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Entry version 190 (29 Sep 2021)
Sequence version 1 (01 Dec 2001)
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Protein
Submitted name:

G9a, isoform A

Gene

G9a

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferaseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
G9a, isoform AImported (EC:2.1.1.354Imported)
Submitted name:
LD10743pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:G9aImported
Synonyms:cab65850 G9a DmImported, dG9aImported, Dmel\CG2995Imported, EG:BACR37P7.2Imported, EHMTImported
ORF Names:CG2995Imported, Dmel_CG2995Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0040372, G9a

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0040372

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0040372, Expressed in egg chamber and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q95RU8, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q95RU8, 8 interactors

Molecular INTeraction database

More...
MINTi
Q95RU8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q95RU8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1155 – 1177ANKPROSITE-ProRule annotationAdd BLAST23
Repeati1198 – 1230ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1231 – 1264ANKPROSITE-ProRule annotationAdd BLAST34
Repeati1265 – 1297ANKPROSITE-ProRule annotationAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1396 – 1460Pre-SETInterPro annotationAdd BLAST65
Domaini1463 – 1578SETInterPro annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni51 – 75DisorderedSequence analysisAdd BLAST25
Regioni94 – 192DisorderedSequence analysisAdd BLAST99
Regioni239 – 275DisorderedSequence analysisAdd BLAST37
Regioni315 – 389DisorderedSequence analysisAdd BLAST75
Regioni482 – 519DisorderedSequence analysisAdd BLAST38
Regioni543 – 589DisorderedSequence analysisAdd BLAST47
Regioni632 – 688DisorderedSequence analysisAdd BLAST57
Regioni989 – 1013DisorderedSequence analysisAdd BLAST25
Regioni1604 – 1637DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi94 – 136Basic and acidic residuesSequence analysisAdd BLAST43
Compositional biasi148 – 162Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi169 – 192Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi239 – 258Polar residuesSequence analysisAdd BLAST20
Compositional biasi362 – 381Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi485 – 503Polar residuesSequence analysisAdd BLAST19
Compositional biasi505 – 519Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi553 – 570Polar residuesSequence analysisAdd BLAST18
Compositional biasi648 – 663Basic residuesSequence analysisAdd BLAST16

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000172292

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTDIVSF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q95RU8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR043550, EHMT1/EHMT2
IPR007728, Pre-SET_dom
IPR001214, SET_dom

