Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 144 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
Add a publicationFeedback
Protein

Netrin receptor unc-5

Gene

unc-5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • netrin receptor activity involved in chemorepulsion Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-373752, Netrin-1 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Netrin receptor unc-5
Alternative name(s):
Unc5 netrin receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-5
ORF Names:CG8166
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0034013, unc-5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 440ExtracellularSequence analysisAdd BLAST410
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 1072CytoplasmicSequence analysisAdd BLAST611

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003608231 – 1072Netrin receptor unc-5Add BLAST1042

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi149 ↔ 207By similarity
Disulfide bondi253 ↔ 303By similarity
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi336 ↔ 375By similarity
Disulfide bondi338 ↔ 378By similarity
Disulfide bondi352 ↔ 364By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on different cytoplasmic tyrosine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q95TU8

PRoteomics IDEntifications database

More...
PRIDEi
Q95TU8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Prior to gastrulation, it is strongly expressed in the presumptive mesoderm. Mesodermal expression begins to fade during stages 13-14, persisting only in the cells that form the dorsal vessel. Expressed within the CNS from late stage 13, shortly after the first axons have extended. Detected in several dispersed clusters of cells within the CNS, increasing in number as development proceeds. Also expressed in the peripheral and exit glia, which migrate laterally out of the CNS between stages 14 and 17. Strongly expressed in motor axons that exit the CNS ipsilaterally via the segmental nerve root (SN). Not expressed on either commissural or longitudinal axons within the CNS, nor on motor axons that exit via the intersegmental nerve (ISN). In the periphery, it is detected on all branches of the SN. Also expressed at high level in exit and peripheral glia along both the SN and ISN.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0034013, Expressed in embryo and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q95TU8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q95TU8, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
62440, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q95TU8, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086514

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q95TU8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini128 – 224Ig-likeAdd BLAST97
Domaini232 – 314Ig-like C2-typeAdd BLAST83
Domaini324 – 379TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini398 – 499TSP type-1 2PROSITE-ProRule annotationAdd BLAST102
Domaini654 – 802ZU5PROSITE-ProRule annotationAdd BLAST149
Domaini980 – 1067DeathPROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 100DisorderedSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the unc-5 family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1480, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182815

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014383_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q95TU8

Identification of Orthologs from Complete Genome Data

More...
OMAi
QTAECRG

Database of Orthologous Groups

More...
OrthoDBi
334938at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q95TU8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 1 hit
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR037936, UNC5
IPR033772, UPA
IPR000906, ZU5_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12582, PTHR12582, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00531, Death, 1 hit
PF07679, I-set, 1 hit
PF00090, TSP_1, 2 hits
PF17217, UPA, 1 hit
PF00791, ZU5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00005, DEATH, 1 hit
SM00409, IG, 2 hits
SM00408, IGc2, 1 hit
SM00209, TSP1, 2 hits
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48726, SSF48726, 1 hit
SSF82895, SSF82895, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50017, DEATH_DOMAIN, 1 hit
PS50835, IG_LIKE, 1 hit
PS50092, TSP1, 2 hits
PS51145, ZU5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q95TU8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVINKAGNV IALLLVKLQL ILLFTLSVSG ELPQLDYGSL SASLEEDAID
60 70 80 90 100
PLTAMAPFAN SLVTEESAQH KNNAELLGNS SEDENVRPQQ GSSSSGLGSS
110 120 130 140 150
GAAGGSGILL EEFNSGKLSP GEASNTLPIF LIEPESVFVV KNRPAVLKCK
160 170 180 190 200
ASHSLQVIFK CSGSSQPPPS THETHVDPHT GVNMEEVTAT IHRDLVDEFF
210 220 230 240 250
GDGPFKCECH AWSSRGVVKS QAATVHIAYI RKSFNQSPTS LRLELGSRAE
260 270 280 290 300
LRCEPPGGFP EPKLTWHKNN AVITADSEPG ITVSAGTLIF RQVALQHMAN
310 320 330 340 350
YSCSAENIAG RRVSDSAVLI VYVNGGWSTW SPWRECKCAG KPSQGRKRSR
360 370 380 390 400
TCNNPMPLNG GAQCPGPQIQ KSADCAACPE DTQIVSPDGF DISSSKRMAR
410 420 430 440 450
WSAWSDWSIC SAECIQVRRR KCLTQGQTQI SSEAEEAGDL LLGAPGVGMA
460 470 480 490 500
ALIAAAGVGA VGSPSEATGS SSDIIPGYGK SLCAGKDIQT AECRGEQCQI
510 520 530 540 550
GKDDFDWTLY LGLAFITAVC FAFGTALICC ARRGIRTNPH YNMARSVMDA
560 570 580 590 600
DYMPGVVEKK EMRMHIEASN MGYDYVNPGH RYLPGEHIMG MGIGCGGVTE
610 620 630 640 650
HHYDVPNLSA NYTNPIDHLS VDYLSETGES STADTSNSTF DMNGKLSILN
660 670 680 690 700
ASKSSTYEML GSAGGQLRLY GGELLLFVPE HAIGKHVKKH VSLLLLSDEC
710 720 730 740 750
SRVSCATESS ILCSSVVHSA PRNYSFVKPV ILKIPHCLVA PEQWHVHIYH
760 770 780 790 800
ADSEHDELSV NWRRAVSVGE ETINTPMFVQ LEATHVFIMT EQLGHFTVVA
810 820 830 840 850
EPRIQQPSIK MKLLAFSQHT PPSNANCSLR IYVVKDFPNS RDICANVEAK
860 870 880 890 900
LGGSFLGESQ VFAFTLNSRN LNIRVRSADV EAAAPYEHAI PYQHILSNNS
910 920 930 940 950
ILHCEFSLRR QDQNSLCVDF GQGSEDDYYT FNIPAHSMSG SAEELASTTN
960 970 980 990 1000
TTISIDRQGN YVNESCVMDF VQLPHATKRL ICGALDPPRA DERDWRLLAK
1010 1020 1030 1040 1050
KLNTDRYIAY FATKASPTEQ ILNLWECRAN SSPGSSSNSV SHTIMALLLT
1060 1070
LKEMGRQDVL DIIVETIGPL WI
Length:1,072
Mass (Da):116,418
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0A6B5A96B10138F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LFH9A0A0B4LFH9_DROME
Netrin receptor UNC5
unc-5 AAF7419, CG8168, CT20824, Dmel\CG8166, Dunc5
1,072Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti885P → S in AAF74193 (PubMed:11719202).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF247762 mRNA Translation: AAF74193.1
AE013599 Genomic DNA Translation: AAF58143.2
AY058501 mRNA Translation: AAL13730.1

