKFYELST NQSECKWQSGMAVDKTWIIG GDPVSATCRDSVSPISRSNG PMKYAYLIRDDSVSWGSNEL HTSQSVAAQPLYEGPKRGHR QVILVDAQPGGQARQVCAPP CRFHGDVPVREAARQGQEAG GGTASGGRGGPQRCHALAQQ QRQRGAGSLSRESAPQVTIN CDD in isoform A. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_053042305 – 613Missing in isoform D. 1 PublicationAdd BLAST309
Alternative sequenceiVSP_053043448 – 613Missing in isoform E. 1 PublicationAdd BLAST166

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF426831 mRNA Translation: AAL28078.1
AF416728 mRNA Translation: AAL09043.1
AE014297 Genomic DNA Translation: AAF55012.2
AE014297 Genomic DNA Translation: AAS65147.1
AE014297 Genomic DNA Translation: AAS65148.1
AE014297 Genomic DNA Translation: ACL83512.1
AY058718 mRNA Translation: AAL13947.1 Different initiation.
AY089542 mRNA Translation: AAL90280.1

NCBI Reference Sequences

More...
RefSeqi
NP_001262557.1, NM_001275628.1
NP_650330.3, NM_142073.5
NP_996204.1, NM_206482.3 [Q95V55-1]
NP_996205.1, NM_206483.3 [Q95V55-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082886; FBpp0089343; FBgn0038197 [Q95V55-1]
FBtr0082887; FBpp0089344; FBgn0038197 [Q95V55-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
41709

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG3143

UCSC genome browser

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UCSCi
CG3143-RA d. melanogaster
CG3143-RB d. melanogaster [Q95V55-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426831 mRNA Translation: AAL28078.1
AF416728 mRNA Translation: AAL09043.1
AE014297 Genomic DNA Translation: AAF55012.2
AE014297 Genomic DNA Translation: AAS65147.1
AE014297 Genomic DNA Translation: AAS65148.1
AE014297 Genomic DNA Translation: ACL83512.1
AY058718 mRNA Translation: AAL13947.1 Different initiation.
AY089542 mRNA Translation: AAL90280.1
RefSeqiNP_001262557.1, NM_001275628.1
NP_650330.3, NM_142073.5
NP_996204.1, NM_206482.3 [Q95V55-1]
NP_996205.1, NM_206483.3 [Q95V55-1]

3D structure databases

SMRiQ95V55
ModBaseiSearch...

Protein-protein interaction databases

BioGridi66786, 182 interactors
IntActiQ95V55, 4 interactors
STRINGi7227.FBpp0293589

PTM databases

iPTMnetiQ95V55

Proteomic databases

PaxDbiQ95V55
PRIDEiQ95V55

Genome annotation databases

EnsemblMetazoaiFBtr0082886; FBpp0089343; FBgn0038197 [Q95V55-1]
FBtr0082887; FBpp0089344; FBgn0038197 [Q95V55-1]
GeneIDi41709
KEGGidme:Dmel_CG3143
UCSCiCG3143-RA d. melanogaster
CG3143-RB d. melanogaster [Q95V55-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
41709
FlyBaseiFBgn0038197 foxo

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00940000170843
InParanoidiQ95V55
KOiK09408
OMAiCLHNARD

Enzyme and pathway databases

ReactomeiR-DME-110478 Insulin signaling pathway
R-DME-1181150 Signaling by NODAL
R-DME-198693 AKT phosphorylates targets in the nucleus
R-DME-211163 AKT-mediated inactivation of FOXO1A
R-DME-5687128 MAPK6/MAPK4 signaling
R-DME-5689880 Ub-specific processing proteases
R-DME-9614399 Regulation of localization of FOXO transcription factors
R-DME-9617629 Regulation of FOXO transcriptional activity by acetylation
R-DME-9617828 FOXO-mediated transcription of cell cycle genes
R-DME-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
SignaLinkiQ95V55

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
foxo fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
41709

Protein Ontology

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PROi
PR:Q95V55

Gene expression databases

BgeeiFBgn0038197 Expressed in tagma (Drosophila) and 44 other tissues
ExpressionAtlasiQ95V55 baseline and differential
GenevisibleiQ95V55 DM

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOXO_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95V55
Secondary accession number(s): Q7KF42, Q95TK1, Q9VFN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 1, 2001
Last modified: February 26, 2020
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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