The PANTHER Classification System

More...
PANTHERi
PTHR46307, PTHR46307, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF05033, Pre-SET, 1 hit
PF00856, SET, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits
SM00468, PreSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50088, ANK_REPEAT, 4 hits
PS50867, PRE_SET, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q95RU8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDFVELMNS MSSTFNSDCA TSTAEGGTLL NLNLAEDKTL KWRNLANNQF
60 70 80 90 100
ASKEKKHKDK EEEERKEARN QEEIEDIKAL LADVVDAAAV KLEEEEAQNA
110 120 130 140 150
EKVEPHTKCE IEEEGRKEME YDQDVAKQDS EMEKKQNGKA TSITVKMESN
160 170 180 190 200
ERAEKHATEI ATTSTERWEN ESFKTEQQNK KAAEKEEEPI LAATQKLEAN
210 220 230 240 250
AEPLTTTRIE VAVASPLVVS SASVKLAADA TNQMRAATSA GAATLADKNV
260 270 280 290 300
QVSPGGTRRS RRTPRPIDTP TSVTDEHVQV ENKKFGKSEQ YTDCSSHLER
310 320 330 340 350
FTLDDNTAIV RLQLKSEPDK PSLTALSPEE NSAPAPKRGR GRARKIRPDA
360 370 380 390 400
EVETSEVILP CEDSLGEKKP GRKRKLPDEP IDQQQLSDLV VVKTEQEELG
410 420 430 440 450
DAPLGDVKRM RRSVRLGNRL HADGSPWEEV KTEALHPQPS AELSFAEVTS
460 470 480 490 500
EILPLAVLDE KTPPKKRGRK AKTPCVKLES ETSCGLPFAN GNKKTNSSGG
510 520 530 540 550
CELQLPKRSK RRIKPTPKIL ENDELRCEFE TKHIERMTQW ESAAAVDGDF
560 570 580 590 600
ETPTTGGNGS NSSTSRQKSD KSDGSNFEGG PGHPAGTSAI KKRLFSKSQR
610 620 630 640 650
DIENYGAAML AKSKLPPCPD VEQFLNDIKA SRINANRSPE ERKLNKKQQR
660 670 680 690 700
KLAKQKEKHL KHLGLQKNHR DEPSDNDSSN TDNEFFPTTR VQVGKPSVTL
710 720 730 740 750
RVRNSVTKEL PTTATLKSRR NPVVQAAKLT RRIGARAAGE VTEAARASVP
760 770 780 790 800
ISTPDAEQLH SLDTSIQADV TPIRDLDMRP STSRVSKFIC LCQKPSQYYA
810 820 830 840 850
RNAPDSSYCC AIDHIDDQKI GCCNELSSEV HNLLRPSQRV SYMILCDEHK
860 870 880 890 900
KRLQSHNCCA GCGIFCTQGK FVLCKQQHFF HPDCAQRFIL STSYEKELGD
910 920 930 940 950
EEDQGVKFSS PVLVLKCPHC GLDTPERTST VTMKCQSLPV FLRTQKYKIK
960 970 980 990 1000
PARLTTSSHL TQFGTVENAN TPGATARNKG GLSTAVTLSA ASSPASKTNG
1010 1020 1030 1040 1050
AQRGRAGTSN SNSRHALNSI NFAQLIPESV MNVVLRGHVV SASGRVTAEF
1060 1070 1080 1090 1100
TPRDMYYAVQ NDDLERVAEI LAADFNVLTP IREYLNGTCL HLVAHSGTLQ
1110 1120 1130 1140 1150
MAYLLLCKGA SSPDFVNIVD YELRTALMCA VMNEKCDMLN LFLQCGADVA
1160 1170 1180 1190 1200
IKGPDGKTSL HIAAQLGNLE ATQLIVDSYR TSRNITSFLS FIDAQDEGGW
1210 1220 1230 1240 1250
TAMVWAAELG HTDIVSFLLN QDADPNICDN DNNTVLHWST LHNDGLDTIT
1260 1270 1280 1290 1300
VLLQSGADCN VQNVEGDTPL HIACRHSVTR MCIALIANGA DLMIKNKAEQ
1310 1320 1330 1340 1350
LPFDCIPNEE SECGRTVGFN MQMRSFRPLG LRTFVVCADA SNGREARPIQ
1360 1370 1380 1390 1400
VVRNELAMSE NEDEADSLMW PDFRYVTQCI IQQNSVQIDR RVSQMRICSC
1410 1420 1430 1440 1450
LDSCSSDRCQ CNGASSQNWY TAESRLNADF NYEDPAVIFE CNDVCGCNQL
1460 1470 1480 1490 1500
SCKNRVVQNG TRTPLQIVEC EDQAKGWGVR ALANVPKGTF VGSYTGEILT
1510 1520 1530 1540 1550
AMEADRRTDD SYYFDLDNGH CIDANYYGNV TRFFNHSCEP NVLPVRVFYE
1560 1570 1580 1590 1600
HQDYRFPKIA FFSCRDIDAG EEICFDYGEK FWRVEHRSCV GCRCLTTTCK
1610 1620 1630
YASQSSSTNA SPTNATTAPE NETGTLSSTN TEKIGHA
Length:1,637
Mass (Da):181,242
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1DCC1356F1DDC88
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PGH7M9PGH7_DROME
G9a, isoform B
G9a cab65850 G9a Dm, dG9a, Dmel\CG2995, EG:BACR37P7.2, EHMT
1,657Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45487.2
AY061125 mRNA Translation: AAL28673.1

NCBI Reference Sequences

More...
RefSeqi
NP_569834.1, NM_130478.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070063; FBpp0070062; FBgn0040372

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
30971

UCSC genome browser

More...
UCSCi
CG2995-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45487.2
AY061125 mRNA Translation: AAL28673.1
RefSeqiNP_569834.1, NM_130478.3

3D structure databases

SMRiQ95RU8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ95RU8, 8 interactors
MINTiQ95RU8

Genome annotation databases

EnsemblMetazoaiFBtr0070063; FBpp0070062; FBgn0040372
GeneIDi30971
UCSCiCG2995-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30971
FlyBaseiFBgn0040372, G9a
VEuPathDBiVectorBase:FBgn0040372

Phylogenomic databases

GeneTreeiENSGT00940000172292
OMAiHTDIVSF
PhylomeDBiQ95RU8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
30971, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
30971

Gene expression databases

BgeeiFBgn0040372, Expressed in egg chamber and 39 other tissues
ExpressionAtlasiQ95RU8, baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR043550, EHMT1/EHMT2
IPR007728, Pre-SET_dom
IPR001214, SET_dom
PANTHERiPTHR46307, PTHR46307, 4 hits
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF05033, Pre-SET, 1 hit
PF00856, SET, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM00468, PreSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 4 hits
PS50867, PRE_SET, 1 hit
PS50280, SET, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ95RU8_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95RU8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 29, 2021
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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