NCBI Reference Sequences

More...
RefSeqi
NP_001286450.1, NM_001299521.1
NP_611033.2, NM_137189.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087382; FBpp0086514; FBgn0034013
FBtr0339998; FBpp0309017; FBgn0034013

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36703

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8166

UCSC genome browser

More...
UCSCi
CG8166-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247762 mRNA Translation: AAF74193.1
AE013599 Genomic DNA Translation: AAF58143.2
AY058501 mRNA Translation: AAL13730.1
RefSeqiNP_001286450.1, NM_001299521.1
NP_611033.2, NM_137189.3

3D structure databases

SMRiQ95TU8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi62440, 8 interactors
IntActiQ95TU8, 3 interactors
STRINGi7227.FBpp0086514

Proteomic databases

PaxDbiQ95TU8
PRIDEiQ95TU8

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
36703

Genome annotation databases

EnsemblMetazoaiFBtr0087382; FBpp0086514; FBgn0034013
FBtr0339998; FBpp0309017; FBgn0034013
GeneIDi36703
KEGGidme:Dmel_CG8166
UCSCiCG8166-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36703
FlyBaseiFBgn0034013, unc-5

Phylogenomic databases

eggNOGiKOG1480, Eukaryota
GeneTreeiENSGT00950000182815
HOGENOMiCLU_014383_0_0_1
InParanoidiQ95TU8
OMAiQTAECRG
OrthoDBi334938at2759
PhylomeDBiQ95TU8

Enzyme and pathway databases

ReactomeiR-DME-373752, Netrin-1 signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36703, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36703

Protein Ontology

More...
PROi
PR:Q95TU8

Gene expression databases

BgeeiFBgn0034013, Expressed in embryo and 24 other tissues
ExpressionAtlasiQ95TU8, baseline and differential
GenevisibleiQ95TU8, DM

Family and domain databases

Gene3Di2.20.100.10, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR037936, UNC5
IPR033772, UPA
IPR000906, ZU5_dom
PANTHERiPTHR12582, PTHR12582, 1 hit
PfamiView protein in Pfam
PF00531, Death, 1 hit
PF07679, I-set, 1 hit
PF00090, TSP_1, 2 hits
PF17217, UPA, 1 hit
PF00791, ZU5, 1 hit
SMARTiView protein in SMART
SM00005, DEATH, 1 hit
SM00409, IG, 2 hits
SM00408, IGc2, 1 hit
SM00209, TSP1, 2 hits
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48726, SSF48726, 1 hit
SSF82895, SSF82895, 2 hits
PROSITEiView protein in PROSITE
PS50017, DEATH_DOMAIN, 1 hit
PS50835, IG_LIKE, 1 hit
PS50092, TSP1, 2 hits
PS51145, ZU5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUNC5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95TU8
Secondary accession number(s): Q9NBL0, Q9V7B5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again